DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and aox5

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	NP_001265725.1	Gene:	aox5 / 64265	ZFINID:	ZDB-GENE-001205-2	Length:	1336	Species:	Danio rerio

Alignment Length:	1359	Identity:	395/1359 - (29%)
Similarity:	640/1359 - (47%)	Gaps:	169/1359 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 INGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWAVNS 71
            ||| ...|..:|.|.::.| .::|...||||.|:.|..||||.|...::...|....:..|:||:
Zfish    14 ING-KKIVEKNADPEEMLL-AYLRRKVGLTGAKYGCGGGGCGACTVMVSRYDPLQDTVLHWSVNA 76

  Fly    72 CLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGKVTM 136
            ||..:.:..|..|.|.||:|:.:...|.:|:|:.|.:|:|||:|:||:||:||.||:: ....|:
Zfish    77 CLQPICSLHGAAVVTVEGIGSTKTKLHPVQERIVKAHGSQCGFCTPGMVMSMYTLLRN-NPHPTI 140

  Fly   137 EEVENSFGGNICRCTGYRPILDAMKSFAVDSNIQVPAECIDIEDLSTKKCPKTGQT-----CSG- 195
            |::..:.|||:|||||||||:|..|:|.     :.|. |......:.|.|.:.|.:     .||
Zfish   141 EDIRETLGGNLCRCTGYRPIIDGFKTFC-----ETPV-CCQNGGGNGKCCMENGNSHNESDISGE 199

  Fly   196 -----SCKKQQPKGSQLYP------------------DGSRWSWPVSLGDLFAALQGAVKEKLPY 237
                 :.....|....::|                  :..||..|..|.||       :|.|..:
Zfish   200 LFIMDNVLPLDPTQDLIFPPELLIMGKKKAERHCFQGEKVRWISPSDLKDL-------IKLKAEH 257

  Fly   238 M---LVAGNTAHG-VYRRSPDIKAFIDVSG-LAELKGHKLSADNSSLTLGGNLSLSETMELCRQL 297
            .   |:.|||..| ....:..:...:...| :|||:..|..  .:.:|:|...|||...::.:|.
Zfish   258 SDAPLLVGNTTIGPKMNLNKTVHPLVIYGGSIAELQAIKWR--KNCITVGAGCSLSVLKDVLQQR 320

  Fly   298 ENTKGFEYLSQVW----QHLDWIANVPVRNAGTLAGNLSIKHAHPEFPSDVFIVLEALDAQVIVQ 358
            ....|.| .|:|:    |.|..:|...:||..|:.||  |..|:|::  |:..:|.|.:..:.:
Zfish   321 IEDLGPE-KSRVYQALVQTLQCLAGKQIRNMATIGGN--ILSANPKY--DLSSILAAAECTLHI- 379

  Fly   359 EAVDKQQTVSLASYLGSSMEGKIIRGLVLRAYPKE-RFAFD-----------SYKIMPRAQNAHA 411
            .:.|..:.:.|:....:......:|       |:| ..|.|           :::...|.:.|.:
Zfish   380 ASKDGDREICLSEEFFTDFGKTALR-------PEEILLAIDIPHSKPWEFVSAFRQAQRREFAFS 437

  Fly   412 YVNAAFLVEFTADAK-VKSARICFGGIHPEFVHAT-AIENLIRDKNPFENGLVEKAFGQLSTLLQ 474
            .|||...|.|..|:. |:...|.:||:....|.|. ..:.||..|      ..||...:.:.||:
Zfish   438 IVNAGMRVAFRHDSNVVEHLDIFYGGVGCTLVKARHTCKELIGRK------WDEKLLAEGTQLLE 496

  Fly   475 PD----AVLPDASPVYRRKLACGLFYKFLLKI---AAQRKQGLGS---RFVTGGSLLKRPVSSGQ 529
            .:    |.:|.....||:.|....|:||.:::   ..||:.|:..   .:::.....|..|..|.
Zfish   497 EEISVPATVPGGREEYRKALVLSFFFKFYMQVLLELQQREVGVNDLPLEYLSALKPFKNEVPQGN 561

  Fly   530 QSF----ETFQEHYPVTKATEKHEGLIQCSGEATYSNDLPTQHNQLWAAFVIAKKVGAKVTKVDT 590
            .|:    ||.....||.:.......|.|.:|||.|.:|:|:...:|:.:.|.:.:..||:..:|.
Zfish   562 YSYQLVPETQSSSDPVGRPNVHLAALQQATGEAVYYDDIPSVKGELFVSMVTSTRAHAKIISIDA 626

  Fly   591 QPALDLPGVVAYLDAKDIPGPNYVGPKIRDQFFFPKDEELFATGEIKFYGQPVGIILANSNSLAN 655
            ..||.:||||.::.|||:||.|       .:.:|...|||||..|:...||.:|.|:|.:...|.
Zfish   627 SVALAMPGVVDFISAKDVPGQN-------RRLWFNNPEELFAEEEVICVGQIIGAIVAETREQAK 684

  Fly   656 RAAELVKLTYEGGAEEILPSLKAVLDKVGSEA--GNNKRLEQPIKSTIDVLQLEEPF---DVSSS 715
            |||:.|.:||    :::.|....:.:.:..|:  ...::||:.        .:||.|   |....
Zfish   685 RAAQQVDITY----QDMQPVFFTIEEAIEHESFFDPKRKLERG--------NVEEGFAKADQILE 737

  Fly   716 GQLDMGLQYHYYMEPQTTVVLPF--EGGLQVYAATQWMDLTQDTIANVLNLKSNDVQVKTRRIGG 778
            |::.||.|.|:|||.|..:.:|.  ...:::|.|:|....||:.:...|.:.||.:....:|:||
Zfish   738 GEMYMGGQEHFYMETQGVIAIPTGEASEIELYVASQHAAYTQEVVGITLGIDSNKITCHVKRLGG 802

  Fly   779 GYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMTSLGKRWAFHCDYDFFVQKSGKISGIVS 843
            |:|||..:....:|.||.||.|....:|.|......|.....|..|...|.......|.|.....
Zfish   803 GFGGKVMKIASLSAIAATAAIKTGHAVRCVLERGDDMLITSGRSPFLGRYKIGYMNDGTILAADI 867

  Fly   844 RFYEDAGYLANESPIGHTVLLSKNCYEFSDNYKLDGY----LVC-TDSPSNTPCRAPGSVEGIAM 903
            .:|.:.|...:||    :.::.|......:.||:...    ||| |..||.|..|..|..:|:.:
Zfish   868 TYYSNGGCTLDES----SFIMEKALLHMDNGYKIPNLRGRGLVCKTFLPSYTAFRGFGGPQGLTI 928

  Fly   904 MENIIEHIAFETGVDPADVRFAN-------------LLPAHKMGDMMPRFLESTKYRERKAEAIA 955
            :|:::..:|.:.|:....||..|             |...|.|.......||.:.|.:|......
Zfish   929 IESVLHEVAVKCGLPAHQVRDINLYKEEKCFTHHKQLFSPHDMVRCWNECLEKSNYTQRCQYIEQ 993

  Fly   956 HNKENRWHKRGLGLCIMEYQI----GYFGQYPATVAIYHSDGTVVVSHGGIEMGQGMNTKISQVA 1016
            .|..|.|.|||:.:..:::.|    |::.|..|.|.:| .||:||:||||.|||||:|||..|:|
Zfish   994 FNGHNHWKKRGISIVPIKFGIGFSKGFYNQGAALVNVY-KDGSVVISHGGTEMGQGINTKAIQIA 1057

  Fly  1017 AHTLGIPMEQVRIEASDTINGANSMVTGGAVGSETLCFAVRKACETLNERLKPVREEVKPENWQD 1081
            :..|.:.|..:.|:.:.|.|..|:..:..:.|::.:..||:..||.|..||:|:.::.....||.
Zfish  1058 SRILKVSMSSIHIKETCTGNVPNAAPSAASFGTDAVGMAVKNGCEKLMRRLEPLIKKHPQYTWQQ 1122

  Fly  1082 LIQEAYNRKINLIASD-----------QCKQGDMDPYSVCGLCLTEVELDVLTGNYIVGRVDILE 1135
            |:.|||.:||:|.|:.           :..:|:...|...|.|.:|||:|.|||::...|.||:.
Zfish  1123 LVVEAYCQKISLSATGFFMGPHTSVDWEKSEGNAYYYFTFGACCSEVEIDCLTGDHKNIRTDIVM 1187

  Fly  1136 DTGESLNPNVDIGQIEGAFMMGLGYWTSEQVIADPKTGECLTNRTWTYKPPGAKDIPTDLRIELL 1200
            |.|.|:||.:|:||:||.|:.|:|.:|.|::...|: |..||.....||.|...|:|..:.:.||
Zfish  1188 DVGRSINPALDVGQVEGGFVQGIGLYTIEELQFSPQ-GVLLTRGPSQYKIPALCDVPPQINVHLL 1251

  Fly  1201 PKSPNKAGFMRSKATGEPAICLSIAVAFALQQALQSARDDAGVPKSWVTLTAPMTPEHL 1259
            ..:.|......||..|||.:.....:.||:::|:.:||.:.|:.:|: :.::|.|.|.:
Zfish  1252 RNADNPHAIYSSKGIGEPPVFFGCTLFFAIKEAIAAARKERGLSESF-SFSSPATAEKI 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	fer2	4..85	CDD:238126	26/77 (34%)
		PLN02906	28..1259	CDD:215491	388/1336 (29%)
		Fer2_2	86..159	CDD:280048	35/72 (49%)
		FAD_binding_4	211..373	CDD:303082	44/170 (26%)
		CO_deh_flav_C	399..502	CDD:281449	29/108 (27%)
		Ald_Xan_dh_C	555..666	CDD:214971	41/110 (37%)
		Ald_Xan_dh_C2	711..1192	CDD:280834	162/515 (31%)
aox5	NP_001265725.1	mam_aldehyde_ox	8..1336	CDD:132014	395/1359 (29%)
		Fer2_2	91..162	CDD:280048	35/71 (49%)
		FAD_binding_5	237..417	CDD:279309	49/201 (24%)
		CO_deh_flav_C	424..528	CDD:281449	29/109 (27%)
		Ald_Xan_dh_C	591..696	CDD:214971	42/115 (37%)
		Ald_Xan_dh_C2	718..1243	CDD:280834	167/538 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820