DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX2 and Xdh

DIOPT Version :9

Sequence 1:	NP_732047.2	Gene:	AOX2 / 41895	FlyBaseID:	FBgn0038348	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_035853.2	Gene:	Xdh / 22436	MGIID:	98973	Length:	1335	Species:	Mus musculus

Alignment Length:	1389	Identity:	403/1389 - (29%)
Similarity:	634/1389 - (45%)	Gaps:	233/1389 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSRAA 69
            |.|||.....:.||  |:|||..:||..|.|..||..|.|||||:|..:|.:...:..::...:.
Mouse    11 FFVNGKKVVEKNAD--PETTLLVYLRRKLGLCGTKLGCGEGGCGACTVMISKYDRLQNKIVHFSV 73

  Fly    70 NSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRGQV 134
            |:|||.:.:.....:.|.||:|| ....||:|:|:|:.:|:|||:|:||.||:||.|| :::.:.
Mouse    74 NACLTPICSLHHVAVTTVEGIGN-TKKLHPVQERIAKSHGSQCGFCTPGIVMSMYTLL-RNKPEP 136

  Fly   135 SMSQVEDAFGGNLCRCTGYRPILDAMKSFAVD--------------------------SNVEVPA 173
            ::.::|:||.|||||||||||||...::||.|                          |::..|.
Mouse   137 TVEEIENAFQGNLCRCTGYRPILQGFRTFAKDGGCCGGSGNNPNCCMSQTKDQTIAPSSSLFNPE 201

  Fly   174 ESVDIEDSFELLCPRTGQSCKGSCSRPPLRDHGDS-QWYWPKTLTELFGALSQVANGELYMLVAG 237
            :...::.:.|.:.|......|.: .|..||..|:. .|....|:.||....:|..:.:   ||.|
Mouse   202 DFKPLDPTQEPIFPPELLRLKDT-PRKTLRFEGERVTWIQVSTMEELLDLKAQHPDAK---LVVG 262

  Fly   238 NTAHGVYRR-----------PRDIRHFIDVNMVPELRQYSIETDHLLLGGNVTLTDAMQVFLLAA 291
            ||..|:..:           |..|.....|...||...:.......|:  ...|.||  :..|..
Mouse   263 NTEIGIEMKFKNMLFPLIICPAWILELTSVAHGPEGISFGAACPLSLV--ESVLADA--IATLPE 323

  Fly   292 KRPGFEYCAQLWQHFNLIANVPVRNNGTLAGNINIKKQHFEFPSDVFITFEAL-DVHVLVYDNPS 355
            :|.  |....:.:.....|...|::..::.|||              ||...: |:      ||.
Mouse   324 QRT--EVFRGVMEQLRWFAGKQVKSVASIGGNI--------------ITASPISDL------NPV 366

  Fly   356 TQRVMNLLTYLGDTTSKLV------LGGF-------------ILKAYPKDRFLFRSYKILPRAQN 401
            .......||.....|.:.|      ..|:             |:..|.:....|.::|...|.::
Mouse   367 LMASRAKLTLASRGTKRTVWMDHTFFPGYRRTLLSPEEILVSIVIPYSRKGEFFSAFKQASRRED 431

  Fly   402 VHAYVNAGFLI-------EWQDIQHRIVHSARICFGNI----------RPDYIHDDQVEQLLPGR 449
            ..|.|.:|..:       |.|::.        :|||.:          .|..:.....|:||  :
Mouse   432 DIAKVTSGMRVLFKPGTTEVQELS--------LCFGGMADRTVSALKTTPKQLSKSWNEELL--Q 486

  Fly   450 DLYDPATVAQIFQELPASLQPEERPPEASPEYRQMLACSLLYKFLLATAPK----------ERVR 504
            |:     .|.:.:||  .|.|:  .|....|:|:.|..|..:||.|....|          .::.
Mouse   487 DV-----CAGLAEEL--HLAPD--APGGMVEFRRTLTLSFFFKFYLTVLQKLGRADLEGMCGKLD 542

  Fly   505 ERFRTGGLLLERPLSSGSQSFETIKKNYP----VTQPVQKLEGLIQCSGEATYMNDLLTTSNAVH 565
            ..|.:..||.::...:..|.|:.:.|...    |.:|:..|...:|.||||.|.:|:....|.:.
Mouse   543 PTFASATLLFQKDPPANVQLFQEVPKGQSEEDMVGRPMPHLAADMQASGEAVYCDDIPRYENELS 607

  Fly   566 CAFVTAKRVGATIEQIDPSAALQCKGVVAFYSAEDIPGSNNFVLVNQLTP-EVDEVFVAGRVKYF 629
            ...||:.|..|.|..||.|.|.:..|.|.|.::||:||||...:.|..|. ..|||...|.:
Mouse   608 LRLVTSTRAHAKIMSIDTSEAKKVPGFVCFLTSEDVPGSNITGIFNDETVFAKDEVTCVGHI--- 669

  Fly   630 DQPLGVIAALTHDAAVYAATLVVVTYARDQRKIFTTMN----------QVLAEK--------QTD 676
               :|.:.|.|.:.|..||..|.:|| .|...|.|..:          :|..||        :.|
Mouse   670 ---IGAVVADTPEHAHRAARGVKITY-EDLPAIITIQDAIKNNSFYGPEVKIEKGDLKKGFSEAD 730

  Fly   677 RIVSTKKDTVEPLKLPPLAPGDVLGRGILELASQYHFTMEPQTTIVVPLDNI--LQVYCATQWMD 739
            .:||                      |.|.:..|.||.:|...||.||....  ::::.:||...
Mouse   731 NVVS----------------------GELYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTM 773

  Fly   740 ATQGAIAHMLKVSVNSIQLQVRRVGGAYGAKVTRGNIVACATALVASKLRRPARFVQTIESMMET 804
            .||..||.||.|..|.|.::|:|:||.:|.|.||..:::.|.||.|.|..||.|.:...:..|..
Mouse   774 KTQSFIAKMLGVPDNRIVVRVKRMGGGFGGKETRSTLISTAVALAAYKTGRPVRCMLDRDEDMLI 838

  Fly   805 IGKRWACRSDYEFRARANGSIIMLSNNYYEDSGC--NLNENVVDFLTLPILRNVYNLTDA----N 863
            .|.|....:.|:......|:|:.|...::.:.|.  :|:.::::       |.|:::.:|    |
Mouse   839 TGGRHPFLAKYKVGFMKTGTIVALEVAHFSNGGNSEDLSRSIME-------RAVFHMDNAYKIPN 896

  Fly   864 YRTQGSAIRTDAPSSTWCRAPGSAEGIAMTETALEHIAFTCQLDPADVRLVNLQPGNKMVQL--- 925
            .|..|...:|:.||:|..|..|..:|:.:.|..:..:|.||.|...:||..|:.....:...
Mouse   897 IRGTGRICKTNLPSNTAFRGFGGPQGMLIAEYWMSEVAVTCGLPAEEVRRKNMYKEGDLTHFNQK 961

  Fly   926 -----LPK----FLASTEYHKRRDQINLFNSQNRWRKRGLGLALMSFPLNTTVAF-NYPVTVAIY 980
                 ||:    .:||::|..|:.::..||.:|.|:||||.:....|.::.|::| |....:...
Mouse   962 LEGFTLPRCWDECIASSQYQARKMEVEKFNRENCWKKRGLCIIPTKFGISFTLSFLNQGGALVHV 1026

  Fly   981 HEDGSVVISHGGIEIGQGVNTKAAQVAAFVLGVPLDQVRVEASNTVNGANSMLTANSMTSEMIGL 1045
            :.||||:::|||.|:|||::||..|||:..|.:|..::.:..::|....|:..||.|.::::.|.
Mouse  1027 YTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIHITETSTNTVPNTSPTAASASADLNGQ 1091

  Fly  1046 AVRKACDTLNKRLAPVKERLGPRASWVQVLQAAFLQSVFLIATESYRL-----------GDIPNY 1099
            |:.:||.|:.|||.|.|:: .|..||...:..|:..:|.|.||..|:.           |:..:|
Mouse  1092 AIYEACQTILKRLEPFKKK-NPSGSWESWVMDAYTSAVSLSATGFYKTPNLGYSFETNSGNPFHY 1155

  Fly  1100 NIFGLSLTELELDILTGNHLIRRVDILEDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLVYDRQT 1164
            ..:|::.:|:|:|.|||:|...|.||:.|.|.||:|.||:||||||||.|||.:..|:|.|..:
Mouse  1156 FSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTMEELHYSPE- 1219

  Fly  1165 GQILTNRTWNYHPPGAKDIPIDFRIELLQKSPNPVGFMRSKATGEPALCLAVGALFAMQHAIQSA 1229
            |.:.|.....|..|....|||:||:.||:..||......|||.|||.|.||....||::.||::|
Mouse  1220 GSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKRAIYASKAVGEPPLFLASSIFFAIKDAIRAA 1284

  Fly  1230 RNDAG--LPREWVRLGAPTTPETV 1251
            |...|  ..::..:|.:|.|||.:
Mouse  1285 RAQHGDSNAKQLFQLDSPATPEKI 1308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	fer2	3..84	CDD:238126	28/78 (36%)
		PLN02906	24..1251	CDD:215491	395/1368 (29%)
		Fer2_2	86..159	CDD:280048	39/72 (54%)
		FAD_binding_4	206..366	CDD:303082	36/172 (21%)
		CO_deh_flav_C	391..497	CDD:281449	28/122 (23%)
		Ald_Xan_dh_C	548..655	CDD:214971	38/107 (36%)
		Ald_Xan_dh_C2	702..1184	CDD:280834	165/513 (32%)
Xdh	NP_035853.2	PLN02906	26..1321	CDD:215491	396/1372 (29%)
		Fer2_2	90..160	CDD:280048	38/71 (54%)
		FAD_binding_5	234..414	CDD:279309	39/208 (19%)
		CO_deh_flav_C	421..525	CDD:281449	28/122 (23%)
		Ald_Xan_dh_C	590..696	CDD:279635	41/112 (37%)
		Ald_Xan_dh_C2	714..1239	CDD:280834	171/555 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820