DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX2 and Aox3

DIOPT Version :9

Sequence 1:	NP_732047.2	Gene:	AOX2 / 41895	FlyBaseID:	FBgn0038348	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_076106.2	Gene:	Aox3 / 71724	MGIID:	1918974	Length:	1335	Species:	Mus musculus

Alignment Length:	1345	Identity:	400/1345 - (29%)
Similarity:	633/1345 - (47%)	Gaps:	147/1345 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSRAA 69
            |.|||.....:.||  |:..|..:||:.:.||.|||.|..|.||:|..:|.|..|:::.:...:|
Mouse    12 FFVNGKKVTERNAD--PEVNLLFYLRKVIRLTGTKYGCGGGDCGACTVMISRYDPISKRISHFSA 74

  Fly    70 NSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRGQV 134
            .:||..:.:...|.:.|.||:|:..:..||:|:|:|:.:|||||:|:||.||::|.||..| .:.
Mouse    75 TACLVPICSLHGAAVTTVEGIGSTKTRIHPVQERIAKGHGTQCGFCTPGMVMSIYTLLRNH-PEP 138

  Fly   135 SMSQVEDAFGGNLCRCTGYRPILDAMKSF---------------AVDSNVEVP------------ 172
            |..|:.:..|||||||||||||:::.|||               .:|.....|
Mouse   139 STEQIMETLGGNLCRCTGYRPIVESAKSFCPSSTCCQMNGEGKCCLDEEKNEPERKNSVCTKLYE 203

  Fly   173 -AESVDIEDSFELLCPRTGQSCKGSCSRPPLRDHGD-SQWYWPKTLTELFGALSQVANGELYM-- 233
             .|...::.:.||:.|..............|...|: :.|..|.||.:|.         ||.|
Mouse   204 KKEFQPLDPTQELIFPPELMRMAEESQNTVLTFRGERTTWIAPGTLNDLL---------ELKMKH 259

  Fly   234 ----LVAGNTAHGVYRRPRDIRHFIDVN--MVPELRQYSIETDHLLLGGNVTLTDAMQVFLLAAK 292
                ||.|||..|::.:..|:.:.|.::  .:.||...:.....|.||..::||....|......
Mouse   260 PSAPLVIGNTYLGLHMKFTDVSYPIIISPARILELFVVTNTKQGLTLGAGLSLTQVKNVLSDVVS 324

  Fly   293 RPGFE----YCAQLWQHFNLIANVPVRNNGTLAGNINIKKQHFEFP-SDVFITFEALDVHVLVYD 352
            |...|    |||.|.| ...:|...:||..:|.|:|..:     .| ||:   ...|.:...:.:
Mouse   325 RLPKEKTQIYCALLKQ-LKTLAGQQIRNVASLGGHIISR-----LPTSDL---NPILGIGNCILN 380

  Fly   353 NPSTQRVMNL------LTYLGDTTSK---LVLGGFILKAYPKDRFLFRSYKILPRAQNVHAYVNA 408
            ..||:.:..:      |..:.|...|   :::..|:.:: .|..|: .:::..||.||..|.|||
Mouse   381 VASTEGIQQIPLNDHFLAGVPDAILKPEQVLISVFVPRS-SKWEFV-SAFRQAPRQQNAFATVNA 443

  Fly   409 GFLIEWQDIQHRIVHSARICFGNIRPDYIHDDQVEQLLPGR----DLYDPATVAQIFQELPASLQ 469
            |..:.:::..:.|. ...|.:|.|....|..|:..:.|.||    ::.|.|. ..|.:|:...:
Mouse   444 GMKVVFKEDTNTIT-DLGILYGGIGATVISADKSCRQLIGRCWDEEMLDDAG-KMICEEVSLLM- 505

  Fly   470 PEERPPEASPEYRQMLACSLLYKFLLATAPKERVRERFRTGG-------LLLERPLSS--GSQSF 525
               ..|....|||:.||.|.|:.|.|....:.:.|:..:...       :|.:.||:.  |.|||
Mouse   506 ---AAPGGMEEYRKTLAISFLFMFYLDVLKQLKTRDPHKYPDISQKLLHILEDFPLTMPYGMQSF 567

  Fly   526 ETIKKNY----PVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCAFVTAKRVGATIEQIDPSAA 586
            :.:....    |:.:|:....|:...:|||.:.:|:......:..|.||:.:..|.|..:|.|.|
Mouse   568 QDVDFQQPLQDPIGRPIMHQSGIKHATGEAVFCDDMSVLPGELFLAVVTSSKSHAKIISLDASEA 632

  Fly   587 LQCKGVVAFYSAEDIPGSNNFVLVNQLTPEVDEVFVAGRVKYFDQPLGVIAALTHDAAVYAATLV 651
            |...|||...:|.|:||.|.        .|.:.::....|....|.:..:||.::..|..||..|
Mouse   633 LASLGVVDVVTARDVPGDNG--------REEESLYAQDEVICVGQIVCAVAADSYAHAQQAAKKV 689

  Fly   652 VVTYARDQRKIFTTMNQVLAEKQTDRIVSTKKDTVEPLKLPPLAPGDVLGRGILELASQYHFTME 716
            .:.| :|...:..|:...|   |.:..:..::...:..........|.:..|.:.|..|.||.||
Mouse   690 KIVY-QDIEPMIVTVQDAL---QYESFIGPERKLEQGNVEEAFQCADQILEGEVHLGGQEHFYME 750

  Fly   717 PQTTIVVPL--DNILQVYCATQWMDATQGAIAHMLKVSVNSIQLQVRRVGGAYGAKVTRGNIVAC 779
            .|:..|||.  |..:.:|.::|....||..:|..|.:..|.|...|:|||||:|.|.::..::|.
Mouse   751 TQSVRVVPKGEDKEMDIYVSSQDAAFTQEMVARTLGIPKNRINCHVKRVGGAFGGKASKPGLLAS 815

  Fly   780 ATALVASKLRRPARFVQTIESMMETIGKRWACRSDYEFRARANGSIIMLSNNYYEDSGCNLNEN- 843
            ..|:.|.|..||.||:......|...|.|......|:.....||.|.......|.:.||..:::
Mouse   816 VAAVAAQKTGRPIRFILERRDDMLITGGRHPLLGKYKIGFMNNGKIKAADIQLYINGGCTPDDSE 880

  Fly   844 -VVDFLTLPILRNVYNLTDANYRTQGSAIRTDAPSSTWCRAPGSAEGIAMTETALEHIAFTCQLD 907
             |:::..|. |.|.|.:  .|.|.:|...:|:.||:|..|..|..:|..:|||.:..:|..|:|.
Mouse   881 LVIEYALLK-LENAYKI--PNLRVRGRVCKTNLPSNTAFRGFGFPQGAFVTETCMSAVAAKCRLP 942

  Fly   908 PADVRLVNL-------------QPGNKMVQLLPKFLASTEYHKRRDQINLFNSQNRWRKRGLGLA 959
            |..||.:|:             .|.| ::|.....:.::.|:.|:..::.||.|..|:|||:.:.
Mouse   943 PEKVRELNMYRTIDRTIHNQEFDPTN-LLQCWEACVENSSYYNRKKAVDEFNQQRFWKKRGIAII 1006

  Fly   960 LMSFPLNTTVAFNYPVT--VAIYHEDGSVVISHGGIEIGQGVNTKAAQVAAFVLGVPLDQVRVEA 1022
            .|.|.:.....|.|...  |.|| .||||:::|||:|:|||:|||..|||:..|.:|:..:.::.
Mouse  1007 PMKFSVGFPKTFYYQAAALVQIY-TDGSVLVAHGGVELGQGINTKMIQVASRELKIPMSYIHLDE 1070

  Fly  1023 SNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKRLAPVKERLGPRASWVQVLQAAFLQSVFLIA 1087
            .:||...|::.|..|..:::.|.||:.||..|.|||.|:.:: .|..:|.:.::.||:||:.|.|
Mouse  1071 MSTVTVPNTVTTGASTGADVNGRAVQNACQILMKRLEPIIKQ-NPSGTWEEWVKEAFVQSISLSA 1134

  Fly  1088 TESYR-----------LGDIPNYNIFGLSLTELELDILTGNHLIRRVDILEDAGESLSPHIDVGQ 1141
            |..:|           .|||..|.:||.:.:|:|:|.|||.|...|.||:.|...|::|.:|:||
Mouse  1135 TGYFRGYQADMDWEKGEGDIFPYFVFGAACSEVEIDCLTGAHKNIRTDIVMDGSFSINPAVDIGQ 1199

  Fly  1142 VEGAFVMGLGYYLTEQLVYDRQTGQILTNRTWNYHPPGAKDIPIDFRIELLQKSPNPVGFMRSKA 1206
            :|||||.|||.|..|:|.|..: |.:.|.....|......|||.:|.:.||..:|||.....||.
Mouse  1200 IEGAFVQGLGLYTLEELKYSPE-GVLYTRGPHQYKIASVTDIPEEFHVSLLTPTPNPKAIYSSKG 1263

  Fly  1207 TGEPALCLAVGALFAMQHAIQSARNDAGLPREWVRLGAPTTPETV 1251
            .||....|.....||:..|:.:||.:.||...|. :.:|.|.|.:
Mouse  1264 LGEAGTFLGCSVFFAIAAAVAAAREERGLSPIWA-INSPATAEVI 1307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	fer2	3..84	CDD:238126	27/78 (35%)
		PLN02906	24..1251	CDD:215491	393/1324 (30%)
		Fer2_2	86..159	CDD:280048	38/72 (53%)
		FAD_binding_4	206..366	CDD:303082	45/179 (25%)
		CO_deh_flav_C	391..497	CDD:281449	32/109 (29%)
		Ald_Xan_dh_C	548..655	CDD:214971	30/106 (28%)
		Ald_Xan_dh_C2	702..1184	CDD:280834	172/511 (34%)
Aox3	NP_076106.2	mam_aldehyde_ox	9..1334	CDD:132014	400/1345 (30%)
		Fer2_2	91..162	CDD:280048	38/71 (54%)
		FAD_binding_5	239..419	CDD:279309	47/197 (24%)
		CO_deh_flav_C	426..530	CDD:281449	32/109 (29%)
		Ald_Xan_dh_C	594..697	CDD:214971	32/111 (29%)
		Ald_Xan_dh_C2	709..1241	CDD:280834	173/538 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820