DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and XDH1

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	NP_195215.2	Gene:	XDH1 / 829641	AraportID:	AT4G34890	Length:	1361	Species:	Arabidopsis thaliana

Alignment Length:	1376	Identity:	413/1376 - (30%)
Similarity:	655/1376 - (47%)	Gaps:	181/1376 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 INGTSHEVNLSALP---ADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWA 68
            :||...     .||   |.::|..::|: .||||||..|.|||||.|...::....::.....:|
plant    21 VNGVRR-----VLPDGLAHMTLLEYLRD-LGLTGTKLGCGEGGCGACTVMVSSYDRKSKTSVHYA 79

  Fly    69 VNSCLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGK 133
            ||:||..|.:..|:.|.:.||||::::|.|.:|:.||..:|:|||:|:||.:|:||.||:|....
plant    80 VNACLAPLYSVEGMHVISIEGLGHRKLGLHPVQESLASSHGSQCGFCTPGFIMSMYSLLRSSKNS 144

  Fly   134 VTMEEVENSFGGNICRCTGYRPILDAMKSFA-VDSNIQVPAECIDIEDLSTKKCPKTGQTCS--- 194
            .:.||:|....||:|||||||||:||.:.|| .|..:......:.::|.|| .||.||:.||
plant   145 PSEEEIEECLAGNLCRCTGYRPIVDAFRVFAKSDDALYCGVSSLSLQDGST-ICPSTGKPCSCGS 208

  Fly   195 ------GSCKKQQPKGSQLYPD-------------------------------GSRWSWPVSLGD 222
                  .||.:.:.: |..|.|                               |..|..||.|.:
plant   209 KTTNEVASCNEDRFQ-SISYSDIDGAKYTDKELIFPPELLLRKLTPLKLRGNGGITWYRPVCLQN 272

  Fly   223 LFAALQGAVKEKLP-YMLVAGNTAHGVYRRSPDI--KAFIDVSGLAELKGHKLSADNSSLTLGGN 284
            |.     .:|...| ..|:.|||..|:..|...:  :..|.|:.:.||  :.|:.:::.:.:|..
plant   273 LL-----ELKANYPDAKLLVGNTEVGIEMRLKRLQYQVLISVAQVPEL--NALNVNDNGIEVGSA 330

  Fly   285 LSLSETMELCRQL-------ENTKGFEYLSQVWQHLDWIANVPVRNAGTLAGNLSIKHAHPEFPS 342
            |.|||.:.|.|::       |.:....::.|    |.|.|...:||...:.||:..  |.|  .|
plant   331 LRLSELLRLFRKIVKERPAHETSACKAFIEQ----LKWFAGTQIRNVACIGGNICT--ASP--IS 387

  Fly   343 DVFIVLEALDAQVIVQEAVDKQQTVSLASY--------LGSSMEGKIIRGLVL-----RAYPKER 394
            |:..:..|..|:..:.......:::....:        :||:   :|:..:.|     ..|.||
plant   388 DLNPLWMASRAEFRITNCNGDVRSIPAKDFFLGYRKVDMGSN---EILLSVFLPWTRPLEYVKE- 448

  Fly   395 FAFDSYKIMPRAQNAHAYVNA---AFLVEFTADAKVKSARICFGGIHPEFVHATAIENLIRDKNP 456
                 :|...|..:..|.||.   .||.:......|..|.|.:||:.|..:.|...|..:..||
plant   449 -----FKQAHRRDDDIAIVNGGMRVFLEDKGQQLFVSDASIAYGGVAPLSLCARKTEEFLIGKN- 507

  Fly   457 FENGLVEKAFGQLSTLLQPDAVLPDASP----VYRRKLACGLFYKFLLKIA--AQRKQGLGSRFV 515
            :...|::.|.    .::|.|.|:.:.:|    .:|:.|....|:||.|.::  ..........|.
plant   508 WNKDLLQDAL----KVIQSDVVIKEDAPGGMVEFRKSLTLSFFFKFFLWVSHNVNNANSAIETFP 568

  Fly   516 TGGSLLKRPVSS----GQQSFETFQEHYPVTKATEKHEGLIQCSGEATYSNDLPTQHNQLWAAFV 576
            .......:||..    |:|.:||.::...|..:.......:|.:|||.|::|.|...|.|.||||
plant   569 PSHMSAVQPVPRLSRIGKQDYETVKQGTSVGSSEVHLSARMQVTGEAEYTDDTPVPPNTLHAAFV 633

  Fly   577 IAKKVGAKVTKVDTQPALDLPGVVAYLDAKDIPGPNYVGPKIRDQFFFPKDEELFATGEIKFYGQ 641
            ::|...|::..:|...|....|.|....||||||.|.:||.:       .|||||||..:...||
plant   634 LSKVPHARILSIDDSAAKSSSGFVGLFLAKDIPGDNMIGPIV-------PDEELFATDVVTCVGQ 691

  Fly   642 PVGIILANSNSLANRAAELVKLTYEGGAEEILPSLKAVLDKVGSEA---GNNKRLEQPIKSTIDV 703
            .:|:::|:::..|..||..|.:.||.     ||::.::.:.:.:::   ...|||.   |..:::
plant   692 VIGVVVADTHENAKTAAGKVDVRYEE-----LPAILSIKEAINAKSFHPNTEKRLR---KGDVEL 748

  Fly   704 LQLEEPFDVSSSGQLDMGLQYHYYMEPQTTVVLPFEGGLQVY--AATQWMDLTQDTIANVLNLKS 766
            .......|....|::.||.|.|:|:||..::|...:||.:|:  ::||.....|..:::||.|..
plant   749 CFQSGQCDRVIEGEVQMGGQEHFYLEPNGSLVWTVDGGSEVHMISSTQAPQKHQKYVSHVLGLPM 813

  Fly   767 NDVQVKTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMTSLGKRWAFHCDYDFF 831
            :.|..||:|||||:|||.||....||||::.::.||||::.:...:..|...|.|.:|...|...
plant   814 SKVVCKTKRIGGGFGGKETRSAFIAAAASVPSYLLNRPVKLILDRDVDMMITGHRHSFLGKYKVG 878

  Fly   832 VQKSGKISGIVSRFYEDAGYLANESPIGHTVL-----LSKNCYEFSDNYKLDGYLVCTDSPSNTP 891
            ....|||..:....|.:.|   |...:..:||     .|.|.||. .:.::.|.:..|:.||||.
plant   879 FTNEGKILALDLEIYNNGG---NSLDLSLSVLERAMFHSDNVYEI-PHVRIVGNVCFTNFPSNTA 939

  Fly   892 CRAPGSVEGIAMMENIIEHIAFETGVDPADVR------------FANLLPAHKMGDMMPRFLEST 944
            .|..|..:|:.:.||.|:.||.|....|.:::            :...|....:..:......|.
plant   940 FRGFGGPQGMLITENWIQRIAAELNKSPEEIKEMNFQVEGSVTHYCQTLQHCTLHQLWKELKVSC 1004

  Fly   945 KYRERKAEAIAHNKENRWHKRGLGLCIMEYQIG----YFGQYPATVAIYHSDGTVVVSHGGIEMG 1005
            .:.:.:.||...|..|||.|||:.:...::.|.    :..|..|.|.:| :||||:|:|||:|||
plant  1005 NFLKARREADEFNSHNRWKKRGVAMVPTKFGISFTTKFMNQAGALVHVY-TDGTVLVTHGGVEMG 1068

  Fly  1006 QGMNTKISQVAAHTLGIPMEQVRIEASDTINGANSMVTGGAVGSETLCFAVRKACETLNERLKPV 1070
            ||::||::||||....||:..|.:..:.|....|:..|..:..|:....||..|||.:..|::||
plant  1069 QGLHTKVAQVAASAFNIPLSSVFVSETSTDKVPNASPTAASASSDMYGAAVLDACEQIIARMEPV 1133

  Fly  1071 REEVKPENWQDLIQEAYNRKINL------IASDQ-----CKQGDMDPYSVCGLCLTEVELDVLTG 1124
            ..:.....:.:|:...|.::|:|      |..|.     ..:|:...|...|....|||:|.|||
plant  1134 ASKHNFNTFTELVSACYFQRIDLSAHGFHIVPDLGFDWISGKGNAFRYYTYGAAFAEVEIDTLTG 1198

  Fly  1125 NYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTSEQV-IADP-----KTGECLTNRTWTY 1183
            ::.....||:.|.|.||||.:|:|||||||:.|||:...|:: ..|.     |.|..||.....|
plant  1199 DFHTRAADIMLDLGYSLNPAIDVGQIEGAFVQGLGWVALEELKWGDAAHKWIKPGSLLTCGPGNY 1263

  Fly  1184 KPPGAKDIPTDLRIELLPKSPNKAGFMRSKATGEPAICLSIAVAFALQQALQSARDDAGVPKSWV 1248
            |.|...|:|.:|.:.||..:||......|||.|||...|:.:|.||:::|:::||.:.|: ..|.
plant  1264 KIPSINDMPFNLNVSLLKGNPNTKAIHSSKAVGEPPFFLASSVFFAIKEAIKAARTEVGL-TDWF 1327

  Fly  1249 TLTAPMTPEHL 1259
            .|.:|.|||.:
plant  1328 PLESPATPERI 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	fer2	4..85	CDD:238126	27/80 (34%)
		PLN02906	28..1259	CDD:215491	407/1350 (30%)
		Fer2_2	86..159	CDD:280048	36/72 (50%)
		FAD_binding_4	211..373	CDD:303082	41/179 (23%)
		CO_deh_flav_C	399..502	CDD:281449	29/109 (27%)
		Ald_Xan_dh_C	555..666	CDD:214971	42/110 (38%)
		Ald_Xan_dh_C2	711..1192	CDD:280834	168/520 (32%)
XDH1	NP_195215.2	PLN02906	34..1352	CDD:215491	408/1358 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720