back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX2 and Aox1

DIOPT Version :9

Sequence 1:	NP_732047.2	Gene:	AOX2 / 41895	FlyBaseID:	FBgn0038348	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_033806.2	Gene:	Aox1 / 11761	MGIID:	88035	Length:	1333	Species:	Mus musculus

Alignment Length:	1385	Identity:	412/1385 - (29%)
Similarity:	636/1385 - (45%)	Gaps:	216/1385 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSIKFNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQ 65
            :.:.|.|||  .:|...:..|:..|..:||::|.||.|||.|..||||:|..:|.|.:|.|:.::
Mouse     4 IQLLFYVNG--QKVVEKNVDPEMMLLPYLRKNLRLTGTKYGCGGGGCGACTVMISRYNPSTKAIR 66

  Fly    66 SRAANSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQH 130
            ....|:|||.:.:.....:.|.|||||..:..||||:|:|:.:|||||:|:||.||:||.||..|
Mouse    67 HHPVNACLTPICSLHGTAVTTVEGLGNTRTRLHPIQERIAKCHGTQCGFCTPGMVMSMYALLRNH 131

  Fly   131 RGQVSMSQVEDAFGGNLCRCTGYRPILDAMKSF---------------AVDSNVEVPAESVD--- 177
             .:.::.|:.||.|||||||||||||:||.|:|               .:|..:...|||.:
Mouse   132 -PEPTLDQLTDALGGNLCRCTGYRPIIDACKTFCKASGCCQSKENGVCCLDQEINGLAESQEEDK 195

  Fly   178 ------IEDSF-------ELLCP----RTGQSCKGSCSRPPLRD--HGDS-QWYWPKTLTELFGA 222
                  .|:.|       ||:.|    |..:      .:||...  :|:. .|..|.||.||..|
Mouse   196 TSPELFSEEEFLPLDPTQELIFPPELMRIAE------KQPPKTRVFYGERVTWISPVTLKELVEA 254

  Fly   223 LSQVANGELYMLVAGNTAHGVYRRPRDIRH--FIDVNMVPELRQYSIETDHLLLGGNVTLTDAMQ 285
            ..:.....:.|   |.|:.|...:.:.:.|  .|..:.:.||...|...|.|.||..::|.....
Mouse   255 KFKYPQAPIVM---GYTSVGPEVKFKGVFHPIIISPDRIEELGVISQARDGLTLGAGLSLDQVKD 316

  Fly   286 VFL-LAAKRPGFE---YCAQLWQHFNLIANVPVRNNGTLAGNINIKKQHFEFPSDVFITFEALDV 346
            :.. :..|.|..:   |.| |.:|...:|...:||..:|.|  :|..:|.:           .|:
Mouse   317 ILADIVQKLPEEKTQTYRA-LLKHLRTLAGSQIRNMASLGG--HIVSRHLD-----------SDL 367

  Fly   347 HVLVYDNPSTQRVMNLLTYLGDTTSKLVLGGFILKAYP-------------------KDRFLFRS 392
            :.|:.....|   :|||:..|:  .::.|....|:..|                   |..|: .:
Mouse   368 NPLLAVGNCT---LNLLSKDGE--RRIPLSEEFLRKCPEADLKPQEVLVSVNIPWSRKWEFV-SA 426

  Fly   393 YKILPRAQNVHAYVNAGFLIEWQDIQHRIVHSARICFGNIRPDYIHDDQVEQLLPGRD------- 450
            ::...|.||..|.||:|..:.::: ...::....|.:|.:....|......|.|.||.
Mouse   427 FRQAQRQQNALAIVNSGMRVLFRE-GGGVIEELSILYGGVGSTIISAKNSCQRLIGRPWNEGMLD 490

  Fly   451 -----LYDPATVAQIFQELPASLQPEERPPEASPEYRQMLACSLLYKFLLATAPKERVRERFRTG 510
                 :.|..|:|       ||      .|....|:::.|..|.|:||.|..:.
Mouse   491 TACRLVLDEVTLA-------AS------APGGKVEFKRTLIISFLFKFYLEVSQ----------- 531

  Fly   511 GLLLERPLSSGS------QSFETIKKNY------------------PVTQPVQKLEGLIQCSGEA 551
            ||..|.|..|.|      .:.:.:...:                  |:.:|:..|.|:...:|||
Mouse   532 GLKREDPGHSPSLAGNHESALDDLHSKHPWRTLTHQNVDPAQLPQDPIGRPIMHLSGIKHATGEA 596

  Fly   552 TYMNDLLTTSNAVHCAFVTAKRVGATIEQIDPSAALQCKGVVAFYSAEDIPGSNNFVLVNQLTPE 616
            .|.:|:......:...|||:.|..|.|..||.|.||...|||...:|:.:..:|.|.....|.
Mouse   597 IYCDDMPAVDRELFLTFVTSSRAHAKIVSIDLSEALSLPGVVDIITADHLQEANTFGTETFLA-- 659

  Fly   617 VDEVFVAGRVKYFDQPLGVIAALTHDA---AVYAATLVVVTYARDQRKIFTTMNQVLAEKQTDRI 678
            .|||...|.         ::.|:..|:   |..||..|.|.| :|...:..|:.:.:..|...:
Mouse   660 TDEVHCVGH---------LVCAVIADSETRAKQAAKQVKVVY-QDLAPLILTIEEAIQHKSFFK- 713

  Fly   679 VSTKK----DTVEPLKLPPLAPGDVLGRGILELASQYHFTMEPQTTIVVPL--DNILQVYCATQW 737
             |.:|    :..|..|:.     |.:..|.:.:..|.||.||.|:.:|||.  |..:.:|.:||:
Mouse   714 -SERKLECGNVDEAFKIV-----DQILEGEIHIGGQEHFYMETQSMLVVPKGEDGEIDIYVSTQF 772

  Fly   738 MDATQGAIAHMLKVSVNSIQLQVRRVGGAYGAKVTRGNIVACATALVASKLRRPAR-FVQTIESM 801
            ....|..:|..||:|.|.:...|||||||:|.||.:.:|:|..||..|||..|..| .::..|.|
Mouse   773 PKYIQDIVAATLKLSANKVMCHVRRVGGAFGGKVGKTSILAAITAFAASKHGRAVRCILERGEDM 837

  Fly   802 METIGKRWACRSDYEFRARANGSIIMLSNNYYEDSGCNLNENV-VDFLTLPILRNVYNLTDANYR 865
            :.| |.|......|:.....:|.|:.|...:|.:.||:|:|:: |..:.|..|.|.|..  .|.|
Mouse   838 LIT-GGRHPYLGKYKAGFMNDGRILALDVEHYCNGGCSLDESLWVIEMGLLKLDNAYKF--PNLR 899

  Fly   866 TQGSAIRTDAPSSTWCRAPGSAEGIAMTETALEHIAFTCQLDPADVRLVNLQPGNKMVQLLPKF- 929
            .:|.|.||:.||:|..|..|..:...:||..:..:|..|.|.|..||.:|:...........:|
Mouse   900 CRGWACRTNLPSNTALRGFGFPQAGLVTEACITEVAIKCGLSPEQVRTINMYKHVDTTHYKQEFS 964

  Fly   930 -----------LASTEYHKRRDQINLFNSQNRWRKRGLGLALMSFPLNT-TVAFNYPVTVAIYHE 982
                       :|...|.:|:..|..||::|.|:|||:.:..:.||:.. :||......:...:.
Mouse   965 AKALSECWRECMAKCSYFERKAAIGKFNAENSWKKRGMAVIPLKFPVGIGSVAMGQAAALVHIYL 1029

  Fly   983 DGSVVISHGGIEIGQGVNTKAAQVAAFVLGVPLDQVRVEASNTVNGANSMLTANSMTSEMIGLAV 1047
            |||.::||||||:||||:||..||.:..|.:|:..|.:..::|....|:..:..|:.:::.||||
Mouse  1030 DGSALVSHGGIEMGQGVHTKMIQVVSRELRMPMSSVHLRGTSTETVPNTNASGGSVVADLNGLAV 1094

  Fly  1048 RKACDTLNKRLAPVKERLGPRASWVQVLQAAFLQSVFLIATESYR-----------LGDIPNYNI 1101
            :.||.||.|||.|:..: .|:.:|....|.||.||:.|.|...:|           .|....|.:
Mouse  1095 KDACQTLLKRLEPIISK-NPQGTWKDWAQTAFDQSISLSAVGYFRGYESNIDWEKGEGHPFEYFV 1158

  Fly  1102 FGLSLTELELDILTGNHLIRRVDILEDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLVYDRQTGQ 1166
            ||.:.:|:|:|.|||:|...|.:|:.|.|.|::|.:|:|||||||:.|:|.|..|:|.|..| |.
Mouse  1159 FGAACSEVEIDCLTGDHKNIRTNIVMDVGHSINPALDIGQVEGAFIQGMGLYTIEELSYSPQ-GT 1222

  Fly  1167 ILTNRTWNYHPPGAKDIPIDFRIELLQKSPNPVGFMRSKATGEPALCLAVGALFAMQHAIQSARN 1231
            :.:.....|..|...|||.:..|..|..|.:......||..||..:.|.....||:..|:::||.
Mouse  1223 LYSRGPNQYKIPAICDIPTEMHISFLPPSEHSNTLYSSKGLGESGVFLGCSVFFAIHDAVKAARQ 1287

  Fly  1232 DAGLPREWVRLGAPTTPETV 1251
            :.|:...| :|.:|.|||.:
Mouse  1288 ERGISGPW-KLNSPLTPEKI 1306

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.