DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh6 and OPN1MW

DIOPT Version :9

Sequence 1:	NP_524368.5	Gene:	Rh6 / 41889	FlyBaseID:	FBgn0019940	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_000504.1	Gene:	OPN1MW / 2652	HGNCID:	4206	Length:	364	Species:	Homo sapiens

Alignment Length:	398	Identity:	103/398 - (25%)
Similarity:	171/398 - (42%)	Gaps:	72/398 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASLHPPS----------FAYMR--------DGRNLSLAESVPAEIMHMVDPYWYQWPPLEPMWF 47
            :|..||..          |.|..        :|.|..:|   |..:.|           |..:|
Human    10 LAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIA---PRWVYH-----------LTSVW- 59

  Fly    48 GIIGFVIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMMFTMFPPVVLNGFYGT 112
             :|..|||     |:..|.:|:......|.||.|.|..:||||.:|...........|:|..||.
Human    60 -MIFVVIA-----SVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGY 118

  Fly   113 WIMGPFLCELYGMFGSLFGCVSIWSMTLIAYDRYCVIVKGMARKPLTATAAVLRLMVVWTICGAW 177
            :::|..:|.|.|...||.|...:||:.:|:::|:.|:.|........|..|::.:...|.....|
Human   119 FVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVW 183

  Fly   178 ALMPLFGWNRYVPEGNMTACGTDYFAKDWWN--RSYIIVYSLWVYLTPLLTIIFSY---WHIMKA 237
            ...|:|||:||.|.|..|:||.|.|:...:.  :||:||..:...:|||..|:..|   |..::|
Human   184 TAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRA 248

  Fly   238 VAAHEKAMREQAKKMNVASLRNSEADKSKAIEIKLAKVALTTISLWFFAWTPYTIIN-YAGIFES 301
            ||..:|                 |::.::..|.::.::.:..:..:.|.|.||.... :|.....
Human   249 VAKQQK-----------------ESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPG 296

  Fly   302 MHLSPLSTICGSVFAKANAVCNPIVYGLSHPKYKQVLREKMPCLACGK--DD---LTSDSRTQAT 361
            ....||.....:.|||:..:.||::|...:.:::..:.:..     ||  ||   |:|.|:|:.:
Human   297 YPFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLF-----GKKVDDGSELSSASKTEVS 356

  Fly   362 AEISESQA 369
            :..|.|.|
Human   357 SVSSVSPA 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh6	NP_524368.5	7tmA_photoreceptors_insect	48..338	CDD:320207	80/295 (27%)
		TM helix 1	50..74	CDD:320207	7/23 (30%)
		TM helix 2	83..105	CDD:320207	6/21 (29%)
		TM helix 3	121..143	CDD:320207	8/21 (38%)
		TM helix 4	165..181	CDD:320207	2/15 (13%)
		TM helix 5	209..232	CDD:320207	9/25 (36%)
		TM helix 6	273..295	CDD:320207	4/22 (18%)
		TM helix 7	306..331	CDD:320207	8/24 (33%)
OPN1MW	NP_000504.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		3/12 (25%)
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000269\|PubMed:30948514	17..43		2/25 (8%)
		7tm_4	61..>178	CDD:304433	36/121 (30%)
		7tm_1	71..322	CDD:278431	74/267 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910