DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment obe and AT5G61140

DIOPT Version :9

Sequence 1:	NP_650472.2	Gene:	obe / 41891	FlyBaseID:	FBgn0038344	Length:	2183	Species:	Drosophila melanogaster
Sequence 2:	NP_001190584.1	Gene:	AT5G61140 / 836235	AraportID:	AT5G61140	Length:	2157	Species:	Arabidopsis thaliana

Alignment Length:	2244	Identity:	975/2244 - (43%)
Similarity:	1389/2244 - (61%)	Gaps:	243/2244 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PRLSASLRAKTEL-EARSRRLNVLRQARTTSAASTTTNSQNKEEQTIARL----LAQMPTEKQPA 64
            |||::|||...:: :|..||..:|:             :.||...:..||    ||:....:...
plant    77 PRLTSSLREPFDIDQAYLRRKTILQ-------------TLNKPRSSGNRLDESDLAKRIVHQWEG 128

  Fly    65 AKVQLQKLRNLVQECMGYEEQPQVVEHAALFLFWLLLDQRV------LLVATTQRLHGMFGQTFD 123
            |.::   :|...::.:|     .|||         |:|:.|      .:..:..||   |....:
plant   129 ASLE---VRQAYKQFIG-----AVVE---------LIDREVPSDEFREVAFSAYRL---FNNPVE 173

  Fly   124 RKKTQIHDCVQAIGDLLE-----DHERS------------ALKRWRQTHH------KVPGVGPLW 165
            ...:.|:|.:...|..||     .|..|            ||...:.||.      :|.| |..:
plant   174 EDDSDINDNISISGKKLELQNLVGHAVSDANVKNVASFAQALYSIQPTHQSETYADEVNG-GAEF 237

  Fly   166 GAHIHVKCTPSEW-----MDISLLTDL-APDA-------------LLKNRTVNKFSMKHTTKAAP 211
            ||.: |...|:.:     :|.:...|: :.||             ...|.:..||::.....|..
plant   238 GADL-VFNLPARFLVEASLDETGFVDVESNDAHTSFSEGWSGVSDTKNNLSAGKFNLSWLRDACG 301

  Fly   212 VASTSSEAAKLSPELQTLLEISAKLDDEHLIIRVGDILGSQRSSEVLQNELMEILGFDYFELVEK 276
                           :.:.|.:::|..|.|.:.:...|.|.:..|.:..:|::::|...||.|:.
plant   302 ---------------RMVRETNSQLSREELAMAICRFLDSDKPGEEIAGDLLDLVGDGAFETVQD 351

  Fly   277 LLMERDKIARQL--DQFATRSRRVMEVKQKRMEAAASGGAAERRPTVASAVVVQSAQEKQLSKMQ 339
            |:|.|.:|...:  .|...:|.:.....|.||            ||..:.|.||:...||:.|::
plant   352 LIMHRKEIVDAIHHGQMILKSDKAASNTQSRM------------PTYGTQVTVQTESAKQIEKLR 404

  Fly   340 RREEKKLQRIMRSIKDEEAEDDPNCAVAVSVQQLRMQHQRKLLEAAQREPLLLSTKAAKAEYKQS 404
            |:||||.:|              |..:.:. .::...:...||||::               |::
plant   405 RKEEKKNKR--------------NADLGLE-SEISEANFSSLLEASE---------------KKT 439

  Fly   405 SYNQPIHYPYVFDSQLLAKQHAGFIGGSRITLPDNAQRIDNKQWEEVKIPASEPPPLSVGNKRVQ 469
            ::...|              .:|......:.||....|...|.:|||.||.:....:..|.|.::
plant   440 AFEDLI--------------GSGEANSLALALPQGTVRKHLKGYEEVFIPPTPTAQMKPGEKLIE 490

  Fly   470 IEELDDVGRLAFANCKELNRIQSVVFPVAYHSNENMLVCAPTGAGKTNVAMLSIVHTIRCHLEQG 534
            |:||||..:.||...|.||||||.:|...||:|||:||||||||||||:||:|::|.|:.|...|
plant   491 IKELDDFAQAAFHGYKSLNRIQSRIFQTVYHTNENILVCAPTGAGKTNIAMISVLHEIKQHFRDG 555

  Fly   535 VINRDEFKIVYIAPMKALAAEMVDNFSKRLKSLQIAVRELTGDIQLTKAEMAATQILVTTPEKWD 599
            .::::||||||:|||||||||:...||:||..|.:.|:|||||:||||.|:..||::||||||||
plant   556 YLHKNEFKIVYVAPMKALAAEVTSAFSRRLAPLNMVVKELTGDMQLTKTELEETQMIVTTPEKWD 620

  Fly   600 VVTRKGSGDVALISLVELLIIDEVHLLHGERGPVVEALVARTLRLVESSQSMIRIVGLSATLPNY 664
            |:||| |.|:::..||:||||||||||:.:||.|:|||||||||.|||:|:||||||||||||:|
plant   621 VITRK-SSDMSMSMLVKLLIIDEVHLLNDDRGAVIEALVARTLRQVESTQTMIRIVGLSATLPSY 684

  Fly   665 IDVAHFLRVNPMKGLFYFDSRFRPVPLDTNFVGIKSVKQLQQIADMDQCCYQKCVEMVQEGHQIM 729
            :.||.|||||...|||||||.:|||||...::||.......:...:::.||:|.|:.:::|||.|
plant   685 LQVAQFLRVNTDTGLFYFDSSYRPVPLAQQYIGITEHNFAARNELLNEICYKKVVDSIKQGHQAM 749

  Fly   730 VFVHARNATVRTANVIRELAQQNNTSALFLPKDSAAHGLATRSIQRSRNKQLVELFSCGLAMHHA 794
            :|||:|..|.:||..:.:||:|..|..||..:......|..:.:.:||||.||:.|..|..:|||
plant   750 IFVHSRKDTSKTAEKLVDLARQYETLDLFTNETHPQFQLMKKDVMKSRNKDLVKFFEAGFGIHHA 814

  Fly   795 GMLRADRQMVEKYFVEGHISVLVCTATLAWGVNLPAHAVIIRGTDIYDAKHGSFVDLGILDVLQI 859
            ||||:||.:.|:.|.:|.:.|||||||||||||||||.|:|:||.:||||.|.:.|||:|||:||
plant   815 GMLRSDRTLTERLFSDGLLKVLVCTATLAWGVNLPAHTVVIKGTQLYDAKAGGWKDLGMLDVMQI 879

  Fly   860 FGRAGRPQFDKSGVGTIITSYDKLNHYLSLLTNQFPIESNFVNCLADNLNAEIGLGTITNVDEAI 924
            |||||||||||||.|.||||:|||.:||.|||:|.||||.|::.|.||||||:.|||:|||.||.
plant   880 FGRAGRPQFDKSGEGIIITSHDKLAYYLRLLTSQLPIESQFISSLKDNLNAEVVLGTVTNVKEAC 944

  Fly   925 EWLSYTYLFVRMRINPHVYGIEYSELEKDPTLEARRRALIMSAAMSLDKARMMRFNQRTMDMNIT 989
            .||.||||.:||::||..|||.:.|:..||:|..::|||:..||.|||||:||||::::.:...|
plant   945 AWLGYTYLSIRMKLNPLAYGIGWEEIIADPSLSLKQRALVADAARSLDKAKMMRFDEKSGNFYCT 1009

  Fly   990 DLGRTASYFYIKYDTVETFNELMKPFMTQAEILAMISQAQEFQQLKVRDDEMEELDELKNAYCKI 1054
            :|||.||:|||:|.:|||:||::|..|.::||:.|::.:.||:.:.||::|..||:.|..:.|.:
plant  1010 ELGRVASHFYIQYSSVETYNEMLKRHMNESEIINMVAHSSEFENIVVREEEQHELETLARSCCPL 1074

  Fly  1055 KPYGGSENVHGKVNILIQTYLSNGYVKSFSLSSDMSYITTNIGRISRALFSIVLRQNNAVLSGNM 1119
            :..||..|.|||::||||.|:|.|.:.:|||.||.|||:.::.||.||||.|.||:....::..|
plant  1075 EVKGGPSNKHGKISILIQLYISRGSIDAFSLVSDASYISASLARIMRALFEICLRKGWCEMTLFM 1139

  Fly  1120 LQLCKMFERRQWDFDCHLKQFP-TINAETIDKLERRGLSVYRLRDMEHRELKEWLRSNTYADLVI 1183
            |:.||..:|:.|.....|:||. .:.::.:.|||.|...:..|.:||.:|:...:|.|....||.
plant  1140 LEYCKAVDRQLWPHQHPLRQFERDLPSDILRKLEERRDDLDHLYEMEEKEIGALIRYNPGGRLVK 1204

  Fly  1184 RSAHELPLLEVEASLQPITRTVLRIKVDIWPSFTWNDRVHGKTCQSFWLWIEDPESNYIYHSELF 1248
            :.....|.:::.|::.|||||||::.:.|.|:|.|.||.|| |...:|:.|||.|::|||||:||
plant  1205 QHLGYFPSIQLAATVSPITRTVLKVDLLITPNFIWKDRFHG-TALRWWILIEDTENDYIYHSDLF 1268

  Fly  1249 QVTRKLVMSGQSQQLVMTIPLKEPLPPQYYIRVSSDNWLGSTTCIPLSFQHLVLPEHHPPLTELL 1313
            .:|:::. .|:.|:|..|:|:.||.|||||:...||:||.:.|...:||.:|.|||.....||||
plant  1269 TLTKRMA-RGEPQKLSFTVPIFEPHPPQYYVHAVSDSWLHAETYFTISFHNLALPEARTSHTELL 1332

  Fly  1314 PLRPLPVSCLKNVVYESLYKFTHFNPIQTQIFHCLYHTDNNVLLGAPTGSGKTIVAEIAIFRALN 1378
            .|:||||:.|.|.:|||||||:|||||||||||.|||||||||:||||||||||.||:|:.|..:
plant  1333 DLKPLPVTSLGNKLYESLYKFSHFNPIQTQIFHVLYHTDNNVLVGAPTGSGKTISAELAMLRLFS 1397

  Fly  1379 QNPKCKVVYIAPLKALVKERIADWEQRFQRSSLGLKVVELTGDVTPDIQAIRESQLIVTTPEKWD 1443
            ..|..||||||||||:|:||:.||::... :.||.::||:|||.|||:.|:..:.:|::||||||
plant  1398 TQPDMKVVYIAPLKAIVRERMNDWKKHLV-APLGKEMVEMTGDYTPDLVALLSADIIISTPEKWD 1461

  Fly  1444 GISRSWQTREYVQHVSLIVIDEIHLLGEDRGPVIEVIVSRTNFISSHTGRAIRIVGLSTALANAQ 1508
            ||||:|.||.||:.|.|:::|||||||.||||::||||||..:|||.|.|::|.||||||||||.
plant  1462 GISRNWHTRSYVKKVGLVILDEIHLLGADRGPILEVIVSRMRYISSQTERSVRFVGLSTALANAG 1526

  Fly  1509 DLANWLGINKMGLYNFKPSVRPVPLQVHINGFPGKHYCPRMATMNRPTFQAIRTYSPCEPTIVFV 1573
            |||:|||:.::||:||||||||||::|||.|:|||:|||||.:||:|.:.||.|:||.:|.::||
plant  1527 DLADWLGVGEIGLFNFKPSVRPVPIEVHIQGYPGKYYCPRMNSMNKPAYAAICTHSPTKPVLIFV 1591

  Fly  1574 SSRRQTRLTALDLITFVAGESNPKQFLHIPEDEIELILQNIREQNLKFCLAFGIGLHHAGLQEQD 1638
            ||||||||||||||.|.|.:.:|:|||.:.|::::::|..|.:|||:..|.||||||||||.:.|
plant  1592 SSRRQTRLTALDLIQFAASDEHPRQFLSVSEEDLQMVLSQITDQNLRHTLQFGIGLHHAGLNDHD 1656

  Fly  1639 RKCVEELFLNRKIQILVATATLAWGVNLPAHLVVIKGTEYFDGKVKKYVDMPITDVLQMMGRAGR 1703
            |..|||||.|.|||:||:|:|||||||||||||:||||||||||.|:|||.|:|::|||||||||
plant  1657 RSAVEELFTNNKIQVLVSTSTLAWGVNLPAHLVIIKGTEYFDGKTKRYVDFPLTEILQMMGRAGR 1721

  Fly  1704 PQFDNEGVAVVLVHDEKKNFYKKFLYDPFPVESSLLGVLPEHINAEIVAGTVQSKQAALDYLTWT 1768
            ||||..|.||:|||:.||:|||||||:||||||||...|.:|.|||||:||:.:|:.|:.|||||
plant  1722 PQFDQHGKAVILVHEPKKSFYKKFLYEPFPVESSLKEKLHDHFNAEIVSGTIGNKEDAVHYLTWT 1786

  Fly  1769 YFFRRLLRNPSYYQLQDIEPENVNNFMSNLVERVVYELSAAACLVERDGCLIPTFLGRISSYYYL 1833
            |.||||:.||:||.|:..:.|.:.:::|.||:....:|..:.||...:..:.||.||.|:|.|||
plant  1787 YLFRRLMANPAYYGLEGTQDETICSYLSRLVQTTFEDLEDSGCLKVNEDSVEPTMLGTIASQYYL 1851

  Fly  1834 SYRTMKHFLEDLQPGMNTKKVLLAIADSYEFDQLPVRHNEDKHNEEMAEVSRFRPPSSSWDSSYT 1898
            .|.|:..|..::.|..:.:..|..:|.:.|:|:|||||||:.:|:.:::..|:...::..|..:.
plant  1852 CYMTVSMFGSNIGPDTSLEAFLHILAGASEYDELPVRHNEENYNKTLSDRVRYPVDNNHLDDPHV 1916

  Fly  1899 KTFLLLQAHFARQSLPNSDYLTDTKSALDNATRVMQAMVDYTAERGWLSTTLVVQQLMQSVIQAR 1963
            |..||.||||::.:||.|||.||.||.||.:.|::|||:|..|..||||::|...:|:|.|:|..
plant  1917 KANLLFQAHFSQLALPISDYNTDLKSVLDQSIRILQAMIDICANSGWLSSSLTCMRLLQMVMQGM 1981

  Fly  1964 WFD-GSEFLTLPGVNE-----------DNLDAFLNIPHDDYDYLTLPVLKELCKQEYEVLAKPLR 2016
            |.| .|....:|.:|:           ..|...||:|.:                       .|:
plant  1982 WSDQDSSLWMIPCMNDLLLGSLTARGIHTLHQLLNLPRE-----------------------TLQ 2023

  Fly  2017 DAFEEHEIEKMYKVIQDLPEIAIQIFVEGRHMENEYAKRPLSLSDDTRGEWMSLHANEDYVLIVN 2081
            ...|.....::.:.:|..|.|.:.:.::.:  :::..|:|.:|.                   :.
plant  2024 SVTENFPASRLSQDLQRFPRIQMNVRLQKK--DSDGKKKPSTLE-------------------IR 2067

  Fly  2082 LQRLNVSGQRRGGGQSYTVHCPKYPKPKNEAWFLTLGSQANDELLAMKRVSIRGQRCT------N 2140
            |::.:    :|...::.   .|::||.|:|||:|.||..:..||.|:||||..|:..|      |
plant  2068 LEKTS----KRNSSRAL---APRFPKVKDEAWWLVLGDTSTSELFAVKRVSFTGRLITRMELPPN 2125

  Fly  2141 RISFQATPRLGRLQLTLYLMSDCLMGFDQQYDLQ 2174
            ..|||.|        .|.|:|||.:||:|::.::
plant  2126 ITSFQDT--------KLILVSDCYLGFEQEHSIE 2151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	BRR2	450..1254	CDD:224125	419/804 (52%)
		DEAD	488..666	CDD:278688	118/177 (67%)
		HELICc	790..866	CDD:197757	51/75 (68%)
		Sec63	989..1296	CDD:280962	128/307 (42%)
		DEXDc	1332..1532	CDD:214692	131/199 (66%)
		DEAD	1338..1510	CDD:278688	110/171 (64%)
		HELICc	1605..1704	CDD:197757	67/98 (68%)
		SEC63	1818..2176	CDD:214744	111/375 (30%)
AT5G61140	NP_001190584.1	BRR2	478..1273	CDD:224125	415/796 (52%)
		DEXHc_ASCC3_2	1355..1543	CDD:350780	121/188 (64%)
		BRR2	1356..2006	CDD:224125	366/650 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	236	1.000	Domainoid score	I619
eggNOG	1	0.900	-	-		E1_COG1204
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4973
Inparanoid	1	1.050	1663	1.000	Inparanoid score	I6
OMA	1	1.010	-	-		QHG54133
OrthoDB	1	1.010	-	-		D154891at2759
OrthoFinder	1	1.000	-	-		FOG0001085
OrthoInspector	1	1.000	-	-		oto3432
orthoMCL	1	0.900	-	-		OOG6_100305
Panther	1	1.100	-	-	LDO	PTHR24075
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3726
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840