DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNAJB9 and CG3061

DIOPT Version :9

Sequence 1:	NP_036460.1	Gene:	DNAJB9 / 4189	HGNCID:	6968	Length:	223	Species:	Homo sapiens
Sequence 2:	NP_650328.1	Gene:	CG3061 / 41707	FlyBaseID:	FBgn0038195	Length:	370	Species:	Drosophila melanogaster

Alignment Length:	142	Identity:	51/142 - (35%)
Similarity:	76/142 - (53%)	Gaps:	16/142 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    25 KSYYDILGVPKSASERQIKKAFHKLAMKYHPDKNKSPDAEAKFREIAEAYETLSDANRRKEYDTL 89
            |.||::|||.|:|::.:||||:.|||::.||||||:|.|...|:.:..|...|:||.:||.||..
  Fly   105 KDYYEVLGVSKTATDSEIKKAYKKLALQLHPDKNKAPGAVEAFKALGNAAGVLTDAEKRKNYDLY 169

Human    90 GHSAFTSGKGQRGSG---------SSFEQSFNFNFD----DLFKDF---GFFGQNQNTGSKKRFE 138
            |.:...:|.|..|.|         :.:..|..|..|    :||..|   ||..||.:...::|.:
  Fly   170 GINESHNGHGNNGGGHHGHGQYYNNEYGYSRGFQADISAEELFNMFFNGGFPQQNVHMRQQRRRQ 234

Human   139 NHFQTRQDGGSS 150
            ...:.|:...||
  Fly   235 QAREDREGNNSS 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAJB9	NP_036460.1	type 2 signal-anchor for ER localization	7..23
		DnaJ	26..>136	CDD:333066	46/125 (37%)
		Divergent targeting domain. /evidence=ECO:0000250\|UniProtKB:Q9QYI6	91..223		18/76 (24%)
CG3061	NP_650328.1	DnaJ	105..>224	CDD:223560	45/118 (38%)
		DnaJ	106..167	CDD:278647	29/60 (48%)
		DUF1977	269..366	CDD:286411
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1173544at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820