DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX2 and F15E6.6

DIOPT Version :9

Sequence 1:	NP_732047.2	Gene:	AOX2 / 41895	FlyBaseID:	FBgn0038348	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_500531.2	Gene:	F15E6.6 / 177192	WormBaseID:	WBGene00017487	Length:	1256	Species:	Caenorhabditis elegans

Alignment Length:	1348	Identity:	349/1348 - (25%)
Similarity:	588/1348 - (43%)	Gaps:	231/1348 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IKFNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSR 67
            |.|||||  .:::..:..|:.||..:||..|.|..||..|.||.||||..|:........:....
Worm     6 IFFNVNG--KDIKEENVDPELTLAYYLRNKLGLRGTKLGCEEGVCGSCTVVLGTWDDSLNKAVYS 68

  Fly    68 AANSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRG 132
            |.|:||..|.......::|.||:|:: ...||||.|:|:.:..|||:|||||||:.|.||..|..
Worm    69 AVNACLVPLFHVHKTFVITVEGVGSR-DKIHPIQDRMARGHAVQCGFCSPGFVMSAYALLRNHPN 132

  Fly   133 QVSMSQVEDAFGGNLCRCTGYRPILDAMKSFA-------------------VDSNVEVPAESVDI 178
            . ::.|:..|...||||||||||||:|:.||:                   :.|..|...:....
Worm   133 P-TIEQINAAIRANLCRCTGYRPILEALYSFSSSGGGCCGGKKAGAGCCKDLSSEDEAYEKLTSF 196

  Fly   179 ED------SFELLCPRTGQSCKGSCSRPPLRDHGDS-----------QWYWPKTLTELFGALSQ- 225
            .|      |.|::.|            |.||...||           :...||:: |.|....:
Worm   197 NDFPEYDPSQEIIFP------------PSLRIFVDSENPVTLKGDRIELLLPKSI-EQFKEFKKD 248

  Fly   226 ---VANGELYMLVAGNTAHGVYRRPRDI-RHFIDVNMVPELRQYSIETDHLLLGGNVTLTDAMQV 286
               :::|.:...:|       .|.|::. :.:|....|.|..:.....:.:::|..|.:.....:
Worm   249 RTVISSGLITRFIA-------TRNPKEFSQKWITTKYVKEFNEVIENPETVVIGAAVNIQKMSDI 306

  Fly   287 FLLA-AKRPGFEYCAQLWQHFN--LIANVPVRNNGTLAG---NINIKKQHFEFPSDVFITFEALD 345
            ...: ::..|.|..|.: :.|:  .|||......|.::|   :|::        ||:.:.|..|:
Worm   307 LSRSLSQNIGKEVDAFI-KKFSSPQIANFATWTGGIVSGAKSSISV--------SDLLLLFNVLN 362

  Fly   346 VHVLVYDNPSTQRVMNLLTYLGDTTSKLVLGGFILKAYPKDRFLFRSYKILPRAQNVHAYVNAGF 410
            ..            :.|||..||.| ::.:..|:      ::.||.:..|          ||..|
Worm   363 AK------------LTLLTDSGDLT-QVNIEEFV------EKKLFATNTI----------VNTVF 398

  Fly   411 ------------LIEWQDIQHRIVHSARICFGNIRPDYIHDDQVEQLLPGRDLYDPATVAQIFQE 463
                        |.|..:......:.|.:...||                         ::||..
Worm   399 SSSITGQLFCLKLGETSEQDSTSFNFAALVGNNI-------------------------SRIFVG 438

  Fly   464 LPASLQPEERPPEASPEYRQMLACSLLYKFLLATAPKERVRERFRTGGL-----------LLERP 517
            |..       ||:......:.:       |.|....   |.:..:|.|:           .|.:.
Worm   439 LGG-------PPKRLTSLEEHI-------FALKNLD---VPDLCKTSGMGENKNIKIALTRLSKF 486

  Fly   518 LSSGSQSFETIK-KNY----------PVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCAFVTA 571
            :.:..::.||:. .||          .|.:|:.........:|||.|:|| :.|.|.||..||.:
Worm   487 MKNVEKTAETVDGLNYLQYFKPTERKSVGRPLANYFNERAITGEALYVND-IQTYNPVHLGFVLS 550

  Fly   572 KRVGATIEQIDPSAALQCKGVVAFYSAEDIPGSNN--FVLVNQLTPEVDEVFVAGRVKYFDQPLG 634
            ....|.|..||.:.||:.:|||.|:.|.|:||:|:  ..:.|...|:...:|...:|:...|.:|
Worm   551 TVPHAEILSIDATEALKLEGVVGFFGASDVPGNNSPGLQISNMNLPDDATIFADKKVESVGQVVG 615

  Fly   635 VIAALTHDAAVYAATLVVVTYARDQRKIFTTMNQVLAEKQTDRIVSTKKDTVEPLKLPPLAPGDV 699
            ||||.....|..||.||.:.| ::...:....:.::|:....::....|.  |.|....|.....
Worm   616 VIAANDVLLARRAAKLVKLEY-KELPALVELKDAIVAKSLLGKVRHFGKS--EYLVNESLVHSYK 677

  Fly   700 LGRGILELASQYHFTMEPQTTIVVPLDNILQ-VYCATQWMDATQGAIAHMLKVSVNSIQLQVRRV 763
            :..|...|.||.||.:|.|:::|:|.:.... |:|:||....||..:|..:|:..:.|.::.:|:
Worm   678 VLEGESSLGSQEHFYLETQSSLVIPGEGDESIVHCSTQGTSFTQLMVAETMKIPAHKIIVKTKRM 742

  Fly   764 GGAYGAKVTRGNIVACATALVASKLRRPARFVQTIESMMETIGKRWACRSDYEFRARANGSIIML 828
            |||:|.|:...:.:||..::||.||.||.....:.|..:...|||....:.|.....::|.:..:
Worm   743 GGAFGGKLNNASWIACICSVVAKKLNRPTYGYLSREEDLAITGKRHGVYTKYRVGINSDGKVQGI 807

  Fly   829 SNNYYEDSGCNLNENV-VDFLTLPILRNVYNLTDANYRTQGSAIRTDAPSSTWCRAPGSAEGIAM 892
            .:..:.:.|.:.:... |..:....:.:|||:....|  .|..::|:..|:|..|..|:.:...:
Worm   808 HHQAWLNGGWSKDHTEGVTMVMGQFVDDVYNMGTVRY--DGYPVKTNTNSNTAFRGYGNPQAKLV 870

  Fly   893 TETALEHIAFTCQLDPADVRLVNLQ-PGNKMVQLLPKFLAS-----------------TEYHKRR 939
            :|..:..||........:|:.:|.. .|.|      ::|:.                 :::.||:
Worm   871 SEGVMRRIAREVGKSTEEVKKLNFAFEGEK------RYLSGNIYSDAHIECWEYCTRWSDFEKRK 929

  Fly   940 DQINLFNSQNRWRKRGLGLALMSFPLNTTVAFNYPVTVAIYHEDGSVVISHGGIEIGQGVNTKAA 1004
            :.|..||..::..|||:.::.:...|:......:.|...:.:.|||:.:|.||.|:|||:|.|..
Worm   930 ETIENFNKTSKIVKRGIAMSSVRLALSHPGPPGHGVASLMINLDGSIQLSIGGTEMGQGLNQKML 994

  Fly  1005 QVAAFVLGVPLDQVRVEASNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKRLAPVKERLGPRA 1069
            ||.:..|..|:|.:.:...:|....|:..|..|..::..||||...|:.:..||.|:.::  ...
Worm   995 QVCSEALKRPIDTITIVDCSTDKITNAPETGASHNADTNGLAVLACCERIMSRLQPIIDK--NDG 1057

  Fly  1070 SWVQVLQAAFLQSVFLIAT-------ESYRLGDIP-NYNIFGLSLTELELDILTGNHLIRRVDIL 1126
            .|.:.::.|:...|.|..|       |...:|:.. .||..|....|:|:|.:||.:.:.||||:
Worm  1058 DWEKSIRDAYGAYVPLQCTEYGSVDREKLSIGEFEYPYNTTGACAVEMEVDTMTGYNRLLRVDIV 1122

  Fly  1127 EDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLVYDRQTGQILTNRTWNYHPPGAKDIPIDFRIEL 1191
            .|.||||:|.||:||:||||:.|.|....|::.::::|||:..|....|..|.:.|:|.|||::|
Worm  1123 MDVGESLNPAIDIGQIEGAFMQGYGLVTCEKITFNKETGQLNQNSAGQYKIPKSSDVPKDFRVKL 1187

  Fly  1192 LQ-KSPNPVGFMRSKATGEPALCLAVGALFA-MQHAIQSARNDAGLPR 1237
            |. ...|......||..|||.|.::.||:.: :.:.|...|.:.|:.:
Worm  1188 LGINKANGAKVYSSKGIGEPPLMMSCGAVHSCIMNCIDDWRKENGIDK 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX2	NP_732047.2	fer2	3..84	CDD:238126	28/80 (35%)
		PLN02906	24..1251	CDD:215491	342/1327 (26%)
		Fer2_2	86..159	CDD:280048	38/72 (53%)
		FAD_binding_4	206..366	CDD:303082	32/181 (18%)
		CO_deh_flav_C	391..497	CDD:281449	16/117 (14%)
		Ald_Xan_dh_C	548..655	CDD:214971	42/108 (39%)
		Ald_Xan_dh_C2	702..1184	CDD:280834	141/509 (28%)
F15E6.6	NP_500531.2	fer2	6..77	CDD:238126	27/72 (38%)
		PLN02906	23..1253	CDD:215491	342/1329 (26%)
		Fer2_2	87..158	CDD:280048	38/72 (53%)
		FAD_binding_4	<279..382	CDD:303082	24/124 (19%)
		Ald_Xan_dh_C	528..640	CDD:279635	43/113 (38%)
		Ald_Xan_dh_C2	678..1180	CDD:280834	141/511 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163375
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750