DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment obe and Ascc3

DIOPT Version :9

Sequence 1:	NP_650472.2	Gene:	obe / 41891	FlyBaseID:	FBgn0038344	Length:	2183	Species:	Drosophila melanogaster
Sequence 2:	NP_001263986.1	Gene:	Ascc3 / 309887	RGDID:	1307995	Length:	2201	Species:	Rattus norvegicus

Alignment Length:	2236	Identity:	1118/2236 - (50%)
Similarity:	1500/2236 - (67%)	Gaps:	116/2236 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PRLSASLRAKTELEARSRRLNVLRQARTTSAASTTTNSQNK-EEQTIA-----RLLAQMPTEKQP 63
            |||:.:||:.:         ||.:|.......:.....::| .||.:.     :.:.:...||..
  Rat     4 PRLTGALRSFS---------NVTKQDNYNEEVADLKLKRSKLHEQALDFGLSWKKIVKFLNEKLE 59

  Fly    64 AAKVQL--QKLRNLVQ---ECMGYEEQPQVVEHAALFLFWLLLDQRVLLVATTQRLHGMFGQTFD 123
            ..|:|.  :.|::::|   :.:|.:...:.:|..|.|||........:....|:.:..|||....
  Rat    60 KNKMQTINEDLKDILQAAKQIVGTDNGNEAIESGAAFLFMTFHMTDSVGYTETKAIRQMFGPFPS 124

  Fly   124 RKKTQIHDCVQAIGDLLEDHERSALKRWRQTHHKVPGVGPLWGAHIHVKCTPSEWMD-------I 181
            ...|...:....|.......:.:||                      |:.|.::..|       :
  Rat   125 SSATSACNATSRIISHFSQDDLTAL----------------------VQATENQCNDRVVFGRNL 167

  Fly   182 SLLTDLAP----DALLKN----RTVN---------KFSMKHTTKAAPVASTSSEAAKLSPELQ-- 227
            :...|:..    |.|..|    :|::         :|...:|.:..||  ..|..:.|..|::
  Rat   168 AFSFDMHDLDHFDELPVNGEAQKTISLDYKKFLNEQFQEPYTPELKPV--EKSNGSLLWCEVEKY 230

  Fly   228 ---TLLEISAKLDDEHLIIRVGDILGSQRSSEVLQNELMEILGFDYFELVEKLLMERDKIARQLD 289
               ||.|::.....|.|...:.|:|.|.:|.:.||:||.|:||....:|:||||..|..|   :|
  Rat   231 LNATLKEMTEAPRVEDLCCTLYDMLASAKSGDELQDELFELLGPGGLDLIEKLLQNRITI---VD 292

  Fly   290 QFA-TRSRRVMEVKQKRMEAAASGGAAERRPTVASAVVVQSAQEKQLSKMQRREEKKLQRIMRSI 353
            :|. :.|....:|.|...:......|   :|.....|.:||.|||||.|..|||||::.|
  Rat   293 RFLNSSSDHKFQVLQDNCKKILGENA---KPNYGCQVTIQSEQEKQLMKQYRREEKRIAR----- 349

  Fly   354 KDEEAEDDPNCA----VAVSVQQLRMQHQRKLLEAAQREPLLLSTKAAKAEYKQSSYNQPIHYPY 414
            ::::|.:|...:    :....::||:|.:..||. |:..|:|...:..:.|        .|.||:
  Rat   350 REKKAGEDGEVSGEGLLPFDPKELRLQREHALLN-ARSAPILGRQRDTEVE--------KIRYPH 405

  Fly   415 VFDSQLLAKQHAGFIGGSRITLPDNAQRIDNKQWEEVKIPASEPPPLSVGNKRVQIEELDDVGRL 479
            |:|||..|::.:.||.|:::.||:..||.:.|.:|||:||.|||.|:....|.|.|::||:||:|
  Rat   406 VYDSQAAARETSAFIAGAKMILPEGIQRENTKLYEEVRIPYSEPMPVGFEEKPVYIQDLDEVGQL 470

  Fly   480 AFANCKELNRIQSVVFPVAYHSNENMLVCAPTGAGKTNVAMLSIVHTIRCHLEQGVINRDEFKIV 544
            ||...|.||||||:||..||::|||||:||||||||||:|||:::|.||.|..|||:.::|||||
  Rat   471 AFKGMKRLNRIQSIVFDTAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFHQGVLKKNEFKIV 535

  Fly   545 YIAPMKALAAEMVDNFSKRLKSLQIAVRELTGDIQLTKAEMAATQILVTTPEKWDVVTRKGSGDV 609
            |:||||||||||.:.|||||:.|.|.|:|||||:||:|:|:..||:||||||||||||||..|||
  Rat   536 YVAPMKALAAEMTNYFSKRLEPLGIVVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDV 600

  Fly   610 ALISLVELLIIDEVHLLHGERGPVVEALVARTLRLVESSQSMIRIVGLSATLPNYIDVAHFLRVN 674
            ||..:|:|||:|||||||.:||||:|::||||||.|||:||||||:|||||||||:|||.||.||
  Rat   601 ALSQIVKLLILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVN 665

  Fly   675 PMKGLFYFDSRFRPVPLDTNFVGIKSVKQLQQIADMDQCCYQKCVEMVQEGHQIMVFVHARNATV 739
            |..||||||.|||||||...|:||||..::||:.:||:.||:..::.|:.|||:|||||||||||
  Rat   666 PYIGLFYFDGRFRPVPLGQTFLGIKSANKMQQLNNMDEVCYESVLKQVKAGHQVMVFVHARNATV 730

  Fly   740 RTANVIRELAQQNNTSALFLPKDSAAHGLATRSIQRSRNKQLVELFSCGLAMHHAGMLRADRQMV 804
            |||..:.|.|:.:...:.|||.....:|.|.:.:|:|||||:.||||.|.::|||||||.||.:|
  Rat   731 RTAMSLIERAKNSGQISCFLPTQGPEYGHALKQVQKSRNKQVRELFSDGFSIHHAGMLRQDRNLV 795

  Fly   805 EKYFVEGHISVLVCTATLAWGVNLPAHAVIIRGTDIYDAKHGSFVDLGILDVLQIFGRAGRPQFD 869
            |..|..|||.|||||||||||||||||||||:||.||.||.|||||||||||:||||||||||||
  Rat   796 ENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFD 860

  Fly   870 KSGVGTIITSYDKLNHYLSLLTNQFPIESNFVNCLADNLNAEIGLGTITNVDEAIEWLSYTYLFV 934
            |.|.|.|||::|||:|||||||.|.||||.|:..|||||||||.|||:|||:||::|:|||||:|
  Rat   861 KFGEGIIITTHDKLSHYLSLLTQQNPIESQFLESLADNLNAEIALGTVTNVEEAVKWMSYTYLYV 925

  Fly   935 RMRINPHVYGIEYSELEKDPTLEARRRALIMSAAMSLDKARMMRFNQRTMDMNITDLGRTASYFY 999
            |||.||..|||.:...:.||||...|..|::.....||||||:||.:||...:.||||||||::|
  Rat   926 RMRANPLAYGISHKAYQMDPTLRKHREQLLIEVGQKLDKARMIRFEERTGYFSSTDLGRTASHYY 990

  Fly  1000 IKYDTVETFNELMKPFMTQAEILAMISQAQEFQQLKVRDDEMEELDELKNAYCKIKPYGGSENVH 1064
            |||:|:||||||.....|:.:|.|::|:|:||.|:|||::|:||||.|.|.:|::...||.||.:
  Rat   991 IKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDALLNNFCELSAPGGVENSY 1055

  Fly  1065 GKVNILIQTYLSNGYVKSFSLSSDMSYITTNIGRISRALFSIVLRQNNAVLSGNMLQLCKMFERR 1129
            ||:|||:|||:|.|.:.||||.||.:|:..|..||.||||.|.||:....::..:|.|.|:.::|
  Rat  1056 GKINILLQTYISRGEMDSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKR 1120

  Fly  1130 QWDFDCHLKQFPTINAETIDKLERRGLSVYRLRDMEHRELKEWLRSNTYADLVIRSAHELPLLEV 1194
            .|.:...|:||..:....:.:||.:.|:|.:|:||...|:...|........|.:..|::|.:.:
  Rat  1121 LWGWASPLRQFSVLPPHILTRLEEKNLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVTM 1185

  Fly  1195 EASLQPITRTVLRIKVDIWPSFTWNDRVHGKTCQSFWLWIEDPESNYIYHSELFQVTRKLVMSGQ 1259
            |||:|||||||||:.::|:|.|:|||:|||...:.:|:|:|||.:::|||||.|...:|.|::.:
  Rat  1186 EASIQPITRTVLRVSLNIYPDFSWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVINKE 1250

  Fly  1260 SQQLVMTIPLKEPLPPQYYIRVSSDNWLGSTTCIPLSFQHLVLPEHHPPLTELLPLRPLPVSCLK 1324
            :|.||.|||:.||||.|||||..||.|||:.....::||||:|||.|||.||||.|:||||:.|.
  Rat  1251 AQLLVFTIPIFEPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPVTALG 1315

  Fly  1325 NVVYESLYKFTHFNPIQTQIFHCLYHTDNNVLLGAPTGSGKTIVAEIAIFRALNQNPKCKVVYIA 1389
            ...||:||.|:||||:||||||.|||||.|||||||||||||:.||:||||..|:.|..|.||||
  Rat  1316 CKAYEALYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIA 1380

  Fly  1390 PLKALVKERIADWEQRFQRSSLGLKVVELTGDVTPDIQAIRESQLIVTTPEKWDGISRSWQTREY 1454
            ||||||:||:.||:.|.: ..||.||:|||||||||:::|.::.|||||||||||:|||||.|.|
  Rat  1381 PLKALVRERMDDWKIRIE-EKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRSY 1444

  Fly  1455 VQHVSLIVIDEIHLLGEDRGPVIEVIVSRTNFISSHTGRAIRIVGLSTALANAQDLANWLGINKM 1519
            ||.|::::|||||||||:||||:||||||||||||||.:.:||||||||||||:|||:||.|.:|
  Rat  1445 VQQVNILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQM 1509

  Fly  1520 GLYNFKPSVRPVPLQVHINGFPGKHYCPRMATMNRPTFQAIRTYSPCEPTIVFVSSRRQTRLTAL 1584
            ||:||:||||||||:|||.||||:|||||||:||:|.|||||::||.:|.::|||||||||||||
  Rat  1510 GLFNFRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTAL 1574

  Fly  1585 DLITFVAGESNPKQFLHIPEDEIELILQNIREQNLKFCLAFGIGLHHAGLQEQDRKCVEELFLNR 1649
            :||.|:|.|.:|||:|::.|.|:|.|:..:|:.|||..||||||:|||||.|:|||.|||||:|.
  Rat  1575 ELIAFLATEEDPKQWLNMDEQEMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNC 1639

  Fly  1650 KIQILVATATLAWGVNLPAHLVVIKGTEYFDGKVKKYVDMPITDVLQMMGRAGRPQFDNEGVAVV 1714
            |:|:|:||:|||||||.|||||:||||||:|||.::|||.||||||||||||||||||::|.||:
  Rat  1640 KVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVI 1704

  Fly  1715 LVHDEKKNFYKKFLYDPFPVESSLLGVLPEHINAEIVAGTVQSKQAALDYLTWTYFFRRLLRNPS 1779
            ||||.||:|||||||:||||||||||||.:|:||||..||:.|||.||||:|||||||||:.|||
  Rat  1705 LVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPS 1769

  Fly  1780 YYQLQDIEPENVNNFMSNLVERVVYELSAAACLV--ERDGCLIPTFLGRISSYYYLSYRTMKHFL 1842
            ||.|.|:..:.:|.|:|:|:.:.:.||..:.|:.  |.:..:.|...|||:|||||.::|:|.|.
  Rat  1770 YYNLGDVSQDAINKFLSHLIGQSLVELELSHCIEVGEDNRSIEPLTCGRIASYYYLKHKTVKMFK 1834

  Fly  1843 EDLQPGMNTKKVLLAIADSYEFDQLPVRHNEDKHNEEMAEVSRFRPPSSSWDSSYTKTFLLLQAH 1907
            :.|:|..:|:::|..::|:.|:..||||||||..|.|:|:.........|:||.:||..||||||
  Rat  1835 DRLKPECSTEELLSILSDAEEYTDLPVRHNEDHTNNELAKCLPIELNPHSFDSPHTKAHLLLQAH 1899

  Fly  1908 FARQSLPNSDYLTDTKSALDNATRVMQAMVDYTAERGWLSTTLVVQQLMQSVIQARWFDGSEFLT 1972
            .:|..||..||.||||:.||.|.||.|||:|..|.:|||.|||.:..|:|.|||.||...|..||
  Rat  1900 LSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAASQGWLVTTLNITHLIQMVIQGRWLKDSSLLT 1964

  Fly  1973 LPGVNEDNLDAF------LNIPHDD--YDYLTLPVLKELCKQEYEVLAKPLRDAFEEHEIEKMYK 2029
            :|.:.:.:|..|      :..||..  .....||.|...|:.:..|.:..:....:..:.::.:.
  Rat  1965 IPNIEQHHLHLFRKWKPPVKGPHAKCRTSIECLPELIHACEGKEHVFSSMVEKELQPAKTKQAWN 2029

  Fly  2030 VIQDLPEIAIQIFVEGRHMENEYAKRPLSLSD---DTRGE--WMSLHANEDYVLIVNLQRLNVSG 2089
            .:..||.|.:.|.|:|...::......||:|.   |.|.|  |:.|||::.|||.|:|||::..
  Rat  2030 FLSHLPVINVGISVKGSWDDSVEGHNELSISTLTADKRDENTWIKLHADQQYVLQVSLQRVHFE- 2093

  Fly  2090 QRRGGGQSYTVHCPKYPKPKNEAWFLTLGSQANDELLAMKRVSIRGQRCTNRISFQATPRLGRLQ 2154
            ..:...:|:.| .|::||.|:|.|||.||.....||:|:|||..........|||......||..
  Rat  2094 FHKVKHESHAV-TPRFPKLKDEGWFLILGEVDKRELVAVKRVGFVRTHHEASISFFTPEAPGRYI 2157

  Fly  2155 LTLYLMSDCLMGFDQQYDLQFEIIDA 2180
            .||||||||.:|.|||||:...:..|
  Rat  2158 FTLYLMSDCYLGLDQQYDIFLNVTKA 2183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	BRR2	450..1254	CDD:224125	472/803 (59%)
		DEAD	488..666	CDD:278688	128/177 (72%)
		HELICc	790..866	CDD:197757	60/75 (80%)
		Sec63	989..1296	CDD:280962	143/306 (47%)
		DEXDc	1332..1532	CDD:214692	144/199 (72%)
		DEAD	1338..1510	CDD:278688	124/171 (73%)
		HELICc	1605..1704	CDD:197757	70/98 (71%)
		SEC63	1818..2176	CDD:214744	145/370 (39%)
Ascc3	NP_001263986.1	BRR2	478..1240	CDD:224125	452/761 (59%)
		DEVH box	612..615		2/2 (100%)
		DEXHc_ASCC3_2	1327..1515	CDD:350780	136/188 (72%)
		BRR2	1328..2061	CDD:224125	426/733 (58%)
		DEIH box	1454..1457		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351028
Domainoid	1	1.000	304	1.000	Domainoid score	I1334
eggNOG	1	0.900	-	-		E1_COG1204
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4973
Inparanoid	1	1.050	2053	1.000	Inparanoid score	I44
OMA	1	1.010	-	-		QHG54133
OrthoDB	1	1.010	-	-		D154891at2759
OrthoFinder	1	1.000	-	-		FOG0001085
OrthoInspector	1	1.000	-	-		oto95478
orthoMCL	1	0.900	-	-		OOG6_100305
Panther	1	1.100	-	-	LDO	PTHR24075
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3726
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770