DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5213 and HNRNPA1

DIOPT Version :9

Sequence 1:	NP_650473.1	Gene:	CG5213 / 41892	FlyBaseID:	FBgn0038345	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_112420.1	Gene:	HNRNPA1 / 3178	HGNCID:	5031	Length:	372	Species:	Homo sapiens

Alignment Length:	207	Identity:	49/207 - (23%)
Similarity:	90/207 - (43%)	Gaps:	21/207 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MFQTGRPVDPPPPLPNLRMKTNLILNYLPQDMTESELHRLFSKFGEIRKAKIIRHRRTGISCCYG 85
            |.::..|.:|    ..||   .|.:..|..:.|:..|...|.::|.:....::|...|..|..:|
Human     1 MSKSESPKEP----EQLR---KLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFG 58

  Fly    86 FVDYVSERQAAAAVNG----MDGYETRGKRL--KVAFARPSEYESTSSSLYVGNLPTYMDEKKVR 144
            ||.|.:..:..||:|.    :||.....||.  :....||..: .|...::||.:....:|..:|
Human    59 FVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAH-LTVKKIFVGGIKEDTEEHHLR 122

  Fly   145 ELFATYGNIVDVNLLRHKFNNRSRGVAFLQF---ELVRDAEVAKYGMDRYMIEGASRPLTVKFVE 206
            :.|..||.|..:.::..:.:.:.||.||:.|   :.|....:.||    :.:.|.:..:.....:
Human   123 DYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKY----HTVNGHNCEVRKALSK 183

  Fly   207 REKKGSSSTSSG 218
            :|...:||:..|
Human   184 QEMASASSSQRG 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5213	NP_650473.1	RRM1_Hu_like	41..117	CDD:240821	20/81 (25%)
CG5213	NP_650473.1	RRM	128..202	CDD:214636	17/76 (22%)
HNRNPA1	NP_112420.1	Globular A domain	4..94		24/96 (25%)
		RRM1_hnRNPA1	12..92	CDD:410154	22/82 (27%)
		Globular B domain	95..185		20/94 (21%)
		RRM2_hnRNPA3	105..184	CDD:409996	17/82 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..216		4/14 (29%)
		RNA-binding RGG-box	218..240
		HnRNPA1	307..344	CDD:402981
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..372
		Nuclear targeting sequence (M9)	320..357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920