Protein Alignment AOX1 and F15E6.6

DIOPT Version :10

• Sequence 1: NP_650475.1
• Gene: AOX1 / 41894
• FlyBaseID: FBgn0267408
• Length: 1273
• Species: Drosophila melanogaster
• Sequence 2: NP_500531.2
• Gene: F15E6.6 / 177192
• WormBaseID: WBGene00017487
• Length: 1256
• Species: Caenorhabditis elegans
• Alignment Length: 1374
• Identity: 378/1374 - (27%)
• Similarity: 611/1374 - (44%)
• Gaps: 250/1374 - (18%)

  Fly     5 ITINGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTW-- 67
            |..|....::....:..:::|..::|...||.|||..|:||.||.|          |..|.||
 Worm     6 IFFNVNGKDIKEENVDPELTLAYYLRNKLGLRGTKLGCEEGVCGSC----------TVVLGTWDD 60

  Fly    68 --------AVNSCLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMY 124
                    |||:||..|.......|.|.||:|: |...|.||.|:|:.:..|||:||||.||:.|
 Worm    61 SLNKAVYSAVNACLVPLFHVHKTFVITVEGVGS-RDKIHPIQDRMARGHAVQCGFCSPGFVMSAY 124

  Fly   125 GLLKSKGGKVTMEEVENSFGGNICRCTGYRPILDAMKSFAVD-----SNIQVPAECIDIEDLSTK 184
            .||::.... |:|::..:...|:||||||||||:|:.||:..     ...:..|.|  .:|||::
 Worm   125 ALLRNHPNP-TIEQINAAIRANLCRCTGYRPILEALYSFSSSGGGCCGGKKAGAGC--CKDLSSE 186

  Fly   185 KCPKTGQTCSGSCKKQQPKGSQLYPDGSR----WSWPVSL-GDLFAAL------QGAVKEKLPYM 238
            .......|......:..|....::|...|    ...||:| ||....|      |....:|...:
 Worm   187 DEAYEKLTSFNDFPEYDPSQEIIFPPSLRIFVDSENPVTLKGDRIELLLPKSIEQFKEFKKDRTV 251

  Fly   239 LVAGNTAHGVYRRSPD-----------IKAFIDVSGLAELKGHKLSADNSSLTLGGNLSLSETME 292
            :.:|.....:..|:|.           :|.|.:|....|           ::.:|..:::.:..:
 Worm   252 ISSGLITRFIATRNPKEFSQKWITTKYVKEFNEVIENPE-----------TVVIGAAVNIQKMSD 305

  Fly   293 -LCRQLENTKGFEYLSQVWQHLD-WIANVPVRNAGTLAG---NLSIKHAHPEFPSDVFIVLEALD 352
             |.|.|....|.|..:.:.:... .|||......|.::|   ::|:        ||:.::...|:
 Worm   306 ILSRSLSQNIGKEVDAFIKKFSSPQIANFATWTGGIVSGAKSSISV--------SDLLLLFNVLN 362

  Fly   353 A------------QVIVQEAVDKQ----QTVSLASYLGSSMEGKIIRGLVLRAYPKERFAFDSYK 401
            |            ||.::|.|:|:    .|: :.:...||:.|::.                ..|
 Worm   363 AKLTLLTDSGDLTQVNIEEFVEKKLFATNTI-VNTVFSSSITGQLF----------------CLK 410

  Fly   402 IMPRAQNAHAYVNAAFLVEFTADAKVKSARICFG-GIHPEFV-----HATAIEN-----LIRDKN 455
            :...::......|.|.||....      :||..| |..|:.:     |..|::|     |.:...
 Worm   411 LGETSEQDSTSFNFAALVGNNI------SRIFVGLGGPPKRLTSLEEHIFALKNLDVPDLCKTSG 469

  Fly   456 PFENGLVEKAFGQLSTLLQPDAVLPDASPVYRRKLACGLFYKFLLKIAAQRKQGLGSRFVTGGSL 520
            ..||..::.|..:||..::  .|...|..|      .||.|....|...::..|
 Worm   470 MGENKNIKIALTRLSKFMK--NVEKTAETV------DGLNYLQYFKPTERKSVG----------- 515

  Fly   521 LKRPVSSGQQSFETFQEHYPVTKATEKHEGLIQCSGEATYSNDLPTQHNQLWAAFVIAKKVGAKV 585
              ||:::      .|.|.              ..:|||.|.||:.| :|.:...||::....|::
 Worm   516 --RPLAN------YFNER--------------AITGEALYVNDIQT-YNPVHLGFVLSTVPHAEI 557

  Fly   586 TKVDTQPALDLPGVVAYLDAKDIPGPNYVGPKIRDQFFFPKDEELFATGEIKFYGQPVGIILANS 650
            ..:|...||.|.|||.:..|.|:||.|..|.:| .....|.|..:||..:::..||.||:|.||.
 Worm   558 LSIDATEALKLEGVVGFFGASDVPGNNSPGLQI-SNMNLPDDATIFADKKVESVGQVVGVIAAND 621

  Fly   651 NSLANRAAELVKLTYEGGAEEILPSL---------KAVLDKVGSEAGNNKRLEQPIKSTIDVLQL 706
            ..||.|||:||||.|:.     ||:|         |::|.||.....:...:.:.:..:..||:
 Worm   622 VLLARRAAKLVKLEYKE-----LPALVELKDAIVAKSLLGKVRHFGKSEYLVNESLVHSYKVLE- 680

  Fly   707 EEPFDVSSSGQLDMGLQYHYYMEPQTTVVLPFEGGLQ-VYAATQWMDLTQDTIANVLNLKSNDVQ 770
                     |:..:|.|.|:|:|.|:::|:|.||... |:.:||....||..:|..:.:.::.:.
 Worm   681 ---------GESSLGSQEHFYLETQSSLVIPGEGDESIVHCSTQGTSFTQLMVAETMKIPAHKII 736

  Fly   771 VKTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMTSLGKRWAFHCDYDFFVQKS 835
            |||:|:||.:|||....:..|...::.|.|||||.....|.|..:...|||...:..|...:...
 Worm   737 VKTKRMGGAFGGKLNNASWIACICSVVAKKLNRPTYGYLSREEDLAITGKRHGVYTKYRVGINSD 801

  Fly   836 GKISGIVSRFYEDAGYLANESPIGHTVLLSKNCYEFSDN------YKLDGYLVCTDSPSNTPCRA 894
            ||:.||..:.:.:.|: :.:...|.|:::.    :|.|:      .:.|||.|.|::.|||..|.
 Worm   802 GKVQGIHHQAWLNGGW-SKDHTEGVTMVMG----QFVDDVYNMGTVRYDGYPVKTNTNSNTAFRG 861

  Fly   895 PGSVEGIAMMENIIEHIAFETGVDPADVRFANL-LPAHKMGDMMPRFLESTKYR----------- 947
            .|:.:...:.|.::..||.|.|....:|:..|. ....|      |:|....|.
 Worm   862 YGNPQAKLVSEGVMRRIAREVGKSTEEVKKLNFAFEGEK------RYLSGNIYSDAHIECWEYCT 920

  Fly   948 -----ERKAEAIAH-NKENRWHKRGLGLCIMEYQIGYFGQYPATVA--IYHSDGTVVVSHGGIEM 1004
                 |::.|.|.: ||.::..|||:.:..:...:.:.|.....||  :.:.||::.:|.||.||
 Worm   921 RWSDFEKRKETIENFNKTSKIVKRGIAMSSVRLALSHPGPPGHGVASLMINLDGSIQLSIGGTEM 985

  Fly  1005 GQGMNTKISQVAAHTLGIPMEQVRIEASDTINGANSMVTGGAVGSETLCFAVRKACETLNERLKP 1069
            |||:|.|:.||.:..|..|::.:.|....|....|:..||.:..::|...||...||.:..||:|
 Worm   986 GQGLNQKMLQVCSEALKRPIDTITIVDCSTDKITNAPETGASHNADTNGLAVLACCERIMSRLQP 1050

  Fly  1070 VREEVKPENWQDLIQEAYNRKINLIASDQCKQ-GDMD-----------PYSVCGLCLTEVELDVL 1122
            :.:: ...:|:..|::||...:.|    ||.: |.:|           ||:..|.|..|:|:|.:
 Worm  1051 IIDK-NDGDWEKSIRDAYGAYVPL----QCTEYGSVDREKLSIGEFEYPYNTTGACAVEMEVDTM 1110

  Fly  1123 TGNYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTSEQVIADPKTGECLTNRTWTYKPPG 1187
            ||...:.||||:.|.||||||.:||||||||||.|.|..|.|::..:.:||:...|....||.|.
 Worm  1111 TGYNRLLRVDIVMDVGESLNPAIDIGQIEGAFMQGYGLVTCEKITFNKETGQLNQNSAGQYKIPK 1175

  Fly  1188 AKDIPTDLRIELLP-KSPNKAGFMRSKATGEPAICLSI-AVAFALQQALQSARDDAGVPKSWVTL 1250
            :.|:|.|.|::||. ...|.|....||..|||.:.:|. ||...:...:...|.:.|:.| :|..
 Worm  1176 SSDVPKDFRVKLLGINKANGAKVYSSKGIGEPPLMMSCGAVHSCIMNCIDDWRKENGIDK-FVDT 1239

  Fly  1251 TAPMTPEHL 1259
            .:|::.:.:
 Worm  1240 ISPLSADKI 1248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	PLN02906	28..1259	CDD:215491	375/1349 (28%)
F15E6.6	NP_500531.2	PLN02906	23..1253	CDD:215491	376/1357 (28%)