DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and AOX1

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	XP_011509364.1	Gene:	AOX1 / 316	HGNCID:	553	Length:	1350	Species:	Homo sapiens

Alignment Length:	1398	Identity:	412/1398 - (29%)
Similarity:	650/1398 - (46%)	Gaps:	242/1398 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 INGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWAVNS 71
            :||  .:|....:..:..|..::|:...|||||:.|..||||.|...::..:|.|..:|....|:
Human    11 VNG--RKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPITKRIRHHPANA 73

  Fly    72 CLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGKVTM 136
            ||..:.:..|..|||.||:|:.....|.:|:|:||.:|||||:|:||:||::|.||::. .:.|:
Human    74 CLIPICSLYGAAVTTVEGIGSTHTRIHPVQERIAKCHGTQCGFCTPGMVMSIYTLLRNH-PEPTL 137

  Fly   137 EEVENSFGGNICRCTGYRPILDAMKSFAVDSNIQVPAE----CID--IEDL-----STKKCPKTG 190
            :::.::.|||:|||||||||:||.|:|...|......|    |:|  |..|     .:|..||.
Human   138 DQLTDALGGNLCRCTGYRPIIDACKTFCKTSGCCQSKENGVCCLDQGINGLPEFEEGSKTSPKL- 201

  Fly   191 QTCSGSCKKQQPKGSQLYPD----------------GSR---WSWPVSLGDLFAALQGAVKEKLP 236
             ..........|....::|.                ||.   |..||:|.:|.     ..|.|.|
Human   202 -FAEEEFLPLDPTQELIFPPELMIMAEKQSQRTRVFGSERMMWFSPVTLKELL-----EFKFKYP 260

  Fly   237 YM-LVAGNTAHGVYRRSPDIKAFIDVSGLAELKG------------HKLSADN---SSLTLGGNL 285
            .. ::.|||:.|     |::|          .||            .:||..|   :.||||..|
Human   261 QAPVIMGNTSVG-----PEVK----------FKGVFHPVIISPDRIEELSVVNHAYNGLTLGAGL 310

  Fly   286 SLSETMELCRQL------ENTKGFEYLSQVWQHLDWIANVPVRNAGTLAGNLSIKHAHPEFPSDV 344
            ||::..::...:      |.|:.:..|   .:||..:|...:||..:|.|::..:  ||:  ||:
Human   311 SLAQVKDILADVVQKLPEEKTQMYHAL---LKHLGTLAGSQIRNMASLGGHIISR--HPD--SDL 368

  Fly   345 FIVLEALDAQVIVQEAVDKQQTVSLASYL----GSSMEGKIIRGLVLRAYPKERFAFDSYKIMPR 405
            ..:|...:..:.:.....|:|......:|    .:.::.:.|...|...|.::.....:::...|
Human   369 NPILAVGNCTLNLLSKEGKRQIPLNEQFLSKCPNADLKPQEILVSVNIPYSRKWEFVSAFRQAQR 433

  Fly   406 AQNAHAYVNAAFLVEF-TADAKVKSARICFGGIHPEFVHA-TAIENLI-RDKNPFENGLVEKAFG 467
            .:||.|.||:...|.| ..|..::...|.:||:.|..:.| .:.:.|| |..|       |:...
Human   434 QENALAIVNSGMRVFFGEGDGIIRELCISYGGVGPATICAKNSCQKLIGRHWN-------EQMLD 491

  Fly   468 QLSTLLQPDAVLPDASP----VYRRKLACGLFYKFLLKIAAQRKQGLGSRFVTGGSLLKR--PVS 526
            ....|:..:..|..::|    .::|.|.....:||.|:::               .:||:  ||
Human   492 IACRLILNEVSLLGSAPGGKVEFKRTLIISFLFKFYLEVS---------------QILKKMDPV- 540

  Fly   527 SGQQSFETFQEHYPVTKATEKHEGLIQ-------CS----------------------------- 555
                       |||  ...:|:|..::       ||
Human   541 -----------HYP--SLADKYESALEDLHSKHHCSTLKYQNIGPKQHPEDPIGHPIMHLSGVKH 592

  Fly   556 --GEATYSNDLPTQHNQLWAAFVIAKKVGAKVTKVDTQPALDLPGVVAYLDAKDIPGPNYVGPKI 618
              |||.|.:|:|....:|:..||.:.:..||:..:|...||.:||||..:.|:.:...|
Human   593 ATGEAIYCDDMPLVDQELFLTFVTSSRAHAKIVSIDLSEALSMPGVVDIMTAEHLSDVN------ 651

  Fly   619 RDQF-FFPKDEELFATGEIKFYGQPVGIILANSNSLANRAAELVKLTYEGGAEEILPSLKAVLDK 682
              .| ||.:.|:..||.::...||.|..:||:|...|.|||:.||:.|    :::.|.:..:.:.
Human   652 --SFCFFTEAEKFLATDKVFCVGQLVCAVLADSEVQAKRAAKRVKIVY----QDLEPLILTIEES 710

  Fly   683 V--GSEAGNNKRLEQPIKSTIDVLQLEEPFDVSS---SGQLDMGLQYHYYMEPQTTVVLP--FEG 740
            :  .|.....::||..        .::|.|.|..   .|::.||.|.|:|||.|:.:|:|  .:.
Human   711 IQHNSSFKPERKLEYG--------NVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQ 767

  Fly   741 GLQVYAATQWMDLTQDTIANVLNLKSNDVQVKTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPI 805
            .:.||.:||:....||.:|:.|.|.:|.|....||:||.:|||..:..:.||..|.||:|..|.:
Human   768 EMDVYVSTQFPKYIQDIVASTLKLPANKVMCHVRRVGGAFGGKVLKTGIIAAVTAFAANKHGRAV 832

  Fly   806 RFVQSLESIMTSLGKRWAFHCDYDFFVQKSGKISGIVSRFYEDAGYLANES--PIGHTVLLSKNC 868
            |.|......|...|.|..:...|.......|:|..:....|.:||...:||  .|...:|...|.
Human   833 RCVLERGEDMLITGGRHPYLGKYKAGFMNDGRILALDMEHYSNAGASLDESLFVIEMGLLKMDNA 897

  Fly   869 YEFSDNYKLDGYLVCTDSPSNTPCRAPGSVEGIAMMENIIEHIAFETGVDPADVRFANLLPAHKM 933
            |:| .|.:..|:...|:.||||..|..|..:...:.|:.|..:|.:.|:.|..||..|:   :|.
Human   898 YKF-PNLRCRGWACRTNLPSNTAFRGFGFPQAALITESCITEVAAKCGLSPEKVRIINM---YKE 958

  Fly   934 GDMMP---------------RFLESTKYRERKAEAIAHNKENRWHKRGLGLCIMEYQIGY----F 979
            .|..|               ..:..:.|..||......|.||.|.|:||.:..:::.:|.    .
Human   959 IDQTPYKQEINAKNLIQCWRECMAMSSYSLRKVAVEKFNAENYWKKKGLAMVPLKFPVGLGSRAA 1023

  Fly   980 GQYPATVAIYHSDGTVVVSHGGIEMGQGMNTKISQVAAHTLGIPMEQVRIEASDTINGANSMVTG 1044
            ||..|.|.|| .||:|:|:|||||||||::||:.||.:..|.:||..|.:..:.|....|:.::|
Human  1024 GQAAALVHIY-LDGSVLVTHGGIEMGQGVHTKMIQVVSRELRMPMSNVHLRGTSTETVPNANISG 1087

  Fly  1045 GAVGSETLCFAVRKACETLNERLKPVREEVKPENWQDLIQEAYNRKINLIA--------SD-QCK 1100
            |:|.::....||:.||:||.:||:|:..:.....|:|..|.|::..|||.|        || ..:
Human  1088 GSVVADLNGLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAFDESINLSAVGYFRGYESDMNWE 1152

  Fly  1101 QGDMDP--YSVCGLCLTEVELDVLTGNYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTS 1163
            :|:..|  |.|.|...:|||:|.|||::...|.||:.|.|.|:||.:|||||||||:.|:|.:|.
Human  1153 KGEGQPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAIDIGQIEGAFIQGMGLYTI 1217

  Fly  1164 EQVIADPKTGECLTNRTWTYKPPGAKDIPTDLRIELLPKSPNKAGFMRSKATGEPAICLSIAVAF 1228
            |::...|: |...|.....||.|...|:||:|.|.|||.|.|......||..||..:.|..:|.|
Human  1218 EELNYSPQ-GILHTRGPDQYKIPAICDMPTELHIALLPPSQNSNTLYSSKGLGESGVFLGCSVFF 1281

  Fly  1229 ALQQALQSARDDAGV--PKSWVTLTAPMTPEHL 1259
            |:..|:.:||.:.|:  |   :||.:|:|||.:
Human  1282 AIHDAVSAARQERGLHGP---LTLNSPLTPEKI 1311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	fer2	4..85	CDD:238126	23/77 (30%)
		PLN02906	28..1259	CDD:215491	408/1375 (30%)
		Fer2_2	86..159	CDD:280048	35/72 (49%)
		FAD_binding_4	211..373	CDD:303082	45/186 (24%)
		CO_deh_flav_C	399..502	CDD:281449	27/109 (25%)
		Ald_Xan_dh_C	555..666	CDD:214971	39/142 (27%)
		Ald_Xan_dh_C2	711..1192	CDD:280834	177/517 (34%)
AOX1	XP_011509364.1	mam_aldehyde_ox	5..1328	CDD:132014	412/1398 (29%)
		Fer2_2	88..161	CDD:280048	36/72 (50%)
		FAD_binding_5	239..419	CDD:279309	45/205 (22%)
		CO_deh_flav_C	426..530	CDD:281449	22/111 (20%)
		Ald_Xan_dh_C	594..701	CDD:214971	31/109 (28%)
		Ald_Xan_dh_C2	720..1245	CDD:280834	196/558 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720