DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment obe and hfm1

DIOPT Version :9

Sequence 1:	NP_650472.2	Gene:	obe / 41891	FlyBaseID:	FBgn0038344	Length:	2183	Species:	Drosophila melanogaster
Sequence 2:	XP_021322847.1	Gene:	hfm1 / 557052	ZFINID:	ZDB-GENE-061207-43	Length:	1461	Species:	Danio rerio

Alignment Length:	1119	Identity:	293/1119 - (26%)
Similarity:	478/1119 - (42%)	Gaps:	242/1119 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1190 PLLEVEASLQPITRTVLRIKVDIWPSFTWNDR------------------VHGKTCQSF-----W 1231
            |.|....|.|.|.|......     ||:::.|                  :.|:|.||.     .
Zfish    40 PSLSQIPSTQDIQREAAHAS-----SFSFSQRSKTFLPPAQKPIHNPTEGIQGQTVQSHELEEPG 99

  Fly  1232 LWIEDPESN---------------------YIYHSELFQV-TRKLVMSGQ---SQQLVMT----- 1266
            ||..:|.|.                     ..:.:.|||. ||:...:|:   |.|.:.|
Zfish   100 LWSHEPSSTGEQAVFRMGFAETRPLPTASAPPFKTRLFQASTRRTSGNGEDGISNQTLSTTNDTA 164

  Fly  1267 ----IPLKEPLPPQYYIRVSSDNWLG----STTC-IPLSFQ-HLVL-PEHHPPLTELLPLRPLPV 1320
                .|.:...|...:...:...::|    ...| :|.|.. ||.| |......:|...||.:..
Zfish   165 FQSQAPRRTSGPQAAHAVAACSPFIGLAQTEEKCDVPSSHSLHLGLKPAEFKGSSEKGTLRSVSE 229

  Fly  1321 SCLKNVVYESLYK-FTHFNPIQTQIFHCLYHTDNNVLLGAPTGSGKTIVAEIAIFRALNQNPK-- 1382
            ...|   :.|::| |.:||.:|:|....:.:::.|.:..||||||||::.|:||.|.|.:..:
Zfish   230 IPAK---FRSVFKDFPYFNYVQSQALDDVLYSNKNFVACAPTGSGKTVLFELAIVRLLIEASEPW 291

  Fly  1383 --CKVVYIAPLKALVKERIADWEQRFQRSSLGLKVVELTGDV-TPDIQAIRESQLIVTTPEKWDG 1444
              .:.||:||:|||..::..:|:|:|  ..||||..|||||. ..|...|:::.||.||.||||.
Zfish   292 HNVRAVYMAPIKALCSQQYDNWKQKF--GPLGLKCKELTGDTEIDDFFEIQDAHLIFTTAEKWDS 354

  Fly  1445 ISRSWQTREYVQHVSLIVIDEIHLL-GEDRGPVIEVIVSR-------TNFISSHTGRAIRIVGLS 1501
            ::|.|:....:..:.|.::||:|:: .:.||..:||:|||       ...|:..:..::|.|.:|
Zfish   355 MTRRWKDNCLLTSIRLFLVDEVHVVKDKTRGATLEVVVSRMKTMHFYRQAINPESKASVRFVAVS 419

  Fly  1502 TALANAQDLANWLGINKMG---LYNFKPSVRPVPLQVHINGFP---GKHYCPRMATMNRPTFQAI 1560
            ..:.|.||::.||. ::.|   ......|.|||.|:..:.|||   .::......::|......|
Zfish   420 ATIPNIQDVSEWLS-DESGPATCLEMDESHRPVKLRKVVLGFPCGSNQNEFKFDLSLNYKLANII 483

  Fly  1561 RTYSPCEPTIVFVSSRRQTRLTALDLITFVAGESNPKQFLHIPEDEIELI--LQNIREQNLKFCL 1623
            :|||..:||:||.|:|:..:.:|..|       :...:|:...:.:..|:  ..::.:..|:...
Zfish   484 QTYSDQKPTLVFCSTRKGVQQSASVL-------AKDARFIMSIDHKQRLVKYANSLLDAKLRDLF 541

  Fly  1624 AFGIGLHHAGLQEQDRKCVEELFLNRKIQILVATATLAWGVNLPAHLVVIKGT-EYFDGKVKKYV 1687
            .:|||.||||:...|||..|..|....:.:|..|:|||.|||:||||||||.| .|..|..::|.
Zfish   542 VYGIGYHHAGMDVSDRKITENAFTVGDLPVLFTTSTLAMGVNMPAHLVVIKSTMHYVGGACEEYS 606

  Fly  1688 DMPITDVLQMMGRAGRPQFDNEGVAVVLVHDEKKNFYKKFLYDPFPVESSLLGVLPEHINAEIVA 1752
            :   .|:|||:|||||||||....||::...:.|:.|..||.....:||||...|.||:|||||.
Zfish   607 E---ADLLQMIGRAGRPQFDTTATAVIMTRPQTKDKYMHFLSGLDCIESSLHTNLVEHLNAEIVL 668

  Fly  1753 GTVQSKQAALDYLTWTYFFRRLLRNPSYY-------------QLQDIEPENVNNFMS-NLVERVV 1803
            .|:.....|||::..|:.:.|.|:||.:|             :||::..:|:|:..| ||:
Zfish   669 HTISDVNMALDWIRSTFLYIRALKNPKHYGFPPEVDKCGIETKLQELCLKNLNSLASFNLI---- 729

  Fly  1804 YELSAAACLVERDGCLIPTFLGRISSYYYLSYRTMKHFLEDLQPGMNTKKVLL-AIADSYEFDQL 1867
                    .::.|..:.||..|::.:.|.:::.|:|.|  .:..|..|...|: .|:.:.||..:
Zfish   730 --------TMDEDINIKPTETGKLMARYCVAFDTVKQF--SMVTGTETLPELIEMISKAKEFSDM 784

  Fly  1868 PVRHNEDK-----HNEEMAEVSRFRPPSSSWDSSYTKTFLLLQAHFARQSLPNSDYLTDTKSALD 1927
            .:|.||.|     :.::.....|| |......|:..|...|:||......:.....:.||.....
Zfish   785 QLRVNERKTLNTLNKDKNRTTIRF-PIEGKIKSNDMKVNCLIQAQLGCIPIQEFGLIQDTGKIFR 848

  Fly  1928 NATRVMQAMVDYTAERGWLSTTLVVQQLMQSVIQARWFDGSEFLTLPGVNEDNLDAFLNIPHDDY 1992
            ||.||.:.:.::.....  .:....|  :.::|.|:.|....:...|.::
Zfish   849 NAVRVSRYLTEFLCHHS--KSNFAAQ--LNALILAKCFRAKLWENSPYIS--------------- 894

  Fly  1993 DYLTLPVLKELCKQEYEVLAKPLRDAFEEHEIEKMYKVIQDLPEIAIQIFVEGRHMENEYAKRPL 2057
                         ::.|.:...|..|.....:....|:.|..|. .:::.| .||..
Zfish   895 -------------KQLERIGLSLATALVNAGLTTFSKIEQTSPR-ELELIV-NRHPP-------- 936

  Fly  2058 SLSDDTRGEWMSLHANEDYVLIVNLQRLNVSGQRRGGGQSYTVHCPKYPKPKNEAWFLTLGSQAN 2122
                         ..|:....|..|.|..||.::          .|:|.....|..|..  :..|
Zfish   937 -------------FGNQIKEAISKLPRCEVSLEQ----------IPRYSPSTAEIVFTV--NMNN 976

  Fly  2123 DELLAMKRVS--------IRGQRCTNRISFQ---------------------ATPRLGRLQLTLY 2158
            .:.||:||.:        |.|. |.|::.||                     .:|: |. :|:::
Zfish   977 FKELALKRTAPDHHYVTLIVGD-CDNKVVFQQKISDTLLLKSGSWSKRIEVTRSPK-GE-ELSIH 1038

  Fly  2159 LMSDCLMGFDQQYD 2172
            |:|...:|.|.|.|
Zfish  1039 LISSEYVGLDIQQD 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	BRR2	450..1254	CDD:224125	22/108 (20%)
		DEAD	488..666	CDD:278688
		HELICc	790..866	CDD:197757
		Sec63	989..1296	CDD:280962	31/167 (19%)
		DEXDc	1332..1532	CDD:214692	75/216 (35%)
		DEAD	1338..1510	CDD:278688	65/184 (35%)
		HELICc	1605..1704	CDD:197757	42/101 (42%)
		SEC63	1818..2176	CDD:214744	75/390 (19%)
hfm1	XP_021322847.1	CiPC	<36..>205	CDD:318094	32/169 (19%)
hfm1	XP_021322847.1	BRR2	226..967	CDD:333051	232/836 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D154891at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920