Protein Alignment AOX2 and AOX1

DIOPT Version :10

• Sequence 1: NP_732047.2
• Gene: AOX2 / 41895
• FlyBaseID: FBgn0038348
• Length: 1264
• Species: Drosophila melanogaster
• Sequence 2: XP_011509364.1
• Gene: AOX1 / 316
• HGNCID: 553
• Length: 1350
• Species: Homo sapiens
• Alignment Length: 1376
• Identity: 400/1376 - (29%)
• Similarity: 639/1376 - (46%)
• Gaps: 202/1376 - (14%)

  Fly     5 FNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSRAA 69
            |.|||  .:|...:..|:|.|..:||:.|.||.|||.|..||||:|..:|.|.:|:|:.::...|
Human     9 FYVNG--RKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPITKRIRHHPA 71

  Fly    70 NSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRGQV 134
            |:||..:.:...|.:.|.||:|:..:..||:|:|:|:.:|||||:|:||.||::|.||..| .:.
Human    72 NACLIPICSLYGAAVTTVEGIGSTHTRIHPVQERIAKCHGTQCGFCTPGMVMSIYTLLRNH-PEP 135

  Fly   135 SMSQVEDAFGGNLCRCTGYRPILDAMKSF---------------AVDSNVE-------------- 170
            ::.|:.||.|||||||||||||:||.|:|               .:|..:.
Human   136 TLDQLTDALGGNLCRCTGYRPIIDACKTFCKTSGCCQSKENGVCCLDQGINGLPEFEEGSKTSPK 200

  Fly   171 --VPAESVDIEDSFELLCPRTGQSCKGSCSRPPLRDHGDSQ-------------WYWPKTLTELF 220
              ...|.:.::.:.||:.|            |.|....:.|             |:.|.||.||.
Human   201 LFAEEEFLPLDPTQELIFP------------PELMIMAEKQSQRTRVFGSERMMWFSPVTLKELL 253

  Fly   221 GALSQVANGELYMLVAGNTAHGVYRRPRDIRH--FIDVNMVPELRQYSIETDHLLLGGNVTLTDA 283
            ....:.....:.|   |||:.|...:.:.:.|  .|..:.:.||...:...:.|.||..::|...
Human   254 EFKFKYPQAPVIM---GNTSVGPEVKFKGVFHPVIISPDRIEELSVVNHAYNGLTLGAGLSLAQV 315

  Fly   284 MQVFL-LAAKRPGFEYCAQLW----QHFNLIANVPVRNNGTLAGNINIKKQHFEFPSDVFITFEA 343
            ..:.. :..|.|  |...|::    :|...:|...:||..:|.|  :|..:|   |..
Human   316 KDILADVVQKLP--EEKTQMYHALLKHLGTLAGSQIRNMASLGG--HIISRH---PDS------- 366

  Fly   344 LDVH-VLVYDNPSTQRVMNLLTYLG-----------------DTTSKLVLGGFILKAYPKDRFLF 390
             |:: :|...|.:    :|||:..|                 |...:.:|....:....|..|:
Human   367 -DLNPILAVGNCT----LNLLSKEGKRQIPLNEQFLSKCPNADLKPQEILVSVNIPYSRKWEFV- 425

  Fly   391 RSYKILPRAQNVHAYVNAGFLIEWQDIQHRIVHSARICFGNIRPDYIHDDQVEQLLPGR----DL 451
            .:::...|.:|..|.||:|..:.:.: ...|:....|.:|.:.|..|......|.|.||    .:
Human   426 SAFRQAQRQENALAIVNSGMRVFFGE-GDGIIRELCISYGGVGPATICAKNSCQKLIGRHWNEQM 489

  Fly   452 YDPATVAQIFQELPASLQPEERPPEASPEYRQMLACSLLYKFLLATA-----------PKERVRE 505
            .|.| ...|..|:  ||...  .|....|:::.|..|.|:||.|..:           |.  :.:
Human   490 LDIA-CRLILNEV--SLLGS--APGGKVEFKRTLIISFLFKFYLEVSQILKKMDPVHYPS--LAD 547

  Fly   506 RFRTGGLLLERPLSSGSQSFETI-KKNY---PVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHC 566
            ::.:....|.......:..::.| .|.:   |:..|:..|.|:...:|||.|.:|:......:..
Human   548 KYESALEDLHSKHHCSTLKYQNIGPKQHPEDPIGHPIMHLSGVKHATGEAIYCDDMPLVDQELFL 612

  Fly   567 AFVTAKRVGATIEQIDPSAALQCKGVVAFYSAEDIPGSNNFVLVNQLTP--EVDEVFVAGRVKYF 629
            .|||:.|..|.|..||.|.||...|||...:||.:...|:|....:...  ..|:||..|:
Human   613 TFVTSSRAHAKIVSIDLSEALSMPGVVDIMTAEHLSDVNSFCFFTEAEKFLATDKVFCVGQ---- 673

  Fly   630 DQPLGVIAALTHDAAVY---AATLVVVTYARDQRKIFTTMNQVLAEKQTDRIVSTKK----DTVE 687
                 ::.|:..|:.|.   ||..|.:.| :|...:..|:.:.:....:.:  ..:|    :..|
Human   674 -----LVCAVLADSEVQAKRAAKRVKIVY-QDLEPLILTIEESIQHNSSFK--PERKLEYGNVDE 730

  Fly   688 PLKLPPLAPGDVLGRGILELASQYHFTMEPQTTIVVPL--DNILQVYCATQWMDATQGAIAHMLK 750
            ..|:.     |.:..|.:.:..|.||.||.|:.:|||.  |..:.||.:||:....|..:|..||
Human   731 AFKVV-----DQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKYIQDIVASTLK 790

  Fly   751 VSVNSIQLQVRRVGGAYGAKVTRGNIVACATALVASKLRRPARFV-QTIESMMETIGKRWACRSD 814
            :..|.:...|||||||:|.||.:..|:|..||..|:|..|..|.| :..|.|:.| |.|......
Human   791 LPANKVMCHVRRVGGAFGGKVLKTGIIAAVTAFAANKHGRAVRCVLERGEDMLIT-GGRHPYLGK 854

  Fly   815 YEFRARANGSIIMLSNNYYEDSGCNLNENVVDFLTLPILR--NVYNLTDANYRTQGSAIRTDAPS 877
            |:.....:|.|:.|...:|.::|.:|:|::. .:.:.:|:  |.|..  .|.|.:|.|.||:.||
Human   855 YKAGFMNDGRILALDMEHYSNAGASLDESLF-VIEMGLLKMDNAYKF--PNLRCRGWACRTNLPS 916

  Fly   878 STWCRAPGSAEGIAMTETALEHIAFTCQLDPADVRLVNLQP------------GNKMVQLLPKFL 930
            :|..|..|..:...:||:.:..:|..|.|.|..||::|:..            ...::|...:.:
Human   917 NTAFRGFGFPQAALITESCITEVAAKCGLSPEKVRIINMYKEIDQTPYKQEINAKNLIQCWRECM 981

  Fly   931 ASTEYHKRRDQINLFNSQNRWRKRGLGLALMSFP--LNTTVAFNYPVTVAIYHEDGSVVISHGGI 993
            |.:.|..|:..:..||::|.|:|:||.:..:.||  |.:..|......|.|| .||||:::||||
Human   982 AMSSYSLRKVAVEKFNAENYWKKKGLAMVPLKFPVGLGSRAAGQAAALVHIY-LDGSVLVTHGGI 1045

  Fly   994 EIGQGVNTKAAQVAAFVLGVPLDQVRVEASNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKRL 1058
            |:||||:||..||.:..|.:|:..|.:..::|....|:.::..|:.:::.||||:.||.||.|||
Human  1046 EMGQGVHTKMIQVVSRELRMPMSNVHLRGTSTETVPNANISGGSVVADLNGLAVKDACQTLLKRL 1110

  Fly  1059 APVKERLGPRASWVQVLQAAFLQSVFLIATESYR-----------LGDIPNYNIFGLSLTELELD 1112
            .|:..: .|:.:|....|.||.:|:.|.|...:|           .|....|.::|.:.:|:|:|
Human  1111 EPIISK-NPKGTWKDWAQTAFDESINLSAVGYFRGYESDMNWEKGEGQPFEYFVYGAACSEVEID 1174

  Fly  1113 ILTGNHLIRRVDILEDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLVYDRQTGQILTNRTWNYHP 1177
            .|||:|...|.||:.|.|.|::|.||:||:||||:.|:|.|..|:|.|..| |.:.|.....|..
Human  1175 CLTGDHKNIRTDIVMDVGCSINPAIDIGQIEGAFIQGMGLYTIEELNYSPQ-GILHTRGPDQYKI 1238

  Fly  1178 PGAKDIPIDFRIELLQKSPNPVGFMRSKATGEPALCLAVGALFAMQHAIQSARNDAGL--PREWV 1240
            |...|:|.:..|.||..|.|......||..||..:.|.....||:..|:.:||.:.||  |   :
Human  1239 PAICDMPTELHIALLPPSQNSNTLYSSKGLGESGVFLGCSVFFAIHDAVSAARQERGLHGP---L 1300

  Fly  1241 RLGAPTTPETV 1251
            .|.:|.|||.:
Human  1301 TLNSPLTPEKI 1311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	PLN02906	24..1251	CDD:215491	393/1355 (29%)
AOX1	XP_011509364.1	mam_aldehyde_ox	5..1328	CDD:132014	400/1376 (29%)