DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and AAO3

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	NP_001077966.1	Gene:	AAO3 / 817257	AraportID:	AT2G27150	Length:	1332	Species:	Arabidopsis thaliana

Alignment Length:	1360	Identity:	426/1360 - (31%)
Similarity:	656/1360 - (48%)	Gaps:	209/1360 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 INGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWAVNS 71
            :||...:::  ::....:|..|:|........|..|.|||||.|:..|:...||..:::...:||
plant     7 VNGERFKID--SVDPSTTLLEFLRLNTPFKSVKLGCGEGGCGACLVVLSKYDPELDQVKECCINS 69

  Fly    72 CLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLL----KSKGG 132
            |||||.:..|..:||||||||.:.|:|.|.:|.|..:.:|||:|:||:.:::|..|    .:...
plant    70 CLTLLCSVNGCSITTSEGLGNTKKGFHPIHKRFAGFHASQCGFCTPGMCISLYSSLANAENNSSK 134

  Fly   133 KVTMEEVENSFGGNICRCTGYRPILDAMKSFAVDSNIQVPAECIDIEDLSTKKCPKTGQTCSGSC 197
            ..|:.|.|.|..||:|||||||||:||.||||.|         :|||||......|.|::.....
plant   135 DFTVSEAEKSVSGNLCRCTGYRPIVDACKSFASD---------VDIEDLGLNSFWKKGESKEVMF 190

  Fly   198 KKQQP--------------KGSQLYPDGS-----RWSWPVSLGDLFAALQGAVK-EKLPYMLVAG 242
            |...|              |..:...:||     ||:.|.|:.:|...::.|.. :.|  .||.|
plant   191 KNLPPYNPKDHLVTFPEFLKKKEKVDNGSDHLKYRWTTPFSVAELHNIMEAANSGDSL--KLVVG 253

  Fly   243 NTAHGVYRRSPDIKAFIDVSGLAELKGHKLSADNSSLTLGGNLSLSETMELCRQLENTKGFEYL- 306
            ||..|.|:.......:||:|.:.|:.  .:..|...:.:|..:::|..::   .||......|:
plant   254 NTGTGYYKDEERFDRYIDISNIPEMS--MIKKDEKGIEIGAAVTISNAID---ALEKESKSSYVF 313

  Fly   307 SQVWQHLDWIANVPVRNAGTLAGNLSIKHAHPEFPSDVFIVLEALDAQVIV-----QEAVDKQQT 366
            .::..|::.|.|..:||:|::.|||.:..:. :|||||..:|.|:||.|.:     .|.|..|:.
plant   314 KKMATHMEKIGNRSIRNSGSIGGNLVMAQSR-KFPSDVTTLLLAVDASVYMLNGRKTEKVTLQEF 377

  Fly   367 VSLASYLGSSMEGKIIRGLVLRAYPK--------ERFAFDSYKIMPRA-QNAHAYVNAAFLVEFT 422
            :.|:..|.|.      |.|:....|.        ..|.|:||:..||: .||..|:|||||...:
plant   378 LELSPVLDSK------RVLLKVEIPSWTAPSGDDTEFLFESYRAAPRSIGNALPYLNAAFLALVS 436

  Fly   423 ---ADAKVKSARICF------GGIHPEFVHATAIENLIRDKNPFENGLVEKAFGQLSTLLQP--D 476
               |..|..:...||      ||.|.  :.|..:|..:..| .....::.:|.|.|..::.|  |
plant   437 RQEASRKGVTVEKCFLAFGSYGGDHS--IRAIEVETFLTGK-LLSYSVLYEAVGLLKGIIVPGKD 498

  Fly   477 AVLPDASPVYRRKLACGLFYKFLLKIAAQRKQGLGSRFVTGGSLLKRP------------VSSGQ 529
            .:..:    ||:.||.|..::|...:...     |.|..:..|..|..            :||.|
plant   499 TLHSE----YRKSLAVGYLFEFFYPLIES-----GHRICSLDSGNKHNNSHVDTVKSLPFLSSSQ 554

  Fly   530 QSFETFQEHYPVTKATEKHEGLIQCSGEATYSNDLPTQHNQLWAAFVIAKKVGAKVTKVDTQPAL 594
            |..|: .|..|:.:|..|....:|.||||.:.:|:||..:.|..||:.:.:..||:..:..:..:
plant   555 QVLES-NEFKPIGEAVIKVGAALQASGEAVFVDDIPTLPDCLHGAFIYSTEPLAKIKSLSFRENV 618

  Fly   595 DLPGVVAYLDAKDIP--GPNYVGPKIRDQFFFPKDEELFATGEIKFYGQPVGIILANSNSLANRA 657
            ...||.|.|..||||  |.| :|.|   ..|.|  ..|||....:..||.:.:::|::...|:.|
plant   619 TPTGVFAVLTFKDIPQQGQN-IGSK---TLFGP--GPLFADELTRCAGQRIALVVADTQKHADMA 677

  Fly   658 AELVKLTYEGGAEEILPSLKAVLDKVGSEAGNNKRLEQPIKSTIDVLQLEEPFDVSS-------- 714
            |:|..:.|:                       .|.|||||.:..|.::....|:|..
plant   678 AKLAVVEYD-----------------------TKNLEQPILTVEDAVKRSSFFEVHPMFYPEPVG 719

  Fly   715 --------------SGQLDMGLQYHYYMEPQTTVVLPFEGG-LQVYAATQWMDLTQDTIANVLNL 764
                          |.:|.:|.||.:||||||.:.||.|.. ::|::::|..:.....||..|.:
plant   720 DVIKGMEEAERKIISSELRLGSQYFFYMEPQTALALPDEDNCVKVFSSSQAPEYVHSVIATCLGI 784

  Fly   765 KSNDVQVKTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMTSLGKRWAFHCDYD 829
            :.::|:|.|||:|||:||||.:....|.|.||.|:||.||::...:.::.|...|.|.....:|:
plant   785 QEHNVRVITRRVGGGFGGKAVKSMPVATACALGAYKLQRPVKMFLNRKTDMIMAGGRHPMKINYN 849

  Fly   830 FFVQKSGKISGIVSRFYEDAGYLANESPIGHTVLLSKNC------YEF---SDNYKLDGYLVC-T 884
            ...:..||::.:......|||...:.|||     :.:|.      |::   |.:.|     || |
plant   850 VGFRSDGKLTALELTMLIDAGLEPDVSPI-----MPRNIMGPLRKYDWGALSFDVK-----VCKT 904

  Fly   885 DSPSNTPCRAPGSVEGIAMMENIIEHIAFETGVDPADVRFANL--------LPAHKMGD----MM 937
            :..|.|..||||.|:|..:.|:|||::|....:|...||..||        ...|..||    .:
plant   905 NCLSRTAMRAPGEVQGSYIAESIIENVASSLQMDVDAVRKINLHTYDSLRKFYNHIAGDPDEYTL 969

  Fly   938 PRFLE----STKYRERKAEAIAHNKENRWHKRGLGLCIMEYQIGYFGQYPATVAIYHSDGTVVVS 998
            |...|    |:|::||.......|..|.|.|||:....:.:|: .....|..|:|. |||:|||.
plant   970 PLLWEKLEISSKFKERSEMVKEFNLCNVWRKRGISRVPIVHQV-MQRPTPGKVSIL-SDGSVVVE 1032

  Fly   999 HGGIEMGQGMNTKISQVAAHTLGIP--------MEQVRIEASDTINGANSMVTGGAVGSETLCFA 1055
            .||||:|||:.||:.|:.|:.||:.        ::::|:..|||:.......|.|:..||:.|.|
plant  1033 VGGIEIGQGLWTKVQQMVAYGLGMVKCEGNEKLLDRIRVVQSDTLGMIQGGFTAGSTTSESSCEA 1097

  Fly  1056 VRKACETLNERLKPVREEVKPE-----NWQDLIQEAYNRKINLIASDQCK--QGDMDPYSVCGLC 1113
            ||..|..|.|||||:.:::..|     .|..|||:||.:.|||.||...|  ...|: |...|:.
plant  1098 VRLCCVILVERLKPIMDQMMMEKSGSVTWNILIQQAYGQYINLSASTLYKPEYSSME-YLNYGVG 1161

  Fly  1114 LTEVELDVLTGNYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTSEQVIADPKTGECLTN 1178
            ::|||:|::||...:.|.||:.|.|:||||.||:||.||||:.|:|::..|:...|.| |..:..
plant  1162 VSEVEVDLVTGKTEILRSDIIYDCGKSLNPAVDLGQTEGAFVQGIGFFMMEEYTTDEK-GLVVQQ 1225

  Fly  1179 RTWTYKPPGAKDIPTDLRIELLPKSPNKAGFMRSKATGEPAICLSIAVAFALQQALQSAR 1238
            .||.||.|....||....:|::....:|...:.|||:|||.:.|:.:|..|.:.|::.||
plant  1226 GTWDYKIPTVDTIPKHFNVEIVNTGHHKNRVLSSKASGEPPLLLAASVHCATRSAIREAR 1285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	fer2	4..85	CDD:238126	24/77 (31%)
		PLN02906	28..1259	CDD:215491	423/1339 (32%)
		Fer2_2	86..159	CDD:280048	35/76 (46%)
		FAD_binding_4	211..373	CDD:303082	49/173 (28%)
		CO_deh_flav_C	399..502	CDD:281449	33/114 (29%)
		Ald_Xan_dh_C	555..666	CDD:214971	36/112 (32%)
		Ald_Xan_dh_C2	711..1192	CDD:280834	185/544 (34%)
AAO3	NP_001077966.1	PLN00192	1..1331	CDD:215096	426/1360 (31%)
		Fer2_2	84..162	CDD:280048	36/77 (47%)
		FAD_binding_5	223..398	CDD:279309	52/188 (28%)
		CO_deh_flav_C	412..520	CDD:281449	33/114 (29%)
		Ald_Xan_dh_C	579..689	CDD:279635	37/138 (27%)
		Ald_Xan_dh_C2	718..1239	CDD:280834	184/534 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	83	1.000	Domainoid score	I2880
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H98597
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720