DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh6 and OPN1SW

DIOPT Version :9

Sequence 1:	NP_524368.5	Gene:	Rh6 / 41889	FlyBaseID:	FBgn0019940	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001372054.1	Gene:	OPN1SW / 611	HGNCID:	1012	Length:	345	Species:	Homo sapiens

Alignment Length:	343	Identity:	90/343 - (26%)
Similarity:	168/343 - (48%)	Gaps:	42/343 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LEPMWFGIIGFVI--AILGTMSLAG---NFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMM-MFTM 100
            :.|:|    .|.:  |.:||:.|.|   |.:|:......|.||.|.|..:||::|..|:: :|::
Human    25 IAPVW----AFYLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSV 85

  Fly   101 FPPVV--LNGFYGTWIMGPFLCELYGMFGSLFGCVSIWSMTLIAYDRYCVIVKGMARKPLTATAA 163
            ||..|  .||::   :.|..:|.|.|..|::.|.|:.||:..:|::||.||.|.......::..|
Human    86 FPVFVASCNGYF---VFGRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGNFRFSSKHA 147

  Fly   164 VLRLMVVWTICGAWALMPLFGWNRYVPEGNMTACGTDYF--AKDWWNRSYIIVYSLWVYLTPLLT 226
            :..::..|||....::.|.|||:|::|||...:||.|::  ...:.:.||.....::.::.||..
Human   148 LTVVLATWTIGIGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSL 212

  Fly   227 IIFSYWHIMKAVAAHEKAMREQAKKMNVASLRNSEADKSKAIEIKLAKVALTTISLWFFAWTPYT 291
            |.|||..:::|:.|             ||:.:...|...|| |.:::::.:..:..:...:.||.
Human   213 ICFSYTQLLRALKA-------------VAAQQQESATTQKA-EREVSRMVVVMVGSFCVCYVPYA 263

  Fly   292 IINYAGIFESMHLSPLSTI-CGSVFAKANAVCNPIVYGLSHPKYKQVLREKMPCLACGK-----D 350
            ......:....|...|..: ..|.|:|:..:.|||:|...:.:::..:.:    :.|||     .
Human   264 AFAMYMVNNRNHGLDLRLVTIPSFFSKSACIYNPIIYCFMNKQFQACIMK----MVCGKAMTDES 324

  Fly   351 DLTSDSRTQATAEISESQ 368
            |..|..:|:.:. :|.:|
Human   325 DTCSSQKTEVST-VSSTQ 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh6	NP_524368.5	7tmA_photoreceptors_insect	48..338	CDD:320207	80/300 (27%)
		TM helix 1	50..74	CDD:320207	8/28 (29%)
		TM helix 2	83..105	CDD:320207	8/22 (36%)
		TM helix 3	121..143	CDD:320207	7/21 (33%)
		TM helix 4	165..181	CDD:320207	3/15 (20%)
		TM helix 5	209..232	CDD:320207	7/22 (32%)
		TM helix 6	273..295	CDD:320207	2/21 (10%)
		TM helix 7	306..331	CDD:320207	8/25 (32%)
OPN1SW	NP_001372054.1	7tmA_SWS1_opsin	32..311	CDD:320204	79/295 (27%)
		TM helix 1	34..58	CDD:320204	7/23 (30%)
		TM helix 2	67..89	CDD:320204	8/21 (38%)
		TM helix 3	105..127	CDD:320204	7/21 (33%)
		TM helix 4	149..165	CDD:320204	3/15 (20%)
		TM helix 5	195..218	CDD:320204	7/22 (32%)
		TM helix 6	245..267	CDD:320204	2/21 (10%)
		TM helix 7	279..304	CDD:320204	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910