Protein Alignment AOX2 and Aox3

DIOPT Version :10

• Sequence 1: NP_732047.2
• Gene: AOX2 / 41895
• FlyBaseID: FBgn0038348
• Length: 1264
• Species: Drosophila melanogaster
• Sequence 2: NP_076106.2
• Gene: Aox3 / 71724
• MGIID: 1918974
• Length: 1335
• Species: Mus musculus
• Alignment Length: 1345
• Identity: 400/1345 - (29%)
• Similarity: 633/1345 - (47%)
• Gaps: 147/1345 - (10%)

  Fly     5 FNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSRAA 69
            |.|||.....:.||  |:..|..:||:.:.||.|||.|..|.||:|..:|.|..|:::.:...:|
Mouse    12 FFVNGKKVTERNAD--PEVNLLFYLRKVIRLTGTKYGCGGGDCGACTVMISRYDPISKRISHFSA 74

  Fly    70 NSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRGQV 134
            .:||..:.:...|.:.|.||:|:..:..||:|:|:|:.:|||||:|:||.||::|.||..| .:.
Mouse    75 TACLVPICSLHGAAVTTVEGIGSTKTRIHPVQERIAKGHGTQCGFCTPGMVMSIYTLLRNH-PEP 138

  Fly   135 SMSQVEDAFGGNLCRCTGYRPILDAMKSF---------------AVDSNVEVP------------ 172
            |..|:.:..|||||||||||||:::.|||               .:|.....|
Mouse   139 STEQIMETLGGNLCRCTGYRPIVESAKSFCPSSTCCQMNGEGKCCLDEEKNEPERKNSVCTKLYE 203

  Fly   173 -AESVDIEDSFELLCPRTGQSCKGSCSRPPLRDHGD-SQWYWPKTLTELFGALSQVANGELYM-- 233
             .|...::.:.||:.|..............|...|: :.|..|.||.:|.         ||.|
Mouse   204 KKEFQPLDPTQELIFPPELMRMAEESQNTVLTFRGERTTWIAPGTLNDLL---------ELKMKH 259

  Fly   234 ----LVAGNTAHGVYRRPRDIRHFIDVN--MVPELRQYSIETDHLLLGGNVTLTDAMQVFLLAAK 292
                ||.|||..|::.:..|:.:.|.::  .:.||...:.....|.||..::||....|......
Mouse   260 PSAPLVIGNTYLGLHMKFTDVSYPIIISPARILELFVVTNTKQGLTLGAGLSLTQVKNVLSDVVS 324

  Fly   293 RPGFE----YCAQLWQHFNLIANVPVRNNGTLAGNINIKKQHFEFP-SDVFITFEALDVHVLVYD 352
            |...|    |||.|.| ...:|...:||..:|.|:|..:     .| ||:   ...|.:...:.:
Mouse   325 RLPKEKTQIYCALLKQ-LKTLAGQQIRNVASLGGHIISR-----LPTSDL---NPILGIGNCILN 380

  Fly   353 NPSTQRVMNL------LTYLGDTTSK---LVLGGFILKAYPKDRFLFRSYKILPRAQNVHAYVNA 408
            ..||:.:..:      |..:.|...|   :::..|:.:: .|..|: .:::..||.||..|.|||
Mouse   381 VASTEGIQQIPLNDHFLAGVPDAILKPEQVLISVFVPRS-SKWEFV-SAFRQAPRQQNAFATVNA 443

  Fly   409 GFLIEWQDIQHRIVHSARICFGNIRPDYIHDDQVEQLLPGR----DLYDPATVAQIFQELPASLQ 469
            |..:.:::..:.|. ...|.:|.|....|..|:..:.|.||    ::.|.|. ..|.:|:...:
Mouse   444 GMKVVFKEDTNTIT-DLGILYGGIGATVISADKSCRQLIGRCWDEEMLDDAG-KMICEEVSLLM- 505

  Fly   470 PEERPPEASPEYRQMLACSLLYKFLLATAPKERVRERFRTGG-------LLLERPLSS--GSQSF 525
               ..|....|||:.||.|.|:.|.|....:.:.|:..:...       :|.:.||:.  |.|||
Mouse   506 ---AAPGGMEEYRKTLAISFLFMFYLDVLKQLKTRDPHKYPDISQKLLHILEDFPLTMPYGMQSF 567

  Fly   526 ETIKKNY----PVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCAFVTAKRVGATIEQIDPSAA 586
            :.:....    |:.:|:....|:...:|||.:.:|:......:..|.||:.:..|.|..:|.|.|
Mouse   568 QDVDFQQPLQDPIGRPIMHQSGIKHATGEAVFCDDMSVLPGELFLAVVTSSKSHAKIISLDASEA 632

  Fly   587 LQCKGVVAFYSAEDIPGSNNFVLVNQLTPEVDEVFVAGRVKYFDQPLGVIAALTHDAAVYAATLV 651
            |...|||...:|.|:||.|.        .|.:.::....|....|.:..:||.::..|..||..|
Mouse   633 LASLGVVDVVTARDVPGDNG--------REEESLYAQDEVICVGQIVCAVAADSYAHAQQAAKKV 689

  Fly   652 VVTYARDQRKIFTTMNQVLAEKQTDRIVSTKKDTVEPLKLPPLAPGDVLGRGILELASQYHFTME 716
            .:.| :|...:..|:...|   |.:..:..::...:..........|.:..|.:.|..|.||.||
Mouse   690 KIVY-QDIEPMIVTVQDAL---QYESFIGPERKLEQGNVEEAFQCADQILEGEVHLGGQEHFYME 750

  Fly   717 PQTTIVVPL--DNILQVYCATQWMDATQGAIAHMLKVSVNSIQLQVRRVGGAYGAKVTRGNIVAC 779
            .|:..|||.  |..:.:|.::|....||..:|..|.:..|.|...|:|||||:|.|.::..::|.
Mouse   751 TQSVRVVPKGEDKEMDIYVSSQDAAFTQEMVARTLGIPKNRINCHVKRVGGAFGGKASKPGLLAS 815

  Fly   780 ATALVASKLRRPARFVQTIESMMETIGKRWACRSDYEFRARANGSIIMLSNNYYEDSGCNLNEN- 843
            ..|:.|.|..||.||:......|...|.|......|:.....||.|.......|.:.||..:::
Mouse   816 VAAVAAQKTGRPIRFILERRDDMLITGGRHPLLGKYKIGFMNNGKIKAADIQLYINGGCTPDDSE 880

  Fly   844 -VVDFLTLPILRNVYNLTDANYRTQGSAIRTDAPSSTWCRAPGSAEGIAMTETALEHIAFTCQLD 907
             |:::..|. |.|.|.:  .|.|.:|...:|:.||:|..|..|..:|..:|||.:..:|..|:|.
Mouse   881 LVIEYALLK-LENAYKI--PNLRVRGRVCKTNLPSNTAFRGFGFPQGAFVTETCMSAVAAKCRLP 942

  Fly   908 PADVRLVNL-------------QPGNKMVQLLPKFLASTEYHKRRDQINLFNSQNRWRKRGLGLA 959
            |..||.:|:             .|.| ::|.....:.::.|:.|:..::.||.|..|:|||:.:.
Mouse   943 PEKVRELNMYRTIDRTIHNQEFDPTN-LLQCWEACVENSSYYNRKKAVDEFNQQRFWKKRGIAII 1006

  Fly   960 LMSFPLNTTVAFNYPVT--VAIYHEDGSVVISHGGIEIGQGVNTKAAQVAAFVLGVPLDQVRVEA 1022
            .|.|.:.....|.|...  |.|| .||||:::|||:|:|||:|||..|||:..|.:|:..:.::.
Mouse  1007 PMKFSVGFPKTFYYQAAALVQIY-TDGSVLVAHGGVELGQGINTKMIQVASRELKIPMSYIHLDE 1070

  Fly  1023 SNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKRLAPVKERLGPRASWVQVLQAAFLQSVFLIA 1087
            .:||...|::.|..|..:::.|.||:.||..|.|||.|:.:: .|..:|.:.::.||:||:.|.|
Mouse  1071 MSTVTVPNTVTTGASTGADVNGRAVQNACQILMKRLEPIIKQ-NPSGTWEEWVKEAFVQSISLSA 1134

  Fly  1088 TESYR-----------LGDIPNYNIFGLSLTELELDILTGNHLIRRVDILEDAGESLSPHIDVGQ 1141
            |..:|           .|||..|.:||.:.:|:|:|.|||.|...|.||:.|...|::|.:|:||
Mouse  1135 TGYFRGYQADMDWEKGEGDIFPYFVFGAACSEVEIDCLTGAHKNIRTDIVMDGSFSINPAVDIGQ 1199

  Fly  1142 VEGAFVMGLGYYLTEQLVYDRQTGQILTNRTWNYHPPGAKDIPIDFRIELLQKSPNPVGFMRSKA 1206
            :|||||.|||.|..|:|.|..: |.:.|.....|......|||.:|.:.||..:|||.....||.
Mouse  1200 IEGAFVQGLGLYTLEELKYSPE-GVLYTRGPHQYKIASVTDIPEEFHVSLLTPTPNPKAIYSSKG 1263

  Fly  1207 TGEPALCLAVGALFAMQHAIQSARNDAGLPREWVRLGAPTTPETV 1251
            .||....|.....||:..|:.:||.:.||...|. :.:|.|.|.:
Mouse  1264 LGEAGTFLGCSVFFAIAAAVAAAREERGLSPIWA-INSPATAEVI 1307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	PLN02906	24..1251	CDD:215491	393/1324 (30%)
Aox3	NP_076106.2	mam_aldehyde_ox	9..1334	CDD:132014	400/1345 (30%)