Protein Alignment AOX2 and aox5

DIOPT Version :10

• Sequence 1: NP_732047.2
• Gene: AOX2 / 41895
• FlyBaseID: FBgn0038348
• Length: 1264
• Species: Drosophila melanogaster
• Sequence 2: NP_001265725.1
• Gene: aox5 / 64265
• ZFINID: ZDB-GENE-001205-2
• Length: 1336
• Species: Danio rerio
• Alignment Length: 1353
• Identity: 385/1353 - (28%)
• Similarity: 611/1353 - (45%)
• Gaps: 161/1353 - (11%)

  Fly     5 FNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSRAA 69
            |.:||.....:.||  |:..|..:||..:.||..||.|..||||:|..::.|..|:...|...:.
Zfish    12 FYINGKKIVEKNAD--PEEMLLAYLRRKVGLTGAKYGCGGGGCGACTVMVSRYDPLQDTVLHWSV 74

  Fly    70 NSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRGQV 134
            |:||..:.:...|.::|.||:|:..:..||:|:|:.:.:|:|||:|:||.||:||.|| ::....
Zfish    75 NACLQPICSLHGAAVVTVEGIGSTKTKLHPVQERIVKAHGSQCGFCTPGMVMSMYTLL-RNNPHP 138

  Fly   135 SMSQVEDAFGGNLCRCTGYRPILDAMKSFAVDSNVEVPAESVDIEDSFELLCPRTGQSCKGSCSR 199
            ::..:.:..|||||||||||||:|..|:|.     |.|            :|.:.|.. .|.|..
Zfish   139 TIEDIRETLGGNLCRCTGYRPIIDGFKTFC-----ETP------------VCCQNGGG-NGKCCM 185

  Fly   200 PPLRDHGDS---------------------------------------------QWYWPKTLTEL 219
            .....|.:|                                             :|..|..|.:|
Zfish   186 ENGNSHNESDISGELFIMDNVLPLDPTQDLIFPPELLIMGKKKAERHCFQGEKVRWISPSDLKDL 250

  Fly   220 FGALSQVANGELYMLVAGNTAHGVYRRPRDIRHFIDV--NMVPELRQYSIETDHLLLGGNVTLTD 282
            ....::.::..   |:.|||..|.........|.:.:  ..:.||:......:.:.:|...:|:.
Zfish   251 IKLKAEHSDAP---LLVGNTTIGPKMNLNKTVHPLVIYGGSIAELQAIKWRKNCITVGAGCSLSV 312

  Fly   283 AMQVFLLAAKRPGFE----YCAQLWQHFNLIANVPVRNNGTLAGNINIKKQHFEFPSDVFITFEA 343
            ...|.....:..|.|    |.| |.|....:|...:||..|:.|||......::..|  .:....
Zfish   313 LKDVLQQRIEDLGPEKSRVYQA-LVQTLQCLAGKQIRNMATIGGNILSANPKYDLSS--ILAAAE 374

  Fly   344 LDVHVLVYDNPSTQRVMNL----LTYLGDTT---SKLVLGGFILKAYPKDRFLFRSYKILPRAQN 401
            ..:|:...|.   .|.:.|    .|..|.|.   .:::|...|..:.|.:  ...:::...|.:.
Zfish   375 CTLHIASKDG---DREICLSEEFFTDFGKTALRPEEILLAIDIPHSKPWE--FVSAFRQAQRREF 434

  Fly   402 VHAYVNAGFLIEWQDIQHRIVHSARICFGNIRPDYIHDDQVEQLLPGRDLYDPATVAQIFQELPA 466
            ..:.||||..:.::. ...:|....|.:|.:....:......:.|.||. :|...:|:..|.|..
Zfish   435 AFSIVNAGMRVAFRH-DSNVVEHLDIFYGGVGCTLVKARHTCKELIGRK-WDEKLLAEGTQLLEE 497

  Fly   467 SLQPEERPPEASPEYRQMLACSLLYKFLLATAPKERVRERFRTGGLLLE-----RPLSS----GS 522
            .:......|....|||:.|..|..:||.:....:.:.|| .....|.||     :|..:    |:
Zfish   498 EISVPATVPGGREEYRKALVLSFFFKFYMQVLLELQQRE-VGVNDLPLEYLSALKPFKNEVPQGN 561

  Fly   523 QSF----ETIKKNYPVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCAFVTAKRVGATIEQIDP 583
            .|:    ||...:.||.:|...|..|.|.:|||.|.:|:.:....:..:.||:.|..|.|..||.
Zfish   562 YSYQLVPETQSSSDPVGRPNVHLAALQQATGEAVYYDDIPSVKGELFVSMVTSTRAHAKIISIDA 626

  Fly   584 SAALQCKGVVAFYSAEDIPGSNNFVLVNQLTPEVDEVFVAGRVKYFDQPLGVIAALTHDAAVYAA 648
            |.||...|||.|.||:|:||.|..:..|  .||  |:|....|....|.:|.|.|.|.:.|..||
Zfish   627 SVALAMPGVVDFISAKDVPGQNRRLWFN--NPE--ELFAEEEVICVGQIIGAIVAETREQAKRAA 687

  Fly   649 TLVVVTYARDQRKIFTTMNQVLA-EKQTDRIVSTKKDTVEPLKLPPLAPGDVLGRGILELASQYH 712
            ..|.:|| :|.:.:|.|:.:.:. |...|.....::..||    ...|..|.:..|.:.:..|.|
Zfish   688 QQVDITY-QDMQPVFFTIEEAIEHESFFDPKRKLERGNVE----EGFAKADQILEGEMYMGGQEH 747

  Fly   713 FTMEPQTTIVVPLDNI--LQVYCATQWMDATQGAIAHMLKVSVNSIQLQVRRVGGAYGAKVTRGN 775
            |.||.|..|.:|....  :::|.|:|....||..:...|.:..|.|...|:|:||.:|.||.:
Zfish   748 FYMETQGVIAIPTGEASEIELYVASQHAAYTQEVVGITLGIDSNKITCHVKRLGGGFGGKVMK-- 810

  Fly   776 IVACATALVASKLRRPARFVQTI----ESMMETIGKRWACRSDYEFRARANGSIIMLSNNYYEDS 836
             :|..:|:.|:...:....|:.:    :.|:.|.| |......|:.....:|:|:.....||.:.
Zfish   811 -IASLSAIAATAAIKTGHAVRCVLERGDDMLITSG-RSPFLGRYKIGYMNDGTILAADITYYSNG 873

  Fly   837 GCNLNENVVDFL---TLPILRNVYNLTDANYRTQGSAIRTDAPSSTWCRAPGSAEGIAMTETALE 898
            ||.|:|:  .|:   .|..:.|.|.:  .|.|.:|...:|..||.|..|..|..:|:.:.|:.|.
Zfish   874 GCTLDES--SFIMEKALLHMDNGYKI--PNLRGRGLVCKTFLPSYTAFRGFGGPQGLTIIESVLH 934

  Fly   899 HIAFTCQLDPADVRLVNLQPGNK-------------MVQLLPKFLASTEYHKRRDQINLFNSQNR 950
            .:|..|.|....||.:||....|             ||:...:.|..:.|.:|...|..||..|.
Zfish   935 EVAVKCGLPAHQVRDINLYKEEKCFTHHKQLFSPHDMVRCWNECLEKSNYTQRCQYIEQFNGHNH 999

  Fly   951 WRKRGLGLALMSFPLNTTVAF-NYPVTVAIYHEDGSVVISHGGIEIGQGVNTKAAQVAAFVLGVP 1014
            |:|||:.:..:.|.:..:..| |....:...::||||||||||.|:|||:||||.|:|:.:|.|.
Zfish  1000 WKKRGISIVPIKFGIGFSKGFYNQGAALVNVYKDGSVVISHGGTEMGQGINTKAIQIASRILKVS 1064

  Fly  1015 LDQVRVEASNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKRLAPVKERLGPRASWVQVLQAAF 1079
            :..:.::.:.|.|..|:..:|.|..::.:|:||:..|:.|.:||.|:.:: .|:.:|.|::..|:
Zfish  1065 MSSIHIKETCTGNVPNAAPSAASFGTDAVGMAVKNGCEKLMRRLEPLIKK-HPQYTWQQLVVEAY 1128

  Fly  1080 LQSVFLIATESY-----------RLGDIPNYNIFGLSLTELELDILTGNHLIRRVDILEDAGESL 1133
            .|.:.|.||..:           ..|:...|..||...:|:|:|.|||:|...|.||:.|.|.|:
Zfish  1129 CQKISLSATGFFMGPHTSVDWEKSEGNAYYYFTFGACCSEVEIDCLTGDHKNIRTDIVMDVGRSI 1193

  Fly  1134 SPHIDVGQVEGAFVMGLGYYLTEQLVYDRQTGQILTNRTWNYHPPGAKDIPIDFRIELLQKSPNP 1198
            :|.:|||||||.||.|:|.|..|:|.:..| |.:||.....|..|...|:|....:.||:.:.||
Zfish  1194 NPALDVGQVEGGFVQGIGLYTIEELQFSPQ-GVLLTRGPSQYKIPALCDVPPQINVHLLRNADNP 1257

  Fly  1199 VGFMRSKATGEPALCLAVGALFAMQHAIQSARNDAGLPREWVRLGAPTTPETV 1251
            .....||..|||.:.......||::.||.:||.:.|| .|.....:|.|.|.:
Zfish  1258 HAIYSSKGIGEPPVFFGCTLFFAIKEAIAAARKERGL-SESFSFSSPATAEKI 1309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	PLN02906	24..1251	CDD:215491	379/1332 (28%)
aox5	NP_001265725.1	mam_aldehyde_ox	8..1336	CDD:132014	385/1353 (28%)