Protein Alignment obe and brr2

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: NP_593346.1
• Gene: brr2 / 2543676
• PomBaseID: SPAC9.03C
• Length: 2176
• Species: Schizosaccharomyces pombe
• Alignment Length: 2171
• Identity: 737/2171 - (33%)
• Similarity: 1155/2171 - (53%)
• Gaps: 224/2171 - (10%)

  Fly    74 NLVQECMGYEEQPQVVEHAALFLFWLLLD---------QRVLLVATTQRLHGMFGQTFDRKKTQI 129
            :.:|:.:| ::.|:::..||..:..||.|         :::..|.:|:.....|.|..:
pombe   147 SFIQQYLG-DQSPEILRSAADLIIELLKDSSLDEQGRKKQIEEVLSTELPQDRFSQLVN------ 204

  Fly   130 HDCVQAIGDLLEDHERSALKRWRQTHHKVPGVGPLW--------GAHIHVKCTPSEWMDISLLTD 186
                  :|:.|.|:.....:...:......||..|:        ......:...:|..|:.|.|.
pombe   205 ------LGNRLTDYTVEQEEELNEEGVNESGVPVLFNEADEEEEAVEAMEEDEVAEDEDVVLETS 263

  Fly   187 LAPDALLKN-------RTVNKFSMKHTTKAAPVASTSSEAAKLSPEL---------------QTL 229
            ::.:...||       .|......|..|:...|.....:|..|..|:               |..
pombe   264 ISQEEEKKNIENPDTEVTFISADTKKVTEIPTVHPREIDAFWLQREIAKYFADAVVCQEKTNQAF 328

  Fly   230 LEISAKLDDEHLIIRVGDILGSQRSSEVLQNELMEILGFDYFELVEKLLMERDKI--ARQLDQFA 292
            ..:||..|           ||.      |:||||.|..:::|.||:.|...|..|  ...|.:.|
pombe   329 EALSADYD-----------LGE------LENELMSIFDYEHFYLVQLLTKNRWTIVSCTMLKRAA 376

  Fly   293 TRSRRVMEVKQKRMEAAASGGAAERRPTVASAVVVQSAQEKQLSKMQRREEKKLQRIMRSIKDEE 357
            |...| :.|:::...|..|......||   .|:.:              .:..|..:..::. |:
pombe   377 TDEER-LGVEEQIRAAGRSWILEALRP---GAITI--------------PDDGLNELNNNVV-EK 422

  Fly   358 AEDDPNCAVAVS----VQQLRMQHQRKLLEAAQREPLLLSTKAAKAEYKQSSYNQPIHYPYVFDS 418
            ||..|...:.:|    ..::..:||..|                            .:|.:...|
pombe   423 AEPAPVSEIPLSKTLTSHKIVPKHQVDL----------------------------ENYVFTEGS 459

  Fly   419 QLLAKQHAGFIGGSRITLPDNAQRIDNKQWEEVKIPASEPPPLSVGNKRVQIEELDDVGRLAFAN 483
            :|::.:        .:.||:.:.|...|.:||:.:||.....|....:.|:|:||.:....||.|
pombe   460 RLMSNK--------AVKLPEGSFRRTGKGYEEIHVPAPNKAVLGADERLVKIKELPEWSHQAFLN 516

  Fly   484 CKELNRIQSVVFPVAYHSNENMLVCAPTGAGKTNVAMLSIVHTIRCHLEQGV-INRDEFKIVYIA 547
            .:.||||||.::|:|:.::||:|:||||||||||||||.|::.::.||.:.: .|...|||||||
pombe   517 TQSLNRIQSHLYPIAFGTDENILLCAPTGAGKTNVAMLCILNELQKHLREDLSFNLQNFKIVYIA 581

  Fly   548 PMKALAAEMVDNFSKRLKSLQIAVRELTGDIQLTKAEMAATQILVTTPEKWDVVTRKGSGDVALI 612
            |:|||..|||:||||||....|.|.|||||.||||.:::.|||:||||||||::||| :.|::.:
pombe   582 PLKALVQEMVNNFSKRLTPYNIRVAELTGDSQLTKQQISETQIIVTTPEKWDIITRK-ANDLSYV 645

  Fly   613 SLVELLIIDEVHLLHGERGPVVEALVARTLRLVESSQSMIRIVGLSATLPNYIDVAHFLRVNPMK 677
            :||.|:|||||||||.|||||:|::|||..|..|.:...:|:||||||||||.|||.||.|:|.|
pombe   646 NLVRLVIIDEVHLLHDERGPVLESIVARIFRHQEETLEQVRLVGLSATLPNYTDVASFLHVDPKK 710

  Fly   678 GLFYFDSRFRPVPLDTNFVGIKSVKQLQQIADMDQCCYQKCVEMVQEGHQIMVFVHARNATVRTA 742
            |||||||.:||.||...|:||......:::...::.||:|.::...: :|:::|||:|..|.:||
pombe   711 GLFYFDSTYRPCPLKQEFIGITEKTPFKRMQTTNEACYEKVMQHAGK-NQVLIFVHSRKETAKTA 774

  Fly   743 NVIRELAQQNNTSALFLPKDSAAHGLATRSIQRSRNKQLVELFSCGLAMHHAGMLRADRQMVEKY 807
            ..||:.|.:..|....|..|:|:..:.......:.::.|.:|...|.|:|||||.|.|||..|..
pombe   775 RFIRDKALEEETIGHLLRSDAASREILRAEADSTSDENLKDLLPYGFAIHHAGMRREDRQTSEDL 839

  Fly   808 FVEGHISVLVCTATLAWGVNLPAHAVIIRGTDIYDAKHGSFVDLGILDVLQIFGRAGRPQFDKSG 872
            |.:|.|.|||.|||||||||||||.|||:||.:|..:.|.:.:|...||||:.|||||||||..|
pombe   840 FADGTIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGIWTELSPQDVLQMLGRAGRPQFDTYG 904

  Fly   873 VGTIITSYDKLNHYLSLLTNQFPIESNFVNCLADNLNAEIGLGTITNVDEAIEWLSYTYLFVRMR 937
            .|.|||::.:|.:||||:..|.||||.|:..|||.||||:.|||:.::::.::||.||||:|||.
pombe   905 EGIIITAHSELQYYLSLMNQQLPIESQFMRRLADCLNAEVSLGTVRSIEDGVDWLGYTYLYVRML 969

  Fly   938 INPHVY--GIEYSELEKDPTLEARRRALIMSAAMSLDKARMMRFNQRTMDMNITDLGRTASYFYI 1000
            .:|.:|  |.||.:   |..|..:|..|:.|||:.|:|.:::.:|:::..:..|:||:.|:.:|:
pombe   970 RSPALYSVGPEYDD---DKYLVQKRADLLHSAAILLEKCKLLVYNRQSGTLTATELGKVAASYYV 1031

  Fly  1001 KYDTVETFNELMKPFMTQAEILAMISQAQEFQQLKVRDDEMEELDELKNAYCKIKPYGGSENVH- 1064
            .::::..:|.|:....:..|:..:.|.:.||:.:.||::|..||.:|....    |....|.:.
pombe  1032 THNSMAIYNRLLMQTTSFIELFRVFSFSDEFKHIPVREEEKVELAKLLERV----PIPIRERLDE 1092

  Fly  1065 --GKVNILIQTYLSNGYVKSFSLSSDMSYITTNIGRISRALFSIVLRQNNAVLSGNMLQLCKMFE 1127
              .|:|.|:|:|:|...:..|:|.:||.|:|.:.|||.||:|.|.||:..:.::...|..|||.|
pombe  1093 PAAKINALLQSYISRQRLDGFALVADMVYVTQSAGRIMRAIFEISLRRGWSSVATLSLDTCKMIE 1157

  Fly  1128 RRQWDFDCHLKQFPTINAETIDKLERRGLSVYRLRDMEHRELKEWLRSNTYADLVIRSAHELPLL 1192
            :|.|.....|:|||...:|.|.::|::.....|..|::..||.|.:........|.......|.|
pombe  1158 KRLWPTMSPLRQFPNCPSEVIRRVEKKEFPWQRYFDLDPAELGELVGVPKEGRRVYNMVQSFPRL 1222

  Fly  1193 EVEASLQPITRTVLRIKVDIWPSFTWNDRVHGKTCQSFWLWIEDPESNYIYHSELFQVTRKLVMS 1257
            .|||.:|||||:::|:::.|...|.|:|.:.| |.::||:.:||.:.:.:.|.|.|.:.:|.
pombe  1223 SVEAHVQPITRSLVRVELVINSQFNWDDHLSG-TSEAFWILVEDVDGDRLLHYEQFFLLKKY--- 1283

  Fly  1258 GQSQQLV-MTIPLKEPLPPQYYIRVSSDNWLGSTTCIPLSFQHLVLPEHHPPLTELLPLRPLPVS 1321
            ...:.:| .|:||.|||||.|:|::.||.||.|.|.:|||||.|::||..|..|.||.|:..|||
pombe  1284 KDDEHIVNFTVPLLEPLPPCYFIKIVSDRWLHSITKVPLSFQRLIMPEKFPAPTPLLDLQNAPVS 1348

  Fly  1322 CLKNVVYESLY-KFTHFNPIQTQIFHCLYHTDNNVLLGAPTGSGKTIVAEIAIFRALNQNPKCKV 1385
            .|.|..:.||| .|..||.||||:|:.:|.|:::|.:|||.|||||:.||:|:....:|......
pombe  1349 SLNNPSFISLYPNFKFFNKIQTQVFNSVYKTNDSVFIGAPNGSGKTVCAELALLHHWSQEDYGTA 1413

  Fly  1386 VYIAPLKALVKERIADWEQRFQRSSLGLKVVELTGDVTPDIQAIRESQLIVTTPEKWDGISRSWQ 1450
            |||||::.:|..|..:|..:|.....|..:|:|||:.:.|::.|:.:.||..||.:||.:|:.|:
pombe  1414 VYIAPIQEIVDRRYEEWYGKFSDLGDGKVLVKLTGERSQDLKLIQVADLIFCTPSQWDSLSKRWR 1478

  Fly  1451 TREYVQHVSLIVIDEIHLLGEDRGPVIEVIVSRTNFISSHTGRAIRIVGLSTALANAQDLANWLG 1515
            :...:|.|...:.||:.|||...||:.|:::||..:::....:.||:||||.::|||:||..|||
pombe  1479 SMRSIQKVDFYICDELQLLGGFYGPLYEIVISRIRYMAVQLEKNIRVVGLSVSVANARDLGEWLG 1543

  Fly  1516 INKMGLYNFKPSVRPVPLQVHINGFPGKHYCPRMATMNRPTFQAIRTY-SPCEPTIVFVSSRRQT 1579
            .:...::||.|..||.||.:|:..|...|:...|..|::|.:::::.: |..:.||||...|:..
pombe  1544 TSPQCIFNFSPKDRPNPLTIHLQSFSITHFPSLMLAMSKPIYRSLKNFISQRKSTIVFTPDRKVA 1608

  Fly  1580 RLTALDLITFVAGESNPKQFLHIPEDEIELILQNIREQNLKFCLAFGIGLHHAGLQE----QDRK 1640
            :..|.||:||...:.:...|..:..:....:.....:|:||..:|:        :.|    .|:.
pombe  1609 KQLAFDLVTFSMADEDEYLFSLMENEAFNKVEDAALQQSLKHGIAY--------ISEITSSNDQN 1665

  Fly  1641 CVEELFLNRKIQILVATATLAWGVNLPAHLVVIKGTEYFDGKVKKYVDMPITDVLQMMGRAGRPQ 1705
            .|:.|:.:..|::|:|:..:.:.:...::.|::.||:|:|||..:|:|.||:::|||:|......
pombe  1666 IVQYLYRHGLIKVLIASRDVIYSLKAKSNAVIVMGTQYYDGKEHRYIDYPISELLQMLGFTASIG 1730

  Fly  1706 FDNEGVAVVLVHDEKKNFYKKFLYDPFPVESSLLGVLPEHINAEIVAGTVQSKQAALDYLTWTYF 1770
            .......:::....||.:|||||.:|.|:||.|...|.:...:||...|::|||.|:|:|||:|.
pombe  1731 SSELSQVILMTVTTKKEYYKKFLNEPLPMESHLQVWLHDAFVSEISTQTIESKQDAVDWLTWSYM 1795

  Fly  1771 FRRLLRNPSYYQLQDIEPENVNNFMSNLVERVVYELSAAACLV---ERDGCLIPTFLGRISSYYY 1832
            :|||:.||:||.||||..|:|:.|:|:|||..:.:||.|..:.   |.|.| :...|..|:|:|.
pombe  1796 YRRLVANPAYYGLQDITHESVSEFLSDLVETTMNDLSEARLITVDDEDDSC-VALNLAMIASHYG 1859

  Fly  1833 LSYRTMKHFLEDLQPGMNTKKVLLAIADSYEFDQLPVRHNEDKHNEEMAEVSRFRPPSSSWDSSY 1897
            ::|.||:.|...|......|.:|..:..:.|::|||:|..||...|.:......|..:.:::..:
pombe  1860 ITYITMQTFALSLSERTKMKGLLEIVTSAAEYEQLPIRKYEDIVLERIHSRLPVRLSNPNYEDPH 1924

  Fly  1898 TKTFLLLQAHFARQSLPNSDYLTDTKSALDNATRVMQAMVDYTAERGWLSTTLVVQQLMQSVIQA 1962
            ||:|:||.|||:|..|| ...:.|.|..|.....::.|.||..:..|.|...:...::.|.|.||
pombe  1925 TKSFILLAAHFSRFELP-PGLVIDQKFILTRVHNLLGACVDTLSSEGHLIACIRPMEMSQMVTQA 1988

  Fly  1963 RWFDGSEFLTLPGVNEDNLDAFLNI-----PHDDYDYLTLPVLK--ELCKQEYEVLAKPLRDAFE 2020
            .|...|....:|..:    ||.:..     .||.:|.:.|...|  ||...:...||
pombe  1989 LWDRDSPLKQIPYFD----DALIERCNKEGVHDVFDIIDLDDEKRTELLHMDNAHLA-------- 2041

  Fly  2021 EHEIEKMYKVIQDLPEIAIQIFVEGRHMENEYAKRPLSLSDDTRGEWMSLHANEDYVLIVNLQRL 2085
                 |..:.|...|:|.|...:|.              |:|       :|||...||||.|.|.
pombe  2042 -----KCAEFINKYPDIDIDFEIED--------------SED-------VHANSPSVLIVQLTRE 2080

  Fly  2086 NVSGQRRGGGQSYTVHCPKYPKPKNEAWFLTLGSQANDELLAMKRVSIRGQRCTNRISFQATPRL 2150
            ....:.    ...||..|.:|..|.|.|:|.:..  :..|||:|:::: |:..|.::.| ..|.:
pombe  2081 LEEDEE----VDTTVIAPYFPAQKTEHWWLVISD--DKTLLAIKKITL-GRSLTTKMEF-VPPAM 2137

  Fly  2151 GRLQLTLYLMSDCLMGFDQQYDLQFE 2176
            |.|:..|...||..||.|  |:.:||
pombe  2138 GTLKYKLSCFSDSYMGVD--YEKEFE 2161

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309	13/36 (36%)
		BRR2	485..1025	CDD:440817	261/542 (48%)
		DEXHc_ASCC3_1	486..683	CDD:350778	121/197 (61%)
		SEC63	985..1298	CDD:214744	105/316 (33%)
		BRR2	1334..1859	CDD:440817	184/532 (35%)
		DEXHc_ASCC3_2	1336..1525	CDD:350780	73/188 (39%)
		SEC63	1818..2176	CDD:214744	100/364 (27%)
brr2	NP_593346.1	Helicase_PWI	296..400	CDD:436309	29/121 (24%)
		BRR2	502..1032	CDD:440817	264/534 (49%)
		DEXHc_Brr2_1	503..716	CDD:350777	127/213 (60%)
		Sec63	1019..1323	CDD:460740	103/311 (33%)
		BRR2	1347..1885	CDD:440817	191/546 (35%)
		DEXHc_Brr2_2	1362..1553	CDD:350779	74/190 (39%)
		SEC63	1845..2163	CDD:214744	102/367 (28%)