DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh6 and Opn1mw

DIOPT Version :9

Sequence 1:	NP_524368.5	Gene:	Rh6 / 41889	FlyBaseID:	FBgn0019940	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_446000.1	Gene:	Opn1mw / 89810	RGDID:	620978	Length:	359	Species:	Rattus norvegicus

Alignment Length:	348	Identity:	92/348 - (26%)
Similarity:	158/348 - (45%)	Gaps:	40/348 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VDPYW-YQWPPLEPMWFGIIGFVIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFM 95
            :.|.| |.   |...|..::  |||     |:..|.:|:......|.||.|.|..:||||.:|..
  Rat    42 IAPRWVYH---LTSTWMILV--VIA-----SVFTNGLVLAATMRFKKLRHPLNWILVNLAVADLA 96

  Fly    96 MMFTMFPPVVLNGFYGTWIMGPFLCELYGMFGSLFGCVSIWSMTLIAYDRYCVIVKGMARKPLTA 160
            .........|:|..||.:::|..||.:.|...||.|...:||:.:|:::|:.|:.|........|
  Rat    97 ETIIASTISVVNQIYGYFVLGHPLCVIEGYIVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDA 161

  Fly   161 TAAVLRLMVVWTICGAWALMPLFGWNRYVPEGNMTACGTDYFAKDWWN--RSYIIVYSLWVYLTP 223
            ..|.:.::..|.....|...|:|||:||.|.|..|:||.|.|:...:.  :||::|..:...:.|
  Rat   162 KLATVGIVFSWVWAAVWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIFP 226

  Fly   224 LLTIIFSY---WHIMKAVAAHEKAMREQAKKMNVASLRNSEADKSKAIEIKLAKVALTTISLWFF 285
            |..|:..|   |..::|||..:|                 |::.::..|.::.::.:..:..:..
  Rat   227 LSIIVLCYLQVWLAIRAVAKQQK-----------------ESESTQKAEKEVTRMVVVMVFAYCL 274

  Fly   286 AWTPYTIINYAGIFESMH----LSPLSTICGSVFAKANAVCNPIVYGLSHPKYKQVLREKMPCLA 346
            .|.|||   :...|.:.|    ..||.....|.|||:..:.|||:|...:.:::..:.:......
  Rat   275 CWGPYT---FFACFATAHPGYAFHPLVASLPSYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKV 336

  Fly   347 CGKDDLTSDSRTQATAEISESQA 369
            ....:|:|.|:|:.::..|.|.|
  Rat   337 DDSSELSSTSKTEVSSVSSVSPA 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh6	NP_524368.5	7tmA_photoreceptors_insect	48..338	CDD:320207	80/298 (27%)
		TM helix 1	50..74	CDD:320207	6/23 (26%)
		TM helix 2	83..105	CDD:320207	6/21 (29%)
		TM helix 3	121..143	CDD:320207	7/21 (33%)
		TM helix 4	165..181	CDD:320207	2/15 (13%)
		TM helix 5	209..232	CDD:320207	7/25 (28%)
		TM helix 6	273..295	CDD:320207	4/21 (19%)
		TM helix 7	306..331	CDD:320207	10/24 (42%)
Opn1mw	NP_446000.1	Required for 11-cis-retinal regeneration. /evidence=ECO:0000250\|UniProtKB:P04001	12..38
Opn1mw	NP_446000.1	7tm_1	66..317	CDD:278431	75/270 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910