Protein Alignment AOX1 and xdh-1

DIOPT Version :10

• Sequence 1: NP_650475.1
• Gene: AOX1 / 41894
• FlyBaseID: FBgn0267408
• Length: 1273
• Species: Drosophila melanogaster
• Sequence 2: NP_502747.1
• Gene: xdh-1 / 178381
• WormBaseID: WBGene00010083
• Length: 1358
• Species: Caenorhabditis elegans
• Alignment Length: 1400
• Identity: 434/1400 - (31%)
• Similarity: 670/1400 - (47%)
• Gaps: 221/1400 - (15%)

  Fly     7 INGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWAVNS 71
            :||  ..|....:...::|.|::|:...|||||..|.|||||.|...::  |.|.||::.::.||
 Worm    20 VNG--KRVEEKDVDPKMTLATYLRDKLKLTGTKIGCNEGGCGACTIMIS--HIENGEIKHFSANS 80

  Fly    72 CLTLLNTCLGLEVTTSEGLGN-KRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGKVT 135
            ||..:....|..|||.||:|: .:...|.:|:||||.:|:|||:|:||.||.||.||::.... |
 Worm    81 CLMPVCGVFGKAVTTVEGIGSVAKNRLHPVQERLAKAHGSQCGFCTPGFVMAMYALLRNNPNP-T 144

  Fly   136 MEEVENSFGGNICRCTGYRPILDAMKSFAVDSN--IQVPAE--CIDIEDLSTKKCPKTGQT-CSG 195
            :.::.....||:||||||||||:|..|||||.:  ::|..|  |...|:     |.|..:| |.|
 Worm   145 ISDINLGLQGNLCRCTGYRPILEAFYSFAVDESGTLKVTEENGCGMGEN-----CCKVKKTACGG 204

  Fly   196 S-----------------------CKKQQPKGSQLYP-----------------DGSRWSWPVSL 220
            |                       ||...|....::|                 ..::|..|||.
 Worm   205 SDETTPGYTGGERKRKIQLSDMSDCKPYDPTQELIFPPELKLHGYESMSFAYDHHHTKWYQPVSY 269

  Fly   221 GDLFAALQGAVKEKLPY-MLVAGNTAHGVYRRSPDIK-AFIDVSGLAELKG----HKLSADNSSL 279
            .||.     ::|.:||: .|::||:...:     ::| .|||:..:...:.    |:...:|..:
 Worm   270 DDLL-----SLKRELPHARLISGNSELAI-----ELKFRFIDLPAVINPRQVKVLHEKHLENDGV 324

  Fly   280 TLGGNLSLSE----TMELCRQL--ENTKGFEYLSQVWQHLDWIANVPVRNAGTLAGNLSIKHAHP 338
            .:|..:||::    :::|.:.|  |.|   ..|..|.:.|.|.|.:.|||..::|||::.  |.|
 Worm   325 YMGTGMSLTDMDNYSVQLMKDLPREQT---AVLKHVHEMLHWFAGIHVRNVASVAGNIAT--ASP 384

  Fly   339 EFPSDVFIVLEALDAQVIVQEAV--DKQQTVSLASYLGSS----MEGKIIRGLVLRAYPKERFAF 397
              .||:..:..|.:|.|::....  :|:..:....:||..    .:.:||:.:::... :|...|
 Worm   385 --ISDLNPIWMASNALVVLDSEARGEKRVHIDEKFFLGYRKTVIQQDEIIKAVIVPLL-EENEHF 446

  Fly   398 DSYKIMPRAQNAHAYVNAAFLVEFTADAK---VKSARICFGGIHPEFVHA-TAIENLIRDKNPFE 458
            .:||...|.::..|.|..||||:.  |.|   |:..||.:||:.|....| |.:|.||.:|  :.
 Worm   447 AAYKQAQRREDDIAIVTGAFLVKL--DPKTLVVEKIRISYGGMAPTTKLALTTMEKLIGEK--WS 507

  Fly   459 NGLVEKAFGQLSTLLQPDAVLPDASPVYRRKLACGLFYKFLLKIAAQRKQGLGSRFVTGGSLLKR 523
            ...::||.|.||..|:..|.:|.....||..||...|:||.|.::.:.:       :|....:..
 Worm   508 QTFLDKALGLLSDELKLPAGVPGGMSQYRLSLALSFFFKFFLGVSKKLE-------LTEIKYVDA 565

  Fly   524 PVSSGQQSFET------FQE-------HYPVTKATEKHEGLIQCSGEATYSNDLPTQH-NQLWAA 574
            .|..||...||      :||       |.|:.:..:...|....:|||.|.:|:.... |.:  |
 Worm   566 DVKIGQNVPETLYATQLYQEVKANQPAHDPLGRPIKHVSGDKHTTGEAVYCDDINVADCNHI--A 628

  Fly   575 FVIAKKVGAKVTKVDTQPALDLPGVVAYLDAKDIPGPNYVGPKIRDQFFFPKDEELFATGEIKFY 639
            ||::......:..:|...||::.|||..:||.|:.....:|        ...|..:|....|.|:
 Worm   629 FVLSPIAHGTLNSIDYTAALEIDGVVGTIDASDVTTGAQMG--------HHSDTPVFVKETITFH 685

  Fly   640 GQPVGIILANSNSLANRAAELVKLTYEGGAEEILPSLKAVLDK---------VGSEAGNNKRLEQ 695
            |||:..|:|..:.:|.:||.||||.|  ..|:.:.::|..|:.         :.|...:|   ||
 Worm   686 GQPIAAIVATDHEIARKAASLVKLDY--SVEKPIVTIKQALEAESFVFKHFVIHSSLNDN---EQ 745

  Fly   696 PIKSTIDVLQLEEPFDVSSSGQLDMGLQYHYYMEPQTTVVLPFEGG-LQVYAATQWMDLTQDTIA 759
            .|||.      ...:|....|.:|||.|.|:|:|.|..:|:|.|.. |::..:.|.::..|..:|
 Worm   746 VIKSD------WSKYDRIVEGSIDMGGQEHFYLETQQCIVIPHEDDELEIIISNQCVNDVQIEVA 804

  Fly   760 NVLNLKSNDVQVKTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMTSLGKRWAF 824
            ..|.:..:.:..|.:|||||:|||.:...:.|..|:|||.|..||::|.......|...|.|..|
 Worm   805 KCLGMAQHKISTKVKRIGGGFGGKESTGAILAVPASLAAKKFGRPMKFKFERFDDMAITGTRHPF 869

  Fly   825 HCDYDFFVQKSGKISGIVSRFYEDAGYLANESPIGHTVLLS-----------KNCYEFSDNYKLD 878
            ...|...|.::||        :.|..|.| .|..|||:.||           .|.|:| :|..:.
 Worm   870 TLQYKLAVDENGK--------FLDLDYTA-LSNSGHTIDLSMGVMQRAMVHADNVYKF-ENADIT 924

  Fly   879 GYLVCTDSPSNTPCRAPGSVEGIAMMENIIEHIAFETGVDPADVRFANLLPAHKMGDMMP----- 938
            |.:..|:..|||..|..|..:|:...|.:::|:|.:.|.:..:||..|.   :|.||..|
 Worm   925 GKMCKTNLASNTAFRGFGGPQGMFGTEIMVKHVAEKFGFNHDEVRVKNF---YKEGDCTPFGMHL 986

  Fly   939 ----------RFLESTKYRERKAEAIAHNKENRWHKRGLGLCIMEYQIGY----FGQYPATVAIY 989
                      ...:::.|..|..|....|..|::.|||:.|....:.||:    ..|..|.|.:|
 Worm   987 NQCNVTRTWDECRKNSDYDNRLEEVKKFNDSNKFRKRGIYLTPTRFGIGFGLKQLNQAGALVLVY 1051

  Fly   990 HSDGTVVVSHGGIEMGQGMNTKISQVAAHTLGIPMEQVRIEASDTINGANSMVTGGAVGSETLCF 1054
             :||:|:|||||:|||||::|||.|:||..|.||:|::.|..:.|....|:..|..:|||:....
 Worm  1052 -TDGSVLVSHGGMEMGQGLHTKILQIAARCLEIPIERIHIHDTSTDKVPNASATAASVGSDMNGL 1115

  Fly  1055 AVRKACETLNERLKPVREEVKPENWQDLIQEAYNRKINLIASD------------QCKQGDMDPY 1107
            ||:.||..:||||:..::......|.|.::.||..:::|.||.            ..|..::..|
 Worm  1116 AVQDACRQINERLERFKKLDPNGTWDDWVKAAYVDRVSLSASGFGIIHHEPVDFFNGKGAELFGY 1180

  Fly  1108 SVCGLCLTEVELDVLTGNYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTSEQVIADPKT 1172
            ||.|....|||:|.|||::.:.|.||:.|.||||||.:|||||||||:.|.|.:|.|::...| .
 Worm  1181 SVYGTACCEVEIDCLTGDHHLLRTDIVMDVGESLNPAIDIGQIEGAFIQGYGLFTMEEIKIRP-D 1244

  Fly  1173 GECLTNRTWTYKPPGAKDIPTDLRIELLPKSPNKAGFMRSKATGEPAICLSIAVAFALQQALQSA 1237
            |..||.....||.|.|.|.|....:.||..|.||.|...|||.|||.:.|.....||:::|:::.
 Worm  1245 GIRLTRGPGNYKIPSADDAPRHFNVSLLGNSSNKMGIFSSKAIGEPPLFLGSCAFFAIREAVRAY 1309

  Fly  1238 RDDAGVPKSWVTLTAPMTPEHLVLHSGTEPSQFKL 1272
            |...|            ..::.|.||...|.:.::
 Worm  1310 RIQNG------------NADYFVFHSPATPERIRM 1332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	PLN02906	28..1259	CDD:215491	425/1364 (31%)
xdh-1	NP_502747.1	PLN02906	34..1340	CDD:215491	431/1383 (31%)