DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and Aox3

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	NP_076106.2	Gene:	Aox3 / 71724	MGIID:	1918974	Length:	1335	Species:	Mus musculus

Alignment Length:	1374	Identity:	401/1374 - (29%)
Similarity:	645/1374 - (46%)	Gaps:	206/1374 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RITINGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWA 68
            ::|......||||.         .::|:...|||||:.|..|.||.|...::...|.:..:..::
Mouse    18 KVTERNADPEVNLL---------FYLRKVIRLTGTKYGCGGGDCGACTVMISRYDPISKRISHFS 73

  Fly    69 VNSCLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGK 133
            ..:||..:.:..|..|||.||:|:.:...|.:|:|:||.:|||||:|:||:||::|.||::....
Mouse    74 ATACLVPICSLHGAAVTTVEGIGSTKTRIHPVQERIAKGHGTQCGFCTPGMVMSIYTLLRNHPEP 138

  Fly   134 VTMEEVENSFGGNICRCTGYRPILDAMKSFAVDSN-IQVPAE---CIDIEDLSTKKCP-KTGQTC 193
            .| |::..:.|||:|||||||||:::.|||...|. .|:..|   |:|.|    |..| :....|
Mouse   139 ST-EQIMETLGGNLCRCTGYRPIVESAKSFCPSSTCCQMNGEGKCCLDEE----KNEPERKNSVC 198

  Fly   194 SGSCKKQQ-----PKGSQLYPD-----------------GSRWSW--PVSLGDLFAALQGAVKEK 234
            :...:|::     |....::|.                 |.|.:|  |.:|.||.     .:|.|
Mouse   199 TKLYEKKEFQPLDPTQELIFPPELMRMAEESQNTVLTFRGERTTWIAPGTLNDLL-----ELKMK 258

  Fly   235 LPYM-LVAGNTAHGVYRRSPDIKAFIDVSGLAELKGHKLSADNSSLTLGGNLSLSET----MELC 294
            .|.. ||.|||..|::.:..|:...|.:|....|:...::.....||||..|||::.    .::.
Mouse   259 HPSAPLVIGNTYLGLHMKFTDVSYPIIISPARILELFVVTNTKQGLTLGAGLSLTQVKNVLSDVV 323

  Fly   295 RQLENTKGFEYLSQVWQHLDWIANVPVRNAGTLAGNLSIKHAHPEFP-SDV-------FIVLEAL 351
            .:|...|...|.:.:.| |..:|...:||..:|.|     |.....| ||:       ..:|...
Mouse   324 SRLPKEKTQIYCALLKQ-LKTLAGQQIRNVASLGG-----HIISRLPTSDLNPILGIGNCILNVA 382

  Fly   352 DAQVI------------VQEAVDKQQTVSLASYLGSSMEGKIIRGLVLRAYPKERFAFDSYKIMP 404
            ..:.|            |.:|:.|.:.|.::.::..|.:.:.:               .:::..|
Mouse   383 STEGIQQIPLNDHFLAGVPDAILKPEQVLISVFVPRSSKWEFV---------------SAFRQAP 432

  Fly   405 RAQNAHAYVNAAFLVEFTADAK-VKSARICFGGIHPEFVHATAIENLIRDKNPFENGLVEKAFGQ 468
            |.|||.|.|||...|.|..|.. :....|.:|||     .||.|.             .:|:..|
Mouse   433 RQQNAFATVNAGMKVVFKEDTNTITDLGILYGGI-----GATVIS-------------ADKSCRQ 479

  Fly   469 LSTLLQPDAVLPDASPV-----------------YRRKLACGLFYKFLLKIAAQRKQGLGSRFVT 516
            |......:.:|.||..:                 ||:.||....:.|.|.:..|.|.....::..
Mouse   480 LIGRCWDEEMLDDAGKMICEEVSLLMAAPGGMEEYRKTLAISFLFMFYLDVLKQLKTRDPHKYPD 544

  Fly   517 GGSLLKR-----PVSS--GQQSFE--TFQE--HYPVTKATEKHEGLIQCSGEATYSNDLPTQHNQ 570
            ....|..     |::.  |.|||:  .||:  ..|:.:......|:...:|||.:.:|:.....:
Mouse   545 ISQKLLHILEDFPLTMPYGMQSFQDVDFQQPLQDPIGRPIMHQSGIKHATGEAVFCDDMSVLPGE 609

  Fly   571 LWAAFVIAKKVGAKVTKVDTQPALDLPGVVAYLDAKDIPGPNYVGPKIRDQFFFPKDEELFATGE 635
            |:.|.|.:.|..||:..:|...||...|||..:.|:|:||.|           ..::|.|:|..|
Mouse   610 LFLAVVTSSKSHAKIISLDASEALASLGVVDVVTARDVPGDN-----------GREEESLYAQDE 663

  Fly   636 IKFYGQPVGIILANSNSLANRAAELVKLTYEGGAEEILPSLKAVLDKVGSEA--GNNKRLEQPIK 698
            :...||.|..:.|:|.:.|.:||:.||:.|    ::|.|.:..|.|.:..|:  |..::|||.
Mouse   664 VICVGQIVCAVAADSYAHAQQAAKKVKIVY----QDIEPMIVTVQDALQYESFIGPERKLEQG-- 722

  Fly   699 STIDVLQLEEPF---DVSSSGQLDMGLQYHYYMEPQTTVVLP--FEGGLQVYAATQWMDLTQDTI 758
                  .:||.|   |....|::.:|.|.|:|||.|:..|:|  .:..:.:|.::|....||:.:
Mouse   723 ------NVEEAFQCADQILEGEVHLGGQEHFYMETQSVRVVPKGEDKEMDIYVSSQDAAFTQEMV 781

  Fly   759 ANVLNLKSNDVQVKTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMTSLGKRWA 823
            |..|.:..|.:....:|:||.:||||::..|.|:.||:||.|..|||||:......|...|.|..
Mouse   782 ARTLGIPKNRINCHVKRVGGAFGGKASKPGLLASVAAVAAQKTGRPIRFILERRDDMLITGGRHP 846

  Fly   824 FHCDYDFFVQKSGKISGIVSRFYEDAGYLANESP--IGHTVLLSKNCYEFSDNYKLDGYLVCTDS 886
            ....|......:|||.....:.|.:.|...::|.  |.:.:|..:|.|:. .|.::.|.:..|:.
Mouse   847 LLGKYKIGFMNNGKIKAADIQLYINGGCTPDDSELVIEYALLKLENAYKI-PNLRVRGRVCKTNL 910

  Fly   887 PSNTPCRAPGSVEGIAMMENIIEHIAFETGVDPADVRFANLL-------------PAHKMGDMMP 938
            ||||..|..|..:|..:.|..:..:|.:..:.|..||..|:.             |.:.: ....
Mouse   911 PSNTAFRGFGFPQGAFVTETCMSAVAAKCRLPPEKVRELNMYRTIDRTIHNQEFDPTNLL-QCWE 974

  Fly   939 RFLESTKYRERKAEAIAHNKENRWHKRGLGLCIMEYQIG----YFGQYPATVAIYHSDGTVVVSH 999
            ..:|::.|..||......|::..|.|||:.:..|::.:|    ::.|..|.|.|| :||:|:|:|
Mouse   975 ACVENSSYYNRKKAVDEFNQQRFWKKRGIAIIPMKFSVGFPKTFYYQAAALVQIY-TDGSVLVAH 1038

  Fly  1000 GGIEMGQGMNTKISQVAAHTLGIPMEQVRIEASDTINGANSMVTGGAVGSETLCFAVRKACETLN 1064
            ||:|:|||:|||:.|||:..|.|||..:.::...|:...|::.||.:.|::....||:.||:.|.
Mouse  1039 GGVELGQGINTKMIQVASRELKIPMSYIHLDEMSTVTVPNTVTTGASTGADVNGRAVQNACQILM 1103

  Fly  1065 ERLKPVREEVKPENWQDLIQEAYNRKINLIASDQCK--QGDMD---------PYSVCGLCLTEVE 1118
            :||:|:.::.....|::.::||:.:.|:|.|:...:  |.|||         ||.|.|...:|||
Mouse  1104 KRLEPIIKQNPSGTWEEWVKEAFVQSISLSATGYFRGYQADMDWEKGEGDIFPYFVFGAACSEVE 1168

  Fly  1119 LDVLTGNYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTSEQVIADPKTGECLTNRTWTY 1183
            :|.|||.:...|.||:.|...|:||.||||||||||:.|||.:|.|::...|: |...|.....|
Mouse  1169 IDCLTGAHKNIRTDIVMDGSFSINPAVDIGQIEGAFVQGLGLYTLEELKYSPE-GVLYTRGPHQY 1232

  Fly  1184 KPPGAKDIPTDLRIELLPKSPNKAGFMRSKATGEPAICLSIAVAFALQQALQSARDDAGVPKSWV 1248
            |.....|||.:..:.||..:||......||..||....|..:|.||:..|:.:||::.|:...|
Mouse  1233 KIASVTDIPEEFHVSLLTPTPNPKAIYSSKGLGEAGTFLGCSVFFAIAAAVAAAREERGLSPIW- 1296

  Fly  1249 TLTAPMTPE 1257
            .:.:|.|.|
Mouse  1297 AINSPATAE 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	fer2	4..85	CDD:238126	20/80 (25%)
		PLN02906	28..1259	CDD:215491	396/1350 (29%)
		Fer2_2	86..159	CDD:280048	36/72 (50%)
		FAD_binding_4	211..373	CDD:303082	47/188 (25%)
		CO_deh_flav_C	399..502	CDD:281449	31/120 (26%)
		Ald_Xan_dh_C	555..666	CDD:214971	35/110 (32%)
		Ald_Xan_dh_C2	711..1192	CDD:280834	167/512 (33%)
Aox3	NP_076106.2	mam_aldehyde_ox	9..1334	CDD:132014	401/1374 (29%)
		Fer2_2	91..162	CDD:280048	36/71 (51%)
		FAD_binding_5	239..419	CDD:279309	46/190 (24%)
		CO_deh_flav_C	426..530	CDD:281449	31/121 (26%)
		Ald_Xan_dh_C	594..697	CDD:214971	36/117 (31%)
		Ald_Xan_dh_C2	709..1241	CDD:280834	175/543 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720