Protein Alignment obe and HELQ

DIOPT Version :10

• Sequence 1: NP_650472.2
• Gene: obe / 41891
• FlyBaseID: FBgn0038344
• Length: 2183
• Species: Drosophila melanogaster
• Sequence 2: NP_598375.3
• Gene: HELQ / 113510
• HGNCID: 18536
• Length: 1101
• Species: Homo sapiens
• Alignment Length: 1357
• Identity: 281/1357 - (20%)
• Similarity: 468/1357 - (34%)
• Gaps: 431/1357 - (31%)

  Fly    11 LRAKTELEARSR-RLNVLRQARTTSAASTTTNSQNKEEQTIA------RLLAQMPTEKQPAAKVQ 68
            :|.:..|..|:| .|..:..|.|  ||......:.|||:.:.      :....:|.|.||.
Human     8 IRRRVSLPKRNRPSLGCIFGAPT--AAELVPGDEGKEEEEMVAENRRRKTAGVLPVEVQPL---- 66

  Fly    69 LQKLRNLVQECM---GYEEQPQVVEHAALFLFWLLLDQRVLLVATTQRLHG---------MFG-- 119
               |.:...||:   |.:..|.::.|                 ..|.|..|         |||
Human    67 ---LLSDSPECLVLGGGDTNPDLLRH-----------------MPTDRGVGDQPNDSEVDMFGDY 111

  Fly   120 QTFDRKK--TQIHDCVQAIGDLLEDHERSALKRWRQTHHKVPGVGPLWGAHIHVKCTPSEWMDIS 182
            .:|....  .|:.|..|....|.| |::.|
Human   112 DSFTENSFIAQVDDLEQKYMQLPE-HKKHA----------------------------------- 140

  Fly   183 LLTDLAPDALLKNRTVNKFSMKHTTKAAPVASTSSEAAKLSPELQTLLEISAKLDDEHLIIRVG- 246
              ||.|.:.|......||.|:  ||           ...|: ||||......:...|.:.|..|
Human   141 --TDFATENLCSESIKNKLSI--TT-----------IGNLT-ELQTDKHTENQSGYEGVTIEPGA 189

  Fly   247 DILGSQRSSEVLQNELMEILGFDYFELVEKLLMERDKIARQLDQFATRSRRVMEVKQKRMEAAAS 311
            |:|....||:.:           |||          .:....:.....|     :|::..::::.
Human   190 DLLYDVPSSQAI-----------YFE----------NLQNSSNDLGDHS-----MKERDWKSSSH 228

  Fly   312 GGAAERRPTVASAVVVQSAQEKQLSKMQRREEKKLQRIMRSIKDEEAEDDPNCAVAVSVQQLRMQ 376
            ....|..|...    ::..|:...|..:.|....:.| .:||||..    .|.....:..|..:.
Human   229 NTVNEELPHNC----IEQPQQNDESSSKVRTSSDMNR-RKSIKDHL----KNAMTGNAKAQTPIF 284

  Fly   377 HQRKLLEAAQREPLLLSTK--AAKAEYKQSS------YNQPIHYPYVFDSQLLAKQHAGFIGGSR 433
            .:.|     |.:..|||.:  .||...:.||      |:.|         ..:...:|.|.|..:
Human   285 SRSK-----QLKDTLLSEEINVAKKTVESSSNDLGPFYSLP---------SKVRDLYAQFKGIEK 335

  Fly   434 ITLPDNAQRIDNKQWEEVKIPASEPPPLSVGNKRVQIEELDDVGRLAFANCKELNRIQSVVFPVA 498
            :           .:|:.                                .|..||.:|
Human   336 L-----------YEWQH--------------------------------TCLTLNSVQ------- 350

  Fly   499 YHSNENMLVCAPTGAGKTNVAMLSIVHTIRCHLEQGVINRDEFKIVYIAPMKALAAEMVDNFSKR 563
              ..:|::...||..|||.||.:.::..:.|      ..:|   ::.|.|..|:..|.:...|..
Human   351 --ERKNLIYSLPTSGGKTLVAEILMLQELLC------CRKD---VLMILPYVAIVQEKISGLSSF 404

  Fly   564 LKSLQIAVRELTGDIQLTKAEMAATQ------ILVTTPEKWDVVTRKGSGDVALISLVE------ 616
            ...|...|.|..|    :|.....|:      :.:.|.||         |...:.||:|
Human   405 GIELGFFVEEYAG----SKGRFPPTKRREKKSLYIATIEK---------GHSLVNSLIETGRIDS 456

  Fly   617 --LLIIDEVHLL-HGERGPVVEALVARTLRLVESSQSMIRIVGLSATLPNYIDVAHFLRVNPMKG 678
              |:::||:|:: .|.||..:|..:|:.|...:::|    |:|:||||.|..|:..||:..
Human   457 LGLVVVDELHMIGEGSRGATLEMTLAKILYTSKTTQ----IIGMSATLNNVEDLQKFLQAE---- 513

  Fly   679 LFYFDSRFRPVPL-------DT------------NFVGIKSVKQLQQIADMDQCCYQKCVEMVQE 724
              |:.|:||||.|       ||            .|..:.:.|....:..||.......|..|..
Human   514 --YYTSQFRPVELKEYLKINDTIYEVDSKAENGMTFSRLLNYKYSDTLKKMDPDHLVALVTEVIP 576

  Fly   725 GHQIMVFVHARNATVRTANVIRELAQQNNTSALFLPKDSAAHGLATRSIQRSRNKQLVELFS--- 786
            .:..:||..::......|.:|          ..||.|:...|          :.|:..|:..
Human   577 NYSCLVFCPSKKNCENVAEMI----------CKFLSKEYLKH----------KEKEKCEVIKNLK 621

  Fly   787 -------C---------GLAMHHAGMLRADRQMVEKYFVEGHISVLVCTATLAWGVNLPAHAVII 835
                   |         |:|.||:|:...:|:::|:.:..|.:.:..||:|||.||||||..||:
Human   622 NIGNGNLCPVLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVIL 686

  Fly   836 RGTDIYDAKHGSFVDLGILDVLQIFGRAGRPQFDKSGVGTIITSYDKLNHYLSLLTNQFPIESNF 900
            |..  |.||  .|:...  ...|:.|||||...|..|...:|.........|.|:|.  |:|
Human   687 RAP--YVAK--EFLKRN--QYKQMIGRAGRAGIDTIGESILILQEKDKQQVLELITK--PLE--- 740

  Fly   901 VNCLADNLNAE------------IGLGTITNVDEAIEWLSYTYLFVRMRINPHVYGIEYSELEKD 953
             ||.: :|..|            |||...||:|:...:::.|:           :|::...|.|:
Human   741 -NCYS-HLVQEFTKGIQTLFLSLIGLKIATNLDDIYHFMNGTF-----------FGVQQKVLLKE 792

  Fly   954 P-----TLEARRRALIMSAAMSLDKARMMRFNQRTM-DMNITDLGRTA-------SYFYIKYDTV 1005
            .     |:|:.|   .::....|.|..:.:..:... :.:||.|||.:       :|..|.|..:
Human   793 KSLWEITVESLR---YLTEKGLLQKDTIYKSEEEVQYNFHITKLGRASFKGTIDLAYCDILYRDL 854

  Fly  1006 ETFNE------------LMKPFMTQAEILAMISQA--------QEFQQLKVRDDEMEELDELKNA 1050
            :...|            |..|:       .::||.        ::|.||...:..:..:..:..:
Human   855 KKGLEGLVLESLLHLIYLTTPY-------DLVSQCNPDWMIYFRQFSQLSPAEQNVAAILGVSES 912

  Fly  1051 YCKIKPYGGSENVHGKVNILIQTYLSNGYVKSFSLSSDMSYITTNIGRISRALFSIV------LR 1109
            :...|..|.:.......|::.:.||      ||.|.:.:.  .|||..:|.. |::.      |.
Human   913 FIGKKASGQAIGKKVDKNVVNRLYL------SFVLYTLLK--ETNIWTVSEK-FNMPRGYIQNLL 968

  Fly  1110 QNNAVLSGNMLQLCKMFERRQWDFDCHLKQFP-----TINAETIDKLERRGLSVYRLRDMEHREL 1169
            ...|..|..:|..|:..| ..|.:...|.:..     .:.||.|..:|..|:...|.:.:.....
Human   969 TGTASFSSCVLHFCEELE-EFWVYRALLVELTKKLTYCVKAELIPLMEVTGVLEGRAKQLYSAGY 1032

  Fly  1170 KEWLR-SNTYADLVIR--------------SAHELPLLEVEASLQPITRTVLRIKVD 1211
            |..:. :|...::::|              |:.::.|.|...:||.....:||:..|
Human  1033 KSLMHLANANPEVLVRTIDHLSRRQAKQIVSSAKMLLHEKAEALQEEVEELLRLPSD 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
obe	NP_650472.2	Helicase_PWI	<247..>284	CDD:436309	7/36 (19%)
		BRR2	485..1025	CDD:440817	148/629 (24%)
		DEXHc_ASCC3_1	486..683	CDD:350778	53/211 (25%)
		SEC63	985..1298	CDD:214744	54/280 (19%)
		BRR2	1334..1859	CDD:440817
		DEXHc_ASCC3_2	1336..1525	CDD:350780
		SEC63	1818..2176	CDD:214744
HELQ	NP_598375.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..261		7/57 (12%)
		BRR2	319..887	CDD:440817	156/714 (22%)
		DEXHc_POLQ-like	319..521	CDD:350784	61/294 (21%)
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	463..466		2/2 (100%)
		HHH_5	1013..1066	CDD:434010	7/52 (13%)