Protein Alignment obe and Hfm1

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: NP_001399490.1
• Gene: Hfm1 / 330149
• MGIID: 3036246
• Length: 1476
• Species: Mus musculus
• Alignment Length: 1171
• Identity: 328/1171 - (28%)
• Similarity: 520/1171 - (44%)
• Gaps: 279/1171 - (23%)

  Fly   998 FYIKYDTVETF---NELMKPFMTQAEILAMISQAQEFQQLKVRDDEMEELDELK----------- 1048
            |:...|..|.|   .:.:..|:..|.:::.|...||.:         ||::..|
Mouse    15 FFSSPDETENFPVKEKSLDWFLPPAPLISEIPDIQELE---------EEIESYKLLGKGKMPRML 70

  Fly  1049 ---------NAYCKIKPYGGSENVHGKVNILIQTYLSNGYVKSFSLSSDMSYITTNIGRISRALF 1104
                     :..| |.|   ::.:|...|:..|.||:.|    .|.::|||::.   |::
Mouse    71 TSNLKIINEDTNC-ISP---TQKIHFSYNVHEQDYLNLG----GSNNNDMSHVA---GKL----- 119

  Fly  1105 SIVLRQNNAVLSGNMLQLCKMFERRQWDFDCHL-KQFPTINAETID-KL-----ERRGLSVYRLR 1162
                                |:...| .:..|: .:.|:..:...| ||     :|:|.|.::.|
Mouse   120 --------------------MYGSSQ-KYKNHMGAKSPSARSSPGDTKLHDVAEDRQGTSAFKKR 163

  Fly  1163 -----DMEHRELKEWLRSNTYADLVIRSAHELPLLEVEASLQPITRTVLRI-KVDIWPSFTWNDR 1221
                 |.||        ...|||         ..|.:.:.:.|:..|..:| |.:.|
Mouse   164 LSRTCDSEH--------DCDYAD---------GSLNLSSHISPVKLTQTKISKENAW-------- 203

  Fly  1222 VHGKTCQSFWLWIEDPESNYIYHSELFQVTRKLVMSGQSQQLVMTIPLKEPLPP----QYYIRVS 1282
                ||       .:.:....|.:..|:.......||..:.:     .|.|..|    .:.|:..
Mouse   204 ----TC-------SNSKQKRQYSTNKFKANDAFSASGIGKDI-----FKAPSFPAASQPHDIQGI 252

  Fly  1283 SDNWLGS---TTCIPLSFQHLVLPEHHPPLTELLPLRPLPVSCLKNVVYESLYKFTHFNPIQTQI 1344
            :.|.|||   .|.||..|                          :|:..|    |.:||.||::.
Mouse   253 TPNGLGSLKAVTEIPAKF--------------------------RNIFKE----FPYFNYIQSKA 287

  Fly  1345 FHCLYHTDNNVLLGAPTGSGKTIVAEIAIFRALNQNP----KCKVVYIAPLKALVKERIADWEQR 1405
            |..|.:||.|.::.||||||||:|.|:||.|.|.:.|    ..|:||:||:|||..:|..||:::
Mouse   288 FDDLLYTDRNFVICAPTGSGKTVVFELAITRLLMEVPLPWLNMKIVYMAPIKALCSQRFDDWKEK 352

  Fly  1406 FQRSSLGLKVVELTGD-VTPDIQAIRESQLIVTTPEKWDGISRSWQTREYVQHVSLIVIDEIHLL 1469
            |  ..:||...||||| |..|:..|:.:.:|:|||||||.::|.|:...::|.|.|.:|||:|::
Mouse   353 F--GPVGLNCKELTGDTVMDDLFEIQHANIIITTPEKWDSVTRKWRDNSFIQLVRLFLIDEVHVI 415

  Fly  1470 -GEDRGPVIEVIVSR-------TNFISSHTGRAIRIVGLSTALANAQDLANWLGINKMGLYNFKP 1526
             .|:|||.:||:|||       :..:.|.:...:|.|.:|..:.||:|:|.||...:      :|
Mouse   416 KDENRGPTLEVVVSRMKTVQSLSRDLESASPVPVRFVAVSATIPNAEDIAEWLSDGE------RP 474

  Fly  1527 SV--------RPVPLQVHINGFPGKHYCPRMAT-------MNRPTFQAIRTYSPCEPTIVFVSSR 1576
            :|        |||.||..:.|||    |....|       :|...:..|||||..:||:||.|:|
Mouse   475 AVCLKMDESHRPVKLQKVVLGFP----CSSSQTEFKFDLALNYKVYSVIRTYSDQKPTLVFCSTR 535

  Fly  1577 RQTRLTALDLITFVAGESNPKQFLHIPEDEIELILQ----NIREQNLKFCLAFGIGLHHAGLQEQ 1637
            :..:..|..|:         |....|...|.:|.||    :||:..||..|.:|:|.||||::..
Mouse   536 KGVQQAASVLV---------KDAKFIISVEQKLRLQKSAYSIRDSKLKDTLVYGVGYHHAGMELS 591

  Fly  1638 DRKCVEELFLNRKIQILVATATLAWGVNLPAHLVVIKGTEYFDGKV-KKYVDMPITDVLQMMGRA 1701
            |||.||.||.:..:.:|..|:|||.|:|:||||||||.|.::.|.| ::|.:   ||:|||:|||
Mouse   592 DRKLVEGLFTSGDLPVLFTTSTLAMGMNMPAHLVVIKSTMHYSGGVFEEYSE---TDILQMIGRA 653

  Fly  1702 GRPQFDNEGVAVVLVHDEKKNFYKKFLYDPFPVESSLLGVLPEHINAEIVAGTVQSKQAALDYLT 1766
            ||||||....||::.....:..|.:.|.....|||||...|.||:|||||..|:.....|||::.
Mouse   654 GRPQFDTTATAVIMTRLSTREKYVQMLACNDTVESSLHRHLIEHLNAEIVLHTITDVNIALDWIR 718

  Fly  1767 WTYFFRRLLRNPSYYQLQD-IEPENVNNFMSNLVERVVYELSAAACL-VERDGCLIPTFLGRISS 1829
            .|..:.|.|:|||:|.... :..:.:...:..|..:.:.:||:...: ::.|....||..||:.:
Mouse   719 STMLYIRALKNPSHYGFSSGLNKDGIEAKLQELCLKNLKDLSSLDLIKMDEDVNFKPTEAGRLMA 783

  Fly  1830 YYYLSYRTMKHFLEDLQPGMNTKKVLL----AIADSYEFDQLPVRHNEDK----HNEEMAEVSRF 1886
            :||:::.|:|.|.     .::.|:.||    .|:...||..:.:|.:|.:    .|::...::..
Mouse   784 WYYITFETVKKFC-----AISGKETLLDLISMISSCNEFLDVQLRISEKRILNTLNKDPNRITIR 843

  Fly  1887 RPPSSSWDSSYTKTFLLLQAHFARQSLPNSDY-LT-DTKSALDNATRVMQAMVDYTAERGWLSTT 1949
            .|.:....:...|...|:||...  .:|..|: || ||.....|.:|:.:          |||..
Mouse   844 FPMAERIKTREMKVNCLIQAQLG--CIPIQDFALTQDTVKIFRNGSRIAR----------WLSDF 896

  Fly  1950 LVVQQ-----LMQSVIQARWF---------DGSEFLTLPGVNEDN------LDAFLNIPHDDYDY 1994
            :..|:     |:.|||..:.|         ..|:.|...|::..|      |.:|..|...:...
Mouse   897 VAAQEKKFAVLLNSVILTKCFKCKLWENSKHVSKQLDKIGISLSNTMVNAGLTSFKKIEEANARE 961

  Fly  1995 LTLPVLKELCKQEYEVLAKPLRDAFE-----EHEIEKMYKVIQDLPEIAIQIFVEGRHMENEYAK 2054
            |      ||....:......:::|..     |.|:|::.:......||.:.|.:  |:.|....|
Mouse   962 L------ELILNRHPPFGTQIKEAVAHLPKYELEVEQIARYSDIKAEILVTIIL--RNFEQLQTK 1018

  Fly  2055 R 2055
            |
Mouse  1019 R 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309
		BRR2	485..1025	CDD:440817	6/29 (21%)
		DEXHc_ASCC3_1	486..683	CDD:350778
		SEC63	985..1298	CDD:214744	66/342 (19%)
		BRR2	1334..1859	CDD:440817	210/563 (37%)
		DEXHc_ASCC3_2	1336..1525	CDD:350780	82/201 (41%)
		SEC63	1818..2176	CDD:214744	61/273 (22%)
Hfm1	NP_001399490.1	BRR2	263..819	CDD:440817	219/614 (36%)
		DEXHc_HFM1	279..486	CDD:350781	84/214 (39%)
		Sec63	775..1088	CDD:460740	61/270 (23%)