Protein Alignment Rh6 and RGR

DIOPT Version :10

• Sequence 1: NP_524368.5
• Gene: Rh6 / 41889
• FlyBaseID: FBgn0019940
• Length: 363
• Species: Drosophila melanogaster
• Sequence 2: NP_002912.2
• Gene: RGR / 5995
• HGNCID: 9990
• Length: 295
• Species: Homo sapiens
• Alignment Length: 315
• Identity: 81/315 - (25%)
• Similarity: 122/315 - (38%)
• Gaps: 49/315 - (15%)

  Fly    44 PMWFG-----IIGFVIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMMFTMFPP 103
            |..||     .:|.|:.:.....|:.|.:.::.|..:..||||.::.|::||.:|..:.......
Human     8 PTGFGELEVLAVGMVLLVEALSGLSLNTLTIFSFCKTPELRTPCHLLVLSLALADSGISLNALVA 72

  Fly   104 V---VLNGFYGTWIMGPFLCELYGMFGSLFGCVSIWSMTLIA---YDRYCVIVKGMARKPLTATA 162
            .   :|...:..|..|...|:.:|..|.:....||.|...||   |..||      .|..|...:
Human    73 ATSSLLRVSHRRWPYGSDGCQAHGFQGFVTALASICSSAAIAWGRYHHYC------TRSQLAWNS 131

  Fly   163 AVLRLMVVWTICGAWALMPLFGWNRYVPEGNMTACGTDYFAKDWWNRSYIIVYSLWVYLTPLLTI 227
            ||..::.||.....||.:||.||..|..|...|.|..||...|....|::...|.:.:..||...
Human   132 AVSLVLFVWLSSAFWAALPLLGWGHYDYEPLGTCCTLDYSKGDRNFTSFLFTMSFFNFAMPLFIT 196

  Fly   228 IFSYWHIMKAVAAHEKAMREQAKKMNVASLRNSEADKSKAIEIKLAKVALTTISLWFFAWTPYTI 292
            |.||                        ||...:..||..:::.....|.|.:    ..|.||.|
Human   197 ITSY------------------------SLMEQKLGKSGHLQVNTTLPARTLL----LGWGPYAI 233

  Fly   293 IN-YAGIFESMHLSPLSTICGSVFAKANAVCNPIVYGLSHPKYKQVLREKMPCLA 346
            :. ||.|.:...:||...:..::.||.....|.|.|.|.:   :.|.|....||:
Human   234 LYLYAVIADVTSISPKLQMVPALIAKMVPTINAINYALGN---EMVCRGIWQCLS 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rh6	NP_524368.5	7tmA_photoreceptors_insect	48..338	CDD:320207	75/301 (25%)
		TM helix 1	49..75	CDD:320207	5/25 (20%)
		TM helix 2	82..108	CDD:320207	5/28 (18%)
		TM helix 3	120..150	CDD:320207	11/32 (34%)
		TM helix 4	161..181	CDD:320207	6/19 (32%)
		TM helix 5	208..237	CDD:320207	7/28 (25%)
		TM helix 6	267..297	CDD:320207	7/30 (23%)
		TM helix 7	306..331	CDD:320207	7/24 (29%)
RGR	NP_002912.2	7tmA_Retinal_GPR	17..281	CDD:320200	76/300 (25%)
		TM helix 1	18..44	CDD:320200	5/25 (20%)
		TM helix 2	51..77	CDD:320200	4/25 (16%)
		TM helix 3	92..122	CDD:320200	9/29 (31%)
		TM helix 4	130..150	CDD:320200	6/19 (32%)
		TM helix 5	177..206	CDD:320200	9/52 (17%)
		TM helix 6	208..238	CDD:320200	8/33 (24%)
		TM helix 7	248..273	CDD:320200	7/24 (29%)