DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh6 and RHO

DIOPT Version :9

Sequence 1:	NP_524368.5	Gene:	Rh6 / 41889	FlyBaseID:	FBgn0019940	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_000530.1	Gene:	RHO / 6010	HGNCID:	10012	Length:	348	Species:	Homo sapiens

Alignment Length:	339	Identity:	91/339 - (26%)
Similarity:	171/339 - (50%)	Gaps:	24/339 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PYWY-QWPPLEPMWFGIIGFVIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMM 97
            |:.| |:...||..|.::...:.:|..:....||:.:|:....|.||||.|..::|||.:|..|:
Human    23 PFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMV 87

  Fly    98 FTMFPPVVLNGFYGTWIMGPFLCELYGMFGSLFGCVSIWSMTLIAYDRYCVIVKGMARKPLTATA 162
            ...|...:....:|.::.||..|.|.|.|.:|.|.:::||:.::|.:||.|:.|.|:........
Human    88 LGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENH 152

  Fly   163 AVLRLMVVWTICGAWALMPLFGWNRYVPEGNMTACGTDYFA-KDWWNRSYIIVYSLWVYLT-PLL 225
            |::.:...|.:..|.|..||.||:||:|||...:||.||:. |...|....::|...|:.| |::
Human   153 AIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMI 217

  Fly   226 TIIFSYWHIMKAVAAHEKAMREQAKKMNVASLRNSEADKSKAIEIKLAKVALTTISLWFFAWTPY 290
            .|.|.|..::..|  .|.|.::|            |:..::..|.::.::.:..:..:...|.||
Human   218 IIFFCYGQLVFTV--KEAAAQQQ------------ESATTQKAEKEVTRMVIIMVIAFLICWVPY 268

  Fly   291 -TIINYAGIFESMHLSPLSTICGSVFAKANAVCNPIVYGLSHPKYKQVLREKMPCLACGKDDLTS 354
             ::..|....:..:..|:.....:.|||:.|:.||::|.:.:.:::..:   :..:.|||:.|..
Human   269 ASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCM---LTTICCGKNPLGD 330

  Fly   355 DSRTQATAEISESQ 368
            |   :|:|.:|:::
Human   331 D---EASATVSKTE 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh6	NP_524368.5	7tmA_photoreceptors_insect	48..338	CDD:320207	77/292 (26%)
		TM helix 1	50..74	CDD:320207	4/23 (17%)
		TM helix 2	83..105	CDD:320207	7/21 (33%)
		TM helix 3	121..143	CDD:320207	7/21 (33%)
		TM helix 4	165..181	CDD:320207	3/15 (20%)
		TM helix 5	209..232	CDD:320207	6/23 (26%)
		TM helix 6	273..295	CDD:320207	3/22 (14%)
		TM helix 7	306..331	CDD:320207	8/24 (33%)
RHO	NP_000530.1	Rhodopsin_N	3..37	CDD:313611	5/13 (38%)
		7tmA_MWS_opsin	38..317	CDD:381742	77/292 (26%)
		TM helix 1	40..64	CDD:381742	4/23 (17%)
		TM helix 2	73..95	CDD:381742	7/21 (33%)
		TM helix 3	111..133	CDD:381742	7/21 (33%)
		'Ionic lock' involved in activated form stabilization. /evidence=ECO:0000305\|PubMed:26200343	134..136		0/1 (0%)
		TM helix 4	155..171	CDD:381742	3/15 (20%)
		TM helix 5	201..224	CDD:381742	6/22 (27%)
		TM helix 6	251..273	CDD:381742	3/21 (14%)
		TM helix 7	285..310	CDD:381742	8/24 (33%)
		Interaction with SAG. /evidence=ECO:0000269\|PubMed:26200343, ECO:0000269\|PubMed:28753425	330..348		4/15 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6219
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860