DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX2 and aox5

DIOPT Version :9

Sequence 1:	NP_732047.2	Gene:	AOX2 / 41895	FlyBaseID:	FBgn0038348	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_001265725.1	Gene:	aox5 / 64265	ZFINID:	ZDB-GENE-001205-2	Length:	1336	Species:	Danio rerio

Alignment Length:	1353	Identity:	385/1353 - (28%)
Similarity:	611/1353 - (45%)	Gaps:	161/1353 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSRAA 69
            |.:||.....:.||  |:..|..:||..:.||..||.|..||||:|..::.|..|:...|...:.
Zfish    12 FYINGKKIVEKNAD--PEEMLLAYLRRKVGLTGAKYGCGGGGCGACTVMVSRYDPLQDTVLHWSV 74

  Fly    70 NSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRGQV 134
            |:||..:.:...|.::|.||:|:..:..||:|:|:.:.:|:|||:|:||.||:||.|| ::....
Zfish    75 NACLQPICSLHGAAVVTVEGIGSTKTKLHPVQERIVKAHGSQCGFCTPGMVMSMYTLL-RNNPHP 138

  Fly   135 SMSQVEDAFGGNLCRCTGYRPILDAMKSFAVDSNVEVPAESVDIEDSFELLCPRTGQSCKGSCSR 199
            ::..:.:..|||||||||||||:|..|:|.     |.|            :|.:.|.. .|.|..
Zfish   139 TIEDIRETLGGNLCRCTGYRPIIDGFKTFC-----ETP------------VCCQNGGG-NGKCCM 185

  Fly   200 PPLRDHGDS---------------------------------------------QWYWPKTLTEL 219
            .....|.:|                                             :|..|..|.:|
Zfish   186 ENGNSHNESDISGELFIMDNVLPLDPTQDLIFPPELLIMGKKKAERHCFQGEKVRWISPSDLKDL 250

  Fly   220 FGALSQVANGELYMLVAGNTAHGVYRRPRDIRHFIDV--NMVPELRQYSIETDHLLLGGNVTLTD 282
            ....::.::..   |:.|||..|.........|.:.:  ..:.||:......:.:.:|...:|:.
Zfish   251 IKLKAEHSDAP---LLVGNTTIGPKMNLNKTVHPLVIYGGSIAELQAIKWRKNCITVGAGCSLSV 312

  Fly   283 AMQVFLLAAKRPGFE----YCAQLWQHFNLIANVPVRNNGTLAGNINIKKQHFEFPSDVFITFEA 343
            ...|.....:..|.|    |.| |.|....:|...:||..|:.|||......::..|  .:....
Zfish   313 LKDVLQQRIEDLGPEKSRVYQA-LVQTLQCLAGKQIRNMATIGGNILSANPKYDLSS--ILAAAE 374

  Fly   344 LDVHVLVYDNPSTQRVMNL----LTYLGDTT---SKLVLGGFILKAYPKDRFLFRSYKILPRAQN 401
            ..:|:...|.   .|.:.|    .|..|.|.   .:::|...|..:.|.:  ...:::...|.:.
Zfish   375 CTLHIASKDG---DREICLSEEFFTDFGKTALRPEEILLAIDIPHSKPWE--FVSAFRQAQRREF 434

  Fly   402 VHAYVNAGFLIEWQDIQHRIVHSARICFGNIRPDYIHDDQVEQLLPGRDLYDPATVAQIFQELPA 466
            ..:.||||..:.::. ...:|....|.:|.:....:......:.|.||. :|...:|:..|.|..
Zfish   435 AFSIVNAGMRVAFRH-DSNVVEHLDIFYGGVGCTLVKARHTCKELIGRK-WDEKLLAEGTQLLEE 497

  Fly   467 SLQPEERPPEASPEYRQMLACSLLYKFLLATAPKERVRERFRTGGLLLE-----RPLSS----GS 522
            .:......|....|||:.|..|..:||.:....:.:.|| .....|.||     :|..:    |:
Zfish   498 EISVPATVPGGREEYRKALVLSFFFKFYMQVLLELQQRE-VGVNDLPLEYLSALKPFKNEVPQGN 561

  Fly   523 QSF----ETIKKNYPVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCAFVTAKRVGATIEQIDP 583
            .|:    ||...:.||.:|...|..|.|.:|||.|.:|:.:....:..:.||:.|..|.|..||.
Zfish   562 YSYQLVPETQSSSDPVGRPNVHLAALQQATGEAVYYDDIPSVKGELFVSMVTSTRAHAKIISIDA 626

  Fly   584 SAALQCKGVVAFYSAEDIPGSNNFVLVNQLTPEVDEVFVAGRVKYFDQPLGVIAALTHDAAVYAA 648
            |.||...|||.|.||:|:||.|..:..|  .||  |:|....|....|.:|.|.|.|.:.|..||
Zfish   627 SVALAMPGVVDFISAKDVPGQNRRLWFN--NPE--ELFAEEEVICVGQIIGAIVAETREQAKRAA 687

  Fly   649 TLVVVTYARDQRKIFTTMNQVLA-EKQTDRIVSTKKDTVEPLKLPPLAPGDVLGRGILELASQYH 712
            ..|.:|| :|.:.:|.|:.:.:. |...|.....::..||    ...|..|.:..|.:.:..|.|
Zfish   688 QQVDITY-QDMQPVFFTIEEAIEHESFFDPKRKLERGNVE----EGFAKADQILEGEMYMGGQEH 747

  Fly   713 FTMEPQTTIVVPLDNI--LQVYCATQWMDATQGAIAHMLKVSVNSIQLQVRRVGGAYGAKVTRGN 775
            |.||.|..|.:|....  :::|.|:|....||..:...|.:..|.|...|:|:||.:|.||.:
Zfish   748 FYMETQGVIAIPTGEASEIELYVASQHAAYTQEVVGITLGIDSNKITCHVKRLGGGFGGKVMK-- 810

  Fly   776 IVACATALVASKLRRPARFVQTI----ESMMETIGKRWACRSDYEFRARANGSIIMLSNNYYEDS 836
             :|..:|:.|:...:....|:.:    :.|:.|.| |......|:.....:|:|:.....||.:.
Zfish   811 -IASLSAIAATAAIKTGHAVRCVLERGDDMLITSG-RSPFLGRYKIGYMNDGTILAADITYYSNG 873

  Fly   837 GCNLNENVVDFL---TLPILRNVYNLTDANYRTQGSAIRTDAPSSTWCRAPGSAEGIAMTETALE 898
            ||.|:|:  .|:   .|..:.|.|.:  .|.|.:|...:|..||.|..|..|..:|:.:.|:.|.
Zfish   874 GCTLDES--SFIMEKALLHMDNGYKI--PNLRGRGLVCKTFLPSYTAFRGFGGPQGLTIIESVLH 934

  Fly   899 HIAFTCQLDPADVRLVNLQPGNK-------------MVQLLPKFLASTEYHKRRDQINLFNSQNR 950
            .:|..|.|....||.:||....|             ||:...:.|..:.|.:|...|..||..|.
Zfish   935 EVAVKCGLPAHQVRDINLYKEEKCFTHHKQLFSPHDMVRCWNECLEKSNYTQRCQYIEQFNGHNH 999

  Fly   951 WRKRGLGLALMSFPLNTTVAF-NYPVTVAIYHEDGSVVISHGGIEIGQGVNTKAAQVAAFVLGVP 1014
            |:|||:.:..:.|.:..:..| |....:...::||||||||||.|:|||:||||.|:|:.:|.|.
Zfish  1000 WKKRGISIVPIKFGIGFSKGFYNQGAALVNVYKDGSVVISHGGTEMGQGINTKAIQIASRILKVS 1064

  Fly  1015 LDQVRVEASNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKRLAPVKERLGPRASWVQVLQAAF 1079
            :..:.::.:.|.|..|:..:|.|..::.:|:||:..|:.|.:||.|:.:: .|:.:|.|::..|:
Zfish  1065 MSSIHIKETCTGNVPNAAPSAASFGTDAVGMAVKNGCEKLMRRLEPLIKK-HPQYTWQQLVVEAY 1128

  Fly  1080 LQSVFLIATESY-----------RLGDIPNYNIFGLSLTELELDILTGNHLIRRVDILEDAGESL 1133
            .|.:.|.||..:           ..|:...|..||...:|:|:|.|||:|...|.||:.|.|.|:
Zfish  1129 CQKISLSATGFFMGPHTSVDWEKSEGNAYYYFTFGACCSEVEIDCLTGDHKNIRTDIVMDVGRSI 1193

  Fly  1134 SPHIDVGQVEGAFVMGLGYYLTEQLVYDRQTGQILTNRTWNYHPPGAKDIPIDFRIELLQKSPNP 1198
            :|.:|||||||.||.|:|.|..|:|.:..| |.:||.....|..|...|:|....:.||:.:.||
Zfish  1194 NPALDVGQVEGGFVQGIGLYTIEELQFSPQ-GVLLTRGPSQYKIPALCDVPPQINVHLLRNADNP 1257

  Fly  1199 VGFMRSKATGEPALCLAVGALFAMQHAIQSARNDAGLPREWVRLGAPTTPETV 1251
            .....||..|||.:.......||::.||.:||.:.|| .|.....:|.|.|.:
Zfish  1258 HAIYSSKGIGEPPVFFGCTLFFAIKEAIAAARKERGL-SESFSFSSPATAEKI 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	fer2	3..84	CDD:238126	26/78 (33%)
		PLN02906	24..1251	CDD:215491	379/1332 (28%)
		Fer2_2	86..159	CDD:280048	34/72 (47%)
		FAD_binding_4	206..366	CDD:303082	35/214 (16%)
		CO_deh_flav_C	391..497	CDD:281449	23/105 (22%)
		Ald_Xan_dh_C	548..655	CDD:214971	40/106 (38%)
		Ald_Xan_dh_C2	702..1184	CDD:280834	163/515 (32%)
aox5	NP_001265725.1	mam_aldehyde_ox	8..1336	CDD:132014	385/1353 (28%)
		Fer2_2	91..162	CDD:280048	34/71 (48%)
		FAD_binding_5	237..417	CDD:279309	38/188 (20%)
		CO_deh_flav_C	424..528	CDD:281449	23/105 (22%)
		Ald_Xan_dh_C	591..696	CDD:214971	42/109 (39%)
		Ald_Xan_dh_C2	718..1243	CDD:280834	167/538 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820