back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and Aox4

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	NP_001008523.2	Gene:	Aox4 / 316424	RGDID:	1311975	Length:	1333	Species:	Rattus norvegicus

Alignment Length:	1374	Identity:	402/1374 - (29%)
Similarity:	664/1374 - (48%)	Gaps:	205/1374 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 INGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWAVNS 71
            :|| ...:..:.:| :::|..::|:...|||||:.|..||||.|...::..:||:.::..:...:
  Rat    12 VNG-KKVIEKNPVP-EMNLLFYVRKVLHLTGTKYSCGGGGCGACTVMISRYNPESKKIYHYPATA 74

  Fly    72 CLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGKVTM 136
            ||..:.:..|..|||.||:|:.:...|.:|:||||.:|||||:||||:||::|.||::. .:.|.
  Rat    75 CLVPVCSLHGAAVTTVEGVGSIKRRIHPVQERLAKCHGTQCGFCSPGMVMSIYTLLRNH-PEPTP 138

  Fly   137 EEVENSFGGNICRCTGYRPILDAMKSFAVDSNI-QVPAECIDIEDLSTKKCPKTGQTCSGSCKKQ 200
            :::..:.|||:|||||||||:::.|:|:.:|:: |:..        |.|.|....:.||.|.|::
  Rat   139 DQITEALGGNLCRCTGYRPIVESGKTFSPESSVCQMKG--------SGKCCMDLDEGCSESTKER 195

  Fly   201 --------------QPKGSQLYP-----------------DGSR--WSWPVSLGDLFAALQGAVK 232
                          .|....::|                 .|.|  |..||:|.||.     .:|
  Rat   196 MCTKLYNEDEFQPLDPSQEPIFPPELIRMAEDPHKRRLTFQGERTIWIMPVTLNDLL-----ELK 255

  Fly   233 EKLPYM-LVAGNTAHGVYRRSPDIK-------AFIDVSGLAELKGHKLSADNSSLTLGGNLSLSE 289
            ...|.. ||.||||.|     |.:|       .||...||.||  :.:...||.:|:|...||::
  Rat   256 ASYPEAPLVMGNTAVG-----PGMKFNNEFHPVFISPLGLPEL--NLVDTANSGVTIGARHSLAQ 313

  Fly   290 TMELCRQL------ENTKGFEYLSQVWQHLDWIANVPVRNAGTLAGNLSIKHAHPEFPSDVFIVL 348
            ..::...|      |.||..:.|   .:||..:|...:||..||.|::.   :.|:| ||:..:|
  Rat   314 MKDILHSLTLEQPKEKTKTHQAL---LKHLRTLAGPQIRNMATLGGHVV---SRPDF-SDLNPIL 371

  Fly   349 EALDAQVIV-------------------QEAVDKQQTVSLASYLGSSMEGKIIRGLVLRAYPKER 394
            .|.:|.:.|                   .||..|.:.|:|:.::..|.:.:.:.||
  Rat   372 AAGNATINVISKEGQRQIPLNGPFLERLPEASLKPEEVALSVFIPYSGQWQYVSGL--------- 427

  Fly   395 FAFDSYKIMPRAQNAHAYVNAAFLVEFTADAK-VKSARICFGGIHPEFVHAT-AIENLIRDKNPF 457
                  ::..|.:||.|.|||...|||..... :|..::.||.:.|..|.|: ..:.||  ...:
  Rat   428 ------RLAQRQENAFAIVNAGMSVEFEEGTNTIKDLQMLFGSVAPTVVSASQTCKQLI--GRQW 484

  Fly   458 ENGLVEKAFGQLSTLLQPDAVLPDAS---PVYRRKLACGLFYKFLLKIA-------AQRKQGLGS 512
            ::.::..|   ...:|:...:.|||.   ..|||.|...|.:||.||:.       .|:...:..
  Rat   485 DDQMLSDA---CQLVLEEIRIPPDAEGGMVEYRRTLIISLLFKFYLKVRRWLSEMDPQKFPDIPE 546

  Fly   513 RFVTGGSLLKRPVSSGQQSFETFQ----EHYPVTKATEKHEGLIQCSGEATYSNDLPTQHNQLWA 573
            :||:....|......|.|.|:...    |..||........|:...:|||.:.:|:|..:.:|..
  Rat   547 KFVSALDDLPIETPQGIQMFQCVDPNQPEQDPVGHPIMHQSGIKHATGEAKFVDDMPRINQELCL 611

  Fly   574 AFVIAKKVGAKVTKVDTQPALDLPGVVAYLDAKDIPGPNYVGPKIRDQFFFPKDEELFATGEIKF 638
            ..|.:.:..||:|.:|...||..||||..:.|:|:||.|....:|           .:|..|:..
  Rat   612 TVVTSTRAHAKITSIDVSEALAYPGVVDVITAEDVPGDNNHSGEI-----------FYAQNEVIC 665

  Fly   639 YGQPVGIILANSNSLANRAAELVKLTYEGGAEEILPSLKAVLDKV--GSEAGNNKRLEQPIKSTI 701
            .||.:..:.|::...|..||:.||:||    ::|.|::..:...:  .|...:.|::||   ..:
  Rat   666 VGQIICTVAADTYIHAKEAAKRVKITY----DDIEPAIITIEQALEHNSFLSSEKKIEQ---GNV 723

  Fly   702 DVLQLEEPFDVSSSGQLDMGLQYHYYMEPQTTVVLP--FEGGLQVYAATQWMDLTQDTIANVLNL 764
            |  ...:..|....|::.:..|.|:|||.||.:.:|  .:..:.::..||:....|:.::..|.:
  Rat   724 D--YAFKHVDHIIEGEIHVEGQEHFYMETQTILAIPQTEDKEMVLHVGTQFPTHVQEYVSAALKV 786

  Fly   765 KSNDVQVKTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPIRFV--QSLESIMTS-----LGKRW 822
            ..|.:..:.:|.||.:|||.|:..|..|..|:||||..|||||:  :|.:.::|:     |||
  Rat   787 PRNRIACQMKRTGGAFGGKVTKPALLGAVCAVAAHKTGRPIRFILDRSNDMLITAGRHPLLGK-- 849

  Fly   823 AFHCDYDFFVQKSGKISGIVSRFYEDAGYLANESP--IGHTVLLSKNCYEFSDNYKLDGYLVCTD 885
                 |......:|||......:|.:.|...:||.  |...||.|:|.|.. .|::..|....|:
  Rat   850 -----YKIGFMNNGKIKAADVEYYTNGGCTPDESEMVIEFIVLKSENAYHI-PNFRCRGRACKTN 908

  Fly   886 SPSNTPCRAPGSVEGIAMMENIIEHIAFETGVDPADVRFANLL-----PAHK-------MGDMMP 938
            .||||..|..|..:...::|..|..:|.:..:.|.::|..|:.     .|:|       :.....
  Rat   909 LPSNTAFRGFGFPQATVVVEAYIAAVASKCNLLPEEIREINMYKQISKTAYKQTFNPEPLRRCWK 973

  Fly   939 RFLESTKYRERKAEAIAHNKENRWHKRGLGLCIMEYQI----GYFGQYPATVAIYHSDGTVVVSH 999
            ..|:.:.:..||..|...||.|.|.|:||.:..|::.:    .::.|..|.|.|: .||:|:::|
  Rat   974 ECLQKSSFFARKQAAEEFNKNNYWKKKGLAVVPMKFSVAVPMAFYNQAAALVHIF-LDGSVLLTH 1037

  Fly  1000 GGIEMGQGMNTKISQVAAHTLGIPMEQVRIEASDTINGANSMVTGGAVGSETLCFAVRKACETLN 1064
            ||.|:|||::||:.|||:..|.||...|.:..:.|:...|::.|.|::|::....||:.||:||.
  Rat  1038 GGCELGQGLHTKMIQVASRELNIPKSYVHLVETSTVTVPNAVFTAGSMGADINGKAVQNACQTLL 1102

  Fly  1065 ERLKPVREEVKPENWQDLIQEAYNRKINLIASDQCK-----------QGDMDPYSVCGLCLTEVE 1118
            :||:|:.::.....|::.:::|:...|:|.|:...|           :||..||.|.|...:|||
  Rat  1103 DRLQPIIKKNPKGKWEEWVKKAFEESISLSATGYFKGYQTNMDWEKEEGDPYPYYVYGAACSEVE 1167

  Fly  1119 LDVLTGNYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTSEQVIADPKTGECLTNRTWTY 1183
            :|.|||.:.:.|.||..|...|:||.:||||:||||:.|:|::|.|::...|| |...:.....|
  Rat  1168 VDCLTGAHKLLRTDIFMDAAFSINPALDIGQVEGAFIQGMGFYTIEELKYSPK-GVLYSRGPDDY 1231

  Fly  1184 KPPGAKDIPTDLRIELLPKSPNKAGFMRSKATGEPAICLSIAVAFALQQALQSARDDAGVPKSWV 1248
            |.|...:||.:..:.:: :|.|......||..||..:.|..:|.||:..|:.:||.:.|:...:
  Rat  1232 KIPTVTEIPEEFYVTMV-RSRNPIAIYSSKGLGEAGMFLGSSVLFAIYDAVTTARKERGLSDIF- 1294

  Fly  1249 TLTAPMTPE 1257
            .|.:|.|||
  Rat  1295 PLNSPATPE 1303

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.