DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment obe and tst

DIOPT Version :9

Sequence 1:	NP_650472.2	Gene:	obe / 41891	FlyBaseID:	FBgn0038344	Length:	2183	Species:	Drosophila melanogaster
Sequence 2:	NP_001262884.1	Gene:	tst / 42813	FlyBaseID:	FBgn0039117	Length:	1197	Species:	Drosophila melanogaster

Alignment Length:	960	Identity:	204/960 - (21%)
Similarity:	348/960 - (36%)	Gaps:	292/960 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1355 VLLGAPTGSGKTIVAEIAIFRALNQNPKCKVVYIAPLKALVKERIADWEQRFQRSSLGLKVVELT 1419
            |.:.|.|.:|||:|||.||  ||::....:.:|.:|:|||..::..|:.:.|:  .:||    :|
  Fly   280 VFVAAHTSAGKTVVAEYAI--ALSKRDLTRTIYTSPIKALSNQKYRDFRKTFK--DVGL----IT 336

  Fly  1420 GDVTPDIQAIRESQLIVTTPEKWDGISRS--WQTREYVQHVSLIVIDEIHLLGE-DRGPVIEVIV 1481
            ||:..:..|   |.||:||.     |.||  :...:..:.:..::.||:|.:.. :||.|.|.::
  Fly   337 GDLQIEPTA---SCLIMTTE-----ILRSMLYCGSDVTRDLEWVIFDEVHYINNPERGHVWEEVI 393

  Fly  1482 SRTNFISSHTGRAIRIVGLSTALANAQDLANWLG-INKMGLYNFKPSVRPVPLQVHI-------- 1537
            .   .:..|    :.|:.||..:.|..:||:|:| ..|..:|......||||| .|.
  Fly   394 I---LLPEH----VNIIMLSATVPNTLELADWVGSTKKRKVYVISTLKRPVPL-THFLYTGAGGK 450

  Fly  1538 -------------------------------------NGFPGKHYCPRMATMNRPTFQAIRTY-- 1563
                                                 .|.|..|.   .|...:.|:..:..:
  Fly   451 SRDDIFLLVDAQGKYLQGNYEKAVERKKEMQGKAKGGGGGPRNHL---NAKQEQYTWIGLIDFLR 512

  Fly  1564 -SPCEPTIVFVSSRRQ-----TRLTALDLITFVAGESNPKQFLHI------PEDEIELILQNIRE 1616
             |...|.:.|..||.:     ..|.::||.|.....:..|.||..      |:..|..:|.
  Fly   513 RSNMMPVVAFTLSRNRCDSNLAALQSVDLNTEKEKGAVQKFFLQCLAKLKPPDRTIPQVLV---- 573

  Fly  1617 QNLKFCLAFGIGLHHAGLQEQDRKCVEELFLNRKIQILVATATLAWGVNLPAHLVVIKGTEYFDG 1681
              ||..|..|||:||:|:....::.||.||.|..:::|.||.|.|.|||:||..||....:.|||
  Fly   574 --LKDALERGIGVHHSGILPILKEIVEMLFQNGLVKLLFATETFAMGVNMPARTVVFDSCKKFDG 636

  Fly  1682 KVKKYVDMPITDVLQMMGRAGRPQFDNEGVAVVLVHDEKKNFYKKFLYDPFPVESSLLGVLPEHI 1746
            ...:  ::...:.:||.|||||...|..|.|:::.        |..:.....:...:|| |||.:
  Fly   637 LEMR--NLKPGEYIQMAGRAGRRGHDETGTAIIMC--------KGSVPPSMELRPMILG-LPEKL 690

  Fly  1747 NAEIVAGTVQSKQAALDYLTWTYFFRRLLRNPSYYQLQDIEPENVNNFM---SNLVERVVYELSA 1808
            .::.:             |.:......|       :::.|:.|::..|.   .||..::..:...
  Fly   691 QSQFI-------------LRYAVILTCL-------RIESIKVEDIMKFSFKEFNLKLQLPTQQKQ 735

  Fly  1809 AACLVERDGCLIPT----------FLGRISSYYYLSYRTMKHFL------EDLQPG--------- 1848
            .. |.|....::||          |..:...|:...:|.||..:      ::|:.|
  Fly   736 LR-LAEDKFAMLPTLGEHLQPLVNFYDKAVEYWKEKHRIMKFVVTQPKIQKELKAGRVIVITQGK 799

  Fly  1849 --------MNTK---------KVLL---------------------------------------- 1856
                    :|||         |||:
  Fly   800 HYNKLAILLNTKSVPGKDTIYKVLVLDHQFKAKDSNSLQQGELYYKILSLTPRNMTFQPVGIGGH 864

  Fly  1857 AIADSYEFDQLPVRHNEDK-------HNEEMAEVSRFR--PPSSSWDSSYTKTFLLLQAHFARQS 1912
            .:.|....|.:.:..:..|       .|.|..::.||:  |||.|...:.|:...|.:::.  .:
  Fly   865 TVLDIKAIDIISITKSTLKVDADAIIRNWEQRQLERFKDSPPSGSVVKAVTELNQLNESYI--DN 927

  Fly  1913 LPNSDYLTDTKSALDNATRVMQAMVDYTAERGWLSTTLVVQQLMQSVIQARWFDGSEFLTLPGVN 1977
            ..|..|:..:|..:.||...: ||::|            |..|::.|        .|||
  Fly   928 PDNIKYVNLSKEIIVNADSEV-AMLNY------------VDHLLRKV--------GEFL------ 965

  Fly  1978 EDNLDAFLNIPHDDYDYLTLPVLKELCKQEYEVLAKPLR------------DAFEEHEIEKMYKV 2030
                      ||.:.........|...::..|:..:.||            |...:.::.:..|.
  Fly   966 ----------PHTNIAGFEQEFAKVYERRMLEIHIEELRFKNSARNLTLYPDYCNKLKVLRALKY 1020

  Fly  2031 IQDLPEIAIQIFVEGRHMENEYAKRPLSLSDDTRGEWMSLHANEDYVLIVNLQRLNVSGQRRG-G 2094
            |.:|.|:.::..|.....:||.....|.|.:                :..:|:...::....| .
  Fly  1021 IDELDEVTLKGKVACEMGQNELLITELILCN----------------MFNDLEPAEIAALLSGLV 1069

  Fly  2095 GQSYTVHCPKYPKPKNEAWFLTLGSQANDELLAMKRVSIRGQRCTNRISF 2144
            .|:.....|..|:...|.  :....|.||.:||.::.........||::|
  Fly  1070 FQAKMQDKPVIPEALKEC--VAAFEQINDTILAEEQRFQAAIETDNRLNF 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	BRR2	450..1254	CDD:224125
		DEAD	488..666	CDD:278688
		HELICc	790..866	CDD:197757
		Sec63	989..1296	CDD:280962
		DEXDc	1332..1532	CDD:214692	54/180 (30%)
		DEAD	1338..1510	CDD:278688	46/157 (29%)
		HELICc	1605..1704	CDD:197757	37/98 (38%)
		SEC63	1818..2176	CDD:214744	72/431 (17%)
tst	NP_001262884.1	Dob10	193..1194	CDD:226947	204/960 (21%)
		DEAD	267..414	CDD:278688	46/156 (29%)
		HELICc	578..658	CDD:197757	34/81 (42%)
		rRNA_proc-arch	715..996	CDD:289976	53/320 (17%)
		DSHCT	1025..1188	CDD:285374	20/111 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466321
Domainoid	1	1.000	45	1.000	Domainoid score	I721
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840