DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and Aox3

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	NP_001008527.2	Gene:	Aox3 / 493909	RGDID:	1359328	Length:	1334	Species:	Rattus norvegicus

Alignment Length:	1370	Identity:	399/1370 - (29%)
Similarity:	654/1370 - (47%)	Gaps:	198/1370 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 INGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWAVNS 71
            :|| ...:..:|.| :::|..::|:...|||||:.|..|.||.|...::..:|.:.::..::..:
  Rat    14 VNG-KKVIERNADP-EVNLLFYLRKIIQLTGTKYGCGGGDCGACTVMISRYNPISKKISHFSAAA 76

  Fly    72 CLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGKVTM 136
            ||..:.:..|..|||.||:|:.:...|.:|:|:||.:|||||:|:||:||::|.||::.....|
  Rat    77 CLVPICSLHGAAVTTVEGIGSTKTRIHPVQERIAKGHGTQCGFCTPGMVMSIYTLLRNHPEPST- 140

  Fly   137 EEVENSFGGNICRCTGYRPILDAMKSFAVDSNIQVPAE----CIDIEDLSTKKCP-KTGQTCSGS 196
            |::..:.|||:|||||||||:::.:||:.:|......|    |:|    ..|..| :....|:..
  Rat   141 EQIMETLGGNLCRCTGYRPIVESARSFSPNSACCPMNEKWKCCLD----EGKNEPERKNSVCTKL 201

  Fly   197 CKKQQ-----PKGSQLYPD-----------------GSRWSW--PVSLGDLFAALQGAVKEKLPY 237
            .:|::     |....::|.                 |.|.:|  |.:|.||       ::.|:.|
  Rat   202 YEKEEFQPLDPTQELIFPPELMRMAEDSPNTVLTFRGERTTWIAPGTLNDL-------LELKMEY 259

  Fly   238 ---MLVAGNTAHGVYRRSPDIKAFIDVSGLAELKGHKLSADNSSLTLGGNLSLSETMELCRQL-- 297
               .||.|||..|:..:..|:...|.:|....|:...::..|..||||..|||::...:...:
  Rat   260 PSAPLVIGNTCLGLDMKFKDVSYPIIISPARILELFVVTNTNEGLTLGAGLSLTQVKNILSDVVS 324

  Fly   298 ----ENTKGFEYLSQVWQHLDWIANVPVRNAGTLAG----------------------NLSIKHA 336
                |.|:.:..|   .:||..:|...:||..:|.|                      |::....
  Rat   325 RLPKERTQTYRAL---LKHLRTLAGQQIRNVASLGGHIISRLPTSDLNPIFGVGNCKLNVASTEG 386

  Fly   337 HPEFP-SDVFIVLEALDAQVIVQEAVDKQQTVSLASYLGSSMEGKIIRGLVLRAYPKERFAFDSY 400
            ..:.| :|.|:        ..|.||:.|.:.|.::.::..|.:.:.:               .::
  Rat   387 TQQIPLNDHFL--------AGVPEAILKPEQVLISVFVPLSRKWEFV---------------SAF 428

  Fly   401 KIMPRAQNAHAYVNAAFLVEFTADAK-VKSARICFGGIHPEFVHATAIENLIRDKNPFENGLV-- 462
            :..||.|||.|.|||...|.|..|.. :....|.:|||....|.|.:.:.||        |..
  Rat   429 RQAPRQQNAFAIVNAGMRVAFKEDTNTITDLSILYGGIGATVVSAKSCQQLI--------GRCWD 485

  Fly   463 EKAFGQLSTLLQPDAVLPDASP----VYRRKLACGLFYKFLLKIAAQRKQGLGSRFVTGGSLLKR 523
            |:.......:::.:..|..|:|    .||:.||....:||.|.:..|.|:....|.......|.:
  Rat   486 EEMLDDAGRMIREEVSLLTAAPGGMVEYRKTLAISFLFKFYLDVLKQLKRRNPHRCPDISQKLLQ 550

  Fly   524 PVSS-------GQQSFETFQEHY----PVTKATEKHEGLIQCSGEATYSNDLPTQHNQLWAAFVI 577
            .:..       |.|||:......    ||.:......|:...:|||.:.:|:.....:|:.|.|.
  Rat   551 VLEDFPLTMPHGTQSFKDVDSQQPLQDPVGRPIMHQSGIKHATGEAVFCDDMSVLAGELFLAVVT 615

  Fly   578 AKKVGAKVTKVDTQPALDLPGVVAYLDAKDIPGPNYVGPKIRDQFFFPKDEELFATGEIKFYGQP 642
            :.|..|::..:|...||..||||..:.|:|:||.|           ..::|.|:|..|:...||.
  Rat   616 SSKPHARIISLDASEALASPGVVDVITAQDVPGDN-----------GREEESLYAQDEVICVGQI 669

  Fly   643 VGIILANSNSLANRAAELVKLTYEGGAEEILPSLKAVLDKVGSEA--GNNKRLEQ-----PIKST 700
            |..:.|:|.:.|.:|.:.||:.|    |::.|.:..|.|.:..|:  |..|:|||     ..:|.
  Rat   670 VCAVAADSYARAKQATKKVKIVY----EDMEPMIVTVQDALQHESFIGPEKKLEQGNVQLAFQSA 730

  Fly   701 IDVLQLEEPFDVSSSGQLDMGLQYHYYMEPQTTVVLPFEG---GLQVYAATQWMDLTQDTIANVL 762
            ..:|:          |::.:|.|.|:|||.|:..|:| :|   .:.:|.::|....||:.:|..|
  Rat   731 DQILE----------GEVHLGGQEHFYMETQSVRVIP-KGEDMEMDIYVSSQDAAFTQEMVARTL 784

  Fly   763 NLKSNDVQVKTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMTSLGKRWAFHCD 827
            .:..|.:....:|:||.:|||.::..|.|:.||:||.|..|||||:......|...|.|......
  Rat   785 GIPKNRITCHVKRVGGAFGGKTSKPGLLASVAAVAAQKTGRPIRFILERGDDMLITGGRHPLLGK 849

  Fly   828 YDFFVQKSGKISGIVSRFYEDAGYLANESP--IGHTVLLSKNCYEFSDNYKLDGYLVCTDSPSNT 890
            |......:|||.....:.|.:.|...::|.  |.:.:|..:|.|:. .|.::.|.:..|:.||||
  Rat   850 YRVGFMNNGKIKAADIQLYINGGCTPDDSELVIEYALLKLENAYKI-PNLRVRGRVCKTNLPSNT 913

  Fly   891 PCRAPGSVEGIAMMENIIEHIAFETGVDPADVRFANLLPA-----HKMGDMMPRFL--------E 942
            ..|..|..:|..:.|..:..:|.:..:.|..||..|:...     ||. :..|..|        |
  Rat   914 AFRGFGFPQGAFVTETWVSAVAAKCHLPPEKVRELNMYKTIDRTIHKQ-EFDPTNLIKCWETCME 977

  Fly   943 STKYRERKAEAIAHNKENRWHKRGLGLCIMEYQIG----YFGQYPATVAIYHSDGTVVVSHGGIE 1003
            ::.|..||......|:::.|.|||:.:..|::.:|    ::.|..|.|.|| :||:|:|:|||:|
  Rat   978 NSSYYSRKKAVDEFNQQSFWKKRGIAIIPMKFSVGFPKTFYHQAAALVQIY-TDGSVLVAHGGVE 1041

  Fly  1004 MGQGMNTKISQVAAHTLGIPMEQVRIEASDTINGANSMVTGGAVGSETLCFAVRKACETLNERLK 1068
            :|||:|||:.|||:..|.|||..:.::..:|:...|::.|||:.|::....||:.||:.|.:||:
  Rat  1042 LGQGINTKMIQVASRELKIPMSYIHLDEMNTMTVPNTITTGGSTGADVNGRAVQNACQILMKRLE 1106

  Fly  1069 PVREEVKPENWQDLIQEAYNRKINLIASDQCK--QGDMD---------PYSVCGLCLTEVELDVL 1122
            |:..:....:|::.|.||:.:.|:|.|:...:  |.|||         ||.|.|...:|||:|.|
  Rat  1107 PIISQNPNGDWEEWINEAFIQSISLSATGYFRGYQADMDWEKGEGDIYPYFVFGAACSEVEIDCL 1171

  Fly  1123 TGNYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTSEQVIADPKTGECLTNRTWTYKPPG 1187
            ||.:...|.||:.|...|:||.||||||||||:.|||.:|.|::...|: |...|.....||...
  Rat  1172 TGAHKNIRTDIVMDGSFSINPAVDIGQIEGAFVQGLGLYTLEELKYSPE-GVLYTRGPHQYKIAS 1235

  Fly  1188 AKDIPTDLRIELLPKSPNKAGFMRSKATGEPAICLSIAVAFALQQALQSARDDAGVPKSWVTLTA 1252
            ..|||.:..:.||..:.|......||..||..:.|..:|.||:..|:.:||.:.|:|.. :.:.:
  Rat  1236 VSDIPEEFHVSLLTPTQNPKAIYSSKGLGEAGMFLGSSVFFAIAAAVAAARKERGLPLI-LAINS 1299

  Fly  1253 PMTPE 1257
            |.|.|
  Rat  1300 PATAE 1304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	fer2	4..85	CDD:238126	20/77 (26%)
		PLN02906	28..1259	CDD:215491	394/1349 (29%)
		Fer2_2	86..159	CDD:280048	36/72 (50%)
		FAD_binding_4	211..373	CDD:303082	46/195 (24%)
		CO_deh_flav_C	399..502	CDD:281449	32/109 (29%)
		Ald_Xan_dh_C	555..666	CDD:214971	34/110 (31%)
		Ald_Xan_dh_C2	711..1192	CDD:280834	171/513 (33%)
Aox3	NP_001008527.2	mam_aldehyde_ox	9..1333	CDD:132014	399/1370 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820