DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX2 and gad-3

DIOPT Version :9

Sequence 1:	NP_732047.2	Gene:	AOX2 / 41895	FlyBaseID:	FBgn0038348	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_001294662.1	Gene:	gad-3 / 24104108	WormBaseID:	WBGene00015057	Length:	1257	Species:	Caenorhabditis elegans

Alignment Length:	1374	Identity:	368/1374 - (26%)
Similarity:	597/1374 - (43%)	Gaps:	254/1374 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IKFNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSR 67
            |.|||||  .:|...:..|:.||..:||..|.|..||..|.||.||||..|:........:...|
Worm     6 IFFNVNG--KDVNEENVDPELTLAYYLRNKLGLRGTKLGCEEGVCGSCTVVLGTWDDCQNKAVYR 68

  Fly    68 AANSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRG 132
            |.|:||..|.......::|.||:|:: ...||||.|:|:.:..|||:|||||||:.|.|. .::.
Worm    69 AVNACLVPLFHVHKTFVITVEGVGSR-DKIHPIQDRMARGHALQCGFCSPGFVMSAYALF-SNQP 131

  Fly   133 QVSMSQVEDAFGGNLCRCTGYRPILDAMKSFAVDSNVEVPAESVDIEDSFELLC--PRTGQSC-- 193
            ..::.|:..|...||||||||||||:|:.||:.:|..               .|  .:||..|
Worm   132 NPTIQQINAAIRANLCRCTGYRPILEALYSFSSESGG---------------CCGGNKTGGGCCK 181

  Fly   194 -KGSCSR--------------------------PPLRDHGDSQWYWPKTL------------TEL 219
             |.|...                          |.||...||:  .|.||            .:.
Worm   182 DKSSSDEDGGYDEKLLSFNDFPKYDPTQEIIFPPSLRVFSDSE--TPVTLKGDRIELLLPKNIDQ 244

  Fly   220 FGALSQ----VANGELYMLVAGNTAHGVYRRPRDI-RHFIDVNMVPELRQYSIETDHLLLGG--N 277
            |....:    :::|.:...|:       .|.|::. :.:|....|.|..:.::..|.:::|.  |
Worm   245 FKKFKKDRTVISSGLITRFVS-------TRNPKEFSQKWISTKYVKEFNEITVNKDSVVVGAALN 302

  Fly   278 V-----TLTDAMQVFLLAAKRPGFEYCAQLWQHFN--LIANVPVRNNGTLAG---NINIKKQHFE 332
            :     |||.::.:.:      |.|..:.: |.|:  .|||........::|   ::::
Worm   303 IQKMADTLTSSLSINI------GKEIDSFI-QKFSSPQIANFATWTGAIISGAKSSLSV------ 354

  Fly   333 FPSDVFITFEALDVHVLVYDNPSTQRVMNLLTYLGDTTSKLVLGGFILKAYPKDRFLFRSYKILP 397
              ||:.|.|..||..            :.||...|:.| ::.:..|      .::.||.:
Worm   355 --SDLLILFNVLDAK------------LTLLNNSGELT-QVAIEEF------AEKKLFAT----- 393

  Fly   398 RAQNVHAYVNA-------GFLI-------EWQDIQHRIVHSARICF----GNIRPDYIHDDQVEQ 444
                 |..|||       |||.       ..||       |....|    ||         ||.:
Worm   394 -----HTIVNAIFSRSLTGFLFCLKLGETSEQD-------STNFNFAALVGN---------QVSR 437

  Fly   445 LLPGR--------------DLYDPATVAQIFQELPASLQPEERPPEASPEYRQM-LACSLLYKFL 494
            :..|.              |.....:|:.:.|....|            :|:.: :|.:....|:
Worm   438 IFVGLGGQPKRLTSLEVHIDALKGLSVSDLCQTTEMS------------DYKNVKIALTRFSDFM 490

  Fly   495 LATAPKERVRERFRTGGLLLERPLSSGSQSFETIKKNYPVTQPVQKLEGLIQCSGEATYMNDLLT 559
               ..||:..|......|...:|           |.|....:|:.........:|||.|:|| :.
Worm   491 ---NHKEKTEEIEGINYLQYFKP-----------KTNESAGRPIANYFNERAITGEAFYVND-IQ 540

  Fly   560 TSNAVHCAFVTAKRVGATIEQIDPSAALQCKGVVAFYSAEDIPGSN--NFVLVNQLTPEVDEVFV 622
            ..||||..||.:....|.|.:||.|.|||.:||..::...|:||:|  ...:.|...|:...:|.
Worm   541 AYNAVHLGFVLSTVPHAEITKIDVSEALQLEGVAGYFGVSDVPGNNTPGLQISNMNFPDDTTIFA 605

  Fly   623 AGRVKYFDQPLGVIAALTHDAAVYAATLVVVTYARDQRKIFTTMNQVLAEKQTDRIVSTKKDTVE 687
            ..:|:...|.:|||||.....|..||.||.|.| ::...:......:.|:.....:....||  |
Worm   606 DKKVESVGQVIGVIAANDVVLARRAAKLVKVEY-KELPSLVNFKEAIEAKSLLGDVQHFGKD--E 667

  Fly   688 PLKLPPLAPGDVLGRGILELASQYHFTMEPQTTIVVPLD-NILQVYCATQWMDATQGAIAHMLKV 751
            .|....|.....:..|..::..|.|:.:|.|:::|:|.: :.|.|.|:||....||..:|..:|:
Worm   668 NLVKESLENSSKVLEGECDIGGQEHYYLETQSSLVIPGEGDELIVNCSTQGTSFTQLMVAETMKI 732

  Fly   752 SVNSIQLQVRRVGGAYGAKVTRGNIVACATALVASKLRRPA-RFVQTIESMMETIGKRWACRSDY 815
            ..:.|.::.:|:||.:|.||...:.:||..|:||.||.||. .|:...:.:..| |||....:.|
Worm   733 PAHKIIVKTKRLGGGFGGKVNNASWIACMCAIVAKKLNRPTYGFLSRADDLAIT-GKRHEVHAKY 796

  Fly   816 EFRARANGSI------IMLSNNYYEDSGCNLNENVVDFLTLPILRNVYNLTDANYRTQGSAIRTD 874
            ......:|.|      ..|:..:.:|.    :|.|...:.| ::.:|||:  ...|..|..::|:
Worm   797 RVGINFDGKIEGIHYQAWLNGGWSKDH----SEGVTMVMGL-MVDDVYNM--GTIRFDGYPVKTN 854

  Fly   875 APSSTWCRAPGSAEGIAMTETALEHIAFTCQLDPADVRLVN--LQPGNK----------MVQLLP 927
            :.|:|..|..|:.:...:.|..:..||........:::.:|  |:.|.:          :|:...
Worm   855 SNSNTALRGYGNPQSKLINEGVMRRIARDVGKSTEEIKRINFALEGGRRYLGGKIHNDALVECWE 919

  Fly   928 KFLASTEYHKRRDQINLFNSQNRWRKRGLGLALMSFPLNTTVAFNYPVTVAIYHEDGSVVISHGG 992
            .....:|:..|:..|..||..:...|||:.::.:.|.|.......:.:...:.:.||||.:|.||
Worm   920 YCKKWSEFENRQSGIKQFNKNSTAVKRGIAMSSVRFGLPHPGPTGHGIASLLINLDGSVQLSIGG 984

  Fly   993 IEIGQGVNTKAAQVAAFVLGVPLDQVRVEASNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKR 1057
            .|:|||:|.|..||.:..|..|:|.:.:...:|....|:..|..|..::..||||...|..:..|
Worm   985 TEMGQGLNQKMLQVCSEALKRPIDTITIVDCSTDKVTNAPETGGSQNADTNGLAVLACCKKIMSR 1049

  Fly  1058 LAPVKERLGPRASWVQVLQAAFLQSVFLIATE-------SYRLGDIPN-YNIFGLSLTELELDIL 1114
            |.|:.::  ....|.:.::.|:...|.|..||       .:.:|::.: ||..|....|:|:|.|
Worm  1050 LQPIIDK--NDGEWEKSIREAYGAYVPLQCTEYGTVERAKFGVGEMESPYNTTGACAVEMEIDTL 1112

  Fly  1115 TGNHLIRRVDILEDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLVYDRQTGQILTNRTWNYHPPG 1179
            ||.:.:.||||:.|.||||:|.:|:||:||||:.|.|....|::.:::.|||:..|....|..|.
Worm  1113 TGYNRVIRVDIVMDVGESLNPALDIGQIEGAFIQGYGLVTCEKITFNKTTGQLDQNTAGKYKIPK 1177

  Fly  1180 AKDIPIDFRIELLQ-KSPNPVGFMRSKATGEPALCLAVGALF-AMQHAIQSARNDAGLPREWVRL 1242
            |.|:|.|||::||. .:.|......||..|||.|.::.||:. ::.:.|.:.||:.|: .|:|..
Worm  1178 ASDVPKDFRVKLLGINNANGAQVYSSKGIGEPPLMMSCGAVHSSIMNCIDNWRNENGI-HEFVDT 1241

  Fly  1243 GAPTTPETV 1251
            .:|.:.|.:
Worm  1242 ISPLSAEKI 1250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	fer2	3..84	CDD:238126	30/80 (38%)
		PLN02906	24..1251	CDD:215491	360/1351 (27%)
		Fer2_2	86..159	CDD:280048	36/72 (50%)
		FAD_binding_4	206..366	CDD:303082	35/188 (19%)
		CO_deh_flav_C	391..497	CDD:281449	23/138 (17%)
		Ald_Xan_dh_C	548..655	CDD:214971	42/108 (39%)
		Ald_Xan_dh_C2	702..1184	CDD:280834	146/509 (29%)
gad-3	NP_001294662.1	fer2	6..77	CDD:238126	29/72 (40%)
		PLN02906	23..1255	CDD:215491	360/1355 (27%)
		Fer2_2	87..158	CDD:280048	36/72 (50%)
		FAD_binding_4	<277..385	CDD:303082	27/135 (20%)
		Ald_Xan_dh_C	530..642	CDD:279635	43/113 (38%)
		Ald_Xan_dh_C2	661..1182	CDD:280834	151/532 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163374
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750