DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and AO4

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	NP_563711.1	Gene:	AO4 / 839488	AraportID:	AT1G04580	Length:	1337	Species:	Arabidopsis thaliana

Alignment Length:	1368	Identity:	410/1368 - (29%)
Similarity:	656/1368 - (47%)	Gaps:	212/1368 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGR---ITINGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETG 62
            |||.   ..:||...|| ||..|: .:|..|:|........|..|.|||||.|:..|:...|...
plant     1 MAGDDLVFAVNGEKFEV-LSVNPS-TTLLEFLRSNTCFKSVKLSCGEGGCGACIVILSKYDPVLD 63

  Fly    63 ELRTWAVNSCLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLL 127
            ::..:::|||||||.:..|..:|||:||||...|:|.|.:|.|..:.:|||:|:||:.:::|..|
plant    64 QVEEYSINSCLTLLCSLNGCSITTSDGLGNTEKGFHPIHKRFAGFHASQCGFCTPGMCISLYSAL 128

  Fly   128 ------KSKGGKVTMEEVENSFGGNICRCTGYRPILDAMKSFAVDSNIQVPAECIDIEDLSTKKC 186
                  :|....:|....|.|..||:|||||||||.||.||||.|         :|||||.....
plant   129 SKAHNSQSSPDYLTALAAEKSIAGNLCRCTGYRPIADACKSFASD---------VDIEDLGFNSF 184

  Fly   187 PKTGQTCSGSCKKQQP----KGSQLYPDGSR----------------WSWPVSLGDLFAAL---- 227
            .:.|::.....||..|    |....:||..:                ||.|.|:.:|...|
plant   185 WRKGESREEMLKKLPPYNPEKDLITFPDFLKEKIKCQHNVLDQTRYHWSTPGSVAELQEILATTN 249

  Fly   228 ----QGAVKEKLPYMLVAGNTAHGVYRRSPDIKAFIDVSGLAELKGHKLSADNSSLTLGGNLSLS 288
                :|.:|      ||.|||..|.|:.......:||:|.:.|:.  .:..|:..:.:|..:::|
plant   250 PGKDRGLIK------LVVGNTGTGYYKEEKQYGRYIDISHIPEMS--MIKKDDREIEIGAVVTIS 306

  Fly   289 ETMELCRQLENTKGFEYLSQVWQHLDWIANVPVRNAGTLAGNLSIKHAHPEFPSDVFIVLEALDA 353
            :.::...: |||..:.: .::..|::.:||..:||:|::.|||.:..: ..||||:..:|.|.||
plant   307 KVIDALME-ENTSAYVF-KKIGVHMEKVANHFIRNSGSIGGNLVMAQS-KSFPSDITTLLLAADA 368

  Fly   354 QVIVQEAVDKQQTVSLASYLGSS--MEGKIIRGLVLRAYPKERFA-------FDSYKIMPR-AQN 408
            .|.:..| .:.:.:.:..||.|.  ::.|.:   :|:.:.....|       |::|:...| ..:
plant   369 SVHMINA-GRHEKLRMGEYLVSPPILDTKTV---LLKVHIPRWIASSTTGLLFETYRAALRPIGS 429

  Fly   409 AHAYVNAAFLVEFTADAK-----VKSARICF---GGIHPEFVHATAIENLIRDKNPFENGLVEKA 465
            |..|:|||||...:.||.     |...|:.|   ||.|.  :.|..:|:.:..| ...:.::.:|
plant   430 ALPYINAAFLAVVSHDASSSGIIVDKCRLAFGSYGGYHS--IRAREVEDFLTGK-ILSHSVLYEA 491

  Fly   466 FGQLSTLLQPDAVLPDASPVYRRKLACGLFYKFLLKIAAQRKQGLGSRFVTG---GSLLKRPVSS 527
            ...|..::.|.  :..:...|::.||.|..:.||..:..........:.:.|   .::....:||
plant   492 VRLLKGIIVPS--IDTSYSEYKKSLAVGFLFDFLYPLIESGSWDSEGKHIDGHIDPTICLPLLSS 554

  Fly   528 GQQSFETFQEHYPVTKATEKHEGLIQCSGEATYSNDLPTQHNQLWAAFVIAKKVGAKVTKVDTQP 592
            .||.||: :|::||.:|..|....:|.||||.|.:|:|:..:.|..||:.:.|..|.:..|....
plant   555 AQQVFES-KEYHPVGEAIIKFGAEMQASGEAVYVDDIPSLPHCLHGAFIYSTKPLAWIKSVGFSG 618

  Fly   593 ALDLPGVVAYLDAKDIP--GPN--YVGPKIRDQFFFPKDEELFATG-----EIKF-YGQPVGIIL 647
            .:...||:|.:..||||  |.|  |:              .:|.||     |:.. .||.:.:::
plant   619 NVTPIGVLAVITFKDIPEVGQNIGYI--------------TMFGTGLLFADEVTISAGQIIALVV 669

  Fly   648 ANSNSLANRAAELVKLTYEGGAEEILPSLKAVLDKVGSEAGNNKRLEQPIKSTIDVLQLEEPFDV 712
            |::...|:.||.|..:.|:                       ::.:..|:.|..|.::....|:|
plant   670 ADTQKHADMAAHLAVVEYD-----------------------SRNIGTPVLSVEDAVKRSSLFEV 711

  Fly   713 S-----------SSG-----------QLDMGLQYHYYMEPQTTVVLPFEGG-LQVYAATQWMDLT 754
            .           |.|           :|.:|.||.:|||.||.:.||.|.. |.||::||..:.|
plant   712 PPEYQPEPVGDISKGMAEADRKIRSVELRLGSQYFFYMETQTALALPDEDNCLVVYSSTQAPEFT 776

  Fly   755 QDTIANVLNLKSNDVQVKTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMTSLG 819
            |..||..|.:..::|:|.|||:|||:||||.:....|.|.||||.|:.||:|...:.::.|...|
plant   777 QTVIATCLGIPEHNVRVITRRVGGGFGGKAIKSMPVATACALAAKKMQRPVRIYVNRKTDMIMAG 841

  Fly   820 KRWAFHCDYDFFVQKSGKISGIVSRFYEDAGYLANESPIGHTVLLSKNCYEFSDNYKLDGYL--- 881
            .|......|....:..||::.:....:.|||     |.:..::::.:|.......|.. |.|
plant   842 GRHPLKITYSVGFRSDGKLTALDLNLFIDAG-----SDVDVSLVMPQNIMNSLRKYDW-GALSFD 900

  Fly   882 --VC-TDSPSNTPCRAPGSVEGIAMMENIIEHIAFETGVDPADVRFANLLPAHKMGDMMPRF--- 940
              || |:.||.|..||||.|:|..:.|:|||::|....:|...||..||   |.. :.:.:|
plant   901 IKVCKTNLPSRTSLRAPGEVQGSYIAESIIENVASSLKMDVDVVRRINL---HTY-ESLRKFYKQ 961

  Fly   941 ----------------LESTKYRERKAEAIAH-NKENRWHKRGLGLCIMEYQIGYFGQYPATVAI 988
                            ||.:....|:||::.. |:.|.|.|||:....:.:.: .....|..|:|
plant   962 AAGEPDEYTLPLLWDKLEVSADFRRRAESVKEFNRCNIWRKRGISRVPIIHLV-IHRPTPGKVSI 1025

  Fly   989 YHSDGTVVVSHGGIEMGQGMNTKISQVAAHTLGI--------PMEQVRIEASDTINGANSMVTGG 1045
            . :||:|.|...|||:|||:.||:.|:.|:.||:        .:|::|:..:||::.:.|..|.|
plant  1026 L-NDGSVAVEVAGIEVGQGLWTKVQQMVAYGLGMIKCEGSDDLLERIRLLQTDTLSMSQSSYTAG 1089

  Fly  1046 AVGSETLCFAVRKACETLNERLKP----VREEVKPENWQDLIQEAYNRKINLIASDQCK-QGDMD 1105
            :..||..|.|||..|..|.|||:|    :.|..:...|..|||:|..:.::|.|....| :....
plant  1090 STTSENCCEAVRLCCGILVERLRPTMNQILENARSVTWDMLIQQANAQSVDLSARTFYKPESSSA 1154

  Fly  1106 PYSVCGLCLTEVELDVLTGNYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTSEQVIADP 1170
            .|...|:..:|||:|::||...:.|.||:.|.|:||||.||:|||||||:.|:|::..|:...:
plant  1155 EYLNYGVGASEVEVDLVTGRTEIIRSDIIYDCGKSLNPAVDLGQIEGAFVQGIGFFMYEEYTTN- 1218

  Fly  1171 KTGECLTNRTWTYKPPGAKDIPTDLRIELLPKSPNKAGFMRSKATGEPAICLSIAVAFALQQALQ 1235
            :.|......||.||.|....||....:::|....:|...:.|||:|||.:.::.:|..|.:.|::
plant  1219 ENGLVNEEGTWDYKIPTIDTIPKQFNVQILNSGHHKNRVLSSKASGEPPLLVAASVHCATRSAIR 1283

  Fly  1236 SAR 1238
            .||
plant  1284 EAR 1286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	fer2	4..85	CDD:238126	28/83 (34%)
		PLN02906	28..1259	CDD:215491	399/1338 (30%)
		Fer2_2	86..159	CDD:280048	34/78 (44%)
		FAD_binding_4	211..373	CDD:303082	44/185 (24%)
		CO_deh_flav_C	399..502	CDD:281449	29/111 (26%)
		Ald_Xan_dh_C	555..666	CDD:214971	34/120 (28%)
		Ald_Xan_dh_C2	711..1192	CDD:280834	178/542 (33%)
AO4	NP_563711.1	PLN00192	1..1337	CDD:215096	410/1368 (30%)
		fer2	6..86	CDD:238126	28/81 (35%)
		Fer2_2	87..167	CDD:280048	35/79 (44%)
		FAD_binding_5	229..407	CDD:279309	49/192 (26%)
		CO_deh_flav_C	419..526	CDD:281449	29/111 (26%)
		Ald_Xan_dh_C	581..691	CDD:279635	35/146 (24%)
		Ald_Xan_dh_C2	720..1240	CDD:280834	177/532 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	83	1.000	Domainoid score	I2880
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H98597
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720