DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AOX1 and aox1

DIOPT Version :9

Sequence 1:	NP_650475.1	Gene:	AOX1 / 41894	FlyBaseID:	FBgn0267408	Length:	1273	Species:	Drosophila melanogaster
Sequence 2:	XP_017953036.2	Gene:	aox1 / 100379890	XenbaseID:	XB-GENE-6045207	Length:	1322	Species:	Xenopus tropicalis

Alignment Length:	1329	Identity:	406/1329 - (30%)
Similarity:	647/1329 - (48%)	Gaps:	151/1329 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PADISLNTFIREYAGLTGTKFMCQEGGCGVCVCTLTGIHPETGELRTWAVNSCLTLLNTCLGLEV 84
            |.|:.| .::|....|||||:.|..||||.|...::.:||.:.::..:...:||..:.:..|..|
Frog    27 PEDMLL-PYLRRNLHLTGTKYGCGGGGCGACTVMISTVHPVSKKIIHYPALACLLPICSLYGNAV 90

  Fly    85 TTSEGLGNKRVGYHAIQQRLAKMNGTQCGYCSPGIVMNMYGLLKSKGGKVTMEEVENSFGGNICR 149
            ||:||:||.....|.:|:|:||.:|:|||:|:||:||::|.||::. .:.|||::.::..||:||
Frog    91 TTTEGIGNSTTKLHPVQERIAKAHGSQCGFCTPGMVMSIYTLLRNH-PEPTMEQILSALSGNLCR 154

  Fly   150 CTGYRPILDAMKSFAVDSNIQVPAECID------IEDLSTKKCPKTGQTCSGSCKKQ----QPKG 204
            |||||||||..|:|:.|.       |::      :|::  |..||.      ..:|.    .|..
Frog   155 CTGYRPILDGCKTFSKDC-------CLNEKKEHRLEEV--KSFPKL------FYEKDFLPLDPTQ 204

  Fly   205 SQLYPD----------------GSRWSW--PVSLGDLFAALQGAVKEKLPYM-LVAGNTAHGVYR 250
            ..::|.                |.|.:|  |.:|.::.     .:|.|.|.. ||.||||.|...
Frog   205 DLIFPPELMMMFNSQKKMNVFLGERITWYSPSTLDEIL-----ELKTKYPSAPLVVGNTALGPQM 264

  Fly   251 RSPDIKAFIDVSGLAELKGHKLSADNSSLTLGGNLSLSETME-LCR-----QLENTKGFEYLSQV 309
            :...:...:.:|.:..:..:.:|.::..:::|...|||:..| ||.     |.:..|.|..|
Frog   265 KFQGVIHPVLISPVRVMDLYNVSLNDMGISIGAACSLSQVKEILCENISAIQEDKAKIFHAL--- 326

  Fly   310 WQHLDWIANVPVRNAGTLAGNLSIKHAHPEFPSDVFIVLEALDAQV-IVQEAVDKQQTVSLASYL 373
            .|||..:|...:|:..::.|::..|..    .||:..:|.|..|.: ...:...:|..::...:.
Frog   327 LQHLGTLAGEQIRSMASIGGHIISKRT----ISDLNPILAAGGAILNFASKGETRQVELNELFFT 387

  Fly   374 GSSME--GKIIRGLVLRAYPKERFAFDSYKIMPRAQNAHAYVNAAFLVEFTADAK-VKSARICFG 435
            |||.:  .:::..:.:....|:.|. .:::...|.:||:|.|||...|.|..|.. ||...|.:|
Frog   388 GSSPQKSEEVLLSVFIPYSKKDEFV-SAFRQAQRDENANAIVNAGMKVHFEEDTDIVKEMAIYYG 451

  Fly   436 GIHPEFVHATAIENLIRDKNPFENGLVEKAFGQLSTL-LQPDAVLPDASPVYRRKLACGLFYKFL 499
            .:.|..|:|......:..::..|..|.|.....|..: |.|.|  |.....|||.|....|:||.
Frog   452 CMGPSTVYAKNTSQALIGRHWDEEMLNEACKLILEEITLSPSA--PGGKVQYRRALTISFFFKFY 514

  Fly   500 LKIAAQRKQGLGSRFVTGG--SLLKRPVSSGQQSFETFQE-------HYPVTKATEKHEGLIQCS 555
            |::....|:.:.|..|...  |.:|....:..::.:.|||       ..||........|:.|.:
Frog   515 LQVLQCLKKTIKSSSVASDYISAIKDFEINTPKTLQIFQETEQEQPIDDPVGHPIVHTSGIKQAT 579

  Fly   556 GEATYSNDLPTQHNQLWAAFVIAKKVGAKVTKVDTQPALDLPGVVAYLDAKDIPGPNYVGPKIRD 620
            |||.|.:|:||...:|:.|||.:|:..||:..:|...||.||||...:.|:||||.|.:...
Frog   580 GEAIYVDDMPTVDQELFIAFVTSKRAHAKILSIDASEALALPGVCDIIRAEDIPGKNELDGL--- 641

  Fly   621 QFFFPKDEELFATGEIKFYGQPVGIILANSNSLANRAAELVKLTYEGGAEEILPSLKAVLDKVGS 685
                   ..||:..:::..||.:..::|::...|.:||..||:.|: ..|.::.:::
Frog   642 -------NHLFSEDKVECVGQIICAVVADTPKHAKQAAAKVKIDYQ-NLEPVILTME-------- 690

  Fly   686 EAGNNKRLEQPIKSTIDVLQLEEPF---DVSSSGQLDMGLQYHYYMEPQTTVVLP--FEGGLQVY 745
            :|..|....:|.|..|.. ..||.|   |....|::.:|.|..:|||..|.:|:|  .|..|.:|
Frog   691 DAIKNNSFFEPEKKIIHG-NAEEAFKSADHILEGEVHIGGQEQFYMETNTVLVVPKGEENELDIY 754

  Fly   746 AATQWMDLTQDTIANVLNLKSNDVQVKTRRIGGGYGGKATRCNLAAAAAALAAHKLNRPIRFVQS 810
            .:||.....|..:|..||:.||.|....:|:||.:|||.|:.::.|.|:|:||||..||:|.|..
Frog   755 VSTQDPTGVQLAVAACLNVPSNRVMCHVKRVGGAFGGKITKPSIFACASAVAAHKTKRPVRCVLE 819

  Fly   811 LESIMTSLGKRWAFHCDYDFFVQKSGKISGIVSRFYEDAGYLANESPIGHTVLLSK--NCYEFSD 873
            ....|.....|..|...|.......|:|.|:...||.:||...:||.:...|.|.|  |.|.|.:
Frog   820 RGEDMLITAGRHPFFGKYKVGFMNDGRIVGLDVSFYTNAGCSTDESILVLVVALIKMDNAYHFPN 884

  Fly   874 NYKLDGYLVC------TDSPSNTPCRAPGSVEGIAMMENIIEHIAFETGVDPADVRFANLLPAHK 932
                   |.|      |:.||||..|..|..:...:.|.|::.:|.:.|:.|..||..|:.....
Frog   885 -------LTCTATACKTNLPSNTAFRGFGFPQTGLVTETIMDAVAVKCGLQPHQVREKNMYTGIG 942

  Fly   933 MGDMMPRF------------LESTKYRERKAEAIAHNKENRWHKRGLGLCIMEYQIGY----FGQ 981
            .......|            ::.:.|:.|:......||||.|.|:|:.:..:::.:|:    :.|
Frog   943 KTHYNQEFDSTNLMRCWNECMQKSSYQSRRDAIQEFNKENYWKKKGIAIIPLKFTVGFVEKTYHQ 1007

  Fly   982 YPATVAIYHSDGTVVVSHGGIEMGQGMNTKISQVAAHTLGIPMEQVRIEASDTINGANSMVTGGA 1046
            ..|.|.||. ||.|:|||.|:|||||:.|||.||.:..|.|||..:.|..:.|:...||:.:||:
Frog  1008 AAALVHIYR-DGYVLVSHSGVEMGQGLYTKIVQVVSRELKIPMSYIYICETSTVTVPNSIASGGS 1071

  Fly  1047 VGSETLCFAVRKACETLNERLKPVREEVKPENWQDLIQEAYNRKINLIASDQCK----------- 1100
            :|::....||:.||:.|.:||:|:........|::.:.||:.::|:|.::...:
Frog  1072 IGTDITGIAVKNACDILQQRLEPIISRNPNGKWEEWVSEAFEQRISLSSTGYYRGYDTYMDWEKG 1136

  Fly  1101 QGDMDPYSVCGLCLTEVELDVLTGNYIVGRVDILEDTGESLNPNVDIGQIEGAFMMGLGYWTSEQ 1165
            :|...||.:.|...:|:|||.|||.|...|.||:.|.|:|:||.:||||:||||..|.|.:|:|:
Frog  1137 EGHAGPYYIFGAACSEIELDCLTGKYNNLRTDIVMDLGQSINPGIDIGQVEGAFTQGFGLYTTEE 1201

  Fly  1166 VIADPKTGECLTNRTWTYKPPGAKDIPTDLRIELLPKSPNKAGFMRSKATGEPAICLSIAVAFAL 1230
            :...| .|...|.....|..|...|||.:..:.||..|.|......||..||.|:.|..:|.||:
Frog  1202 LQYSP-FGSLYTLGPDKYIMPAVCDIPREFNVYLLASSNNPYTIYSSKGVGETALFLGCSVFFAI 1265

  Fly  1231 QQALQSARDDAGVPKSWVTLTAPMTPEHL 1259
            :.|:.|||.:.|:.|.: ||.:|..||.:
Frog  1266 KDAIDSARAERGLSKDF-TLNSPAGPERI 1293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AOX1	NP_650475.1	fer2	4..85	CDD:238126	20/64 (31%)
		PLN02906	28..1259	CDD:215491	403/1319 (31%)
		Fer2_2	86..159	CDD:280048	37/72 (51%)
		FAD_binding_4	211..373	CDD:303082	41/171 (24%)
		CO_deh_flav_C	399..502	CDD:281449	33/104 (32%)
		Ald_Xan_dh_C	555..666	CDD:214971	37/110 (34%)
		Ald_Xan_dh_C2	711..1192	CDD:280834	171/517 (33%)
aox1	XP_017953036.2	mam_aldehyde_ox	11..1320	CDD:132014	406/1329 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010