Protein Alignment obe and Y54E2A.4

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: NP_497060.2
• Gene: Y54E2A.4 / 190256
• WormBaseID: WBGene00013189
• Length: 2017
• Species: Caenorhabditis elegans
• Alignment Length: 2077
• Identity: 901/2077 - (43%)
• Similarity: 1286/2077 - (61%)
• Gaps: 166/2077 - (7%)

  Fly   175 PSEWMDISLLT------DLAPDALLKNRTVNKFSMKHTTKAAPVASTSSEAAKLSPELQTLL--- 230
            |||:::.|...      ..||:||               ....|.|||...:...|...|||
 Worm    32 PSEFLEWSNCEAEQEGFSEAPEAL---------------SLPQVPSTSGSGSIFQPIADTLLIYF 81

  Fly   231 -----EISAKLDDEHLIIRVGDILGSQRSSEVLQNELMEILGFDYFELVEKLLMERDKIARQLDQ 290
                 .||     ::|:    .:|.|.||...||.||:::||.:.|||...:|.:|:||
 Worm    82 PDTFETIS-----QNLL----QMLCSTRSDMDLQGELIDLLGVELFELAGDILEKRNKI------ 131

  Fly   291 FATRSRRVMEVKQKRMEAAASGGAAERRPTV---ASAVVVQSAQE----KQLSKMQRREEKKLQR 348
                   |.|||.:.:........|:.:|.|   ...|.|||..:    ::|.|.::|..::|.|
 Worm   132 -------VFEVKSQELAKVEHARQAKAKPAVPGFLQTVSVQSTSQNEKRRELRKEEKRTRRELNR 189

  Fly   349 IMRSIKDEEAEDDPNCAVAVSVQQLRMQHQRKL-LEAAQREPLLLSTKAAKAEYKQSSYNQPIHY 412
            ::.:..|||       .:.:.:.|..:|.||:| ::..:.:|.|::......|.          |
 Worm   190 VIHAFGDEE-------KLELELAQKEIQRQRQLEIDQMKWKPSLVAGGPRIEEI----------Y 237

  Fly   413 PYVFDSQLLAKQHAGF-IGGSRITLPDNAQRIDNKQWEEVKIPASEPPPLSVGN----KRVQIEE 472
            |||||::|....|..| |.|.:..||:.::|...|..|.|.:     ||.:.|:    :.|.:::
 Worm   238 PYVFDARLQNVGHTMFDINGMKFALPEGSKRDTFKTHESVYV-----PPSNKGDIEKIQHVYVKD 297

  Fly   473 LDDVGRLAFANCKELNRIQSVVFPVAYHSNENMLVCAPTGAGKTNVAMLSIVHTIRCHL-EQGVI 536
            :|::|:..|...::||.|||:||..||.:.||:|:||||||||||:|||:|::||..|. .:|.|
 Worm   298 MDELGQKGFKGFEKLNVIQSIVFEQAYKTKENLLICAPTGAGKTNIAMLTILNTIHEHQNSRGDI 362

  Fly   537 NRDEFKIVYIAPMKALAAEMVDNFSKRLKSLQIAVRELTGDIQLTKAEMAATQILVTTPEKWDVV 601
            .:|:|||:|||||||||.||.::|.|||..|.:.|:|||||.||::.|:|.||:||.|||||||:
 Worm   363 MKDDFKIIYIAPMKALATEMTESFGKRLAPLGLKVKELTGDTQLSRNEVADTQMLVLTPEKWDVI 427

  Fly   602 TRKGSGDVALISLVELLIIDEVHLLHGERGPVVEALVARTLRLVESSQSMIRIVGLSATLPNYID 666
            |||.:.|.:||::|.|||||||||||.|||||:|.|||||||.||.|||.||||||||||||:||
 Worm   428 TRKSTSDNSLINVVRLLIIDEVHLLHDERGPVIETLVARTLRQVEMSQSGIRIVGLSATLPNFID 492

  Fly   667 VAHFLRVNPMKGLFYFDSRFRPVPLDTNFVGIKSVKQLQ-QIADMDQCCYQKCVEMVQEGHQIMV 730
            ||.||||||.||||:||.|||||||...|:|.:.....: .:..||..||.:.|:.|:.|||::|
 Worm   493 VARFLRVNPYKGLFFFDGRFRPVPLTQKFIGTRKAGNFRDNLTLMDNVCYDEVVDFVKRGHQVLV 557

  Fly   731 FVHARNATVRTANVIRELAQQNNTSALFLPKD--SAAHGLATRSIQRSRNK-QLVELFSCGLAMH 792
            |||.||.|.:........|.......||||||  |:.:..|.::|...||: |:..||..|:.:|
 Worm   558 FVHTRNGTAKLGEAFCARASVLGQMDLFLPKDRASSKYIQADKAINICRNRAQISPLFQRGMGIH 622

  Fly   793 HAGMLRADRQMVEKYFVEGHISVLVCTATLAWGVNLPAHAVIIRGTDIYDAKHGSFVDLGILDVL 857
            |||:.|.||.::|:.|.|||:|||.||||||||||||||||:|:|||::||:.|.|.|||:|||.
 Worm   623 HAGLCRQDRILMERCFAEGHVSVLFCTATLAWGVNLPAHAVVIKGTDVFDAEKGVFTDLGVLDVQ 687

  Fly   858 QIFGRAGRPQFDKSGVGTIITSYDKLNHYLSLLTNQFPIESNFVNCLADNLNAEIGLGTITNVDE 922
            |||||||||||:..|.|.|||:.||::.||::|.:|.||||.|...|.||||||:.|||::.|||
 Worm   688 QIFGRAGRPQFENEGHGIIITTRDKIDKYLTMLVHQNPIESQFYARLHDNLNAEVALGTVSTVDE 752

  Fly   923 AIEWLSYTYLFVRMRINPHVYGIEYSELEKDPTLEARRRALIMSAAMSLDKARMMRFNQRTMDMN 987
            .:|||:|||::.|...||..|||.|:.:|:||.|......:|..|||.||:.:|:||:..|..:|
 Worm   753 GVEWLTYTYMYTRALKNPMAYGIAYNAIERDPNLRDHFGNVIREAAMQLDQNKMIRFDMATEYLN 817

  Fly   988 ITDLGRTASYFYIKYDTVETFNELMK---------PFMTQAEILAMISQAQEFQQLKVRDDEMEE 1043
            .|||||.||.||:||:|::..||..|         .||....::.:||.:.||..||.|::|:.:
 Worm   818 STDLGRIASNFYVKYETIQLLNEAEKGVGLPVTFTSFMPDDMVIGLISMSTEFANLKCREEEIGD 882

  Fly  1044 LDELKNAYCKIKPYGGS-ENVHGKVNILIQTYLSNGYVKSFSLSSDMSYITTNIGRISRALFSIV 1107
            |:||.:..|.:...||. .:|.||||:|:|:.:|....::.:|.|:..|:..|.||:.||:|.:|
 Worm   883 LEELMSYGCMMNVRGGGLASVAGKVNVLLQSLISRTSTRNSALMSEQLYVQQNAGRLCRAMFEMV 947

  Fly  1108 LRQNNAVLSGNMLQLCKMFERRQWDFDCHLKQF-PTINAET--IDKLERRGLSVYRLRDMEHREL 1169
            |:...:..:...|.:.|..|::.|...|.|:|| ..||...  |:|:||:......|.::..::|
 Worm   948 LKNGWSQAANAFLGIAKCVEKQMWMNQCALRQFIQIINIPITWIEKIERKKARESDLLELSAKDL 1012

  Fly  1170 KEWLRSNTYADLVIRSAHELPLLEVEASLQPITRTVLRIKVDIWPSFTWNDRVHGKT-CQSFWLW 1233
            ......:  .|.:......||.::|:|..:|||.|:::::|.:.|:|.|||::|||: .|||:|.
 Worm  1013 GYMFSCD--GDRLYTYLRYLPRMDVQAKFKPITYTIVQVEVTLTPTFIWNDQIHGKSGQQSFYLV 1075

  Fly  1234 IEDPESNYIYHSELFQVTRKLVMSGQSQQLVMTIPLKE-PLPPQYYIRVSSDNWLGSTTCIPLSF 1297
            :|:...|.|.|.|...:.:..|...::|.||.|||:.: .|...:.:|::|:.::.....:|:|.
 Worm  1076 LENLNENLIIHQERIGIGKMKVNRQETQNLVFTIPIVDCQLTNNFQLRLASEYFVTDDVVVPMSL 1140

  Fly  1298 QHLVLPEHHPPLTELLPLRPLPVSCLKNVVYESLYKFTHFNPIQTQIFHCLYHTDNNVLLGAPTG 1362
            .:.:||:.....|:||.|.|||:..|||..:|::|.|.:|||||.|:|.|||.||.:.|:|||||
 Worm  1141 HNCILPKSFKSHTDLLDLEPLPIKTLKNSKFEAIYNFDYFNPIQAQVFFCLYKTDKSALIGAPTG 1205

  Fly  1363 SGKTIVAEIAIFRALNQNPKCKVVYIAPLKALVKERIADWEQRFQRSSLGLKVVELTGDVTPDIQ 1427
            ||||:.||:|:||.|..:|..|||||||||:||:||:.||:::|: ..:|.:|||::||||||.:
 Worm  1206 SGKTLCAELAMFRLLQDHPGMKVVYIAPLKSLVRERVDDWKKKFE-DGMGYRVVEVSGDVTPDPE 1269

  Fly  1428 AIRESQLIVTTPEKWDGISRSWQTREYVQHVSLIVIDEIHLLGEDRGPVIEVIVSRTNFIS--SH 1490
            .:..|.:::|||||||||||||.|||||:.|.|||:||:||||.|||.|:|.||||...|:  ||
 Worm  1270 ELAASSILITTPEKWDGISRSWATREYVRRVGLIVLDEVHLLGVDRGAVLEAIVSRLKMITRRSH 1334

  Fly  1491 -TGRAIRIVGLSTALANAQDLANWLGINKMGLYNFKPSVRPVPLQVHINGFPGKHYCPRMATMNR 1554
             |...:|::|||||||||.|:|.||||.....|||:|||||||:.|||.||||:||||||..||:
 Worm  1335 VTEEPVRLLGLSTALANAGDVAEWLGIPDEACYNFRPSVRPVPISVHIQGFPGQHYCPRMGLMNK 1399

  Fly  1555 PTFQAIRTYSPCEPTIVFVSSRRQTRLTALDLITFVAGESNPKQFLHIPEDEIELILQNIREQNL 1619
            |.::||.||||.:|.::|||||||||||||..:..:..:.||||:|::...|:|.::..|:::||
 Worm  1400 PAYKAILTYSPRKPVLIFVSSRRQTRLTALAFVNLLIADHNPKQWLNMDMLELEDLMAAIKDENL 1464

  Fly  1620 KFCLAFGIGLHHAGLQEQDRKCVEELFLNRKIQILVATATLAWGVNLPAHLVVIKGTEYFDGKVK 1684
            |..|.||||:|||||...:|..||:||:.:|||:|:||||||||:|.|||||::|||||||||..
 Worm  1465 KLTLPFGIGMHHAGLSAHERAIVEQLFIEKKIQVLIATATLAWGINCPAHLVIVKGTEYFDGKKG 1529

  Fly  1685 KYVDMPITDVLQMMGRAGRPQFDNEGVAVVLVHDEKKNFYKKFLYDPFPVESSLLGVLPEHINAE 1749
            ||||.|:||||||||||||||||:..|||:.|.|.||.|||||||:|||||||||.|||.|:|||
 Worm  1530 KYVDFPVTDVLQMMGRAGRPQFDDSAVAVIYVQDAKKTFYKKFLYEPFPVESSLLPVLPNHVNAE 1594

  Fly  1750 IVAGTVQSKQAALDYLTWTYFFRRLLRNPSYYQLQDIEPENVNNFMSNLVERVVYELSAAACL-- 1812
            |.|||:.||||.::||:.||.:|||..||:||.|::...|.:..|::.:|:..|.||.|:.|:
 Worm  1595 ISAGTIDSKQAIVEYLSKTYLYRRLFANPNYYGLEEDSEEAMLKFITKIVDDSVAELLASECIHV 1659

  Fly  1813 -VERDGCLIPTFLGRISSYYYLSYRTMKHFLEDLQPGMNTKKVLLAIADSYEFDQLPVRHNEDKH 1876
             .|:| .:.||..|||:|.|||.:.|::..::.|..|.:.:.:|..:.|..|:.::|||||||..
 Worm  1660 DSEQD-VIKPTPCGRIASVYYLQHETVRFLVKSLHSGCSVENMLKILTDVPEYAEIPVRHNEDLI 1723

  Fly  1877 NEEMAEVSRFRPPSSSWDSSYTKTFLLLQAHFARQSLPNSDYLTDTKSALDNATRVMQAMVDYTA 1941
            |.|:.:..|.|..:|...:|..|..||.||||.|..|| :||.||.||.||...|::|||.:...
 Worm  1724 NTELQKKLRIRFSTSVMGTSACKAHLLFQAHFMRTVLP-TDYRTDLKSVLDQCIRILQAMREMAR 1787

  Fly  1942 ERGWLSTTLVVQQLMQSVIQARWFDGSEFLTLPGVNEDNLDAFLNIPHDDY----DYLTLPVLKE 2002
            .:.|||.|:.:..|.|....|||.|....|.||           ::.|:|.    |.:|:|.|:.
 Worm  1788 LKNWLSATMNIILLQQMCHSARWHDDHPLLCLP-----------HLSHEDARSIGDGMTIPQLQN 1841

  Fly  2003 LCKQEYEV------LAKPLRDAF------EEHEIEKMYKVIQDLPEIAIQIF----VEGRHMENE 2051
            ..:.|...      ||:..:..|      :|.:..::.|.:.:.|.|.::|.    ..|..::.:
 Worm  1842 HLEIEKSTSLDDAKLARRAQKLFRECTKLDEAQSREVLKALCNWPIINMKIMQLVDSRGNCVDID 1906

  Fly  2052 YAKRPLSLSDDTRGEWMSLHANEDYVLIVNLQRLNVSGQRRGGGQSYTVHCPKYPKPKNEAWFLT 2116
            ..|:|:.::           |.|.|.|.:.::|:.      .|..:.::|.|::||||...|.:.
 Worm  1907 ETKKPVKVT-----------AGEVYKLRIVMERVG------PGKNNSSMHLPQWPKPKQAGWIIV 1954

  Fly  2117 LGSQANDELLAMKRVS-IRGQRCTNRISFQATPRLGRLQLTLYLMSDCLMGFDQQYDLQFEI 2177
            :|:.:.|.:|....|: ....|.|.::..:|....|..:|.:.::|||.:|.||:|.|:.::
 Worm  1955 VGNVSADMILNTTTVTGSHSTRSTAKLDIRAPATKGNHELAVLILSDCYLGIDQEYTLRLDV 2016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309	15/36 (42%)
		BRR2	485..1025	CDD:440817	307/553 (56%)
		DEXHc_ASCC3_1	486..683	CDD:350778	134/197 (68%)
		SEC63	985..1298	CDD:214744	106/327 (32%)
		BRR2	1334..1859	CDD:440817	307/530 (58%)
		DEXHc_ASCC3_2	1336..1525	CDD:350780	115/191 (60%)
		SEC63	1818..2176	CDD:214744	111/378 (29%)
Y54E2A.4	NP_497060.2	BRR2	307..838	CDD:440817	302/530 (57%)
		DEXHc_ASCC3_1	311..509	CDD:350778	134/197 (68%)
		SEC63	815..1141	CDD:214744	106/327 (32%)
		BRR2	1177..1692	CDD:440817	304/516 (59%)
		DEXHc_ASCC3_2	1179..1370	CDD:350780	115/191 (60%)
		SEC63	1665..2015	CDD:214744	111/378 (29%)