DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and xdh-1

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	NP_502747.1	Gene:	xdh-1 / 178381	WormBaseID:	WBGene00010083	Length:	1358	Species:	Caenorhabditis elegans

Alignment Length:	1400	Identity:	434/1400 - (31%)
Similarity:	670/1400 - (47%)	Gaps:	221/1400 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 INGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWAVNS 71
            :||  ..|....:...::|.|::|:...|||||..|.|||||.|...::  |.|.||::.::.||
Worm    20 VNG--KRVEEKDVDPKMTLATYLRDKLKLTGTKIGCNEGGCGACTIMIS--HIENGEIKHFSANS 80

  Fly    72 CLTLLNTCLGLEVTTSEGLGN-KRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGKVT 135
            ||..:....|..|||.||:|: .:...|.:|:||||.:|:|||:|:||.||.||.||::.... |
Worm    81 CLMPVCGVFGKAVTTVEGIGSVAKNRLHPVQERLAKAHGSQCGFCTPGFVMAMYALLRNNPNP-T 144

  Fly   136 MEEVENSFGGNICRCTGYRPILDAMKSFAVDSN--IQVPAE--CIDIEDLSTKKCPKTGQT-CSG 195
            :.::.....||:||||||||||:|..|||||.:  ::|..|  |...|:     |.|..:| |.|
Worm   145 ISDINLGLQGNLCRCTGYRPILEAFYSFAVDESGTLKVTEENGCGMGEN-----CCKVKKTACGG 204

  Fly   196 S-----------------------CKKQQPKGSQLYP-----------------DGSRWSWPVSL 220
            |                       ||...|....::|                 ..::|..|||.
Worm   205 SDETTPGYTGGERKRKIQLSDMSDCKPYDPTQELIFPPELKLHGYESMSFAYDHHHTKWYQPVSY 269

  Fly   221 GDLFAALQGAVKEKLPY-MLVAGNTAHGVYRRSPDIK-AFIDVSGLAELKG----HKLSADNSSL 279
            .||.     ::|.:||: .|::||:...:     ::| .|||:..:...:.    |:...:|..:
Worm   270 DDLL-----SLKRELPHARLISGNSELAI-----ELKFRFIDLPAVINPRQVKVLHEKHLENDGV 324

  Fly   280 TLGGNLSLSE----TMELCRQL--ENTKGFEYLSQVWQHLDWIANVPVRNAGTLAGNLSIKHAHP 338
            .:|..:||::    :::|.:.|  |.|   ..|..|.:.|.|.|.:.|||..::|||::.  |.|
Worm   325 YMGTGMSLTDMDNYSVQLMKDLPREQT---AVLKHVHEMLHWFAGIHVRNVASVAGNIAT--ASP 384

  Fly   339 EFPSDVFIVLEALDAQVIVQEAV--DKQQTVSLASYLGSS----MEGKIIRGLVLRAYPKERFAF 397
              .||:..:..|.:|.|::....  :|:..:....:||..    .:.:||:.:::... :|...|
Worm   385 --ISDLNPIWMASNALVVLDSEARGEKRVHIDEKFFLGYRKTVIQQDEIIKAVIVPLL-EENEHF 446

  Fly   398 DSYKIMPRAQNAHAYVNAAFLVEFTADAK---VKSARICFGGIHPEFVHA-TAIENLIRDKNPFE 458
            .:||...|.::..|.|..||||:.  |.|   |:..||.:||:.|....| |.:|.||.:|  :.
Worm   447 AAYKQAQRREDDIAIVTGAFLVKL--DPKTLVVEKIRISYGGMAPTTKLALTTMEKLIGEK--WS 507

  Fly   459 NGLVEKAFGQLSTLLQPDAVLPDASPVYRRKLACGLFYKFLLKIAAQRKQGLGSRFVTGGSLLKR 523
            ...::||.|.||..|:..|.:|.....||..||...|:||.|.::.:.:       :|....:..
Worm   508 QTFLDKALGLLSDELKLPAGVPGGMSQYRLSLALSFFFKFFLGVSKKLE-------LTEIKYVDA 565

  Fly   524 PVSSGQQSFET------FQE-------HYPVTKATEKHEGLIQCSGEATYSNDLPTQH-NQLWAA 574
            .|..||...||      :||       |.|:.:..:...|....:|||.|.:|:.... |.:  |
Worm   566 DVKIGQNVPETLYATQLYQEVKANQPAHDPLGRPIKHVSGDKHTTGEAVYCDDINVADCNHI--A 628

  Fly   575 FVIAKKVGAKVTKVDTQPALDLPGVVAYLDAKDIPGPNYVGPKIRDQFFFPKDEELFATGEIKFY 639
            ||::......:..:|...||::.|||..:||.|:.....:|        ...|..:|....|.|:
Worm   629 FVLSPIAHGTLNSIDYTAALEIDGVVGTIDASDVTTGAQMG--------HHSDTPVFVKETITFH 685

  Fly   640 GQPVGIILANSNSLANRAAELVKLTYEGGAEEILPSLKAVLDK---------VGSEAGNNKRLEQ 695
            |||:..|:|..:.:|.:||.||||.|  ..|:.:.::|..|:.         :.|...:|   ||
Worm   686 GQPIAAIVATDHEIARKAASLVKLDY--SVEKPIVTIKQALEAESFVFKHFVIHSSLNDN---EQ 745

  Fly   696 PIKSTIDVLQLEEPFDVSSSGQLDMGLQYHYYMEPQTTVVLPFEGG-LQVYAATQWMDLTQDTIA 759
            .|||.      ...:|....|.:|||.|.|:|:|.|..:|:|.|.. |::..:.|.::..|..:|
Worm   746 VIKSD------WSKYDRIVEGSIDMGGQEHFYLETQQCIVIPHEDDELEIIISNQCVNDVQIEVA 804

  Fly   760 NVLNLKSNDVQVKTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMTSLGKRWAF 824
            ..|.:..:.:..|.:|||||:|||.:...:.|..|:|||.|..||::|.......|...|.|..|
Worm   805 KCLGMAQHKISTKVKRIGGGFGGKESTGAILAVPASLAAKKFGRPMKFKFERFDDMAITGTRHPF 869

  Fly   825 HCDYDFFVQKSGKISGIVSRFYEDAGYLANESPIGHTVLLS-----------KNCYEFSDNYKLD 878
            ...|...|.::||        :.|..|.| .|..|||:.||           .|.|:| :|..:.
Worm   870 TLQYKLAVDENGK--------FLDLDYTA-LSNSGHTIDLSMGVMQRAMVHADNVYKF-ENADIT 924

  Fly   879 GYLVCTDSPSNTPCRAPGSVEGIAMMENIIEHIAFETGVDPADVRFANLLPAHKMGDMMP----- 938
            |.:..|:..|||..|..|..:|:...|.:::|:|.:.|.:..:||..|.   :|.||..|
Worm   925 GKMCKTNLASNTAFRGFGGPQGMFGTEIMVKHVAEKFGFNHDEVRVKNF---YKEGDCTPFGMHL 986

  Fly   939 ----------RFLESTKYRERKAEAIAHNKENRWHKRGLGLCIMEYQIGY----FGQYPATVAIY 989
                      ...:::.|..|..|....|..|::.|||:.|....:.||:    ..|..|.|.:|
Worm   987 NQCNVTRTWDECRKNSDYDNRLEEVKKFNDSNKFRKRGIYLTPTRFGIGFGLKQLNQAGALVLVY 1051

  Fly   990 HSDGTVVVSHGGIEMGQGMNTKISQVAAHTLGIPMEQVRIEASDTINGANSMVTGGAVGSETLCF 1054
             :||:|:|||||:|||||::|||.|:||..|.||:|::.|..:.|....|:..|..:|||:....
Worm  1052 -TDGSVLVSHGGMEMGQGLHTKILQIAARCLEIPIERIHIHDTSTDKVPNASATAASVGSDMNGL 1115

  Fly  1055 AVRKACETLNERLKPVREEVKPENWQDLIQEAYNRKINLIASD------------QCKQGDMDPY 1107
            ||:.||..:||||:..::......|.|.::.||..:::|.||.            ..|..::..|
Worm  1116 AVQDACRQINERLERFKKLDPNGTWDDWVKAAYVDRVSLSASGFGIIHHEPVDFFNGKGAELFGY 1180

  Fly  1108 SVCGLCLTEVELDVLTGNYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTSEQVIADPKT 1172
            ||.|....|||:|.|||::.:.|.||:.|.||||||.:|||||||||:.|.|.:|.|::...| .
Worm  1181 SVYGTACCEVEIDCLTGDHHLLRTDIVMDVGESLNPAIDIGQIEGAFIQGYGLFTMEEIKIRP-D 1244

  Fly  1173 GECLTNRTWTYKPPGAKDIPTDLRIELLPKSPNKAGFMRSKATGEPAICLSIAVAFALQQALQSA 1237
            |..||.....||.|.|.|.|....:.||..|.||.|...|||.|||.:.|.....||:::|:::.
Worm  1245 GIRLTRGPGNYKIPSADDAPRHFNVSLLGNSSNKMGIFSSKAIGEPPLFLGSCAFFAIREAVRAY 1309

  Fly  1238 RDDAGVPKSWVTLTAPMTPEHLVLHSGTEPSQFKL 1272
            |...|            ..::.|.||...|.:.::
Worm  1310 RIQNG------------NADYFVFHSPATPERIRM 1332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	fer2	4..85	CDD:238126	27/77 (35%)
		PLN02906	28..1259	CDD:215491	425/1364 (31%)
		Fer2_2	86..159	CDD:280048	36/73 (49%)
		FAD_binding_4	211..373	CDD:303082	44/175 (25%)
		CO_deh_flav_C	399..502	CDD:281449	39/106 (37%)
		Ald_Xan_dh_C	555..666	CDD:214971	35/111 (32%)
		Ald_Xan_dh_C2	711..1192	CDD:280834	180/523 (34%)
xdh-1	NP_502747.1	Fer2	18..86	CDD:278537	26/69 (38%)
		PLN02906	34..1340	CDD:215491	431/1383 (31%)
		Fer2_2	95..168	CDD:280048	36/73 (49%)
		FAD_binding_5	260..440	CDD:279309	48/196 (24%)
		CO_deh_flav_C	447..549	CDD:281449	38/105 (36%)
		Ald_Xan_dh_C	610..715	CDD:279635	36/116 (31%)
		Ald_Xan_dh_C2	755..1264	CDD:280834	180/523 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720