DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and aox1

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	XP_012825683.2	Gene:	aox1 / 100495429	-ID:	-	Length:	1323	Species:	Xenopus tropicalis

Alignment Length:	1362	Identity:	420/1362 - (30%)
Similarity:	670/1362 - (49%)	Gaps:	174/1362 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 INGTSHEVNLSALPADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWAVNS 71
            :||.. .|..:|.|.::.| .::|:...|||||:.|..||||.|...::.|||.:.::..::.|:
Frog    14 VNGRK-IVEENADPEELLL-PYLRKKLLLTGTKYGCGGGGCGACTVMVSTIHPVSKKILHFSANA 76

  Fly    72 CLTLLNTCLGLEVTTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGKVTM 136
            ||..:.:..|..|||.||:|:.....|.:|:|:||.:|:|||:|:||:||::|.||::. .:.||
Frog    77 CLLPICSMHGAAVTTIEGIGSTTTKLHPVQERIAKAHGSQCGFCTPGMVMSVYSLLRNH-PEPTM 140

  Fly   137 EEVENSFGGNICRCTGYRPILDAMKSFAVDSNIQVPAECIDIEDLSTKK--CPKT-GQTCSGSCK 198
            |::..|.|||:|||||||||:|..::|...:      :|..:::...:|  .|.| ....:|..|
Frog   141 EQIYESLGGNLCRCTGYRPIVDGCRTFCNKT------DCCQVKENGMEKISTPDTVDNILTGLFK 199

  Fly   199 KQQ-----PKGSQLYP----------------DGSRWSW--PVSLGDLFAALQ-GAVKEKLPYML 239
            ::|     |....::|                .|.|.:|  |.||.:|   || .|...|.|  |
Frog   200 EEQFLPLDPTQELIFPPELLLMDKEKKEKLIFQGGRMTWISPSSLQEL---LQLKATYPKAP--L 259

  Fly   240 VAGNTAHGVYRRSPDIK-------AFIDVSGLAELKG--HKLSADNSSLTLGGNLSLSETMELCR 295
            |.|||..|     |::|       ..|..|.:.||..  ||    :..:|:|...||:...|..:
Frog   260 VVGNTIVG-----PEMKFRGIFHPVIISPSRIPELNFVIHK----DDGITVGAACSLTVLKEALK 315

  Fly   296 QL------ENTKGFEYLSQVWQHLDWIANVPVRNAGTLAGNLSIKHAHPEFPSDVFIVLEALDAQ 354
            ::      |.||.|..|   .|.|:.:....:||..:|.||:..:..    .||:..||.|.:.
Frog   316 EVVTQQPEEKTKLFHAL---LQQLETLGGPQIRNTASLGGNIISRSP----TSDLNPVLAAGNC- 372

  Fly   355 VIVQEAVDKQQTVSL-ASYLGSSMEGKIIRGLVLRAYPKERFAFDSYKIMPRAQNAHAYVNAAFL 418
            ::...|:|..:.:.| .::...|::.:.:...|...|.|:...:..::...|.:||...|.|...
Frog   373 ILTVAAIDGTRQMPLDEAFFAHSLKAEEVLVSVHLPYSKKGDHYSVFRQAQRRENALPIVTAGMK 437

  Fly   419 VEFTADAK-VKSARICFGGIHPEFVHA-TAIENLIRDKNPFENGLVEKAFGQL--STLLQPDAVL 479
            |:|..:.. :|..||.:||:.|..|.| |..::||  ...:::.::.:|...:  ...|.|.|
Frog   438 VQFEENTDIIKVIRIFYGGVGPTTVFAKTTCQDLI--GKHWDDHMLSEACRLMVHEITLSPSA-- 498

  Fly   480 PDASPVYRRKLACGLFYKFLLKIAAQRKQGLGSRFVTGGSLLKRPVSSGQQSFET--------FQ 536
            |.....||..|....|:||.|:: .||...:|:.:....:|         .||||        :|
Frog   499 PGGMVEYRSTLTISFFFKFYLEV-LQRLNHMGTHYSDVSAL---------NSFETLCNENVQLYQ 553

  Fly   537 E-------HYPVTKATEKHEGLIQCSGEATYSNDLPTQHNQLWAAFVIAKKVGAKVTKVDTQPAL 594
            :       ..|:.:....:.|:...:|||.|.:|:|....:|:..||.:.|..||:..:|...||
Frog   554 DVSSRQSVQDPIGRPIMHYSGIKHATGEAVYCDDMPCVDGELFLYFVTSTKAHAKIVSLDFSEAL 618

  Fly   595 DLPGVVAYLDAKDIPGPNYVGPKIRDQFFFPKDEELFATGEIKFYGQPVGIILANSNSLANRAAE 659
            ..||||..:..:|.||       .....|...:..|.|..::...||.:..:||::.:.|.:||.
Frog   619 AQPGVVDVVTTEDCPG-------TCKSMFEEGEVPLLAKDKVLCVGQIICAVLADTPARAKKAAA 676

  Fly   660 LVKLTYEGGAEEILPSLKAVLD---------KVGSEAGNNKRLEQPIKSTIDVLQLEEPFDVSSS 715
            .||:.|| ..|.::.:::..::         |:  |.||   :|:..||.          |....
Frog   677 AVKVVYE-NLEPVILTIQEAIEHNSFFKPQRKL--ENGN---VEEAFKSA----------DQIQE 725

  Fly   716 GQLDMGLQYHYYMEPQTTVVLP--FEGGLQVYAATQWMDLTQDTIANVLNLKSNDVQVKTRRIGG 778
            |::.:|.|.|:|||.|:..|||  .:..:.||.:||.....|:.||.:||:.||.:....:|:||
Frog   726 GEIYIGGQEHFYMETQSIRVLPKGEDKEMDVYVSTQDPTYIQNLIATILNVPSNRITCHVKRVGG 790

  Fly   779 GYGGKATRCNLAAAAAALAAHKLNRPIRFVQSLESIMTSLGKRWAFHCDYDFFVQKSGKISGIVS 843
            .:|||.|:....||..|:||:|..|.:|.|......|...|.|..|...|.......|.|:.:..
Frog   791 AFGGKTTKTGNIAAITAVAANKTRRAVRCVFERGDDMLITGGRHPFLGKYKVGFMNDGHITAVDV 855

  Fly   844 RFYEDAGYLANESPIGHTVLLSK--NCYEFSDNYKLDGYLVCTDSPSNTPCRAPGSVEGIAMMEN 906
            .::.:||...::|.:...:.|..  :.|.. .|.:..|....|:.||||..|..|..:...:.|.
Frog   856 AYFSNAGCTPDDSVLVVEIALMNMDSAYRL-PNVRCTGTACKTNLPSNTAFRGFGYPQAAFVTET 919

  Fly   907 IIEHIAFETGVDPADVRFANL------------LPAHKMGDMMPRFLESTKYRERKAEAIAHNKE 959
            .|..:|.:..:.|..||..||            :.|..:|......:|.:.|..|:......||:
Frog   920 WISEVAIKCRIPPEKVREMNLYKDISQTHFRQEILARTLGMCWNECMEKSSYNSRRLAIENFNKD 984

  Fly   960 NRWHKRGLGLCIMEYQIG----YFGQYPATVAIYHSDGTVVVSHGGIEMGQGMNTKISQVAAHTL 1020
            |.|.|:||.:..|::.||    :|||..|.|.|| .||:|:|:|||||||||::|||.|:|:..|
Frog   985 NYWKKKGLAIIPMKFPIGSLAKFFGQAAALVHIY-LDGSVLVTHGGIEMGQGVHTKIMQIASREL 1048

  Fly  1021 GIPMEQVRIEASDTINGANSMVTGGAVGSETLCFAVRKACETLNERLKPVREEVKPENWQDLIQE 1085
            |||:..:.|..::|.:..|:.|:||::|::....||:.|||.|.:||.|:|.:....:|::.:.|
Frog  1049 GIPLSYIHICETNTSSVPNTQVSGGSLGTDVNGMAVKNACEILMQRLLPIRSKNPKSSWKEWVTE 1113

  Fly  1086 AYNRKINLIASDQCKQ---------GDMDP--YSVCGLCLTEVELDVLTGNYIVGRVDILEDTGE 1139
            ||.:.::|.|:..|:.         |:.:|  |.|.|:..:|||:|.|||::...|.||:.|.|.
Frog  1114 AYMQSVSLSATGFCRSFDRELNWETGEGNPVHYCVYGVACSEVEIDCLTGDHKNLRTDIVIDFGC 1178

  Fly  1140 SLNPNVDIGQIEGAFMMGLGYWTSEQVIADPKTGECLTNRTWTYKPPGAKDIPTDLRIELLPKSP 1204
            |:||.||||||||||:.|||.:|.|::...| .|...|.....||.|..:|||....:.||...|
Frog  1179 SINPAVDIGQIEGAFVQGLGLFTIEELKFSP-NGVLYTRGPAQYKIPSVRDIPEQFNVSLLSNVP 1242

  Fly  1205 NKAGFMRSKATGEPAICLSIAVAFALQQALQSARDDAGVPKSWVTLTAPMTPEHLVLHSGTE 1266
            |......||..||||:.|..::.||::.|:.|||.:.|:.:.: ||.:|.|||.:.:..|.:
Frog  1243 NSCAIYSSKGVGEPALFLGSSIYFAIKDAVLSARRERGMSELF-TLNSPATPEKIRMACGDQ 1303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	fer2	4..85	CDD:238126	25/77 (32%)
		PLN02906	28..1259	CDD:215491	413/1332 (31%)
		Fer2_2	86..159	CDD:280048	37/72 (51%)
		FAD_binding_4	211..373	CDD:303082	51/180 (28%)
		CO_deh_flav_C	399..502	CDD:281449	30/106 (28%)
		Ald_Xan_dh_C	555..666	CDD:214971	34/110 (31%)
		Ald_Xan_dh_C2	711..1192	CDD:280834	178/511 (35%)
aox1	XP_012825683.2	mam_aldehyde_ox	10..1323	CDD:132014	420/1362 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920