Protein Alignment obe and SLH1

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: NP_011787.4
• Gene: SLH1 / 853187
• SGDID: S000003503
• Length: 1967
• Species: Saccharomyces cerevisiae
• Alignment Length: 2137
• Identity: 868/2137 - (40%)
• Similarity: 1239/2137 - (57%)
• Gaps: 273/2137 - (12%)

  Fly   120 QTF--DRKKTQIHDCVQAIGDLLED--HERSALKRWRQTHHKVPGVGPLWGAHIHVKCTPSEWMD 180
            |||  ||.|..:.|....:..:.:|  ::|:.|....|..:.       |....      .|:.|
Yeast    25 QTFNLDRSKISLPDFDDELKKVQKDEQNQRTELTVLSQDRND-------WDDIF------EEFKD 76

  Fly   181 ISLLTDLAPDALLKNRTVNKFSMKHTTKAAPVASTSSEAAKLSPELQTLLEISAKLDDEHLIIRV 245
            ||.       |.|:: .::.:..|:      ..:...:..||..|.:|.|..:..|:....::
Yeast    77 ISF-------AQLQS-IIDSYKTKN------AVAVYKKIGKLINEAETTLSSNVLLETVLQMV-- 125

  Fly   246 GDILGSQRSSEVLQNELMEILGFDYFELVEKLLMERDKIARQLDQFATRSRRVMEVKQKRMEAAA 310
                 .:...:.|:.||::.||....:||..||..|                       ||..|.
Yeast   126 -----YKHQKQELEKELLDFLGTGNIDLVSLLLQHR-----------------------RMIVAT 162

  Fly   311 SGGAAERRPTVASAVVVQSAQEKQLSKMQRREEKKLQRIMRSIKDEEAEDDPNCAVAVSVQQLRM 375
                    |...:.:::::|       :....|...|:.:|:...:.|||..|
Yeast   163 --------PIETTILLIKNA-------VNSTPEFLTQQDIRNQVLKSAEDAKN------------ 200

  Fly   376 QHQRKLLEAAQREPLLLSTKAAKAEYKQSSYNQPIHYPYVFDSQLLAKQHAGFIGGSRITLPDNA 440
               |||..|         ||..|             ||:||.........|....|.:.|||...
Yeast   201 ---RKLNPA---------TKIIK-------------YPHVFRKYEAGSTTAMAFAGQKFTLPVGT 240

  Fly   441 QRIDNKQWEEVKIPASEPPPLSVGNKR------VQIEELDDVGRLAFANCKELNRIQSVVFPVAY 499
            .|:.....||:.|||::    ...||.      ::|.:||...:..|. .:.||:|||:|:||||
Yeast   241 TRMSYNTHEEIIIPAAD----QASNKNYLYTKLLKISDLDHFCKTVFP-YETLNQIQSLVYPVAY 300

  Fly   500 HSNENMLVCAPTGAGKTNVAMLSIVHTIRCHLEQGVIN--------RDEFKIVYIAPMKALAAEM 556
            .:|||||:|||||||||::|:|:|::||:   :..|:|        .|:||::|:||:||||||:
Yeast   301 KTNENMLICAPTGAGKTDIALLTIINTIK---QFSVVNGENEIDIQYDDFKVIYVAPLKALAAEI 362

  Fly   557 VDNFSKRLKSLQIAVRELTGDIQLTKAEMAATQILVTTPEKWDVVTRKGSGDVALISLVELLIID 621
            ||.|||:|....|.|||||||:||||||:.|||::|||||||||||||.:||..|:|.|:|||||
Yeast   363 VDKFSKKLAPFNIQVRELTGDMQLTKAEILATQVIVTTPEKWDVVTRKANGDNDLVSKVKLLIID 427

  Fly   622 EVHLLHGERGPVVEALVARTLRLVESSQSMIRIVGLSATLPNYIDVAHFLRVNPMKGLFYFDSRF 686
            ||||||.:||.|:|.|||||||.||||||||||:||||||||::|||.||.||...|:||||..|
Yeast   428 EVHLLHEDRGSVIETLVARTLRQVESSQSMIRIIGLSATLPNFMDVADFLGVNRQIGMFYFDQSF 492

  Fly   687 RPVPLDTNFVGIK-SVKQLQQIADMDQCCYQKCVEMVQEGHQIMVFVHARNATVRTANVIRELAQ 750
            ||.||:...:|.: .....|...::|:..|.|..||:|.|:|:|||||:|..||::|....:||:
Yeast   493 RPKPLEQQLLGCRGKAGSRQSKENIDKVAYDKLSEMIQRGYQVMVFVHSRKETVKSARNFIKLAE 557

  Fly   751 QNNTSALFLPKDSAAHGLATRSIQRSRNKQLVELFSCGLAMHHAGMLRADRQMVEKYFVEGHISV 815
            .|:...||.| |.......:||:.::|:|.:.|:|..|..:|||||.|:||.:.||.|.:|.|.|
Yeast   558 SNHEVDLFAP-DPIEKDKYSRSLVKNRDKDMKEIFQFGFGIHHAGMARSDRNLTEKMFKDGAIKV 621

  Fly   816 LVCTATLAWGVNLPAHAVIIRGTDIYDAKHGSFVDLGILDVLQIFGRAGRPQF-DKSGVGTIITS 879
            |.|||||||||||||..|||:||.:||:|.|.|:||||.||:|||||.|||.| ..:|.|.:.||
Yeast   622 LCCTATLAWGVNLPADCVIIKGTQVYDSKKGGFIDLGISDVIQIFGRGGRPGFGSANGTGILCTS 686

  Fly   880 YDKLNHYLSLLTNQFPIESNFVNCLADNLNAEIGLGTITNVDEAIEWLSYTYLFVRMRINPHVYG 944
            .|:|:||:||:|.|.||||.|.:.|.|||||||.||::||||||||||.|||:|||||.||..||
Yeast   687 NDRLDHYVSLITQQHPIESRFGSKLVDNLNAEISLGSVTNVDEAIEWLGYTYMFVRMRKNPFTYG 751

  Fly   945 IEYSELEKDPTLEARRRALIMSAAMSLDKARMMRFNQRTMDMNITDLGRTASYFYIKYDTVETFN 1009
            |::.|:..||.|..|||.:|:.||..|...:|:.|::.:|.....||||.:|.||:..::||.||
Yeast   752 IDWEEIANDPQLYERRRKMIVVAARRLHALQMIVFDEVSMHFIAKDLGRVSSDFYLLNESVEIFN 816

  Fly  1010 ELMKPFMTQAEILAMISQAQEFQQLKVRDDEMEELDEL--KNAYCKIKPYGGS--ENVHGKVNIL 1070
            ::..|..|:|::|:|||.:.||..:|.|::|.:||..|  ::..|:|    ||  :...||.|:|
Yeast   817 QMCDPRATEADVLSMISMSSEFDGIKFREEESKELKRLSDESVECQI----GSQLDTPQGKANVL 877

  Fly  1071 IQTYLSNGYVKSFSLSSDMSYITTNIGRISRALFSIVLRQNNAVLSGNMLQLCKMFERRQWDFDC 1135
            :|.|:|...:...:||||.:|:..|..||.||||.|.:.:.....|..||.:||..|:|.|.||.
Yeast   878 LQAYISQTRIFDSALSSDSNYVAQNSVRICRALFLIGVNRRWGKFSNVMLNICKSIEKRLWAFDH 942

  Fly  1136 HLKQFPTINAETIDKLERRGLSVYRLRDMEHRELKEWLRSNTYADLVIRSAHELPLLEVEASLQP 1200
            .|.|| .:....|.::.....|:..|.::|..||.|.:.:......:.:.....|.:.:||.:.|
Yeast   943 PLCQF-DLPENIIRRIRDTKPSMEHLLELEADELGELVHNKKAGSRLYKILSRFPKINIEAEIFP 1006

  Fly  1201 ITRTVLRIKVDIWPSFTWNDRVHGKTCQSFWLWIEDPESNYIYHSELFQVTRKLVMSGQSQQLVM 1265
            ||..|:||.:.:.|.|.|:.|:|| ..|.||:::|:.:.:.|.|.|.|.:.|:.:  ....::..
Yeast  1007 ITTNVMRIHIALGPDFVWDSRIHG-DAQFFWVFVEESDKSQILHFEKFILNRRQL--NNQHEMDF 1068

  Fly  1266 TIPLKEPLPPQYYIRVSSDNWLGSTTCIPLSFQHLVLPEHHPPLTELLPLRPLPVSCLKNVVYES 1330
            .|||.:|||||..::|.||.|:|..:...:|||||:.|.:....|:||.|||||.|.|:|.:.||
Yeast  1069 MIPLSDPLPPQVVVKVVSDTWIGCESTHAISFQHLIRPFNETLQTKLLKLRPLPTSALQNPLIES 1133

  Fly  1331 LYKFTHFNPIQTQIFHCLYHTDNNVLLGAPTGSGKTIVAEIAIFRALNQNPKCKVVYIAPLKALV 1395
            :|.|.:|||:||..|:.||:|:.|..:|:|||||||||||:||:.|....|..|:|||||:||||
Yeast  1134 IYPFKYFNPMQTMTFYTLYNTNENAFVGSPTGSGKTIVAELAIWHAFKTFPGKKIVYIAPMKALV 1198

  Fly  1396 KERIADWEQRFQRSSLGLKVVELTGDVTPDIQAIRESQLIVTTPEKWDGISRSWQTREYVQHVSL 1460
            :||:.||.::....: |.||||||||..||.:.:.::.:::|||||:|||||:||||::||.|||
Yeast  1199 RERVDDWRKKITPVT-GDKVVELTGDSLPDPKDVHDATIVITTPEKFDGISRNWQTRKFVQDVSL 1262

  Fly  1461 IVIDEIHLLGEDRGPVIEVIVSRTNFISSHTGRAIRIVGLSTALANAQDLANWLGINKMGLYNFK 1525
            |::||||||..||||::|:||||.|:|||.|.:.:|::|:|||::||.|:|.|||:...|||||.
Yeast  1263 IIMDEIHLLASDRGPILEMIVSRMNYISSQTKQPVRLLGMSTAVSNAYDMAGWLGVKDHGLYNFP 1327

  Fly  1526 PSVRPVPLQVHINGFPGK-HYCPRMATMNRPTFQAIRTYSPCEPTIVFVSSRRQTRLTALDLITF 1589
            .|||||||:::|:|||.. .:||.|.|||:|.|.||:.:||.:|.::||:|||||||||||||..
Yeast  1328 SSVRPVPLKMYIDGFPDNLAFCPLMKTMNKPVFMAIKQHSPDKPALIFVASRRQTRLTALDLIHL 1392

  Fly  1590 VAGESNPKQFLHI-PEDEIELILQNIREQNLKFCLAFGIGLHHAGLQEQDRKCVEELFLNRKIQI 1653
            ...|.||::||:| .|:|::..|..:.:..||..|.||||||||||.::||....:||...||||
Yeast  1393 CGMEDNPRRFLNIDDEEELQYYLSQVTDDTLKLSLQFGIGLHHAGLVQKDRSISHQLFQKNKIQI 1457

  Fly  1654 LVATATLAWGVNLPAHLVVIKGTEYFDGKVKKYVDMPITDVLQMMGRAGRPQFDNEGVAVVLVHD 1718
            |:||:|||||||||||||:||||::||.|::.|.||.:||:||||||||||.:|..|.|:|...:
Yeast  1458 LIATSTLAWGVNLPAHLVIIKGTQFFDAKIEGYRDMDLTDILQMMGRAGRPAYDTTGTAIVYTKE 1522

  Fly  1719 EKKNFYKKFLYDPFPVESSLLGVLPEHINAEIVAGTVQSKQAALDYLTWTYFFRRLLRNPSYYQL 1783
            .||.|||.||...|||||||..||.:|:.|||.:|::.:||.|||:|:||:.|||...||:||.:
Yeast  1523 SKKMFYKHFLNVGFPVESSLHKVLDDHLGAEITSGSITNKQEALDFLSWTFLFRRAHHNPTYYGI 1587

  Fly  1784 Q-DIEPENVNNFMSNLVERVVYELSAAAC-LVERDGCLIPTFLGRISSYYYLSYRTMKHFLEDLQ 1846
            : |.....|:..:|:|::..:..|..:.| |:..|..:...||. ||||||:|:.|::..|:.:.
Yeast  1588 EDDTSTAGVSEHLSSLIDSTLENLRESQCVLLHGDDIVATPFLS-ISSYYYISHLTIRQLLKQIH 1651

  Fly  1847 PGMNTKKVLLAIADSYEFDQLPVRHNEDKHNEEMAEVSRFRPPSS--------SWDSSYTKTFLL 1903
            .....::||..::.:.|:::||||..|...||||::.||:...|:        .|| .:.|||||
Yeast  1652 DHATFQEVLRWLSLAVEYNELPVRGGEIIMNEEMSQQSRYSVESTFTDEFELPMWD-PHVKTFLL 1715

  Fly  1904 LQAHFARQSLPNSDYLTDTKSALDNATRVMQAMVDYTAERGWLSTTLVVQQLMQSVIQARWFDGS 1968
            ||||.:|..||.:||:.||.|.||.:.|::||.:|..:|.|:..|.|.:.::||.:.|..|::..
Yeast  1716 LQAHLSRVDLPIADYIQDTVSVLDQSLRILQAYIDVASELGYFHTVLTMIKMMQCIKQGYWYEDD 1780

  Fly  1969 EFLTLPGVNEDNLDAFLNIPHDDYDY-------LT-------LPVLKELCKQEYEVLAKPLRDAF 2019
            ....|||:....:        .||.:       :|       |..|:|:.:..|    |.|.:.|
Yeast  1781 PVSVLPGLQLRRI--------KDYTFSEQGFIEMTPQQKKKKLLTLEEIGRFGY----KKLLNVF 1833

  Fly  2020 --------EEHEIEKMY-KVIQDLPEIAIQIFVEGRHMENEYAKRPLSLSDDTRGEWMSLHANED 2075
                    |..:.:|.: .|.|.||      .:||...|.:                   ..||
Yeast  1834 DQLTFGMTESEDTKKRFVSVCQRLP------VLEGMKFEEQ-------------------ENNE- 1872

  Fly  2076 YVLIVNLQRLNVSGQRRGGGQSYTVHCPKYPKPKNEAWFLTLGSQANDELLAMKRV--------- 2131
               ::.....::|.:...|   :.|:|.|:||.:.|.||| :|.: .||||.:||.
Yeast  1873 ---VLTFYSKHLSSKHNNG---FEVYCDKFPKIQKELWFL-IGHK-GDELLMIKRCQPKQMNKEV 1929

  Fly  2132 ----------SIRGQRCTNRISFQATPRLGRLQLTLYLMSDCLMGFDQQYDLQFEII 2178
                      .|||:                 :|...|::|.|   ..:||:..::|
Yeast  1930 IIHCDLFIPEEIRGE-----------------ELQFSLINDAL---GLRYDMVHKLI 1966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309	10/36 (28%)
		BRR2	485..1025	CDD:440817	306/549 (56%)
		DEXHc_ASCC3_1	486..683	CDD:350778	134/204 (66%)
		SEC63	985..1298	CDD:214744	108/316 (34%)
		BRR2	1334..1859	CDD:440817	277/528 (52%)
		DEXHc_ASCC3_2	1336..1525	CDD:350780	107/188 (57%)
		SEC63	1818..2176	CDD:214744	110/407 (27%)
SLH1	NP_011787.4	BRR2	283..832	CDD:440817	307/553 (56%)
		DEXHc_ASCC3_1	287..489	CDD:350778	134/204 (66%)
		Sec63	795..1099	CDD:460740	107/311 (34%)
		BRR2	1136..1655	CDD:440817	275/520 (53%)
		DEXHc_ASCC3_2	1139..1327	CDD:350780	107/188 (57%)
		SEC63	1623..1967	CDD:214744	111/412 (27%)