Protein Alignment obe and snrp-200

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: NP_001366952.1
• Gene: snrp-200 / 174901
• WormBaseID: WBGene00012896
• Length: 2145
• Species: Caenorhabditis elegans
• Alignment Length: 2183
• Identity: 780/2183 - (35%)
• Similarity: 1218/2183 - (55%)
• Gaps: 191/2183 - (8%)

  Fly    60 EKQPAAKVQLQKLRNLV---QECMG-YEEQPQVVEHAALFLFWLLLD------QRVLLVATTQRL 114
            :|:...|.| |..||::   .|.|| |:.:.|..:.....:...:||      :.||..|..:.|
 Worm    72 KKKDDEKAQ-QFGRNVLVDNNELMGAYKPRTQETKQTYEVILSFILDALGDVPREVLCGAADEVL 135

  Fly   115 HGMFGQTFDRKKTQIHDCVQAIGDLLEDHERSALKRWR-------QTHHKVPGVGPLW---GAHI 169
            ..:....| |.|.:..:....:|.|.:|.....:...:       :..:|..|.|.::   |.::
 Worm   136 LTLKNDKF-RDKEKKKEVEALLGPLTDDRIAVLINLSKKISDFSIEEENKPEGDGDIYENEGVNV 199

  Fly   170 HVKCTPSEWMDISLLTDLAPDALLKNRTVNKFSMKHTTKAAPVASTSSEAAKLSPELQTLLEISA 234
            ... :..|..|..::.::..|:..::.........:|       :|......|:.:.|....|..
 Worm   200 QFD-SDEEEDDGGMVNEIKGDSEEESEEEEGVDTDYT-------ATLKGDGHLTEDEQKARGILH 256

  Fly   235 KLD-DEHLIIR------VGDILGSQRSSEVL------------QNELMEILGFDYFELVEKLLME 280
            ..| |.|.|.|      ...::..|:.:||:            :|:|:.:||||.||.::.|...
 Worm   257 PRDIDAHWIQRSLAKYFKDPLIAQQKQTEVIGILKNAADDRDAENQLVLLLGFDQFEFIKCLRQN 321

  Fly   281 RDKIARQLDQFATRSRRVMEVKQKRMEAAASGGAAERRPTVASAVVVQSAQEKQLSKMQRREEKK 345
            |..|.     :.|..|:..|.::.::|     .....||.:          ...|:.:|..:|..
 Worm   322 RLMIL-----YCTLLRQANEKERLQIE-----DDMRSRPEL----------HPILALLQETDEGS 366

  Fly   346 LQRIMRSIKDEEAEDDPNCAVAVSVQQLRMQHQRKLLEAAQREPLLLSTKAAKAEYKQSSYNQPI 410
            :.::.:|.:|.|.......|...::...:.|..||:|:.
 Worm   367 VVQVEKSKRDAEKSKKAATAANEAISAGQWQAGRKMLDL-------------------------- 405

  Fly   411 HYPYVFDSQLLAKQHAGFIGGSRITLPDNAQRIDNKQWEEVKIPASEPPPLSVGNKRVQIEELDD 475
                   :.|...|.:..:...|..|||.:.|...|.:||:.:||.:|.|.:.|.|.|.:.||..
 Worm   406 -------NDLTFSQGSHLMSNKRCELPDGSYRRQKKSYEEIHVPALKPRPFAEGEKLVSVSELPK 463

  Fly   476 VGRLAFANCKELNRIQSVVFPVAYHSNENMLVCAPTGAGKTNVAMLSIVHTIRCHL-EQGVINRD 539
            ..:.||...|.||||||.:...|..|.|::|:||||||||||||:|:::..|..|| |.|.:..|
 Worm   464 WAQPAFDGYKSLNRIQSRLCDSALRSKEHLLLCAPTGAGKTNVALLTMLQEIGNHLAEDGSVKLD 528

  Fly   540 EFKIVYIAPMKALAAEMVDNFSKRLKSLQIAVRELTGDIQLTKAEMAATQILVTTPEKWDVVTRK 604
            |||||||||||:|..|||.:|||||....|.|.|:|||.|::|.:..|||::|.||||:||||||
 Worm   529 EFKIVYIAPMKSLVQEMVGSFSKRLAPFGITVGEMTGDAQMSKEQFMATQVIVCTPEKYDVVTRK 593

  Fly   605 GSGDVALISLVELLIIDEVHLLHGERGPVVEALVARTLRLVESSQSMIRIVGLSATLPNYIDVAH 669
            | |:.|...:|.||||||:||||.:||||:|::|.||:|.:|.:....|:||||||||||.|||.
 Worm   594 G-GERAYNQMVRLLIIDEIHLLHDDRGPVLESIVVRTIRQMEQNHDECRLVGLSATLPNYQDVAT 657

  Fly   670 FLRVNPMKGLFYFDSRFRPVPLDTNFVGIKSVKQLQQIADMDQCCYQKCVEMVQEGHQIMVFVHA 734
            ||||.| :.|.:||:.:|||||:..::|:...|.|::...|::..|.|.:|...:. |::||||:
 Worm   658 FLRVKP-EHLHFFDNSYRPVPLEQQYIGVTEKKALKRFQAMNEVVYDKIMEHAGKS-QVLVFVHS 720

  Fly   735 RNATVRTANVIRELAQQNNTSALFLPKDSAAHGLATRSIQRSRNKQLVELFSCGLAMHHAGMLRA 799
            |..|.:||..||:...:.:|.:.|:.:.||:..:.....::::|..|.:|...|.|:|||||.|.
 Worm   721 RKETAKTAKAIRDACLEKDTLSAFMREGSASTEILRTEAEQAKNLDLKDLLPYGFAIHHAGMNRV 785

  Fly   800 DRQMVEKYFVEGHISVLVCTATLAWGVNLPAHAVIIRGTDIYDAKHGSFVDLGILDVLQIFGRAG 864
            ||.:||..|.:.||.||..|||||||||||||.|||:||.||:.:.|.:.:||.||::|:.||||
 Worm   786 DRTLVEDLFADRHIQVLFSTATLAWGVNLPAHTVIIKGTQIYNPEKGRWTELGALDIMQMLGRAG 850

  Fly   865 RPQFDKSGVGTIITSYDKLNHYLSLLTNQFPIESNFVNCLADNLNAEIGLGTITNVDEAIEWLSY 929
            |||:|..|.|.:||::.:|.:||||:..|.|:||..|:.|.|.||||:.|||:::|.||..||.|
 Worm   851 RPQYDDRGEGILITNHSELQYYLSLMNQQLPVESQMVSRLTDMLNAEVVLGTVSSVSEATNWLGY 915

  Fly   930 TYLFVRMRINPHVYGIEYSELEKDPTLEARRRALIMSAAMSLDKARMMRFNQRTMDMNITDLGRT 994
            |:|||||..||.:|||.:.:...||.||.||..||.:|.:.||||.::::::|:..:..|:|||.
 Worm   916 TFLFVRMLKNPTLYGITHEQARADPLLEQRRADLIHTACVLLDKAGLIKYDKRSGIIQATELGRI 980

  Fly   995 ASYFYIKYDTVETFNELMKPFMTQAEILAMISQAQEFQQLKVRDDEMEELDEL-KNAYCKIKPYG 1058
            ||:||..|::::|:|:|:....:..::..:.|.:.||:.|.|||:|..||.:: ::|...||
 Worm   981 ASHFYCTYESMQTYNKLLVETCSDIDLFRIFSMSSEFKLLSVRDEEKLELQKMAEHAPIPIK--- 1042

  Fly  1059 GSENV---HGKVNILIQTYLSNGYVKSFSLSSDMSYITTNIGRISRALFSIVLRQNNAVLSGNML 1120
              ||:   ..|.|:|:|.|:|...::.|:|.:||.::..:.||:.||||.|||.:..|.|:..:|
 Worm  1043 --ENLDEASAKTNVLLQAYISQLKLEGFALQADMVFVAQSAGRLFRALFEIVLWRGWAGLAQKVL 1105

  Fly  1121 QLCKMFERRQWDFDCHLKQFPTINAETIDKLERRGLSVYRLRDMEHRELKEWLRSNTYADLVIRS 1185
            .||||..:|||.....|.||..|.:|.:..::::..|..||.|::..:|.:.::.......:.:.
 Worm  1106 TLCKMVTQRQWGSLNPLHQFKKIPSEVVRSIDKKNYSFDRLYDLDQHQLGDLIKMPKMGKPLFKF 1170

  Fly  1186 AHELPLLEVEASLQPITRTVLRIKVDIWPSFTWNDRVHGKTCQSFWLWIEDPESNYIYHSELFQV 1250
            ..:.|.||:...:||||||.:||::.|.|.|.|:::||| :.:.||::|||.:...|.|.|.|.:
 Worm  1171 IRQFPKLEMTTLIQPITRTTMRIELTITPDFKWDEKVHG-SAEGFWIFIEDTDGEKILHHEFFLL 1234

  Fly  1251 TRKLVMSGQSQQLVMTIPLKEPLPPQYYIRVSSDNWLGSTTCIPLSFQHLVLPEHHPPLTELLPL 1315
            .:|  .......:.|.:|:.:|:||.||:|:.||.|:|:.|.:|:||:||:|||.:||.||||.|
 Worm  1235 KQK--FCSDEHVVKMIVPMFDPMPPLYYVRIVSDRWIGAETVLPISFRHLILPEKYPPPTELLDL 1297

  Fly  1316 RPLPVSCLKNVVYESLYK---FTHFNPIQTQIFHCLYHTDNNVLLGAPTGSGKTIVAEIAIFRAL 1377
            :|||:|.:.|..:::::.   |..|||||||:|..::.::.||::.||.|||||.:||:|:.|..
 Worm  1298 QPLPISAVTNKEFQTVFAESGFKVFNPIQTQVFRTVFESNENVIVCAPNGSGKTAIAELAVLRHF 1362

  Fly  1378 NQNPKCKVVYIAPLKALVKERIADWEQRFQRSSLGLKVVELTGDVTPDIQAIRESQLIVTTPEKW 1442
            ...|:.|.|||.|::.:..:..|||::|.: .::|..:|.|||:.|.|::..:..|||::|||:|
 Worm  1363 ENTPEAKAVYITPMEDMATKVYADWKRRLE-PAIGHTIVLLTGEQTMDLKLAQRGQLIISTPERW 1426

  Fly  1443 DGISRSWQTREYVQHVSLIVIDEIHLLGEDRGPVIEVIVSRTNFISSHTGRAIRIVGLSTALANA 1507
            |.|||.|:.|:.||:|.|.:.|::|::|...|.|.||:.|||.:|||....|:|:|.||::|.||
 Worm  1427 DNISRRWKQRKSVQNVKLFIADDLHMIGASNGAVFEVVCSRTRYISSQLESAVRVVALSSSLTNA 1491

  Fly  1508 QDLANWLGINKMGLYNFKPSVRPVPLQVHINGFPGKHYCPRMATMNRPTFQAIRTYS----PCEP 1568
            :||..|||.:....:||.||.|||||.:.|..|...|...|.|.|.||.:|||..::    | :|
 Worm  1492 RDLGMWLGCSASATFNFMPSTRPVPLDLEIKSFNLSHNASRFAAMERPVYQAICRHAGKLEP-KP 1555

  Fly  1569 TIVFVSSRRQTRLTALDLITFVAGESNPKQFLHIPE--DEIELILQNIREQNLKFCLAFGIGLHH 1631
            .:|||..|||||..|:.|:|....:..||:||.:.|  |..:.:|.:|.:::|:..::.|:|..|
 Worm  1556 ALVFVPVRRQTRPVAVALLTMALADGAPKRFLRLAEHDDTFQALLADIEDESLRESVSCGVGFLH 1620

  Fly  1632 AGLQEQDRKCVEELFLNRKIQILVATATLAWGVNLPAHLVVIKGTEYFDGKVKKYVDMPITDVLQ 1696
            .|...:|...|::||.:..||:.|....:.:.:.:.|:|||:..|::::||...|.|.||.|:|.
 Worm  1621 EGTAPKDVHIVQQLFESNAIQVCVVPRGMCYQIEMSAYLVVVMDTQFYNGKYHVYEDYPIADMLH 1685

  Fly  1697 MMGRAGRPQFDNEGVAVVLVHDEKKNFYKKFLYDPFPVESSLLGVLPEHINAEIVAGTVQSKQAA 1761
            |:|.|.||..|::...||:....|:.:|||||.||.||||.|...|.:|.|||||..|:::||.|
 Worm  1686 MVGLANRPILDSDAKCVVMCQTSKRAYYKKFLCDPLPVESHLDHCLHDHFNAEIVTKTIENKQDA 1750

  Fly  1762 LDYLTWTYFFRRLLRNPSYYQLQDIEPENVNNFMSNLVERVVYELSAAACLVERDGC-LIPTFLG 1825
            :||||||..:||:.:||:||.||.....::::.:|.|||..:.:|..:.|:..:|.. .:...||
 Worm  1751 IDYLTWTLLYRRMTQNPNYYNLQGTTHRHLSDALSELVELTLKDLENSKCIAVKDEMDTVSLNLG 1815

  Fly  1826 RISSYYYLSYRTMKHFLEDLQPGMNTKKVLLAIADSYEFDQLPVRHNEDKHNEEMAEVSRFRPPS 1890
            .|:||||:||:|::.|...|:....|:.::..|:.|.||..:|:||.||....::||    |.|.
 Worm  1816 MIASYYYISYQTIELFSMSLKEKTKTRALIEIISASSEFGNVPMRHKEDVILRQLAE----RLPG 1876

  Fly  1891 SSWDSSYT----KTFLLLQAHFARQSLPNSDYLTDTKSALDNATRVMQAMVDYTAERGWLSTTLV 1951
            ...:..:|    |..||:.||.:|..| .::...||:..:..|.|::||.||..:..||||..:.
 Worm  1877 QLKNQKFTDPHVKVNLLIHAHLSRVKL-TAELNKDTELIVLRACRLVQACVDVLSSNGWLSPAIH 1940

  Fly  1952 VQQLMQSVIQARWFDGSEFLTLPGVNEDNLDAFLNIPHDDYDYLTLPVLKELCKQEYEVLAKPLR 2016
            ..:|.|.:.||.:           .||..|.   .:||      ....|.|..|      ||.:.
 Worm  1941 AMELSQMLTQAMY-----------SNEPYLK---QLPH------CSAALLERAK------AKEVT 1979

  Fly  2017 DAFEEHEIEKMYKVIQDLPEIAIQIFVEGRHME------NEYAKRPLSLSDDTRGEWMSLHANED 2075
            ..||..|:|.     .|..:|   :.:||..:.      |.|.    |:...|..|...:.:|::
 Worm  1980 SVFELLELEN-----DDRSDI---LQMEGAELADVARFCNHYP----SIEVATELENDVVTSNDN 2032

  Fly  2076 YVLIVNLQRLNVSGQRRGGGQSYTVHCPKYP-KPKNEAWFLTLGSQANDELLAMKRVSIRGQRCT 2139
            .:|.|:|:|.|..     .|.:..|..|.:| |.|.|.|:|.:|...::.||.:||:.| .::.:
 Worm  2033 LMLAVSLERDNDI-----DGLAPPVVAPLFPQKRKEEGWWLVIGDSESNALLTIKRLVI-NEKSS 2091

  Fly  2140 NRISFQATPRLGRLQLTLYLMSDCLMGFDQQYDLQFEI 2177
            .::.| |.||.|..:..|:.:||..:|.||::|:.|::
 Worm  2092 VQLDF-AAPRPGHHKFKLFFISDSYLGADQEFDVAFKV 2128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309	13/48 (27%)
		BRR2	485..1025	CDD:440817	265/540 (49%)
		DEXHc_ASCC3_1	486..683	CDD:350778	115/197 (58%)
		SEC63	985..1298	CDD:214744	109/316 (34%)
		BRR2	1334..1859	CDD:440817	214/531 (40%)
		DEXHc_ASCC3_2	1336..1525	CDD:350780	82/188 (44%)
		SEC63	1818..2176	CDD:214744	106/369 (29%)
snrp-200	NP_001366952.1	Helicase_PWI	254..359	CDD:436309	27/124 (22%)
		BRR2	458..1010	CDD:440817	269/554 (49%)
		DEXHc_Brr2_1	458..670	CDD:350777	120/213 (56%)
		Sec63	974..1278	CDD:460740	108/311 (35%)
		BRR2	1313..1848	CDD:440817	214/536 (40%)
		DEXHc_Brr2_2	1319..1509	CDD:350779	83/190 (44%)
		SEC63	1808..2127	CDD:214744	106/368 (29%)