DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and XDH

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	NP_000370.2	Gene:	XDH / 7498	HGNCID:	12805	Length:	1333	Species:	Homo sapiens

Alignment Length:	1385	Identity:	411/1385 - (29%)
Similarity:	649/1385 - (46%)	Gaps:	220/1385 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 INGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWAVNS 71
            :||.. .|..:|.| :.:|..::|...||:|||..|.|||||.|...|:.......::..::.|:
Human    10 VNGRK-VVEKNADP-ETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSANA 72

  Fly    72 CLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGKVTM 136
            ||..:.:...:.|||.||:|:.:...|.:|:|:||.:|:|||:|:|||||:||.||::: .:.||
Human    73 CLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQ-PEPTM 136

  Fly   137 EEVENSFGGNICRCTGYRPILDAMKSFAVDSNIQVPAECIDIEDLSTKKCPKTGQTCSGS----- 196
            ||:||:|.||:||||||||||...::||.|                       |..|.|.
Human   137 EEIENAFQGNLCRCTGYRPILQGFRTFARD-----------------------GGCCGGDGNNPN 178

  Fly   197 -CKKQQ---------------------PKGSQLYP----------------DGSRWSWPVSLGDL 223
             |..|:                     |....::|                :|.|.:| :....|
Human   179 CCMNQKKDHSVSLSPSLFKPEEFTPLDPTQEPIFPPELLRLKDTPRKQLRFEGERVTW-IQASTL 242

  Fly   224 FAALQGAVKEKLP-YMLVAGNTAHGVYRRSPDI--KAFIDVSGLAELKGHKLSADNSSLTLGGNL 285
            ...|.  :|.:.| ..||.|||..|:..:..::  ...:..:.:.||...:...|..|......|
Human   243 KELLD--LKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPL 305

  Fly   286 SLSE--TMELCRQLENTKGFEYLSQVWQHLDWIANVPVRNAGTLAGNLSIKHAHPEFPSDVFIVL 348
            |:.|  .::...:|...| .|....|.:.|.|.|...|::..::.||  |..|.|  .||:..|.
Human   306 SIVEKTLVDAVAKLPAQK-TEVFRGVLEQLRWFAGKQVKSVASVGGN--IITASP--ISDLNPVF 365

  Fly   349 EALDAQV-IVQEAVDKQQTVSL-----ASYLGSSMEGKIIRGLVLRAYPKERFAFDSYKIMPRAQ 407
            .|..|:: :|....  ::||.:     ..|..:.:..:.|...:...|.:|...|.::|...|.:
Human   366 MASGAKLTLVSRGT--RRTVQMDHTFFPGYRKTLLSPEEILLSIEIPYSREGEYFSAFKQASRRE 428

  Fly   408 NAHAYVNAAFLVEF-TADAKVKSARICFGGIHPEFVHATAI----------ENLIRDKNPFENGL 461
            :..|.|.:...|.| ....:|:...:|:||:....:.|...          |.|::|...   ||
Human   429 DDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISALKTTQRQLSKLWKEELLQDVCA---GL 490

  Fly   462 VEKAFGQLSTLLQPDAVLPDASPVYRRKLACGLFYKFLLKIAAQRKQ--------GLGSRFVTGG 518
            .|:..      |.|||  |.....:|..|....|:||.|.:..:..|        .|...|.:..
Human   491 AEELH------LPPDA--PGGMVDFRCTLTLSFFFKFYLTVLQKLGQENLEDKCGKLDPTFASAT 547

  Fly   519 SLLKRPVSSGQQSFETFQEHYPVTKATEKHEGL--------IQCSGEATYSNDLPTQHNQLWAAF 575
            .|.::...:..|.|    :..|..::.|...|.        :|.||||.|.:|:|...|:|....
Human   548 LLFQKDPPADVQLF----QEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRL 608

  Fly   576 VIAKKVGAKVTKVDTQPALDLPGVVAYLDAKDIPGPNYVGPKIRDQFFFPKDEELFATGEIKFYG 640
            |.:.:..||:..:||..|..:||.|.::.|.|:||.|..|        ...||.:||..::...|
Human   609 VTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITG--------ICNDETVFAKDKVTCVG 665

  Fly   641 QPVGIILANSNSLANRAAELVKLTYEGGAEEILPSLKAVLDKVGSEAGNNKRLEQPIKSTIDVLQ 705
            ..:|.::|::.....|||:.||:|||.     ||::..:.|.:    .||......:|  |:...
Human   666 HIIGAVVADTPEHTQRAAQGVKITYEE-----LPAIITIEDAI----KNNSFYGPELK--IEKGD 719

  Fly   706 LEEPF---DVSSSGQLDMGLQYHYYMEPQTTVVLP--FEGGLQVYAATQWMDLTQDTIANVLNLK 765
            |::.|   |...||::.:|.|.|:|:|...|:.:|  ..|.::::.:||....||..:|.:|.:.
Human   720 LKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVP 784

  Fly   766 SNDVQVKTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMTSLGKRWAFHCDYDF 830
            :|.:.|:.:|:|||:|||.||..:.:.|.||||:|..||:|.:...:..|...|.|..|...|..
Human   785 ANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKV 849

  Fly   831 FVQKSGKISGI-VSRFYEDAGYLANESPIGHTVLLSK-----------NCYEFSDNYKLDGYLVC 883
            ...|:|.:..: |..|          |.:|:|..||:           |||:. .|.:..|.|..
Human   850 GFMKTGTVVALEVDHF----------SNVGNTQDLSQSIMERALFHMDNCYKI-PNIRGTGRLCK 903

  Fly   884 TDSPSNTPCRAPGSVEGIAMMENIIEHIAFETGVDPADVRFANLLPAHKMGDM-----------M 937
            |:.||||..|..|..:|:.:.|..:..:|...|:...:||..||   :|.||:           :
Human   904 TNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNL---YKEGDLTHFNQKLEGFTL 965

  Fly   938 PR----FLESTKYRERKAEAIAHNKENRWHKRGLGLCIMEYQIG------YFGQYPATVAIYHSD 992
            ||    .|.|::|..||:|....||||.|.||  ||||:..:.|      :..|..|.:.:| :|
Human   966 PRCWEECLASSQYHARKSEVDKFNKENCWKKR--GLCIIPTKFGISFTVPFLNQAGALLHVY-TD 1027

  Fly   993 GTVVVSHGGIEMGQGMNTKISQVAAHTLGIPMEQVRIEASDTINGANSMVTGGAVGSETLCFAVR 1057
            |:|:::|||.|||||::||:.|||:..|.||..::.|..:.|....|:..|..:|.::....||.
Human  1028 GSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAASVSADLNGQAVY 1092

  Fly  1058 KACETLNERLKPVREEVKPENWQDLIQEAYNRKINLIA-----------SDQCKQGDMDPYSVCG 1111
            .||:|:.:||:|.:::....:|:|.:..||...::|.|           |.:...|:...|...|
Human  1093 AACQTILKRLEPYKKKNPSGSWEDWVTAAYMDTVSLSATGFYRTPNLGYSFETNSGNPFHYFSYG 1157

  Fly  1112 LCLTEVELDVLTGNYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTSEQVIADPKTGECL 1176
            :..:|||:|.|||::...|.||:.|.|.||||.:||||:||||:.|||.:|.|::...|: |...
Human  1158 VACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPE-GSLH 1221

  Fly  1177 TNRTWTYKPPGAKDIPTDLRIELLPKSPNKAGFMRSKATGEPAICLSIAVAFALQQALQSAR--D 1239
            |....|||.|....||.:.|:.||...|||.....|||.|||.:.|:.::.||::.|:::||  .
Human  1222 TRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAVGEPPLFLAASIFFAIKDAIRAARAQH 1286

  Fly  1240 DAGVPKSWVTLTAPMTPEHL 1259
            .....|....|.:|.|||.:
Human  1287 TGNNVKELFRLDSPATPEKI 1306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	fer2	4..85	CDD:238126	23/77 (30%)
		PLN02906	28..1259	CDD:215491	405/1362 (30%)
		Fer2_2	86..159	CDD:280048	42/72 (58%)
		FAD_binding_4	211..373	CDD:303082	41/172 (24%)
		CO_deh_flav_C	399..502	CDD:281449	28/113 (25%)
		Ald_Xan_dh_C	555..666	CDD:214971	37/110 (34%)
		Ald_Xan_dh_C2	711..1192	CDD:280834	176/526 (33%)
XDH	NP_000370.2	PLN02906	23..1319	CDD:215491	406/1370 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720