DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX2 and AOX4

DIOPT Version :9

Sequence 1:	NP_732047.2	Gene:	AOX2 / 41895	FlyBaseID:	FBgn0038348	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_650478.1	Gene:	AOX4 / 41897	FlyBaseID:	FBgn0038350	Length:	1256	Species:	Drosophila melanogaster

Alignment Length:	1276	Identity:	730/1276 - (57%)
Similarity:	934/1276 - (73%)	Gaps:	33/1276 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSIKFNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQ 65
            ||..|.:||.||.|...|.|||.|||||:|||..|||||:||||||||:|||.      |:....
  Fly     1 MSTTFTINGQPYAVNLTDLPPDITLNTFIREHAQLTATKFMCLEGGCGACVCA------VSDGKS 59

  Fly    66 SRAANSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQH 130
            :...||||.|||||...||:|.||||||::||||||||:|:|||||||:||||||||||||:|||
  Fly    60 TWTVNSCLKLLNTCAQLEIITCEGLGNQVTGYHPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQH 124

  Fly   131 RGQVSMSQVEDAFGGNLCRCTGYRPILDAMKSFAVDSNVEVPAESVDIEDSFELL---CPRTGQS 192
            .|:|:|.:||::||||:||||||||||||||||||||.|||..||||||| ..|.   |||:|:.
  Fly   125 GGRVTMEEVENSFGGNICRCTGYRPILDAMKSFAVDSTVEVSEESVDIED-LNLKARNCPRSGKV 188

  Fly   193 CKGSCSRPPLRDHGDSQWYWPKTLTELFGALSQVANGELYMLVAGNTAHGVYRRPRDIRHFIDVN 257
            |||:|.:..|.....||||||.||.|:|.||..|.:.|.:|||.||||||||||..||:||||||
  Fly   189 CKGTCRQSKLIYEDGSQWYWPSTLAEIFEALENVGDSEEFMLVGGNTAHGVYRRSPDIKHFIDVN 253

  Fly   258 MVPELRQYSIETDHLLLGGNVTLTDAMQVFLLAAKRPGFEYCAQLWQHFNLIANVPVRNNGTLAG 322
            .|.:|.|||.:.:.|.||.:::||:.|::....:|:.||||...||.|.:|:|||||||:|||||
  Fly   254 GVEDLHQYSSDKEKLTLGASLSLTETMEIIQSTSKQSGFEYLEVLWHHIDLVANVPVRNSGTLAG 318

  Fly   323 NINIKKQHFEFPSDVFITFEALDVHVLVYDNPSTQRVMNLLTYLGDTTSKLVLGGFILKAYPKDR 387
            ||..||:|.|||||:||:||||||.|:.......::.|.|..:||||..|::|..|||..||||.
  Fly   319 NICTKKEHPEFPSDIFISFEALDVKVVAMKGIDDEKEMTLEEFLGDTDRKMLLKAFILPRYPKDM 383

  Fly   388 FLFRSYKILPRAQNVHAYVNAGFLIEWQDIQHRIVHSARICFGNIRPDYIHDDQVEQLLPGRDLY 452
            :::.|:||:|||||.|||||||||:|...  :.:|.|||||||.||||:||...:|||:.|...|
  Fly   384 YIYDSFKIMPRAQNAHAYVNAGFLLELDG--NSMVKSARICFGGIRPDFIHATDIEQLMVGHSPY 446

  Fly   453 DPATVAQIFQELPASLQPEERPPEASPEYRQMLACSLLYKFLLATAPKERVRERFRTGGLLLERP 517
            :...|.|.|.:|.:.::|:|..|:|||.||..|||.|||||||..||...|..:|::||.||:||
  Fly   447 ESNLVEQTFNKLESLVKPDEVLPDASPAYRSKLACGLLYKFLLKHAPDAEVSGKFKSGGELLQRP 511

  Fly   518 LSSGSQSFETIKKNYPVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCAFVTAKRVGATIEQID 582
            ||||.|.|:|.|:.|||||.||||||:||||||||||||:|||||:|:||||.|.:|||||:|||
  Fly   512 LSSGLQLFQTNKQTYPVTQGVQKLEGMIQCSGEATYMNDVLTTSNSVYCAFVGATKVGATIDQID 576

  Fly   583 PSAALQCKGVVAFYSAEDIPGSNNFVLVNQLTP----EVDEVFVAGRVKYFDQPLGVIAALTHDA 643
            .:.|||..||||||:|:||||:|.|     ..|    |.:|:|.:|.|::.:||:|||.|||.|.
  Fly   577 ATEALQHPGVVAFYTAKDIPGTNTF-----CEPSFGYEAEEIFCSGMVRHSEQPVGVIVALTADQ 636

  Fly   644 AVYAATLVVVTYARDQR--KIFTTMNQVLAEK--QTDRIVSTKKDTVEPLKLPPLAPGDVLGRGI 704
            |..|..||.::|:....  |:..::..|.:.:  .|.||:......::.:|...  ..|:..|||
  Fly   637 AQRATKLVKISYSSPSSNFKLMPSLKDVFSSETPDTSRIIPLVISKLKEVKFSD--KPDLEVRGI 699

  Fly   705 LELASQYHFTMEPQTTIVVPLDNILQVYCATQWMDATQGAIAHMLKVSVNSIQLQVRRVGGAYGA 769
            .|:..||||||||||||::|.::.|:|:.||||:|.||..|||.|::....:||:|||:||.||.
  Fly   700 FEMGLQYHFTMEPQTTIIIPFEDGLKVFSATQWIDQTQSVIAHTLQMKAKDVQLEVRRLGGGYGC 764

  Fly   770 KVTRGNIVACATALVASKLRRPARFVQTIESMMETIGKRWACRSDYEFRARANGSIIMLSNNYYE 834
            |::|||.||||.||.|.||.||.||||::||||:..||||||||:|:...:.:|.|:.|||::||
  Fly   765 KISRGNQVACAAALAAHKLNRPVRFVQSLESMMDCNGKRWACRSEYQCHVKTSGRIVGLSNDFYE 829

  Fly   835 DSGCNLNENVVDFLTLPILRNVYNLTDANYRTQGSAIRTDAPSSTWCRAPGSAEGIAMTETALEH 899
            |:|.|.||:.|...:.....|.|..||:|::..|.|:.||||||||||||||.|||||.|..:||
  Fly   830 DAGWNTNESPVQGHSTFTAANCYEFTDSNFKLSGHAVLTDAPSSTWCRAPGSVEGIAMMENIIEH 894

  Fly   900 IAFTCQLDPADVRLVNLQPGNKMVQLLPKFLASTEYHKRRDQINLFNSQNRWRKRGLGLALMSFP 964
            :||..|.|||:|||.|:...:||..:.|:||.:.||:.|:.:|..||:.|||:||||||:||:||
  Fly   895 VAFEIQKDPAEVRLANISKKSKMATVFPEFLKTREYYSRKKEIEAFNANNRWKKRGLGLSLMNFP 959

  Fly   965 LNTTVAFNYPVTVAIYHEDGSVVISHGGIEIGQGVNTKAAQVAAFVLGVPLDQVRVEASNTVNGA 1029
            :  .....:|.||.|||.||:||::|||||:|||:|||.|||||:.||:.|..|:||:|.::|||
  Fly   960 I--IYIGQFPATVTIYHVDGTVVVTHGGIEMGQGMNTKIAQVAAYTLGIDLSYVKVESSTSINGA 1022

  Fly  1030 NSMLTANSMTSEMIGLAVRKACDTLNKRLAPVKERLGPRASWVQVLQAAFLQSVFLIATESYRLG 1094
            |||:|..::.||.:..||||.|:|||.||.||::   .:|:||:.::||..|.:.|||::.|:.|
  Fly  1023 NSMVTGYAIGSESVCYAVRKICETLNARLKPVRK---AKATWVETVEAANAQLINLIASDHYKTG 1084

  Fly  1095 DIPNYNIFGLSLTELELDILTGNHLIRRVDILEDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLV 1159
            |:.||::.||:|:|:|:|:||||.|||||||||||||||||.||||||||||||||||:|:|.|:
  Fly  1085 DMQNYHVLGLALSEVEIDVLTGNILIRRVDILEDAGESLSPWIDVGQVEGAFVMGLGYWLSELLI 1149

  Fly  1160 YDRQTGQILTNRTWNYHPPGAKDIPIDFRIELLQK-SPNPVGFMRSKATGEPALCLAVGALFAMQ 1223
            |:...|::||||||||.|.||||||||||:||:.. .|:..|||.|||||||..||||..:||:|
  Fly  1150 YEGDNGRLLTNRTWNYKPLGAKDIPIDFRVELVHNPRPSSSGFMGSKATGEPPCCLAVSVIFALQ 1214

  Fly  1224 HAIQSARNDAGLPREWVRLGAPTTPETVVLNSGSQVEAFAL 1264
            .|:||||.||||||||:||||||||||::||:|.||..|.|
  Fly  1215 QALQSARQDAGLPREWLRLGAPTTPETLLLNAGHQVSEFKL 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	fer2	3..84	CDD:238126	44/80 (55%)
		PLN02906	24..1251	CDD:215491	710/1238 (57%)
		Fer2_2	86..159	CDD:280048	57/72 (79%)
		FAD_binding_4	206..366	CDD:303082	88/159 (55%)
		CO_deh_flav_C	391..497	CDD:281449	59/105 (56%)
		Ald_Xan_dh_C	548..655	CDD:214971	63/110 (57%)
		Ald_Xan_dh_C2	702..1184	CDD:280834	276/481 (57%)
AOX4	NP_650478.1	PLN02906	24..1240	CDD:215491	708/1236 (57%)
		Fer2_2	80..153	CDD:280048	57/72 (79%)
		FAD_binding_5	203..378	CDD:279309	97/174 (56%)
		CO_deh_flav_C	388..489	CDD:281449	57/102 (56%)
		Ald_Xan_dh_C	542..648	CDD:214971	63/110 (57%)
		Ald_Xan_dh_C2	690..1174	CDD:280834	277/490 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439667
Domainoid	1	1.000	83	1.000	Domainoid score	I2880
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H98597
Inparanoid	1	1.050	1220	1.000	Inparanoid score	I588
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19024at33392
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	1	1.000	-	-		mtm9740
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	1	1.100	-	-	P	PTHR11908
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4296
	11	10.900