DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment obe and Hfm1

DIOPT Version :9

Sequence 1:	NP_650472.2	Gene:	obe / 41891	FlyBaseID:	FBgn0038344	Length:	2183	Species:	Drosophila melanogaster
Sequence 2:	XP_017454874.1	Gene:	Hfm1 / 690161	RGDID:	1584010	Length:	1475	Species:	Rattus norvegicus

Alignment Length:	845	Identity:	265/845 - (31%)
Similarity:	418/845 - (49%)	Gaps:	131/845 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1328 YESLYK-FTHFNPIQTQIFHCLYHTDNNVLLGAPTGSGKTIVAEIAIFRALNQNP----KCKVVY 1387
            :.|::| |.:||.||::.|..|.:||.|.::.||||||||:|.|:||.|.|.:.|    ..||||
  Rat   270 FRSVFKEFPYFNYIQSKAFDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEAPLPWLNMKVVY 334

  Fly  1388 IAPLKALVKERIADWEQRFQRSSLGLKVVELTGD-VTPDIQAIRESQLIVTTPEKWDGISRSWQT 1451
            :||:|||..:|..||:::|  ..:||...||||| |..|:..|:.:.:|:|||||||.::|.|:.
  Rat   335 MAPIKALCSQRFDDWKEKF--GPIGLTCKELTGDTVMDDLFEIQHANIIMTTPEKWDSMTRKWRD 397

  Fly  1452 REYVQHVSLIVIDEIHLL-GEDRGPVIEVIVSRTNFISS-------HTGRAIRIVGLSTALANAQ 1508
            ..::|.|.|.:|||:|:: .|:|||.:||:|||...:.|       .:...:|.|.:|..:.||:
  Rat   398 NSFIQLVRLFLIDEVHVIKDENRGPTLEVVVSRMKTVQSLSKTLENASPAPVRFVAVSATIPNAE 462

  Fly  1509 DLANWLGINKMGLYNFKPSV--------RPVPLQVHINGFPGKHYCPRM---ATMNRPTFQAIRT 1562
            |:|.||...:      :|:|        |||.||..:.|||........   ..:|...:..|||
  Rat   463 DIAEWLSDGE------RPAVCLKMDESHRPVKLQKVVLGFPSSSNQTEFKFDLALNYKVYSVIRT 521

  Fly  1563 YSPCEPTIVFVSSRRQTRLTALDLITFVAGESNPKQFLHIPEDEIEL--ILQNIREQNLKFCLAF 1625
            ||..:||:||.::|:..:..|..|:       ...:|:...|.::.|  ...:||:..||..|.:
  Rat   522 YSDQKPTLVFCATRKGVQQAASVLV-------KDAKFIITVEQKLRLQKSAYSIRDSKLKDTLVY 579

  Fly  1626 GIGLHHAGLQEQDRKCVEELFLNRKIQILVATATLAWGVNLPAHLVVIKGT-EYFDGKVKKYVDM 1689
            |:|.||||::..|||.|||||.:..:.:|..|:|||.||||||||||||.| .|..|..::|.:
  Rat   580 GVGYHHAGMELSDRKLVEELFTSGDLPVLFTTSTLAMGVNLPAHLVVIKSTMHYTGGAFEEYSE- 643

  Fly  1690 PITDVLQMMGRAGRPQFDNEGVAVVLVHDEKKNFYKKFLYDPFPVESSLLGVLPEHINAEIVAGT 1754
              ||:|||:|||||||||....||::.....:..|.:.|.....|||||...|.||:|||||..|
  Rat   644 --TDILQMIGRAGRPQFDTTATAVIMTRLSTREKYVQMLACNDTVESSLHRHLIEHLNAEIVLHT 706

  Fly  1755 VQSKQAALDYLTWTYFFRRLLRNPSYYQ-LQDIEPENVNNFMSNLVERVVYELSAAACL-VERDG 1817
            :.....|||::..|..:.|.|:|||:|. :..:..:.:...:..|..:.:.:||:...: ::.|.
  Rat   707 ITDVSIALDWIRSTLLYIRALKNPSHYGFISGLNKDGIEAKLQELCLKNLKDLSSLDLIKMDEDL 771

  Fly  1818 CLIPTFLGRISSYYYLSYRTMKHF--------LEDLQPGMNTKKVLLAIADSYEFDQLPVRHNED 1874
            ....|..||:.::||:::.|:|.|        |.||         :..|:...||..:.:|.:|.
  Rat   772 NFRSTEAGRLMAWYYITFETVKKFCAISGKETLSDL---------ISMISSCSEFLDVQLRISEK 827

  Fly  1875 KH----NEEMAEVSRFRPPSSSWDSSYTKTFLLLQAHFARQSLPNSDY-LT-DTKSALDNATRVM 1933
            :.    |::...::...|......:...|...|:||...  .:|..|: || ||.....|.:|:.
  Rat   828 RTLNTLNKDPNRITIRFPMEGRIKTREMKVNCLIQAQLG--CIPIQDFALTQDTSKIFRNGSRIA 890

  Fly  1934 QAMVDYTAERGWLSTTLVVQQ-----LMQSVIQARWF-----DGSEFLTLP----GVNEDN---- 1980
            :          |||..:..|:     |:.|||.|:.|     :.|:.::..    |::..|
  Rat   891 K----------WLSDFVTAQEQKFAVLLNSVILAKCFKCKLWENSQHVSKQLDKIGISLSNTMVN 945

  Fly  1981 --LDAFLNIPHDDYDYLTLPVLKELCKQEYEVLAKPLRDAF-----EEHEIEKMYKVIQDLPEIA 2038
              |.:|..|...:...|      ||....:......:::|.     .|.|.|::.:......||.
  Rat   946 AGLTSFKKIEEANAREL------ELILNRHPPFGTQIKEAVMYLPKYELEAEQIARYSDTKAEIL 1004

  Fly  2039 IQIFVEGRHMENEYAKRPLS-------LSDDTRGEWMSLHANEDYVLI--------VNLQRLNVS 2088
            :.|.:  |:.|....||...       :..|...:.:..|...|.||:        ::::|..:|
  Rat  1005 VTIIL--RNFEQLQTKRTAPDFHYATLIIGDADNQVVCKHKIMDSVLLKSGNWVKKIDVKRALIS 1067

Fly 2089 2088
Rat 1068 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	BRR2	450..1254	CDD:224125
		DEAD	488..666	CDD:278688
		HELICc	790..866	CDD:197757
		Sec63	989..1296	CDD:280962
		DEXDc	1332..1532	CDD:214692	89/221 (40%)
		DEAD	1338..1510	CDD:278688	78/184 (42%)
		HELICc	1605..1704	CDD:197757	50/101 (50%)
		SEC63	1818..2176	CDD:214744	67/325 (21%)
Hfm1	XP_017454874.1	DEAD	283..464	CDD:278688	77/182 (42%)
		HELICc	501..667	CDD:238034	72/175 (41%)
		Sec63	775..1088	CDD:280962	67/322 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D154891at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820