DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and AOX3

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	NP_001303439.1	Gene:	AOX3 / 41896	FlyBaseID:	FBgn0038349	Length:	1254	Species:	Drosophila melanogaster

Alignment Length:	1278	Identity:	762/1278 - (59%)
Similarity:	961/1278 - (75%)	Gaps:	31/1278 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGRITINGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELR 65
            |..:.:|||..:.|||:.||.||:|||||||:|.||.|||||||||||.|:|.:     ..|: |
  Fly     1 MTTKFSINGLPYAVNLTNLPPDITLNTFIREHAQLTATKFMCQEGGCGACICVV-----RDGK-R 59

  Fly    66 TWAVNSCLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSK 130
            :|||||||||||||..||:.|:|||||:|.||:.||:|||||||||||:||||.|||||||::..
  Fly    60 SWAVNSCLTLLNTCAQLEIVTAEGLGNQRTGYNPIQKRLAKMNGTQCGFCSPGFVMNMYGLMEQN 124

  Fly   131 GGKVTMEEVENSFGGNICRCTGYRPILDAMKSFAVDSNIQVPAECIDIEDLSTKKCPKTGQTCSG 195
            .|||||.||||||||||||||||||||||||||||||||.:||||.|||||..:.||||||.|||
  Fly   125 EGKVTMAEVENSFGGNICRCTGYRPILDAMKSFAVDSNIAIPAECGDIEDLKPRNCPKTGQACSG 189

  Fly   196 SCKKQQPKGSQLYPDGSRWSWPVSLGDLFAALQGAVKEKLPYMLVAGNTAHGVYRRSPDIKAFID 260
            ||.    ..:.:|.||.:|.||.||.:||.||. .||:...:|||||||||||||||.|||.|||
  Fly   190 SCL----PSTLVYEDGVQWHWPKSLSELFDALD-KVKDSEEFMLVAGNTAHGVYRRSTDIKHFID 249

  Fly   261 VSGLAELKGHKLSADNSSLTLGGNLSLSETMELCRQLENTKGFEYLSQVWQHLDWIANVPVRNAG 325
            |.|:.||  |:.|::...|.||.||||::|||:.|......|||||..:|.|:|.||||||||:|
  Fly   250 VQGVEEL--HQHSSEGQQLKLGANLSLTQTMEIIRTTSKQPGFEYLDVLWNHIDLIANVPVRNSG 312

  Fly   326 TLAGNLSIKHAHPEFPSDVFIVLEALDAQVIVQEAVDKQQTVSLASYLGSSMEGKIIRGLVLRAY 390
            |||||:|||..:||||||:||..|||:.:|:..:....::.:|||.|||::.:..:::..||.||
  Fly   313 TLAGNISIKKQNPEFPSDIFISFEALNVKVVALKNAADEKEMSLAEYLGTNDKKLVLKTFVLPAY 377

  Fly   391 PKERFAFDSYKIMPRAQNAHAYVNAAFLVEFTADAKVKSARICFGGIHPEFVHATAIENLIRDKN 455
            ||:::.::||||||||||||||||||||:|..||.||||||||||||.|:|:||:|||.|:..:|
  Fly   378 PKDKYIYESYKIMPRAQNAHAYVNAAFLLELEADNKVKSARICFGGIRPDFIHASAIEKLLVGQN 442

  Fly   456 PFENGLVEKAFGQLSTLLQPDAVLPDASPVYRRKLACGLFYKFLLKIAAQRKQGLGSRFVTGGSL 520
            |:|:.|||:.|.:|..|::||.|||||||.||.|||||||||||||.|...:  :|.:|.:||.:
  Fly   443 PYESSLVEQTFTKLEDLIKPDEVLPDASPAYRSKLACGLFYKFLLKHAPVAE--VGEKFRSGGQI 505

  Fly   521 LKRPVSSGQQSFETFQEHYPVTKATEKHEGLIQCSGEATYSNDLPTQHNQLWAAFVIAKKVGAKV 585
            |:||:|||.|.|:|.:::||||:|.||.||:|||||||||.||:.|..|.|..|||.|.|||:.:
  Fly   506 LQRPLSSGLQVFQTQKKNYPVTQAVEKVEGMIQCSGEATYMNDVLTTSNTLHCAFVGATKVGSTI 570

  Fly   586 TKVDTQPALDLPGVVAYLDAKDIPGPN-YVGPKIRDQFFFPKDEELFATGEIKFYGQPVGIILAN 649
            ..:|...||..|||:|:..||||||.| :..|    .|.| :.||:|.:|.::...||.|:|:|.
  Fly   571 DSIDASEALKQPGVIAFYSAKDIPGTNTFCEP----SFGF-EVEEIFCSGLVRHSEQPAGVIVAL 630

  Fly   650 SNSLANRAAELVKLTYEGGAEE--ILPSLKAVLDKVGSEAGNNKRLEQPIKSTIDVLQLEEPFDV 712
            :...|:|||:||:::|...:.:  :.|||.   |...|...::.|:....|||...::..|..|.
  Fly   631 TADQAHRAAKLVRISYSNPSSDFKLQPSLG---DVFASPTPDSSRIVPASKSTSKKIKFSEQPDK 692

  Fly   713 SSSGQLDMGLQYHYYMEPQTTVVLPFEGGLQVYAATQWMDLTQDTIANVLNLKSNDVQVKTRRIG 777
            ...|...||||||:.|||||||.:|||.||::::||||||.||..||::|.:|:.|||::.||:|
  Fly   693 EVRGIFQMGLQYHFTMEPQTTVAIPFEDGLKIFSATQWMDQTQSVIAHMLQVKAKDVQLQVRRLG 757

  Fly   778 GGYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMTSLGKRWAFHCDYDFFVQKSGKISGIV 842
            ||||.|.||.|..|.||:|.|:|||||:||||||||:|...|||||...||...::.:|||.|:.
  Fly   758 GGYGSKITRGNQVACAASLVAYKLNRPVRFVQSLESMMDCNGKRWACRSDYKCHIKDNGKIVGLT 822

  Fly   843 SRFYEDAGYLANESPI-GHTVLLSKNCYEFS-DNYKLDGYLVCTDSPSNTPCRAPGSVEGIAMME 905
            :.||||||:..||||| ||:...:.|||:.: ||:|.:|..|.||:||:|.||||||||||||:|
  Fly   823 NDFYEDAGWSPNESPIEGHSTFTAVNCYDLNGDNFKNNGNAVLTDAPSSTWCRAPGSVEGIAMIE 887

  Fly   906 NIIEHIAFETGVDPADVRFANLLPAHKMGDMMPRFLESTKYRERKAEAIAHNKENRWHKRGLGLC 970
            |||||:|||...|||:||.||:...:|:.:::|:||||.:|.:||.|..:||.:|||.||||||.
  Fly   888 NIIEHVAFEVQKDPAEVRLANIAAGNKISELLPQFLESREYAQRKKEIESHNAKNRWTKRGLGLA 952

  Fly   971 IMEYQIGYFGQYPATVAIYHSDGTVVVSHGGIEMGQGMNTKISQVAAHTLGIPMEQVRIEASDTI 1035
            :|:|.|.|||||||||||||.||||||:|||||||||||||::||||:||||.:..:::|:||||
  Fly   953 VMDYPIFYFGQYPATVAIYHVDGTVVVTHGGIEMGQGMNTKVAQVAAYTLGIDLSFIKVESSDTI 1017

  Fly  1036 NGANSMVTGGAVGSETLCFAVRKACETLNERLKPVREEVKPENWQDLIQEAYNRKINLIASDQCK 1100
            |||||||||||||||:||:||||||||||.||:||::  |..:|.:.::.||.:.|||||||..|
  Fly  1018 NGANSMVTGGAVGSESLCYAVRKACETLNSRLEPVKK--KDASWIETVEAAYGKSINLIASDHYK 1080

  Fly  1101 QGDMDPYSVCGLCLTEVELDVLTGNYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTSEQ 1165
            :|||..|.:.||.||||||||||||..:.|||||||.||||:|.:|||||||||:|.||||.|||
  Fly  1081 KGDMQNYHIYGLALTEVELDVLTGNSQIKRVDILEDAGESLSPWIDIGQIEGAFVMCLGYWMSEQ 1145

  Fly  1166 VIADPKTGECLTNRTWTYKPPGAKDIPTDLRIELLPK-SPNKAGFMRSKATGEPAICLSIAVAFA 1229
            ::.|.:||..||||||.||||||||||.|.||||:.| :|:.||||||||||||..||:::|.||
  Fly  1146 LVYDRETGRLLTNRTWNYKPPGAKDIPIDFRIELIQKPNPSGAGFMRSKATGEPPCCLAVSVVFA 1210

  Fly  1230 LQQALQSARDDAGVPKSWVTLTAPMTPEHLVLHSGTEPSQFKL 1272
            |:|||.|||.|||:|:.||.|.||.|||.||:::|.|.:.|:|
  Fly  1211 LRQALDSARHDAGLPREWVRLGAPTTPETLVVNAGHEAASFRL 1253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	fer2	4..85	CDD:238126	50/80 (63%)
		PLN02906	28..1259	CDD:215491	742/1236 (60%)
		Fer2_2	86..159	CDD:280048	58/72 (81%)
		FAD_binding_4	211..373	CDD:303082	90/161 (56%)
		CO_deh_flav_C	399..502	CDD:281449	75/102 (74%)
		Ald_Xan_dh_C	555..666	CDD:214971	50/111 (45%)
		Ald_Xan_dh_C2	711..1192	CDD:280834	306/482 (63%)
AOX3	NP_001303439.1	PLN02906	24..1238	CDD:215491	743/1238 (60%)
		Fer2_2	80..153	CDD:280048	58/72 (81%)
		FAD_binding_4	201..360	CDD:303082	90/161 (56%)
		CO_deh_flav_C	386..487	CDD:281449	73/100 (73%)
		Ald_Xan_dh_C	540..646	CDD:214971	50/110 (45%)
		Ald_Xan_dh_C2	688..1172	CDD:280834	307/485 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439670
Domainoid	1	1.000	83	1.000	Domainoid score	I2880
eggNOG	1	0.900	-	-		E1_COG4631
Homologene	1	1.000	-	-		H98597
Inparanoid	1	1.050	1220	1.000	Inparanoid score	I588
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19024at33392
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	1	1.000	-	-		mtm9740
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	1	1.100	-	-	P	PTHR11908
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4296
	12	11.800