Protein Alignment AOX1 and Aox4

DIOPT Version :10

• Sequence 1: NP_650475.1
• Gene: AOX1 / 41894
• FlyBaseID: FBgn0267408
• Length: 1273
• Species: Drosophila melanogaster
• Sequence 2: NP_076120.2
• Gene: Aox4 / 71872
• MGIID: 1919122
• Length: 1336
• Species: Mus musculus
• Alignment Length: 1356
• Identity: 401/1356 - (29%)
• Similarity: 646/1356 - (47%)
• Gaps: 208/1356 - (15%)

  Fly    28 FIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWAVNSCLTLLNTCLGLEVTTSEGLGN 92
            :.|:...|||||:.|..||||.|...::..:|:|.::..:...:||..:....|..:||.||:|:
Mouse    33 YTRKVLNLTGTKYSCGTGGCGACTVMVSRYNPKTRKIHHYPATACLVPICWLHGAAITTVEGVGS 97

  Fly    93 KRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGKVTMEEVENSFGGNICRCTGYRPIL 157
            .:...|.:|:||||.:|||||:||||:||::|.||::. .:.|.:::..:.|||:|||||||||:
Mouse    98 IKKRVHPVQERLAKCHGTQCGFCSPGMVMSIYTLLRNH-PEPTPDQITEALGGNLCRCTGYRPIV 161

  Fly   158 DAMKSFAVDSNI-QVPAE---CID-----IEDLSTKKCPKTGQTCSGSCKKQQPKGSQLYP---- 209
            ::.|:|:..|.: |:...   |:|     :|....|.|.|...  ....:...|....::|
Mouse   162 ESGKTFSQKSTVCQMKGSGKCCMDPDEKCLESREKKMCTKLYN--EDEFQPFDPSQEPIFPPELI 224

  Fly   210 -------------DGSRWSW--PVSLGDLFAALQGAVKEKLPYM-LVAGNTAHGVYRRSPDIK-- 256
                         .|.|.:|  ||:|.||.     .:|...|.. ||.|||..|     |.||
Mouse   225 RMAEDPNKRRLTFQGKRTTWIIPVTLNDLL-----ELKASYPEAPLVMGNTTVG-----PGIKFN 279

  Fly   257 -----AFIDVSGLAELKGHKLSADNSSLTLGGNLSLSETMELCRQL------ENTKGFEYLSQVW 310
                 .||...|:.||  :.:...|:.:|:|...||::..:....|      |.||.|..|.
Mouse   280 DEFYPVFISPLGVPEL--NLMDTTNNGVTIGAGYSLAQLKDTLDFLVSEQPKEKTKTFHALQ--- 339

  Fly   311 QHLDWIANVPVRNAGTLAGNLSIKHAHPEFPSDVFIVLEALDA--QVIVQEAVDKQ--------- 364
            :||..:|...:||..||.|:.:   :.|.| ||:..:|.|.:|  .|:.:|..|:|
Mouse   340 KHLRTLAGPQIRNMATLGGHTA---SRPNF-SDLNPILAAGNATINVVSREGKDRQLPLNGPFLE 400

  Fly   365 ---------QTVSLASYLGSSMEGKIIRGLVLRAYPKERFAFDSYKIMPRAQNAHAYVNAAFLVE 420
                     :.|.|:.::..:.:.:.:.||               ::..|.:||.|.|||...||
Mouse   401 KLPEADLKPEEVILSIFIPYTAQWQFVSGL---------------RLAQRQENAFAIVNAGMSVE 450

  Fly   421 FTADAK-VKSARICFGGIHPEFVHAT-AIENLIRDKNPFENGLVEKAFGQLSTLLQPDAVLPDAS 483
            |..... :|..::.||.:.|..|.|: ..:.||  ...:::.::..|   ...:||...:.|||.
Mouse   451 FEEGTNTIKDLKMFFGSVAPTVVSASQTCKQLI--GRQWDDQMLSDA---CQLVLQEIRIPPDAE 510

  Fly   484 ---PVYRRKLACGLFYKFLLKIA-------AQRKQGLGSRFVTGGSLLKRPVSSGQQSFETFQ-- 536
               ..|||.|...|.:||.||:.       .|:...:..:||:  :|...|:.: .|..:.||
Mouse   511 GGMVEYRRTLIISLLFKFYLKVQRWLNEMDPQKFPDIPGKFVS--ALDDFPIET-PQGIQMFQCV 572

  Fly   537 -----EHYPVTKATEKHEGLIQCSGEATYSNDLPTQHNQLWAAFVIAKKVGAKVTKVDTQPALDL 596
                 :..||........|:...:|||.:.:|:|....:|..|.|.:.:..||:|.:|...||..
Mouse   573 DPKQPQKDPVGHPIMHQSGIKHATGEAIFIDDMPPIDQELCLAVVTSTRAHAKITSLDVSEALAC 637

  Fly   597 PGVVAYLDAKDIPGPNYVGPKIRDQFFFPKDEELFATGEIKFYGQPVGIILANSNSLANRAAELV 661
            ||||..:.|:|:||.|       |.    ..|.|:|..|:...||.:..:.|::...|..||:.|
Mouse   638 PGVVDVITAEDVPGEN-------DH----NGEILYAQSEVICVGQIICTVAADTYIHAKEAAKRV 691

  Fly   662 KLTYEGGAEEILPSLKAVLDKV--GSEAGNNKRLEQPIKSTID-----VLQLEEPFDVSSSGQLD 719
            |:.|    ::|.|::..:.:.:  .|.....|::||   ..:|     |.|:.|       |::.
Mouse   692 KIAY----DDIEPTIITIEEALEHNSFLSPEKKIEQ---GNVDYAFKHVDQIVE-------GEIH 742

  Fly   720 MGLQYHYYMEPQTTVVLP--FEGGLQVYAATQWMDLTQDTIANVLNLKSNDVQVKTRRIGGGYGG 782
            :..|.|:|||.||.:.:|  .:..:.::..||:....|:.::..||:..:.:....:|.||.:||
Mouse   743 VEGQEHFYMETQTILAIPQTEDKEMVLHLGTQFPTHVQEFVSAALNVPRSRIACHMKRAGGAFGG 807

  Fly   783 KATRCNLAAAAAALAAHKLNRPIRFV--QSLESIMTS-----LGKRWAFHCDYDFFVQKSGKISG 840
            |.|:..|..|..|:||:|..|||||:  :|.:.::|:     |||       |......:|:|..
Mouse   808 KVTKPALLGAVCAVAANKTGRPIRFILERSDDMLITAGRHPLLGK-------YKIGFMNNGEIRA 865

  Fly   841 IVSRFYEDAGYLANESP--IGHTVLLSKNCYEFSDNYKLDGYLVCTDSPSNTPCRAPGSVEGIAM 903
            ....:|.:.|...:||.  |...||.|:|.|.. .|::..|....|:.||||..|..|..:...:
Mouse   866 ADVEYYTNGGCTPDESELVIEFVVLKSENTYHI-PNFRCRGRACKTNLPSNTAFRGFGFPQATVV 929

  Fly   904 MENIIEHIAFETGVDPADVRFANLL-----PAHK-------MGDMMPRFLESTKYRERKAEAIAH 956
            :|..|..:|.:..:.|.:||..|:.     .|:|       :.......||.:.:..||..|...
Mouse   930 VEAYIAAVASKCNLLPEEVREINMYKKTSKTAYKQTFNPEPLRRCWKECLEKSSFFARKKAAEEF 994

  Fly   957 NKENRWHKRGLGLCIMEYQ----IGYFGQYPATVAIYHSDGTVVVSHGGIEMGQGMNTKISQVAA 1017
            |..|.|.||||.:..|::.    |.::.|..|.|.|: .||:|:::|||.|:|||::||:.|||:
Mouse   995 NGNNYWKKRGLAVVPMKFSVAVPIAFYNQAAALVHIF-LDGSVLLTHGGCELGQGLHTKMIQVAS 1058

  Fly  1018 HTLGIPMEQVRIEASDTINGANSMVTGGAVGSETLCFAVRKACETLNERLKPVREEVKPENWQDL 1082
            ..|.:|...|....:.|....||..|.|::|::....||:.||:.|.:||:|:..:.....|::.
Mouse  1059 RELNVPKSYVHFSETSTTTVPNSAFTAGSMGADINGKAVQNACQILMDRLRPIIRKNPKGKWEEW 1123

  Fly  1083 IQEAYNRKINLIASDQCK-----------QGDMDPYSVCGLCLTEVELDVLTGNYIVGRVDILED 1136
            |:.|:...|:|.|:...|           :||..||.|.|...:|||:|.|||.:.:.|.||..|
Mouse  1124 IKMAFEESISLSATGYFKGYQTNMDWKKEEGDPYPYYVYGAACSEVEVDCLTGAHKLLRTDIFVD 1188

  Fly  1137 TGESLNPNVDIGQIEGAFMMGLGYWTSEQVIADPKTGECLTNRTWTYKPPGAKDIPTDLRIELLP 1201
            ...|:||.:||||:||||:.|:|::|:|::...|| |...:.....||.|...:||.:..:.|:
Mouse  1189 AAFSINPALDIGQVEGAFIQGMGFYTTEELKYSPK-GVLYSRGPEDYKIPTITEIPEEFYVTLV- 1251

  Fly  1202 KSPNKAGFMRSKATGEPAICLSIAVAFALQQALQSARDDAGVPKSWVTLTAPMTPE 1257
            .|.|......||..||..:.|..:|.||:..|:.:||.:.|:...: .|.:|.|||
Mouse  1252 HSRNPIAIYSSKGLGEAGMFLGSSVLFAIYDAVTTARKERGLSDIF-PLNSPATPE 1306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	PLN02906	28..1259	CDD:215491	401/1356 (30%)
Aox4	NP_076120.2	mam_aldehyde_ox	9..1335	CDD:132014	401/1356 (30%)