Protein Alignment AOX2 and Aox4

DIOPT Version :10

• Sequence 1: NP_732047.2
• Gene: AOX2 / 41895
• FlyBaseID: FBgn0038348
• Length: 1264
• Species: Drosophila melanogaster
• Sequence 2: NP_001008523.2
• Gene: Aox4 / 316424
• RGDID: 1311975
• Length: 1333
• Species: Rattus norvegicus
• Alignment Length: 1371
• Identity: 410/1371 - (29%)
• Similarity: 650/1371 - (47%)
• Gaps: 199/1371 - (14%)

  Fly     5 FNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSRAA 69
            |.|||  .:|...:..|:..|..::|:.||||.|||.|..||||:|..:|.|.:|.::::....|
  Rat    10 FFVNG--KKVIEKNPVPEMNLLFYVRKVLHLTGTKYSCGGGGCGACTVMISRYNPESKKIYHYPA 72

  Fly    70 NSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRGQV 134
            .:||..:.:...|.:.|.||:|:.....||:|:|:|:.:|||||:||||.||::|.||..| .:.
  Rat    73 TACLVPVCSLHGAAVTTVEGVGSIKRRIHPVQERLAKCHGTQCGFCSPGMVMSIYTLLRNH-PEP 136

  Fly   135 SMSQVEDAFGGNLCRCTGYRPILDAMKSFAVDSNV--------------EVPAESVD-------- 177
            :..|:.:|.|||||||||||||:::.|:|:.:|:|              |..:||..
  Rat   137 TPDQITEALGGNLCRCTGYRPIVESGKTFSPESSVCQMKGSGKCCMDLDEGCSESTKERMCTKLY 201

  Fly   178 IEDSFELLCPRTGQSCKGSCSRPP-----------------LRDHGD-SQWYWPKTLTELFGALS 224
            .||.|:.|.|          |:.|                 |...|: :.|..|.||.:|   |.
  Rat   202 NEDEFQPLDP----------SQEPIFPPELIRMAEDPHKRRLTFQGERTIWIMPVTLNDL---LE 253

  Fly   225 QVANGELYMLVAGNTAHGVYRRPRDIRH--FIDVNMVPELRQYSIETDHLLLGGNVTLT---DAM 284
            ..|:.....||.||||.|...:..:..|  ||....:|||.........:.:|...:|.   |.:
  Rat   254 LKASYPEAPLVMGNTAVGPGMKFNNEFHPVFISPLGLPELNLVDTANSGVTIGARHSLAQMKDIL 318

  Fly   285 QVFLLAAKRPGFEYCAQLWQHFNLIANVPVRNNGTLAGNINIKKQHFEFPSDVFITFEALDVHVL 349
            ....|...:...:....|.:|...:|...:||..||.|:: :.:..|   ||:
  Rat   319 HSLTLEQPKEKTKTHQALLKHLRTLAGPQIRNMATLGGHV-VSRPDF---SDL------------ 367

  Fly   350 VYDNP---STQRVMNLLTYLGDTTSKLVLGGFILKAYPKDRF--------LFRSY---------- 393
               ||   :....:|:::..|.  .::.|.|..|:..|:...        :|..|
  Rat   368 ---NPILAAGNATINVISKEGQ--RQIPLNGPFLERLPEASLKPEEVALSVFIPYSGQWQYVSGL 427

  Fly   394 KILPRAQNVHAYVNAGFLIEWQDIQHRIVHSARICFGNIRPDYIHDDQVEQLLPGRDLYDPATVA 458
            ::..|.:|..|.||||..:|:::..:.| ...::.||::.|..:...|..:.|.||. :|...::
  Rat   428 RLAQRQENAFAIVNAGMSVEFEEGTNTI-KDLQMLFGSVAPTVVSASQTCKQLIGRQ-WDDQMLS 490

  Fly   459 QIFQELPASLQPEERPPEAS---PEYRQMLACSLLYKFLLATA-------PKE--RVRERFRTG- 510
            ...|.:   |:....||:|.   .|||:.|..|||:||.|...       |::  .:.|:|.:.
  Rat   491 DACQLV---LEEIRIPPDAEGGMVEYRRTLIISLLFKFYLKVRRWLSEMDPQKFPDIPEKFVSAL 552

  Fly   511 -GLLLERPLSSGSQSFETIKKNY----PVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCAFVT 570
             .|.:|.|  .|.|.|:.:..|.    ||..|:....|:...:|||.:::|:...:..:....||
  Rat   553 DDLPIETP--QGIQMFQCVDPNQPEQDPVGHPIMHQSGIKHATGEAKFVDDMPRINQELCLTVVT 615

  Fly   571 AKRVGATIEQIDPSAALQCKGVVAFYSAEDIPGSNNFVLVNQLTPEVDEVFVA-GRVKYFDQPLG 634
            :.|..|.|..||.|.||...|||...:|||:||.||         ...|:|.| ..|....|.:.
  Rat   616 STRAHAKITSIDVSEALAYPGVVDVITAEDVPGDNN---------HSGEIFYAQNEVICVGQIIC 671

  Fly   635 VIAALTHDAAVYAATLVVVTYARDQRKIFTTMNQVLAEKQTDRIVSTKKDTVEPLKLPPLAPGDV 699
            .:||.|:..|..||..|.:|| .|......|:.|.|   :.:..:|::|         .:..|:|
  Rat   672 TVAADTYIHAKEAAKRVKITY-DDIEPAIITIEQAL---EHNSFLSSEK---------KIEQGNV 723

  Fly   700 ---------LGRGILELASQYHFTMEPQTTIVVPL--DNILQVYCATQWMDATQGAIAHMLKVSV 753
                     :..|.:.:..|.||.||.||.:.:|.  |..:.::..||:....|..::..|||..
  Rat   724 DYAFKHVDHIIEGEIHVEGQEHFYMETQTILAIPQTEDKEMVLHVGTQFPTHVQEYVSAALKVPR 788

  Fly   754 NSIQLQVRRVGGAYGAKVTRGNIVACATALVASKLRRPARFV-QTIESMMETIGKRWACRSDYEF 817
            |.|..|::|.|||:|.|||:..::....|:.|.|..||.||: .....|:.|.| |......|:.
  Rat   789 NRIACQMKRTGGAFGGKVTKPALLGAVCAVAAHKTGRPIRFILDRSNDMLITAG-RHPLLGKYKI 852

  Fly   818 RARANGSIIMLSNNYYEDSGCNLNEN--VVDFLTLPILRNVYNLTDANYRTQGSAIRTDAPSSTW 880
            ....||.|......||.:.||..:|:  |::|:.|. ..|.|::  .|:|.:|.|.:|:.||:|.
  Rat   853 GFMNNGKIKAADVEYYTNGGCTPDESEMVIEFIVLK-SENAYHI--PNFRCRGRACKTNLPSNTA 914

  Fly   881 CRAPGSAEGIAMTETALEHIAFTCQLDPADVRLVNLQPGNKMVQLLPKF------------LAST 933
            .|..|..:...:.|..:..:|..|.|.|.::|.:|:............|            |..:
  Rat   915 FRGFGFPQATVVVEAYIAAVASKCNLLPEEIREINMYKQISKTAYKQTFNPEPLRRCWKECLQKS 979

  Fly   934 EYHKRRDQINLFNSQNRWRKRGLGLALMSFPLNTTVAFNYPVTVAIYH--EDGSVVISHGGIEIG 996
            .:..|:.....||..|.|:|:||.:..|.|.:...:|| |....|:.|  .||||:::|||.|:|
  Rat   980 SFFARKQAAEEFNKNNYWKKKGLAVVPMKFSVAVPMAF-YNQAAALVHIFLDGSVLLTHGGCELG 1043

  Fly   997 QGVNTKAAQVAAFVLGVPLDQVRVEASNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKRLAPV 1061
            ||::||..|||:..|.:|...|.:..::||...|::.||.||.:::.|.||:.||.||..||.|:
  Rat  1044 QGLHTKMIQVASRELNIPKSYVHLVETSTVTVPNAVFTAGSMGADINGKAVQNACQTLLDRLQPI 1108

  Fly  1062 KERLGPRASWVQVLQAAFLQSVFLIAT---ESYRL--------GDIPNYNIFGLSLTELELDILT 1115
            .:: .|:..|.:.::.||.:|:.|.||   :.|:.        ||...|.::|.:.:|:|:|.||
  Rat  1109 IKK-NPKGKWEEWVKKAFEESISLSATGYFKGYQTNMDWEKEEGDPYPYYVYGAACSEVEVDCLT 1172

  Fly  1116 GNHLIRRVDILEDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLVYDRQTGQILTNRTWNYHPPGA 1180
            |.|.:.|.||..||..|::|.:|:|||||||:.|:|:|..|:|.|..: |.:.:....:|..|..
  Rat  1173 GAHKLLRTDIFMDAAFSINPALDIGQVEGAFIQGMGFYTIEELKYSPK-GVLYSRGPDDYKIPTV 1236

  Fly  1181 KDIPIDFRIELLQKSPNPVGFMRSKATGEPALCLAVGALFAMQHAIQSARNDAGLPREWVRLGAP 1245
            .:||.:|.:.:: :|.||:....||..||..:.|....|||:..|:.:||.:.|| .:...|.:|
  Rat  1237 TEIPEEFYVTMV-RSRNPIAIYSSKGLGEAGMFLGSSVLFAIYDAVTTARKERGL-SDIFPLNSP 1299

  Fly  1246 TTPETV 1251
            .|||.:
  Rat  1300 ATPEVI 1305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	PLN02906	24..1251	CDD:215491	404/1350 (30%)
Aox4	NP_001008523.2	mam_aldehyde_ox	7..1332	CDD:132014	410/1371 (30%)