Protein Alignment obe and Ascc3

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: NP_001263986.1
• Gene: Ascc3 / 309887
• RGDID: 1307995
• Length: 2201
• Species: Rattus norvegicus
• Alignment Length: 2223
• Identity: 1116/2223 - (50%)
• Similarity: 1504/2223 - (67%)
• Gaps: 90/2223 - (4%)

  Fly     5 PRLSASLRAKTELEARSRRLNVLRQARTTSAASTTTNSQNK-EEQTIA-----RLLAQMPTEKQP 63
            |||:.:||:.:         ||.:|.......:.....::| .||.:.     :.:.:...||..
  Rat     4 PRLTGALRSFS---------NVTKQDNYNEEVADLKLKRSKLHEQALDFGLSWKKIVKFLNEKLE 59

  Fly    64 AAKVQL--QKLRNLVQ---ECMGYEEQPQVVEHAALFLFWLLLDQRVLLVATTQRLHGMFGQTFD 123
            ..|:|.  :.|::::|   :.:|.:...:.:|..|.|||........:....|:.:..|||....
  Rat    60 KNKMQTINEDLKDILQAAKQIVGTDNGNEAIESGAAFLFMTFHMTDSVGYTETKAIRQMFGPFPS 124

  Fly   124 RKKTQIHDCVQAIGDLLEDHERSALKR--WRQTHHKVPGVGPLWGAHIHVKCTPSEWMDISLLTD 186
            ...|...:....|.......:.:||.:  ..|.:.:|     ::|.::   ....:..|:....:
  Rat   125 SSATSACNATSRIISHFSQDDLTALVQATENQCNDRV-----VFGRNL---AFSFDMHDLDHFDE 181

  Fly   187 LAPDALLKNRTVN---------KFSMKHTTKAAPVASTSSEAAKLSPELQ-----TLLEISAKLD 237
            |..:...: :|::         :|...:|.:..||  ..|..:.|..|::     ||.|::....
  Rat   182 LPVNGEAQ-KTISLDYKKFLNEQFQEPYTPELKPV--EKSNGSLLWCEVEKYLNATLKEMTEAPR 243

  Fly   238 DEHLIIRVGDILGSQRSSEVLQNELMEILGFDYFELVEKLLMERDKIARQLDQFA-TRSRRVMEV 301
            .|.|...:.|:|.|.:|.:.||:||.|:||....:|:||||..|..|   :|:|. :.|....:|
  Rat   244 VEDLCCTLYDMLASAKSGDELQDELFELLGPGGLDLIEKLLQNRITI---VDRFLNSSSDHKFQV 305

  Fly   302 KQKRMEAAASGGAAERRPTVASAVVVQSAQEKQLSKMQRREEKKLQRIMRSIKDEEAEDDPNCA- 365
            .|...:......|   :|.....|.:||.|||||.|..|||||::.|     ::::|.:|...:
  Rat   306 LQDNCKKILGENA---KPNYGCQVTIQSEQEKQLMKQYRREEKRIAR-----REKKAGEDGEVSG 362

  Fly   366 ---VAVSVQQLRMQHQRKLLEAAQREPLLLSTKAAKAEYKQSSYNQPIHYPYVFDSQLLAKQHAG 427
               :....::||:|.:..||. |:..|:|...:..:.|        .|.||:|:|||..|::.:.
  Rat   363 EGLLPFDPKELRLQREHALLN-ARSAPILGRQRDTEVE--------KIRYPHVYDSQAAARETSA 418

  Fly   428 FIGGSRITLPDNAQRIDNKQWEEVKIPASEPPPLSVGNKRVQIEELDDVGRLAFANCKELNRIQS 492
            ||.|:::.||:..||.:.|.:|||:||.|||.|:....|.|.|::||:||:|||...|.||||||
  Rat   419 FIAGAKMILPEGIQRENTKLYEEVRIPYSEPMPVGFEEKPVYIQDLDEVGQLAFKGMKRLNRIQS 483

  Fly   493 VVFPVAYHSNENMLVCAPTGAGKTNVAMLSIVHTIRCHLEQGVINRDEFKIVYIAPMKALAAEMV 557
            :||..||::|||||:||||||||||:|||:::|.||.|..|||:.::||||||:||||||||||.
  Rat   484 IVFDTAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFHQGVLKKNEFKIVYVAPMKALAAEMT 548

  Fly   558 DNFSKRLKSLQIAVRELTGDIQLTKAEMAATQILVTTPEKWDVVTRKGSGDVALISLVELLIIDE 622
            :.|||||:.|.|.|:|||||:||:|:|:..||:||||||||||||||..|||||..:|:|||:||
  Rat   549 NYFSKRLEPLGIVVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVKLLILDE 613

  Fly   623 VHLLHGERGPVVEALVARTLRLVESSQSMIRIVGLSATLPNYIDVAHFLRVNPMKGLFYFDSRFR 687
            |||||.:||||:|::||||||.|||:||||||:|||||||||:|||.||.|||..||||||.|||
  Rat   614 VHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFYFDGRFR 678

  Fly   688 PVPLDTNFVGIKSVKQLQQIADMDQCCYQKCVEMVQEGHQIMVFVHARNATVRTANVIRELAQQN 752
            ||||...|:||||..::||:.:||:.||:..::.|:.|||:||||||||||||||..:.|.|:.:
  Rat   679 PVPLGQTFLGIKSANKMQQLNNMDEVCYESVLKQVKAGHQVMVFVHARNATVRTAMSLIERAKNS 743

  Fly   753 NTSALFLPKDSAAHGLATRSIQRSRNKQLVELFSCGLAMHHAGMLRADRQMVEKYFVEGHISVLV 817
            ...:.|||.....:|.|.:.:|:|||||:.||||.|.::|||||||.||.:||..|..|||.|||
  Rat   744 GQISCFLPTQGPEYGHALKQVQKSRNKQVRELFSDGFSIHHAGMLRQDRNLVENLFSNGHIKVLV 808

  Fly   818 CTATLAWGVNLPAHAVIIRGTDIYDAKHGSFVDLGILDVLQIFGRAGRPQFDKSGVGTIITSYDK 882
            ||||||||||||||||||:||.||.||.|||||||||||:|||||||||||||.|.|.|||::||
  Rat   809 CTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTHDK 873

  Fly   883 LNHYLSLLTNQFPIESNFVNCLADNLNAEIGLGTITNVDEAIEWLSYTYLFVRMRINPHVYGIEY 947
            |:|||||||.|.||||.|:..|||||||||.|||:|||:||::|:|||||:||||.||..|||.:
  Rat   874 LSHYLSLLTQQNPIESQFLESLADNLNAEIALGTVTNVEEAVKWMSYTYLYVRMRANPLAYGISH 938

  Fly   948 SELEKDPTLEARRRALIMSAAMSLDKARMMRFNQRTMDMNITDLGRTASYFYIKYDTVETFNELM 1012
            ...:.||||...|..|::.....||||||:||.:||...:.||||||||::||||:|:||||||.
  Rat   939 KAYQMDPTLRKHREQLLIEVGQKLDKARMIRFEERTGYFSSTDLGRTASHYYIKYNTIETFNELF 1003

  Fly  1013 KPFMTQAEILAMISQAQEFQQLKVRDDEMEELDELKNAYCKIKPYGGSENVHGKVNILIQTYLSN 1077
            ....|:.:|.|::|:|:||.|:|||::|:||||.|.|.:|::...||.||.:||:|||:|||:|.
  Rat  1004 DAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDALLNNFCELSAPGGVENSYGKINILLQTYISR 1068

  Fly  1078 GYVKSFSLSSDMSYITTNIGRISRALFSIVLRQNNAVLSGNMLQLCKMFERRQWDFDCHLKQFPT 1142
            |.:.||||.||.:|:..|..||.||||.|.||:....::..:|.|.|:.::|.|.:...|:||..
  Rat  1069 GEMDSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSV 1133

  Fly  1143 INAETIDKLERRGLSVYRLRDMEHRELKEWLRSNTYADLVIRSAHELPLLEVEASLQPITRTVLR 1207
            :....:.:||.:.|:|.:|:||...|:...|........|.:..|::|.:.:|||:|||||||||
  Rat  1134 LPPHILTRLEEKNLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVTMEASIQPITRTVLR 1198

  Fly  1208 IKVDIWPSFTWNDRVHGKTCQSFWLWIEDPESNYIYHSELFQVTRKLVMSGQSQQLVMTIPLKEP 1272
            :.::|:|.|:|||:|||...:.:|:|:|||.:::|||||.|...:|.|::.::|.||.|||:.||
  Rat  1199 VSLNIYPDFSWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVINKEAQLLVFTIPIFEP 1263

  Fly  1273 LPPQYYIRVSSDNWLGSTTCIPLSFQHLVLPEHHPPLTELLPLRPLPVSCLKNVVYESLYKFTHF 1337
            ||.|||||..||.|||:.....::||||:|||.|||.||||.|:||||:.|....||:||.|:||
  Rat  1264 LPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPVTALGCKAYEALYNFSHF 1328

  Fly  1338 NPIQTQIFHCLYHTDNNVLLGAPTGSGKTIVAEIAIFRALNQNPKCKVVYIAPLKALVKERIADW 1402
            ||:||||||.|||||.|||||||||||||:.||:||||..|:.|..|.||||||||||:||:.||
  Rat  1329 NPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDW 1393

  Fly  1403 EQRFQRSSLGLKVVELTGDVTPDIQAIRESQLIVTTPEKWDGISRSWQTREYVQHVSLIVIDEIH 1467
            :.|.: ..||.||:|||||||||:::|.::.|||||||||||:|||||.|.|||.|::::|||||
  Rat  1394 KIRIE-EKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRSYVQQVNILIIDEIH 1457

  Fly  1468 LLGEDRGPVIEVIVSRTNFISSHTGRAIRIVGLSTALANAQDLANWLGINKMGLYNFKPSVRPVP 1532
            ||||:||||:||||||||||||||.:.:||||||||||||:|||:||.|.:|||:||:|||||||
  Rat  1458 LLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLFNFRPSVRPVP 1522

  Fly  1533 LQVHINGFPGKHYCPRMATMNRPTFQAIRTYSPCEPTIVFVSSRRQTRLTALDLITFVAGESNPK 1597
            |:|||.||||:|||||||:||:|.|||||::||.:|.::|||||||||||||:||.|:|.|.:||
  Rat  1523 LEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEEDPK 1587

  Fly  1598 QFLHIPEDEIELILQNIREQNLKFCLAFGIGLHHAGLQEQDRKCVEELFLNRKIQILVATATLAW 1662
            |:|::.|.|:|.|:..:|:.|||..||||||:|||||.|:|||.|||||:|.|:|:|:||:||||
  Rat  1588 QWLNMDEQEMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAW 1652

  Fly  1663 GVNLPAHLVVIKGTEYFDGKVKKYVDMPITDVLQMMGRAGRPQFDNEGVAVVLVHDEKKNFYKKF 1727
            |||.|||||:||||||:|||.::|||.||||||||||||||||||::|.||:||||.||:|||||
  Rat  1653 GVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKF 1717

  Fly  1728 LYDPFPVESSLLGVLPEHINAEIVAGTVQSKQAALDYLTWTYFFRRLLRNPSYYQLQDIEPENVN 1792
            ||:||||||||||||.:|:||||..||:.|||.||||:|||||||||:.|||||.|.|:..:.:|
  Rat  1718 LYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPSYYNLGDVSQDAIN 1782

  Fly  1793 NFMSNLVERVVYELSAAACLV--ERDGCLIPTFLGRISSYYYLSYRTMKHFLEDLQPGMNTKKVL 1855
            .|:|:|:.:.:.||..:.|:.  |.:..:.|...|||:|||||.::|:|.|.:.|:|..:|:::|
  Rat  1783 KFLSHLIGQSLVELELSHCIEVGEDNRSIEPLTCGRIASYYYLKHKTVKMFKDRLKPECSTEELL 1847

  Fly  1856 LAIADSYEFDQLPVRHNEDKHNEEMAEVSRFRPPSSSWDSSYTKTFLLLQAHFARQSLPNSDYLT 1920
            ..::|:.|:..||||||||..|.|:|:.........|:||.:||..||||||.:|..||..||.|
  Rat  1848 SILSDAEEYTDLPVRHNEDHTNNELAKCLPIELNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDT 1912

  Fly  1921 DTKSALDNATRVMQAMVDYTAERGWLSTTLVVQQLMQSVIQARWFDGSEFLTLPGVNEDNLDAF- 1984
            |||:.||.|.||.|||:|..|.:|||.|||.:..|:|.|||.||...|..||:|.:.:.:|..|
  Rat  1913 DTKTVLDQALRVCQAMLDVAASQGWLVTTLNITHLIQMVIQGRWLKDSSLLTIPNIEQHHLHLFR 1977

  Fly  1985 -----LNIPHDD--YDYLTLPVLKELCKQEYEVLAKPLRDAFEEHEIEKMYKVIQDLPEIAIQIF 2042
                 :..||..  .....||.|...|:.:..|.:..:....:..:.::.:..:..||.|.:.|.
  Rat  1978 KWKPPVKGPHAKCRTSIECLPELIHACEGKEHVFSSMVEKELQPAKTKQAWNFLSHLPVINVGIS 2042

  Fly  2043 VEGRHMENEYAKRPLSLSD---DTRGE--WMSLHANEDYVLIVNLQRLNVSGQRRGGGQSYTVHC 2102
            |:|...::......||:|.   |.|.|  |:.|||::.|||.|:|||::.. ..:...:|:.| .
  Rat  2043 VKGSWDDSVEGHNELSISTLTADKRDENTWIKLHADQQYVLQVSLQRVHFE-FHKVKHESHAV-T 2105

  Fly  2103 PKYPKPKNEAWFLTLGSQANDELLAMKRVSIRGQRCTNRISFQATPRLGRLQLTLYLMSDCLMGF 2167
            |::||.|:|.|||.||.....||:|:|||..........|||......||...||||||||.:|.
  Rat  2106 PRFPKLKDEGWFLILGEVDKRELVAVKRVGFVRTHHEASISFFTPEAPGRYIFTLYLMSDCYLGL 2170

  Fly  2168 DQQYDLQFEIIDA 2180
            |||||:...:..|
  Rat  2171 DQQYDIFLNVTKA 2183

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309	17/36 (47%)
		BRR2	485..1025	CDD:440817	355/539 (66%)
		DEXHc_ASCC3_1	486..683	CDD:350778	141/196 (72%)
		SEC63	985..1298	CDD:214744	143/312 (46%)
		BRR2	1334..1859	CDD:440817	351/526 (67%)
		DEXHc_ASCC3_2	1336..1525	CDD:350780	136/188 (72%)
		SEC63	1818..2176	CDD:214744	145/370 (39%)
Ascc3	NP_001263986.1	BRR2	461..1016	CDD:440817	363/554 (66%)
		DEXHc_ASCC3_1	477..674	CDD:350778	141/196 (72%)
		DEVH box	612..615		2/2 (100%)
		Sec63	979..1287	CDD:460740	143/307 (47%)
		DEXHc_ASCC3_2	1327..1515	CDD:350780	136/188 (72%)
		BRR2	1328..1850	CDD:440817	349/522 (67%)
		DEIH box	1454..1457		2/2 (100%)
		SEC63	1810..2176	CDD:214744	144/367 (39%)