back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and Aox1

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	NP_062236.3	Gene:	Aox1 / 54349	RGDID:	620528	Length:	1333	Species:	Rattus norvegicus

Alignment Length:	1356	Identity:	395/1356 - (29%)
Similarity:	640/1356 - (47%)	Gaps:	162/1356 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 INGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWAVNS 71
            :||  .:|..:.:..::.|..::|:...|||||:.|..||||.|...::..:|.|..:|...||:
  Rat    10 VNG--QKVVENNVDPEMMLLPYLRKNLRLTGTKYGCGGGGCGACTVMISRYNPSTKSIRHHPVNA 72

  Fly    72 CLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGKVTM 136
            |||.:.:..|..|||.||:||.|...|.:|:|:||.:|||||:|:||:||:||.||::. .:.::
  Rat    73 CLTPICSLYGTAVTTVEGIGNTRTRLHPVQERIAKCHGTQCGFCTPGMVMSMYALLRNH-PEPSL 136

  Fly   137 EEVENSFGGNICRCTGYRPILDAMKSF---------------AVDSNIQVPAECIDIEDLSTKK- 185
            :::.::.|||:|||||||||:||.|:|               .:|..|...||..:.::.|.:.
  Rat   137 DQLTDALGGNLCRCTGYRPIIDACKTFCRASGCCESKENGVCCLDQGINGSAEFQEGDETSPELF 201

  Fly   186 CPKTGQTCSGS------------CKKQQPKGSQLYPDGSRWSWPVSLGDLFAALQGAVKEKLP-Y 237
            ..|..|....:            .:||.||....|.:...|..||:|.:|..|     |.|.| .
  Rat   202 SEKEFQPLDPTQELIFPPELMRIAEKQPPKTRVFYSNRMTWISPVTLEELVEA-----KFKYPGA 261

  Fly   238 MLVAGNTAHGVYRRSPDIK-------AFIDVSGLAELKGHKLSADNSSLTLGGNLSLSETMELCR 295
            .:|.|.|:.|     |::|       ..|....:.||.  .::.....||||..|||.:..::..
  Rat   262 PIVMGYTSVG-----PEVKFKGVFHPIIISPDRIEELS--IINQTGDGLTLGAGLSLDQVKDILT 319

  Fly   296 QL------ENTKGFEYLSQVWQHLDWIANVPVRNAGTLAGNLSIKHAHPEFPSDVFIVLEALDAQ 354
            .:      |.|:.:..|   .:||..:|...:||..:|.|::..:|    ..||:..:|...:..
  Rat   320 DVVQKLPEETTQTYRAL---LKHLRTLAGSQIRNMASLGGHIVSRH----LDSDLNPLLAVGNCT 377

  Fly   355 VIVQEAVDKQQTVSLASYLGSSMEG-----KIIRGLVLRAYPKERFAFDSYKIMPRAQNAHAYVN 414
            :.:.....|:|......:|....:.     :::..:.:....|..|. .:::...|.|||.|.||
  Rat   378 LNLLSKDGKRQIPLSEQFLRKCPDSDLKPQEVLVSVNIPCSRKWEFV-SAFRQAQRQQNALAIVN 441

  Fly   415 AAFLVEF-TADAKVKSARICFGGIHPEFVHA-TAIENLIRDKNPFENGLVEKAFGQLSTLLQPDA 477
            :...|.| .....:|...|.:||:.|..:.| .:.:.||  ..|:...:::.|    ..|:..:.
  Rat   442 SGMRVLFREGGGVIKELSILYGGVGPTTIGAKNSCQKLI--GRPWNEEMLDTA----CRLVLDEV 500

  Fly   478 VLPDASP----VYRRKLACGLFYKFLLKIAAQRKQGLGSRFVTGGSLLKRPVSSGQQSFETFQEH 538
            .|..::|    .::|.|.....:||.|::.    |||..........|.....|..:...: :.|
  Rat   501 TLAGSAPGGKVEFKRTLIISFLFKFYLEVL----QGLKREDPGHYPSLTNNYESALEDLHS-KHH 560

  Fly   539 Y----------------PVTKATEKHEGLIQCSGEATYSNDLPTQHNQLWAAFVIAKKVGAKVTK 587
            :                |:.:......|:...:|||.|.:|:|....:|:..||.:.:..||:..
  Rat   561 WRTLTHQNVDSMQLPQDPIGRPIMHLSGIKHATGEAIYCDDMPAVDRELFLTFVTSSRAHAKIVS 625

  Fly   588 VDTQPALDLPGVVAYLDAKDIPGPNYVGPKIRDQFFFPKDEELFATGEIKFYGQPVGIILANSNS 652
            :|...||.|||||..:.|..:......|           .|.|.||.::...||.|..::|:|.:
  Rat   626 IDLSEALSLPGVVDIITADHLQDTTTFG-----------TETLLATDKVHCVGQLVCAVIADSET 679

  Fly   653 LANRAAELVKLTYEGGAEEILPSLKAVLDKVGSEAGNNKRLEQPIKSTIDVLQLEEPFDVSS--- 714
            .|.:||:.||:.|......||...:|:..|...|  :.::||        ...::|.|.::.
  Rat   680 RAKQAAKHVKVVYRDLEPLILTIEEAIQHKSFFE--SERKLE--------CGNVDEAFKIADQIL 734

  Fly   715 SGQLDMGLQYHYYMEPQTTVVLP--FEGGLQVYAATQWMDLTQDTIANVLNLKSNDVQVKTRRIG 777
            .|::.:|.|.|:|||.|:.:|:|  .:|.:.:|.:||:....||.:|..|.|..|.|....||:|
  Rat   735 EGEIHIGGQEHFYMETQSMLVVPKGEDGEIDIYVSTQFPKHIQDIVAATLKLSVNKVMCHVRRVG 799

  Fly   778 GGYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMTSLGKRWAFHCDYDFFVQKSGKISGIV 842
            |.:|||..:.::.||..|.||.|..|.:|........|...|.|..:...|.....:.|:|..:.
  Rat   800 GAFGGKVGKTSIMAAITAFAASKHGRAVRCTLERGEDMLITGGRHPYLGKYKVGFMRDGRIVALD 864

  Fly   843 SRFYEDAGYLANES--PIGHTVLLSKNCYEFSDNYKLDGYLVCTDSPSNTPCRAPGSVEGIAMME 905
            ...|.:.|...:||  .|...:|...|.|:| .|.:..|:...|:.||||..|..|..:...:.|
  Rat   865 VEHYCNGGSSLDESLWVIEMGLLKMDNAYKF-PNLRCRGWACRTNLPSNTALRGFGFPQAGLVTE 928

  Fly   906 NIIEHIAFETGVDPADVRFANL------------LPAHKMGDMMPRFLESTKYRERKAEAIAHNK 958
            ..:..:|...|:.|..||..|:            ..|..:.:.....:....|.|||......|.
  Rat   929 ACVTEVAIRCGLSPEQVRTINMYKQIDNTHYKQEFSAKTLFECWRECMAKCSYSERKTAVGKFNA 993

  Fly   959 ENRWHKRGLGLCIMEYQIGY----FGQYPATVAIYHSDGTVVVSHGGIEMGQGMNTKISQVAAHT 1019
            ||.|.|||:.:..:::.:|.    .||..|.|.|| .||:.:|||||||||||::||:.||.:..
  Rat   994 ENSWKKRGMAVIPLKFPVGVGSVAMGQAAALVHIY-LDGSALVSHGGIEMGQGVHTKMIQVVSRE 1057

  Fly  1020 LGIPMEQVRIEASDTINGANSMVTGGAVGSETLCFAVRKACETLNERLKPVREEVKPENWQDLIQ 1084
            |.:||..|.:..:.|....|:..:||:|.::....||:.||:||.:||:|:..:.....|:|..|
  Rat  1058 LKMPMSSVHLRGTSTETVPNTNASGGSVVADLNGLAVKDACQTLLKRLEPIISKNPQGTWKDWAQ 1122

  Fly  1085 EAYNRKINLIA---------SDQCKQGDMDP--YSVCGLCLTEVELDVLTGNYIVGRVDILEDTG 1138
            .|:::.::|.|         :...::|:..|  |.|.|...:|||:|.|||::...|.||:.|.|
  Rat  1123 TAFDQSVSLSAVGYFRGYESNINWEKGEGHPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVG 1187

  Fly  1139 ESLNPNVDIGQIEGAFMMGLGYWTSEQVIADPKTGECLTNRTWTYKPPGAKDIPTDLRIELLPKS 1203
            .|:||.:||||:||||:.|:|.:|.|::...|: |...:.....||.|...||||::.|..||.|
  Rat  1188 HSINPALDIGQVEGAFIQGMGLYTIEELSYSPQ-GILYSRGPNQYKIPAICDIPTEMHISFLPPS 1251

  Fly  1204 PNKAGFMRSKATGEPAICLSIAVAFALQQALQSARDDAGVPKSWVTLTAPMTPEHL 1259
            .:......||..||..:.|..:|.||:..|:::||.:.|:...| .||:|:|||.:
  Rat  1252 EHSNTLYSSKGLGESGVFLGCSVFFAIHDAVRAARQERGISGPW-KLTSPLTPEKI 1306

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.