DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and AOX2

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	NP_732047.2	Gene:	AOX2 / 41895	FlyBaseID:	FBgn0038348	Length:	1264	Species:	Drosophila melanogaster

Alignment Length:	1288	Identity:	670/1288 - (52%)
Similarity:	900/1288 - (69%)	Gaps:	40/1288 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGRITINGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELR 65
            |:.:..:||..:||..:..|.|.:||||:||:..||.||:||.|||||.|||.:...||.|.|::
  Fly     1 MSIKFNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQ 65

  Fly    66 TWAVNSCLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSK 130
            :.|.||||||||||...|:.|.|||||:..|||.||:|:|:||||||||||||.||||||||:..
  Fly    66 SRAANSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQH 130

  Fly   131 GGKVTMEEVENSFGGNICRCTGYRPILDAMKSFAVDSNIQVPAECIDIEDLSTKKCPKTGQTCSG 195
            .|:|:|.:||::||||:|||||||||||||||||||||::||||.:||||.....||:|||:|.|
  Fly   131 RGQVSMSQVEDAFGGNLCRCTGYRPILDAMKSFAVDSNVEVPAESVDIEDSFELLCPRTGQSCKG 195

  Fly   196 SCKKQQPKGSQLYPDG-SRWSWPVSLGDLFAALQGAVKEKLPYMLVAGNTAHGVYRRSPDIKAFI 259
            ||.:     ..|...| |:|.||.:|.:||.||......:| |||||||||||||||..||:.||
  Fly   196 SCSR-----PPLRDHGDSQWYWPKTLTELFGALSQVANGEL-YMLVAGNTAHGVYRRPRDIRHFI 254

  Fly   260 DVSGLAELKGHKLSADNSSLTLGGNLSLSETMELCRQLENTKGFEYLSQVWQHLDWIANVPVRNA 324
            ||:.:.||:.:.:..|:  |.||||::|::.|::........||||.:|:|||.:.||||||||.
  Fly   255 DVNMVPELRQYSIETDH--LLLGGNVTLTDAMQVFLLAAKRPGFEYCAQLWQHFNLIANVPVRNN 317

  Fly   325 GTLAGNLSIKHAHPEFPSDVFIVLEALDAQVIVQEAVDKQQTVSLASYLGSSMEGKIIRGLVLRA 389
            ||||||::||..|.||||||||..||||..|:|.:....|:.::|.:|||.:....::.|.:|:|
  Fly   318 GTLAGNINIKKQHFEFPSDVFITFEALDVHVLVYDNPSTQRVMNLLTYLGDTTSKLVLGGFILKA 382

  Fly   390 YPKERFAFDSYKIMPRAQNAHAYVNAAFLVEFTADAK---VKSARICFGGIHPEFVHATAIENLI 451
            |||:||.|.||||:|||||.||||||.||:|: .|.:   |.|||||||.|.|:::|...:|.|:
  Fly   383 YPKDRFLFRSYKILPRAQNVHAYVNAGFLIEW-QDIQHRIVHSARICFGNIRPDYIHDDQVEQLL 446

  Fly   452 RDKNPFENGLVEKAFGQLSTLLQPDAVLPDASPVYRRKLACGLFYKFLLKIAAQRKQGLGSRFVT 516
            ..::.::...|.:.|.:|...|||:...|:|||.||:.|||.|.|||||  |...|:.:..||.|
  Fly   447 PGRDLYDPATVAQIFQELPASLQPEERPPEASPEYRQMLACSLLYKFLL--ATAPKERVRERFRT 509

  Fly   517 GGSLLKRPVSSGQQSFETFQEHYPVTKATEKHEGLIQCSGEATYSNDLPTQHNQLWAAFVIAKKV 581
            ||.||:||:|||.|||||.:::||||:..:|.||||||||||||.|||.|..|.:..|||.||:|
  Fly   510 GGLLLERPLSSGSQSFETIKKNYPVTQPVQKLEGLIQCSGEATYMNDLLTTSNAVHCAFVTAKRV 574

  Fly   582 GAKVTKVDTQPALDLPGVVAYLDAKDIPGPNYVGPKIRDQFFF-----PKDEELFATGEIKFYGQ 641
            ||.:.::|...||...||||:..|:||||.|        .|..     |:.:|:|..|.:|::.|
  Fly   575 GATIEQIDPSAALQCKGVVAFYSAEDIPGSN--------NFVLVNQLTPEVDEVFVAGRVKYFDQ 631

  Fly   642 PVGIILANSNSLANRAAELVKLTYEGGAEEILPSLKAVLDKVGSEAGNNKRLEQPIKSTIDVLQL 706
            |:|:|.|.::..|..||.||.:||.....:|..::..||.:..::     |:....|.|::.|:|
  Fly   632 PLGVIAALTHDAAVYAATLVVVTYARDQRKIFTTMNQVLAEKQTD-----RIVSTKKDTVEPLKL 691

  Fly   707 E--EPFDVSSSGQLDMGLQYHYYMEPQTTVVLPFEGGLQVYAATQWMDLTQDTIANVLNLKSNDV 769
            .  .|.||...|.|::..|||:.||||||:|:|.:..||||.||||||.||..||::|.:..|.:
  Fly   692 PPLAPGDVLGRGILELASQYHFTMEPQTTIVVPLDNILQVYCATQWMDATQGAIAHMLKVSVNSI 756

  Fly   770 QVKTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMTSLGKRWAFHCDYDFFVQK 834
            |::.||:||.||.|.||.|:.|.|.||.|.||.||.||||::||:|.::|||||...||:|..:.
  Fly   757 QLQVRRVGGAYGAKVTRGNIVACATALVASKLRRPARFVQTIESMMETIGKRWACRSDYEFRARA 821

  Fly   835 SGKISGIVSRFYEDAGYLANESPIGH-TVLLSKNCYEFSD-NYKLDGYLVCTDSPSNTPCRAPGS 897
            :|.|..:.:.:|||:|...||:.:.. |:.:.:|.|..:| ||:..|..:.||:||:|.||||||
  Fly   822 NGSIIMLSNNYYEDSGCNLNENVVDFLTLPILRNVYNLTDANYRTQGSAIRTDAPSSTWCRAPGS 886

  Fly   898 VEGIAMMENIIEHIAFETGVDPADVRFANLLPAHKMGDMMPRFLESTKYRERKAEAIAHNKENRW 962
            .|||||.|..:|||||...:||||||..||.|.:||..::|:||.||:|.:|:.:....|.:|||
  Fly   887 AEGIAMTETALEHIAFTCQLDPADVRLVNLQPGNKMVQLLPKFLASTEYHKRRDQINLFNSQNRW 951

  Fly   963 HKRGLGLCIMEYQIG--YFGQYPATVAIYHSDGTVVVSHGGIEMGQGMNTKISQVAAHTLGIPME 1025
            .||||||.:|.:.:.  ....||.||||||.||:||:||||||:|||:|||.:||||..||:|::
  Fly   952 RKRGLGLALMSFPLNTTVAFNYPVTVAIYHEDGSVVISHGGIEIGQGVNTKAAQVAAFVLGVPLD 1016

  Fly  1026 QVRIEASDTINGANSMVTGGAVGSETLCFAVRKACETLNERLKPVREEVKPE-NWQDLIQEAYNR 1089
            |||:|||:|:||||||:|..::.||.:..||||||:|||:||.||:|.:.|. :|..::|.|:.:
  Fly  1017 QVRVEASNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKRLAPVKERLGPRASWVQVLQAAFLQ 1081

  Fly  1090 KINLIASDQCKQGDMDPYSVCGLCLTEVELDVLTGNYIVGRVDILEDTGESLNPNVDIGQIEGAF 1154
            .:.|||::..:.||:..|::.||.|||:|||:||||:::.|||||||.||||:|::|:||:||||
  Fly  1082 SVFLIATESYRLGDIPNYNIFGLSLTELELDILTGNHLIRRVDILEDAGESLSPHIDVGQVEGAF 1146

  Fly  1155 MMGLGYWTSEQVIADPKTGECLTNRTWTYKPPGAKDIPTDLRIELLPKSPNKAGFMRSKATGEPA 1219
            :|||||:.:||::.|.:||:.||||||.|.||||||||.|.|||||.||||..||||||||||||
  Fly  1147 VMGLGYYLTEQLVYDRQTGQILTNRTWNYHPPGAKDIPIDFRIELLQKSPNPVGFMRSKATGEPA 1211

  Fly  1220 ICLSIAVAFALQQALQSARDDAGVPKSWVTLTAPMTPEHLVLHSGTEPSQFKL 1272
            :||::...||:|.|:||||:|||:|:.||.|.||.|||.:||:||::...|.|
  Fly  1212 LCLAVGALFAMQHAIQSARNDAGLPREWVRLGAPTTPETVVLNSGSQVEAFAL 1264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	fer2	4..85	CDD:238126	42/80 (53%)
		PLN02906	28..1259	CDD:215491	654/1246 (52%)
		Fer2_2	86..159	CDD:280048	52/72 (72%)
		FAD_binding_4	211..373	CDD:303082	83/162 (51%)
		CO_deh_flav_C	399..502	CDD:281449	53/105 (50%)
		Ald_Xan_dh_C	555..666	CDD:214971	49/115 (43%)
		Ald_Xan_dh_C2	711..1192	CDD:280834	257/485 (53%)
AOX2	NP_732047.2	fer2	3..84	CDD:238126	41/80 (51%)
		PLN02906	24..1251	CDD:215491	657/1250 (53%)
		Fer2_2	86..159	CDD:280048	52/72 (72%)
		FAD_binding_4	206..366	CDD:303082	83/162 (51%)
		CO_deh_flav_C	391..497	CDD:281449	53/108 (49%)
		Ald_Xan_dh_C	548..655	CDD:214971	48/114 (42%)
		Ald_Xan_dh_C2	702..1184	CDD:280834	255/481 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439671
Domainoid	1	1.000	83	1.000	Domainoid score	I2880
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H98597
Inparanoid	1	1.050	1220	1.000	Inparanoid score	I588
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19024at33392
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	1	1.000	-	-		mtm9740
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	1	1.100	-	-	P	PTHR11908
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4296
	11	10.900