Protein Alignment obe and HFM1

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: NP_001017975.5
• Gene: HFM1 / 164045
• HGNCID: 20193
• Length: 1435
• Species: Homo sapiens
• Alignment Length: 1204
• Identity: 330/1204 - (27%)
• Similarity: 519/1204 - (43%)
• Gaps: 288/1204 - (23%)

  Fly   998 FYIKYDTVETFNELMKP---FMTQAEILAMISQAQEFQQLKVRDDEMEELDELKNAYCKIKPYGG 1059
            |:.|.|.||...:..|.   |:..|.:::.|...||.:         |||:..|....:.:|
Human    15 FFEKPDEVENHPDNEKSLDWFLPPAPLISEIPDTQELE---------EELESHKLLGQEKRP--- 67

  Fly  1060 SENVHGKVNILIQTYLSNGYVKSFSLSSDMSYITTNIGRISRALFSIVLRQNNAVLSGNMLQLCK 1124
                                          ..:|:|            |:..|.  ..|.:.|.:
Human    68 ------------------------------KMLTSN------------LKITNE--DTNYISLTQ 88

  Fly  1125 MFERRQWDFDCHLKQFPTINAETIDKLERRGLSVYRLRDMEHRELKEWLRSNTYADLVIRSAHEL 1189
            .|:          ..||:      ||.|:..|:   |..:.:.:|.......|||....:: |..
Human    89 KFQ----------FAFPS------DKYEQDDLN---LEGVGNNDLSHIAGKLTYASQKYKN-HIG 133

  Fly  1190 PLLEVEASLQPITR------------TVLRIKVDIWPSFTWNDRVHGKTCQSFWLWIEDPESNYI 1242
            ..:..|.|:...|:            :|.|.::     |..:|.:||..      :..|.|.:
Human   134 TEIAPEKSVPDDTKLVNFAEDKGESTSVFRKRL-----FKISDNIHGSA------YSNDNELD-- 185

  Fly  1243 YHSELFQVTRKLVMSGQSQQLVMTIPLKEPLPPQYYIRVSSDNWLGSTTCI-------PLSFQHL 1300
            .|....::.:..:..|:|:....:   |:..  ||...|.:.|...|.:.|       | ||...
Human   186 SHIGSVKIVQTEMNKGKSRNYSNS---KQKF--QYSANVFTANNAFSASEIGEGMFKAP-SFSVA 244

  Fly  1301 VLPEHHPPLTE-----LLPLRPLPVSCLKNVVYESLYK-FTHFNPIQTQIFHCLYHTDNNVLLGA 1359
            ..|.....:||     |..:..:|..      :.|::| |.:||.||::.|..|.:||.|.::.|
Human   245 FQPHDIQEVTENGLGSLKAVTEIPAK------FRSIFKEFPYFNYIQSKAFDDLLYTDRNFVICA 303

  Fly  1360 PTGSGKTIVAEIAIFRALNQNP----KCKVVYIAPLKALVKERIADWEQRFQRSSLGLKVVELTG 1420
            |||||||:|.|:||.|.|.:.|    ..|:||:||:|||..:|..||:::|  ..:||...||||
Human   304 PTGSGKTVVFELAITRLLMEVPLPWLNIKIVYMAPIKALCSQRFDDWKEKF--GPIGLNCKELTG 366

  Fly  1421 D-VTPDIQAIRESQLIVTTPEKWDGISRSWQTREYVQHVSLIVIDEIHLL-GEDRGPVIEVIVSR 1483
            | |..|:..|:.:.:|:|||||||.::|.|:....||.|.|.:|||:|:: .|:|||.:||:|||
Human   367 DTVMDDLFEIQHAHIIMTTPEKWDSMTRKWRDNSLVQLVRLFLIDEVHIVKDENRGPTLEVVVSR 431

  Fly  1484 TNFISS------HTGRAI--RIVGLSTALANAQDLANWLGINKMGLYNFKPSV--------RPVP 1532
            ...:.|      :|..||  |.|.:|..:.||:|:|.||...:      :|:|        |||.
Human   432 MKTVQSVSQTLKNTSTAIPMRFVAVSATIPNAEDIAEWLSDGE------RPAVCLKMDESHRPVK 490

  Fly  1533 LQVHINGFPGKHYCPRM-------ATMNRPTFQAIRTYSPCEPTIVFVSSRRQTRLTALDLITFV 1590
            ||..:.|||    |...       .|:|......|:.||..:||:||.::|:..:..|..|:
Human   491 LQKVVLGFP----CSSNQTEFKFDLTLNYKIASVIQMYSDQKPTLVFCATRKGVQQAASVLV--- 548

  Fly  1591 AGESNPKQFLHIPEDE-IELILQNIREQNLKFCLAFGIGLHHAGLQEQDRKCVEELFLNRKIQIL 1654
               .:.|..:.:.:.: ::....::|:..|:..|..|...||||::..|||.||..|....:.:|
Human   549 ---KDAKFIMTVEQKQRLQKYAYSVRDSKLRDILKDGAAYHHAGMELSDRKVVEGAFTVGDLPVL 610

  Fly  1655 VATATLAWGVNLPAHLVVIKGT-EYFDGKVKKYVDMPITDVLQMMGRAGRPQFDNEGVAVVLVHD 1718
            ..|:|||.||||||||||||.| .|..|..::|.:   ||:|||:|||||||||....||::...
Human   611 FTTSTLAMGVNLPAHLVVIKSTMHYAGGLFEEYSE---TDILQMIGRAGRPQFDTTATAVIMTRL 672

  Fly  1719 EKKNFYKKFLYDPFPVESSLLGVLPEHINAEIVAGTVQSKQAALDYLTWTYFFRRLLRNPSYY-- 1781
            ..::.|.:.|.....|||||...|.||:|||||..|:.....|::::..|..:.|.|:|||:|
Human   673 STRDKYIQMLACRDTVESSLHRHLIEHLNAEIVLHTITDVNIAVEWIRSTLLYIRALKNPSHYGF 737

  Fly  1782 -----------QLQDIEPENVNNFMS----NLVERVVYELSAAACLVERDGCLIPTFLGRISSYY 1831
                       :||::..:|:|:..|    .:.|.|.::               ||..||:.::|
Human   738 ASGLNKDGIEAKLQELCLKNLNDLSSLDLIKMDEGVNFK---------------PTEAGRLMAWY 787

  Fly  1832 YLSYRTMKHF--------LEDLQPGMNTKKVLLAIADSYEFDQLPVRHNEDKH----NEEMAEVS 1884
            |:::.|:|.|        |.||         :..||...||..:.:|.||.|.    |::...::
Human   788 YITFETVKKFYTISGKETLSDL---------VTLIAGCKEFLDIQLRINEKKTLNTLNKDPNRIT 843

  Fly  1885 RFRPPSSSWDSSYTKTFLLLQAHFARQSLPNSDY-LT-DTKSALDNATRVMQAMVDYTAERGWLS 1947
            ...|......:...|...|:||...  .:|..|: || ||.....:.:|:.:          |||
Human   844 IRFPMEGRIKTREMKVNCLIQAQLG--CIPIQDFALTQDTAKIFRHGSRITR----------WLS 896

  Fly  1948 TTLVVQQ-----LMQSVIQARWF---------DGSEFLTLPGVNEDN------LDAFLNIPHDDY 1992
            ..:..|:     |:.|:|.|:.|         ..|:.|...|:...|      |.:|..|...|.
Human   897 DFVAAQEKKFAVLLNSLILAKCFRCKLWENSLHVSKQLEKIGITLSNAIVNAGLTSFKKIEETDA 961

  Fly  1993 DYLTL-----PVLKELCKQEYEVLAKPLRDAFEEHEIEKMYKVIQDLPEIAIQIFVEGRHMENEY 2052
            ..|.|     |......|:....|.|      .|.::|::.:......||.:.:.:  |:.|...
Human   962 RELELILNRHPPFGTQIKETVMYLPK------YELKVEQITRYSDTTAEILVTVIL--RNFEQLQ 1018

  Fly  2053 AKRPLS-------LSDDTRGEWMSLHANEDYVLI 2079
            .||..|       :..|...:.:.||...|.||:
Human  1019 TKRTASDSHYVTLIIGDADNQVVYLHKITDSVLL 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309
		BRR2	485..1025	CDD:440817	8/29 (28%)
		DEXHc_ASCC3_1	486..683	CDD:350778
		SEC63	985..1298	CDD:214744	58/321 (18%)
		BRR2	1334..1859	CDD:440817	205/580 (35%)
		DEXHc_ASCC3_2	1336..1525	CDD:350780	86/202 (43%)
		SEC63	1818..2176	CDD:214744	71/308 (23%)
HFM1	NP_001017975.5	BRR2	264..798	CDD:440817	204/575 (35%)
		DEXHc_HFM1	280..488	CDD:350781	88/215 (41%)
		DEAH box	411..414		2/2 (100%)
		Sec63	777..1090	CDD:460740	71/305 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1109..1139
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1295..1315