DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and XDH2

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	NP_195216.2	Gene:	XDH2 / 829642	AraportID:	AT4G34900	Length:	1353	Species:	Arabidopsis thaliana

Alignment Length:	1392	Identity:	406/1392 - (29%)
Similarity:	652/1392 - (46%)	Gaps:	213/1392 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 INGTSHEVNLSALP---ADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWA 68
            :||...     .||   |.::|..::|: .||||||..|.|||||.|...::....|:.....:|
plant    13 VNGVRR-----VLPDGLAHMTLLEYLRD-LGLTGTKLGCGEGGCGSCTVMVSSYDRESKTCVHYA 71

  Fly    69 VNSCLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGK 133
            ||:||..|.:..|:.|.:.||:|::::|.|.:|:.||..:|:|||:|:||.||:||.||:|....
plant    72 VNACLAPLYSVEGMHVISIEGVGHRKLGLHPLQESLASSHGSQCGFCTPGFVMSMYALLRSSKNS 136

  Fly   134 VTMEEVENSFGGNICRCTGYRPILDAMKSFA-VDSNIQVPAECIDIEDLSTKKCPKTGQTCS--- 194
            .:.||:|....||:|||||||||:||.:.|| .|..:......:.::| .:..||.||:.||
plant   137 PSEEEIEECLAGNLCRCTGYRPIIDAFRVFAKSDDALYSGLSSLSLQD-GSNICPSTGKPCSCGS 200

  Fly   195 ------GSCKKQQPK--------GSQ------LYP----------------DGSRWSWPVSLGDL 223
                  .:|.:.:.:        |::      ::|                :|..|..||||.:|
plant   201 KTTSEAATCNEDRFQSISYSDIDGAKYTDKELIFPPELLLRKLAPLKLGGNEGITWYRPVSLQNL 265

  Fly   224 FAALQGAVKEKLP-YMLVAGNTAHGVYRRSPDIK--AFIDVSGLAELKGHKLSADNSSLTLGGNL 285
            .     .:|...| ..|:.|||..|:..|...::  ..|..:.:.||  :.|:.:::.:.:|..|
plant   266 L-----ELKANFPDAKLLVGNTEVGIEMRLKRLQYPVLISAAQVPEL--NALNVNDNGIEVGSAL 323

  Fly   286 SLSETMELCRQL-------ENTKGFEYLSQVWQHLDWIANVPVRNAGTLAGNL----SIKHAHP- 338
            .|||.:.|.|::       |.:....::.|    |.|.|...:||...:.||:    .|...:|
plant   324 RLSELLRLFRKVVKERPAHETSACKAFIEQ----LKWFAGTQIRNVACIGGNICTASPISDLNPL 384

  Fly   339 ------EF-------------PSDVFIVLEALDAQVIVQEAVDKQQTVSLASYLGSSMEGKIIRG 384
                  ||             ..|.|:....:|                    :||:   :|:..
plant   385 WMASRAEFRIINCNGDVRSIPAKDFFLGYRKVD--------------------MGSN---EILLS 426

  Fly   385 LVL-----RAYPKERFAFDSYKIMPRAQNAHAYVNA---AFLVEFTADAKVKSARICFGGIHPEF 441
            :.|     ..|.||      :|...|..:..|.||.   .||.|......|..|.|.:||:.|..
plant   427 VFLPWTRPLEYVKE------FKQAHRRDDDIAIVNGGMRVFLEEKGQQLFVSDASIVYGGVAPLS 485

  Fly   442 VHATAIENLIRDKNPFENGLVEKAFGQLSTLLQPDAVLPDASP----VYRRKLACGLFYKFLLKI 502
            :.|...|.|:..|| :...|::.|.    .::|.|.::.:.:|    .:|:.|....|:||.|.:
plant   486 LRARNTEELLIGKN-WNKCLLQDAL----KVIQSDVLIKEGAPGGMVEFRKSLTLSFFFKFFLWV 545

  Fly   503 AAQRK------QGLGSRFVTGGSLLKRPVSSGQQSFETFQEHYPVTKATEKHEGLIQCSGEATYS 561
            .....      :......::...|:.|....|:|.:||.::...|..........:|.:|||.|:
plant   546 THHVNNVNPTIETFPPSHMSAVQLVPRFSRIGKQDYETVKQGTSVGLPEVHLSARMQVTGEAEYT 610

  Fly   562 NDLPTQHNQLWAAFVIAKKVGAKVTKVDTQPALDLPGVVAYLDAKDIPGPNYVGPKIRDQFFFPK 626
            :|.|.....|.||.|::|...|::..||...|....|.|....|||:||.|.:||.:       .
plant   611 DDTPLPPCTLHAALVLSKVPHARILSVDDSAAKSSSGFVGLFLAKDVPGNNMIGPIV-------A 668

  Fly   627 DEELFATGEIKFYGQPVGIILANSNSLANRAAELVKLTYEGGAEEILPSLKAVLDKVGSEA---G 688
            |||||||..:...||.:|:::|:::..|..||..|.:.|:.     ||::.::.:.:.:::   .
plant   669 DEELFATDVVTCVGQVIGVLVADTHENAKTAARKVDVRYQE-----LPAILSIKEAINAKSFHPN 728

  Fly   689 NNKRLEQPIKSTIDVLQLEEPFDVSSSGQLDMGLQYHYYMEPQTTVVLPFEGGLQVY--AATQWM 751
            ..:||.   |..:::.......|....|::.||.|.|:|:||..::|...:||.:|:  ::||..
plant   729 TERRLR---KGDVELCFQSGQCDRIIEGEVQMGGQEHFYLEPNGSLVWTIDGGNEVHMISSTQAP 790

  Fly   752 DLTQDTIANVLNLKSNDVQVKTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMT 816
            ...|..:::||.|..:.|..||:|:|||:|||.||....||||::.::.||||::.:...:..|.
plant   791 QQHQKYVSHVLGLPMSKVVCKTKRLGGGFGGKETRSAFIAAAASVPSYLLNRPVKLILDRDVDMM 855

  Fly   817 SLGKRWAFHCDYDFFVQKSGKISGIVSRFYEDAG-----YLAN-ESPIGHTVLLSKNCYEFSDNY 875
            ..|.|.:|...|.......|||..:....|.:.|     .|:| |..:.|    |.|.||. .:.
plant   856 ITGHRHSFVGKYKVGFTNEGKILALDLEIYNNGGNSMDLSLSNLERAMFH----SDNVYEI-PHV 915

  Fly   876 KLDGYLVCTDSPSNTPCRAPGSVEGIAMMENIIEHIAFETGVDPADVRFANL------------L 928
            ::.|.:..|:.||||..|..|..:|:.:.||.|:.||.|....|.:::..|.            |
plant   916 RIVGNVCFTNFPSNTAFRGFGGPQGMLITENWIQRIAAELDKIPEEIKEMNFQVEGSITHYFQSL 980

  Fly   929 PAHKMGDMMPRFLESTKYRERKAEAIAHNKENRWHKRGLGLCIMEYQIG----YFGQYPATVAIY 989
            ....:..:......|:.:.:.:.||...|..|||.|||:.:...::.|.    :..|..|.|.:|
plant   981 QHCTLHQLWKELKVSSNFLKTRREADEFNSHNRWKKRGVAMVPTKFGISFTTKFMNQAGALVHVY 1045

  Fly   990 HSDGTVVVSHGGIEMGQGMNTKISQVAAHTLGIPMEQVRIEASDTINGANSMVTGGAVGSETLCF 1054
             :||||:|:|||:|||||::||::||||....|.:..|.:..:.|....|:..|..:..|:....
plant  1046 -TDGTVLVTHGGVEMGQGLHTKVAQVAATAFNILLSSVFVSETSTDKVPNASPTAASASSDMYGA 1109

  Fly  1055 AVRKACETLNERLKPVREEVKPENWQDLIQEAYNRKINLIASD-----------QCKQGDMDPYS 1108
            ||..|||.:..|::||..:.....:.:|....|.::|:|.|..           ...:|:...|.
plant  1110 AVLDACEQIIARMEPVASKHNFNTFSELASACYFQRIDLSAHGFHIVPELEFDWVSGKGNAYRYY 1174

  Fly  1109 VCGLCLTEVELDVLTGNYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTSEQV-IADP-- 1170
            ..|....|||:|.|||::...:.||:.|.|.||||.:|||||||||:.|||:...|:: ..|.
plant  1175 TYGAAFAEVEIDTLTGDFHTRKADIMLDLGYSLNPTIDIGQIEGAFVQGLGWVALEELKWGDAAH 1239

  Fly  1171 ---KTGECLTNRTWTYKPPGAKDIPTDLRIELLPKSPNKAGFMRSKATGEPAICLSIAVAFALQQ 1232
               |.|..||....:||.|...|:|..|.:.||..:||......|||.|||...|:.:..||:::
plant  1240 KWIKPGSLLTCGPGSYKIPSINDMPFQLNVSLLKGNPNAKAIHSSKAVGEPPFFLAASAFFAIKE 1304

  Fly  1233 ALQSARDDAGVPKSWVTLTAPMTPEHL 1259
            |:::||.:.|: .:|..|..|.|||.:
plant  1305 AIKAARSEVGL-TNWFPLETPATPERI 1330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	fer2	4..85	CDD:238126	28/80 (35%)
		PLN02906	28..1259	CDD:215491	400/1366 (29%)
		Fer2_2	86..159	CDD:280048	36/72 (50%)
		FAD_binding_4	211..373	CDD:303082	42/195 (22%)
		CO_deh_flav_C	399..502	CDD:281449	30/109 (28%)
		Ald_Xan_dh_C	555..666	CDD:214971	40/110 (36%)
		Ald_Xan_dh_C2	711..1192	CDD:280834	168/521 (32%)
XDH2	NP_195216.2	PLN02906	26..1344	CDD:215491	401/1374 (29%)
		Fer2_2	90..162	CDD:280048	36/71 (51%)
		FAD_binding_5	252..431	CDD:279309	46/212 (22%)
		CO_deh_flav_C	441..545	CDD:281449	30/108 (28%)
		Ald_Xan_dh_C	604..711	CDD:214971	41/118 (35%)
		Ald_Xan_dh_C2	730..1264	CDD:280834	171/542 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720