Protein Alignment AOX2 and Xdh

DIOPT Version :10

• Sequence 1: NP_732047.2
• Gene: AOX2 / 41895
• FlyBaseID: FBgn0038348
• Length: 1264
• Species: Drosophila melanogaster
• Sequence 2: NP_058850.2
• Gene: Xdh / 497811
• RGDID: 62043
• Length: 1331
• Species: Rattus norvegicus
• Alignment Length: 1374
• Identity: 406/1374 - (29%)
• Similarity: 636/1374 - (46%)
• Gaps: 204/1374 - (14%)

  Fly     5 FNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSRAA 69
            |.|||.....:.||  |:|||..:||..|.|..||..|.|||||:|..:|.:...:..::...:.
  Rat     8 FFVNGKKVVEKNAD--PETTLLVYLRRKLGLCGTKLGCGEGGCGACTVMISKYDRLQNKIVHFSV 70

  Fly    70 NSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRGQV 134
            |:||..:.:.....:.|.||:|| ....||:|:|:|:.:|:|||:|:||.||:||.|| :::.:.
  Rat    71 NACLAPICSLHHVAVTTVEGIGN-TQKLHPVQERIARSHGSQCGFCTPGIVMSMYTLL-RNQPEP 133

  Fly   135 SMSQVEDAFGGNLCRCTGYRPILDAMKSFAVDSNV-------------EVPAESVDIEDS----- 181
            ::.::|:||.|||||||||||||...::||.|...             :...::|.:..|
  Rat   134 TVEEIENAFQGNLCRCTGYRPILQGFRTFAKDGGCCGGSGNNPNCCMNQTKDQTVSLSPSLFNPE 198

  Fly   182 -FELLCPRTGQSCKGSCSRPP------------LRDHGDS-QWYWPKTLTELFGALSQVANGELY 232
             |:.|.|......      ||            ||..|:. .|....|:.||....:|..:.:
  Rat   199 DFKPLDPTQEPIF------PPELLRLKDTPQKKLRFEGERVTWIQASTMEELLDLKAQHPDAK-- 255

  Fly   233 MLVAGNTAHGVYRRPRDIRHFIDV--NMVPELRQYSIETDHLLLGGNVTLTDAMQVFLLA---AK 292
             ||.|||..|:..:.:::...:.|  ..:|||.......:.:..|.:..|:....|  ||   ||
  Rat   256 -LVVGNTEIGIEMKFKNMLFPLIVCPAWIPELNSVVHGPEGISFGASCPLSLVESV--LAEEIAK 317

  Fly   293 RP--GFEYCAQLWQHFNLIANVPVRNNGTLAGNINIKKQHFEFPSDVFITFEALDVHVLVYDNPS 355
            .|  ..|....:.:.....|...|::..::.||| |........:.||:...|    .|...:..
  Rat   318 LPEQKTEVFRGVMEQLRWFAGKQVKSVASIGGNI-ITASPISDLNPVFMASGA----KLTLVSRG 377

  Fly   356 TQRVMNL-LTYLGDTTSKLVLGGFILKA----YPKDRFLFRSYKILPRAQNVHAYVNAGF----- 410
            |:|.:.: .|:.......|:....||.:    |.|:...|.::|...|.::..|.|.:|.
  Rat   378 TRRTVRMDHTFFPGYRKTLLRPEEILLSIEIPYSKEGEFFSAFKQASRREDDIAKVTSGMRVLFK 442

  Fly   411 --LIEWQDIQHRIVHSARICFGNI----------RPDYIHDDQVEQLLPGRDLYDPATVAQIFQE 463
              .||.|::.        :|||.:          .|..:.....|:||       .:..|.:.:|
  Rat   443 PGTIEVQELS--------LCFGGMADRTISALKTTPKQLSKSWNEELL-------QSVCAGLAEE 492

  Fly   464 LPASLQPEERPPEASPEYRQMLACSLLYKFLLATAPK----------ERVRERFRTGGLLLERPL 518
            |  .|.|:  .|....|:|:.|..|..:||.|....|          .::...|.:..||.::..
  Rat   493 L--HLAPD--APGGMVEFRRTLTLSFFFKFYLTVLQKLGRADLEDMCGKLDPTFASATLLFQKDP 553

  Fly   519 SSGSQSFETIKKNYP----VTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCAFVTAKRVGATIE 579
            .:..|.|:.:.|:..    |.:|:..|...:|.||||.|.:|:....|.:....||:.|..|.|.
  Rat   554 PANVQLFQEVPKDQSEEDMVGRPLPHLAANMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIT 618

  Fly   580 QIDPSAALQCKGVVAFYSAEDIPGSNNFVLVNQLTP-EVDEVFVAGRVKYFDQPLGVIAALTHDA 643
            .||.|.|.:..|.|.|.:|||:|.||...|.|..|. ..|||...|.:      :|.:.|.|.:.
  Rat   619 SIDTSEAKKVPGFVCFLTAEDVPNSNATGLFNDETVFAKDEVTCVGHI------IGAVVADTPEH 677

  Fly   644 AVYAATLVVVTYARDQRKIFTTM----------NQVLAEK--------QTDRIVSTKKDTVEPLK 690
            |..||..|.:|| .|...|.|..          :::..||        :.|.:||
  Rat   678 AQRAARGVKITY-EDLPAIITIQDAINNNSFYGSEIKIEKGDLKKGFSEADNVVS---------- 731

  Fly   691 LPPLAPGDVLGRGILELASQYHFTMEPQTTIVVPLDNI--LQVYCATQWMDATQGAIAHMLKVSV 753
                        |.|.:..|.||.:|...||.||....  ::::.:||....||..:|.||.|..
  Rat   732 ------------GELYIGGQEHFYLETNCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPD 784

  Fly   754 NSIQLQVRRVGGAYGAKVTRGNIVACATALVASKLRRPARFVQTIESMMETIGKRWACRSDYEFR 818
            |.|.::|:|:||.:|.|.||..:|:.|.||.|.|..||.|.:...:..|...|.|....:.|:..
  Rat   785 NRIVVRVKRMGGGFGGKETRSTVVSTAVALAAHKTGRPVRCMLDRDEDMLITGGRHPFLAKYKVG 849

  Fly   819 ARANGSIIMLSNNYYEDSGCNLNENVVDFLTLPILRNVYNLTDA----NYRTQGSAIRTDAPSST 879
            ....|:::.|...::.:.|     |..|.....:.|.::::.:|    |.|..|...:|:.||:|
  Rat   850 FMKTGTVVALEVAHFSNGG-----NTEDLSRSIMERALFHMDNAYKIPNIRGTGRICKTNLPSNT 909

  Fly   880 WCRAPGSAEGIAMTETALEHIAFTCQLDPADVRLVNLQPGNKMVQL--------LPK----FLAS 932
            ..|..|..:|:.:.|..:..:|.||.|...:||..|:.....:...        ||:    .:||
  Rat   910 AFRGFGGPQGMLIAEYWMSEVAITCGLPAEEVRRKNMYKEGDLTHFNQKLEGFTLPRCWDECIAS 974

  Fly   933 TEYHKRRDQINLFNSQNRWRKRGLGLALMSFPLNTTVAF-NYPVTVAIYHEDGSVVISHGGIEIG 996
            ::|..|:.::..||.:|.|:||||.:....|.::.|:.| |....:...:.||||:::|||.|:|
  Rat   975 SQYLARKREVEKFNRENCWKKRGLCIIPTKFGISFTLPFLNQGGALVHVYTDGSVLLTHGGTEMG 1039

  Fly   997 QGVNTKAAQVAAFVLGVPLDQVRVEASNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKRLAPV 1061
            ||::||..|||:..|.:|..::.:..::|....|:..||.|.::::.|.||.:||.|:.|||.|.
  Rat  1040 QGLHTKMVQVASRALKIPTSKIHISETSTNTVPNTSPTAASASADLNGQAVYEACQTILKRLEPF 1104

  Fly  1062 KERL--GPRASWVQVLQAAFLQSVFLIATESYRL-----------GDIPNYNIFGLSLTELELDI 1113
            |::.  ||..:||   ..|:..:|.|.||..|:.           |:..:|..:|::.:|:|:|.
  Rat  1105 KKKKPNGPWEAWV---MDAYTSAVSLSATGFYKTPNLGYSFETNSGNPFHYFSYGVACSEVEIDC 1166

  Fly  1114 LTGNHLIRRVDILEDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLVYDRQTGQILTNRTWNYHPP 1178
            |||:|...|.||:.|.|.||:|.||:||||||||.|||.:..|:|.|..: |.:.|.....|..|
  Rat  1167 LTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTMEELHYSPE-GSLHTRGPSTYKIP 1230

  Fly  1179 GAKDIPIDFRIELLQKSPNPVGFMRSKATGEPALCLAVGALFAMQHAIQSARNDAG-LPREWVRL 1242
            ....|||:||:.||:..||......|||.|||.|.||....||::.||::||...| ..::..:|
  Rat  1231 AFGSIPIEFRVSLLRDCPNKRAIYASKAVGEPPLFLASSIFFAIKDAIRAARAQHGDNAKQLFQL 1295

  Fly  1243 GAPTTPETV 1251
            .:|.|||.:
  Rat  1296 DSPATPEKI 1304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	PLN02906	24..1251	CDD:215491	398/1353 (29%)
Xdh	NP_058850.2	PLN02906	23..1317	CDD:215491	399/1357 (29%)