Protein Alignment Rh6 and RHO

DIOPT Version :10

• Sequence 1: NP_524368.5
• Gene: Rh6 / 41889
• FlyBaseID: FBgn0019940
• Length: 363
• Species: Drosophila melanogaster
• Sequence 2: NP_000530.1
• Gene: RHO / 6010
• HGNCID: 10012
• Length: 348
• Species: Homo sapiens
• Alignment Length: 339
• Identity: 91/339 - (26%)
• Similarity: 171/339 - (50%)
• Gaps: 24/339 - (7%)

  Fly    34 PYWY-QWPPLEPMWFGIIGFVIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMM 97
            |:.| |:...||..|.::...:.:|..:....||:.:|:....|.||||.|..::|||.:|..|:
Human    23 PFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMV 87

  Fly    98 FTMFPPVVLNGFYGTWIMGPFLCELYGMFGSLFGCVSIWSMTLIAYDRYCVIVKGMARKPLTATA 162
            ...|...:....:|.::.||..|.|.|.|.:|.|.:::||:.::|.:||.|:.|.|:........
Human    88 LGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENH 152

  Fly   163 AVLRLMVVWTICGAWALMPLFGWNRYVPEGNMTACGTDYFA-KDWWNRSYIIVYSLWVYLT-PLL 225
            |::.:...|.:..|.|..||.||:||:|||...:||.||:. |...|....::|...|:.| |::
Human   153 AIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMI 217

  Fly   226 TIIFSYWHIMKAVAAHEKAMREQAKKMNVASLRNSEADKSKAIEIKLAKVALTTISLWFFAWTPY 290
            .|.|.|..::..|  .|.|.::|            |:..::..|.::.::.:..:..:...|.||
Human   218 IIFFCYGQLVFTV--KEAAAQQQ------------ESATTQKAEKEVTRMVIIMVIAFLICWVPY 268

  Fly   291 -TIINYAGIFESMHLSPLSTICGSVFAKANAVCNPIVYGLSHPKYKQVLREKMPCLACGKDDLTS 354
             ::..|....:..:..|:.....:.|||:.|:.||::|.:.:.:::..:   :..:.|||:.|..
Human   269 ASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCM---LTTICCGKNPLGD 330

  Fly   355 DSRTQATAEISESQ 368
            |   :|:|.:|:::
Human   331 D---EASATVSKTE 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rh6	NP_524368.5	7tmA_photoreceptors_insect	48..338	CDD:320207	77/292 (26%)
		TM helix 1	49..75	CDD:320207	4/25 (16%)
		TM helix 2	82..108	CDD:320207	7/25 (28%)
		TM helix 3	120..150	CDD:320207	12/29 (41%)
		TM helix 4	161..181	CDD:320207	4/19 (21%)
		TM helix 5	208..237	CDD:320207	8/29 (28%)
		TM helix 6	267..297	CDD:320207	5/30 (17%)
		TM helix 7	306..331	CDD:320207	8/24 (33%)
RHO	NP_000530.1	Rhodopsin_N	3..37	CDD:313611	5/13 (38%)
		7tmA_MWS_opsin	38..317	CDD:381742	77/292 (26%)
		TM helix 1	39..65	CDD:381742	4/25 (16%)
		TM helix 2	72..99	CDD:381742	7/26 (27%)
		TM helix 3	110..140	CDD:381742	12/29 (41%)
		'Ionic lock' involved in activated form stabilization. /evidence=ECO:0000305|PubMed:26200343	134..136		0/1 (0%)
		TM helix 4	151..173	CDD:381742	5/21 (24%)
		TM helix 5	200..230	CDD:381742	7/29 (24%)
		TM helix 6	245..275	CDD:381742	4/29 (14%)
		TM helix 7	285..310	CDD:381742	8/24 (33%)
		Interaction with SAG. /evidence=ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425	330..348		4/15 (27%)