Protein Alignment AOX1 and Aox2

DIOPT Version :10

• Sequence 1: NP_650475.1
• Gene: AOX1 / 41894
• FlyBaseID: FBgn0267408
• Length: 1273
• Species: Drosophila melanogaster
• Sequence 2: XP_063123260.1
• Gene: Aox2 / 316421
• RGDID: 1359668
• Length: 1351
• Species: Rattus norvegicus
• Alignment Length: 1391
• Identity: 405/1391 - (29%)
• Similarity: 655/1391 - (47%)
• Gaps: 224/1391 - (16%)

  Fly     7 INGTSHEVNLSALPADISLNTFIRE--YAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWAV 69
            :||  .:|....:..:::|..|:|:  ...|||||:.|..|.||.|...::...|...:.|.::|
  Rat    15 VNG--KKVTEKNVDPEVTLLAFLRKNWTLCLTGTKYACGTGSCGACTVMVSQHDPVCKKTRHFSV 77

  Fly    70 NSCLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGKV 134
            .:||..|.:..|..|||.||:|:.:...|.:|:||||.:|||||:||||:||:||.||::. .:.
  Rat    78 MACLVPLCSLHGAAVTTVEGVGSIKTRLHPVQERLAKSHGTQCGFCSPGMVMSMYALLRNH-PQP 141

  Fly   135 TMEEVENSFGGNICRCTGYRPILDAMKSFAVDSNIQVPAECIDIEDLSTKKCPKTGQTC------ 193
            :.|::..:.|||:||||||||||::.::|.::|:     .|:.         ..|||.|
  Rat   142 SEEQLLEALGGNLCRCTGYRPILESGRTFCMESD-----GCLQ---------KGTGQCCLDQKEG 192

  Fly   194 --SGS----CKK--------------------------QQPKGSQLYPDGSRWSW--PVSLGDLF 224
              |||    |.:                          :.|:...|...|.|.:|  |.:|.:|.
  Rat   193 DSSGSKSDICTELFVKDEFQPLDPTQELIFPPELLRMAENPEKQTLTFYGERITWIAPGTLQELL 257

  Fly   225 AALQGAVKEKLPYM-LVAGNTAHGVYRRS--------------PDIKAFIDVSGLAELKGHKLSA 274
                 .:|.|.|.. |::||||.|...:|              ||::.....||
  Rat   258 -----VLKAKYPEAPLISGNTALGPAMKSQGHFYPVLLSPARIPDLRMVTKTSG----------- 306

  Fly   275 DNSSLTLGGNLSLSETMELCRQL------ENTKGFEYLSQVWQHLDWIANVPVRNAGTLAGNLSI 333
               .||:|...||::..::..:.      |.|:.:..|   .:||..:|...:||..:|.|::..
  Rat   307 ---GLTIGACCSLAQVKDVLAESISELPEEKTQTYRAL---LKHLRSLAGQQIRNMASLGGHVIS 365

  Fly   334 KHAHPEFPSDVFIVLEALDAQV-IVQEAVDKQQTVS---LASYLGSSMEGKIIRGLVLRAYPKER 394
            :|    :.||:..:|...:|.: ::.|...:|..::   ||......::.:.|.|.|...:.::|
  Rat   366 RH----YYSDLNPILSVGNATLNLLSEEGLRQIPLNGHFLAGLANEDLKPEEILGSVYIPHSQKR 426

  Fly   395 FAFDSYKIMPRAQNAHAYVNAAFLVEFTADAK-VKSARICFGGIHPEFV--HATAIENLIRDKNP 456
            ....:::.....|||...|||...|.|..... ::...|.:||:.|..|  |.:..:.|.|..|.
  Rat   427 EFVSAFRQAQCHQNALPDVNAGMRVLFKEGTDIIEELSIAYGGVGPTTVSAHRSCQQLLGRRWNA 491

  Fly   457 FENGLVEKAFGQLSTLLQPDAVLPDAS----PVYRRKLACGLFYKFLLKIAAQRKQGL------- 510
            .   |:::|    ..||..:..||.::    ..:||.|....|:||.|::..:.|...
  Rat   492 L---LLDEA----CRLLLDEVSLPGSAVGGKVEFRRTLIVSFFFKFYLEVLQELKADKRLLPEST 549

  Fly   511 ----------GSRFVTGGSLLKRPVSSGQQSFETFQEHYPVTKATEK---H-EGLIQCSGEATYS 561
                      |||...|...:..|  .|.|:::....|.|:.....:   | .||...:|||.:.
  Rat   550 DSQRYPEIADGSRSSLGDFQVTLP--QGVQTYQRVNSHQPLQDPVGRPIMHLSGLKHATGEAVFC 612

  Fly   562 NDLPTQHNQLWAAFVIAKKVGAKVTKVDTQPALDLPGVVAYLDAKDIPGPNYVGPKIRDQFFFPK 626
            :|:|....:|:.|.|.:.:..|::..:|:...|||||||..:.|:||||.|           ..:
  Rat   613 DDIPRVDKELFMALVTSTRAHARIISIDSSEVLDLPGVVDVITAEDIPGNN-----------GEE 666

  Fly   627 DEELFATGEIKFYGQPVGIILANSNSLANRAAELVKLTYEGGAEEILPSLKAVLDKVGSEAGNN- 690
            |::|.|..::...||.|..::|.::..|.||.:.:|:|||        .||.||..:.....:|
  Rat   667 DDKLLAVDKVLCVGQVVCAVVAETDVQAKRATKKIKITYE--------DLKPVLFTIEDAIQHNS 723

  Fly   691 -----KRLEQPIKSTIDVLQLEEPF---DVSSSGQLDMGLQYHYYMEPQTTVVLP--FEGGLQVY 745
                 |:|||.        .:||.|   |....|::.:|.|.|:|||.|..:|:|  .:..|.:|
  Rat   724 FLCPEKKLEQG--------NMEEAFENVDQIVEGKVHVGGQEHFYMETQRVLVIPKTEDKELDMY 780

  Fly   746 AATQWMDLTQDTIANVLNLKSNDVQVKTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPIRFVQS 810
            .:||.....|.|:::.||:..:.:....:|:|||:|||..|..:..|.||:.|.|..||||.|..
  Rat   781 VSTQDPAHVQKTVSSALNIPLSRITCHVKRVGGGFGGKVGRPAVFGAIAAVGAVKTGRPIRLVLD 845

  Fly   811 LESIMTSLGKRWAFHCDYDFFVQKSGKISGIVSRFYEDAGYLANESPI--GHTVLLSKNCYEFSD 873
            .|..|...|.|......|......||:|..:....|.:.|...::|.:  ...||..:|.|:..
  Rat   846 REDDMLITGGRHPLFAKYKVGFMNSGRIKALDIECYINGGCTLDDSELVTEFLVLKLENAYKIR- 909

  Fly   874 NYKLDGYLVCTDSPSNTPCRAPGSVEGIAMMENIIEHIAFETGVDPADVRFANLLPAHKMGD--- 935
            |.:|.|....|:.||||..|..|..:|..:.|:.|..:|.:.|:.|..:|..|:   :|..|
  Rat   910 NLRLRGRACMTNLPSNTAFRGFGFPQGALVTESCITAVAAKCGLPPEKIREKNM---YKTVDKTI 971

  Fly   936 ------------MMPRFLESTKYRERKAEAIAHNKENRWHKRGLGLCIMEYQIGY----FGQYPA 984
                        .....|:.:.:..|:......||::.|.|||:.:..|::.:|:    :.|..|
  Rat   972 YKQAFNPEPLIRCWNECLDKSSFAIRRTRVDEFNKKSYWRKRGIAVVPMKFSVGFAATSYHQAAA 1036

  Fly   985 TVAIYHSDGTVVVSHGGIEMGQGMNTKISQVAAHTLGIPMEQVRIEASDTINGANSMVTGGAVGS 1049
            .|.|| :||:|:|:|||.|:|||::||:.|||:..|.|||..:....:.|....|::.|..:||:
  Rat  1037 LVHIY-TDGSVLVAHGGNELGQGIHTKMLQVASRELKIPMSYLHTSETCTAAVPNTIATAASVGA 1100

  Fly  1050 ETLCFAVRKACETLNERLKPVREEVKPENWQDLIQEAYNRKINLIASDQCK-----------QGD 1103
            :....||:.||:.|.:||:||.::.....|:|.|:.|:.::|:|.|:...:           :||
  Rat  1101 DVNGRAVQNACQILLKRLEPVIKKNPEGTWRDWIEAAFEQRISLSATGYFRGYKAFMDWEKGEGD 1165

  Fly  1104 MDPYSVCGLCLTEVELDVLTGNYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTSEQVIA 1168
            ..||.|.|...:|||:|.|||.:...|.||:.|...||||.:|:|||||||:.|:|.:|:|::..
  Rat  1166 PFPYYVYGAACSEVEIDCLTGAHKKMRTDIVMDACCSLNPAIDVGQIEGAFIQGMGLYTTEELHY 1230

  Fly  1169 DPKTGECLTNRTWTYKPPGAKDIPTDLRIELLPKSPNKAGFMRSKATGEPAICLSIAVAFALQQA 1233
            .|: |...:.....||.|...|:|....:.|||.|........||..||..:.|..:|.||:..|
  Rat  1231 SPE-GVLYSRSPDKYKIPTVTDVPEQFNVSLLPSSQTPLTIYSSKGLGESGMFLGSSVFFAIADA 1294

  Fly  1234 LQSARDDAGVPKSWVTLTAPMTPEHL 1259
            :.:||....:.:.: |:.:|.|||.:
  Rat  1295 VAAARRQRDIAEDF-TVKSPATPERV 1319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	PLN02906	28..1259	CDD:215491	401/1368 (29%)
Aox2	XP_063123260.1	None