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Protein Alignment AOX2 and Aox1

DIOPT Version :9

Sequence 1:	NP_732047.2	Gene:	AOX2 / 41895	FlyBaseID:	FBgn0038348	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_062236.3	Gene:	Aox1 / 54349	RGDID:	620528	Length:	1333	Species:	Rattus norvegicus

Alignment Length:	1377	Identity:	406/1377 - (29%)
Similarity:	632/1377 - (45%)	Gaps:	208/1377 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSRAA 69
            |.|||  .:|...:..|:..|..:||::|.||.|||.|..||||:|..:|.|.:|.|:.::....
  Rat     8 FYVNG--QKVVENNVDPEMMLLPYLRKNLRLTGTKYGCGGGGCGACTVMISRYNPSTKSIRHHPV 70

  Fly    70 NSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRGQV 134
            |:|||.:.:.....:.|.||:||..:..||:|:|:|:.:|||||:|:||.||:||.||..| .:.
  Rat    71 NACLTPICSLYGTAVTTVEGIGNTRTRLHPVQERIAKCHGTQCGFCTPGMVMSMYALLRNH-PEP 134

  Fly   135 SMSQVEDAFGGNLCRCTGYRPILDAMKSF---------------AVDSNVEVPAESVD------- 177
            |:.|:.||.|||||||||||||:||.|:|               .:|..:...||..:
  Rat   135 SLDQLTDALGGNLCRCTGYRPIIDACKTFCRASGCCESKENGVCCLDQGINGSAEFQEGDETSPE 199

  Fly   178 ---------IEDSFELLCPRTGQSCKGSCSRPPLRDHGDSQ-------------WYWPKTLTELF 220
                     ::.:.||:.|            |.|....:.|             |..|.||.||.
  Rat   200 LFSEKEFQPLDPTQELIFP------------PELMRIAEKQPPKTRVFYSNRMTWISPVTLEELV 252

  Fly   221 GALSQVANGELYMLVAGNTAHGVYRRPRDIRH--FIDVNMVPELRQYSIETDHLLLGGNVT---- 279
            .|..:.....:.|   |.|:.|...:.:.:.|  .|..:.:.||...:...|.|.||..::
  Rat   253 EAKFKYPGAPIVM---GYTSVGPEVKFKGVFHPIIISPDRIEELSIINQTGDGLTLGAGLSLDQV 314

  Fly   280 ---LTDAMQVFLLAAKRPGFEYCAQ----LWQHFNLIANVPVRNNGTLAGNINIKKQHFEFPSDV 337
               |||.:|      |.|  |...|    |.:|...:|...:||..:|.|  :|..:|.:...:.
  Rat   315 KDILTDVVQ------KLP--EETTQTYRALLKHLRTLAGSQIRNMASLGG--HIVSRHLDSDLNP 369

  Fly   338 FITFEALDVHVLVYDN----PSTQRVMNLLTYLGDTTSKLVLGGFILKAYPKDRFLFRSYKILPR 398
            .:......:::|..|.    |.:::.:..... .|...:.||....:....|..|: .:::...|
  Rat   370 LLAVGNCTLNLLSKDGKRQIPLSEQFLRKCPD-SDLKPQEVLVSVNIPCSRKWEFV-SAFRQAQR 432

  Fly   399 AQNVHAYVNAGFLIEWQDIQHRIVHSARICFGNIRPDYIHDDQVEQLLPGR----DLYDPATVAQ 459
            .||..|.||:|..:.::: ...::....|.:|.:.|..|......|.|.||    ::.|.| ...
  Rat   433 QQNALAIVNSGMRVLFRE-GGGVIKELSILYGGVGPTTIGAKNSCQKLIGRPWNEEMLDTA-CRL 495

  Fly   460 IFQELPASLQPEERPPEASPEYRQMLACSLLYKFLLATAPKERVRERFRTGGLLLERPLSSGSQS 524
            :..|:..:    ...|....|:::.|..|.|:||.|....           ||..|.|     ..
  Rat   496 VLDEVTLA----GSAPGGKVEFKRTLIISFLFKFYLEVLQ-----------GLKREDP-----GH 540

  Fly   525 FETIKKNY-----------------------------PVTQPVQKLEGLIQCSGEATYMNDLLTT 560
            :.::..||                             |:.:|:..|.|:...:|||.|.:|:...
  Rat   541 YPSLTNNYESALEDLHSKHHWRTLTHQNVDSMQLPQDPIGRPIMHLSGIKHATGEAIYCDDMPAV 605

  Fly   561 SNAVHCAFVTAKRVGATIEQIDPSAALQCKGVVAFYSAEDIPGSNNFVLVNQLTPEVDEVFVAGR 625
            ...:...|||:.|..|.|..||.|.||...|||...:|:.:..:..|.....|.  .|:|...|:
  Rat   606 DRELFLTFVTSSRAHAKIVSIDLSEALSLPGVVDIITADHLQDTTTFGTETLLA--TDKVHCVGQ 668

  Fly   626 VKYFDQPLGVIAALTHDA---AVYAATLVVVTYARDQRKIFTTMNQVLAEK---QTDRIVSTKKD 684
                     ::.|:..|:   |..||..|.|.| ||...:..|:.:.:..|   :::|.:.. .:
  Rat   669 ---------LVCAVIADSETRAKQAAKHVKVVY-RDLEPLILTIEEAIQHKSFFESERKLEC-GN 722

  Fly   685 TVEPLKLPPLAPGDVLGRGILELASQYHFTMEPQTTIVVPL--DNILQVYCATQWMDATQGAIAH 747
            ..|..|:     .|.:..|.:.:..|.||.||.|:.:|||.  |..:.:|.:||:....|..:|.
  Rat   723 VDEAFKI-----ADQILEGEIHIGGQEHFYMETQSMLVVPKGEDGEIDIYVSTQFPKHIQDIVAA 782

  Fly   748 MLKVSVNSIQLQVRRVGGAYGAKVTRGNIVACATALVASKLRRPAR-FVQTIESMMETIGKRWAC 811
            .||:|||.:...|||||||:|.||.:.:|:|..||..|||..|..| .::..|.|:.| |.|...
  Rat   783 TLKLSVNKVMCHVRRVGGAFGGKVGKTSIMAAITAFAASKHGRAVRCTLERGEDMLIT-GGRHPY 846

  Fly   812 RSDYEFRARANGSIIMLSNNYYEDSGCNLNENV-VDFLTLPILRNVYNLTDANYRTQGSAIRTDA 875
            ...|:.....:|.|:.|...:|.:.|.:|:|:: |..:.|..:.|.|..  .|.|.:|.|.||:.
  Rat   847 LGKYKVGFMRDGRIVALDVEHYCNGGSSLDESLWVIEMGLLKMDNAYKF--PNLRCRGWACRTNL 909

  Fly   876 PSSTWCRAPGSAEGIAMTETALEHIAFTCQLDPADVRLVNLQPGNKMVQLLPKFLAST------- 933
            ||:|..|..|..:...:||..:..:|..|.|.|..||.:|:...........:|.|.|
  Rat   910 PSNTALRGFGFPQAGLVTEACVTEVAIRCGLSPEQVRTINMYKQIDNTHYKQEFSAKTLFECWRE 974

  Fly   934 -----EYHKRRDQINLFNSQNRWRKRGLGLALMSFPLNT-TVAFNYPVTVAIYHEDGSVVISHGG 992
                 .|.:|:..:..||::|.|:|||:.:..:.||:.. :||......:...:.|||.::||||
  Rat   975 CMAKCSYSERKTAVGKFNAENSWKKRGMAVIPLKFPVGVGSVAMGQAAALVHIYLDGSALVSHGG 1039

  Fly   993 IEIGQGVNTKAAQVAAFVLGVPLDQVRVEASNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKR 1057
            ||:||||:||..||.:..|.:|:..|.:..::|....|:..:..|:.:::.||||:.||.||.||
  Rat  1040 IEMGQGVHTKMIQVVSRELKMPMSSVHLRGTSTETVPNTNASGGSVVADLNGLAVKDACQTLLKR 1104

  Fly  1058 LAPVKERLGPRASWVQVLQAAFLQSVFLIATESYRLGDIPNYN------------IFGLSLTELE 1110
            |.|:..: .|:.:|....|.||.|||.|.|...:| |...|.|            ::|.:.:|:|
  Rat  1105 LEPIISK-NPQGTWKDWAQTAFDQSVSLSAVGYFR-GYESNINWEKGEGHPFEYFVYGAACSEVE 1167

  Fly  1111 LDILTGNHLIRRVDILEDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLVYDRQTGQILTNRTWN- 1174
            :|.|||:|...|.||:.|.|.|::|.:|:|||||||:.|:|.|..|:|.|..|  .||.:|..|
  Rat  1168 IDCLTGDHKNIRTDIVMDVGHSINPALDIGQVEGAFIQGMGLYTIEELSYSPQ--GILYSRGPNQ 1230

  Fly  1175 YHPPGAKDIPIDFRIELLQKSPNPVGFMRSKATGEPALCLAVGALFAMQHAIQSARNDAGLPREW 1239
            |..|...|||.:..|..|..|.:......||..||..:.|.....||:..|:::||.:.|:...|
  Rat  1231 YKIPAICDIPTEMHISFLPPSEHSNTLYSSKGLGESGVFLGCSVFFAIHDAVRAARQERGISGPW 1295

  Fly  1240 VRLGAPTTPETV 1251
             :|.:|.|||.:
  Rat  1296 -KLTSPLTPEKI 1306

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.