DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rh6 and Rho

DIOPT Version :9

Sequence 1:	NP_524368.5	Gene:	Rh6 / 41889	FlyBaseID:	FBgn0019940	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	XP_038962987.1	Gene:	Rho / 24717	RGDID:	3573	Length:	358	Species:	Rattus norvegicus

Alignment Length:	347	Identity:	93/347 - (26%)
Similarity:	165/347 - (47%)	Gaps:	34/347 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PYWYQWPPLEPMWFGIIGFVIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMMF 98
            |.:|.   .||..|.::...:.:|..:....||:.:|:....|.||||.|..::|||.:|..|:|
  Rat    27 PQYYL---AEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVF 88

  Fly    99 TMFPPVVLNGFYGTWIMGPFLCELYGMFGSLFGCVSIWSMTLIAYDRYCVIVKGMARKPLTATAA 163
            ..|...:....:|.::.||..|.|.|.|.:|.|.:.:||:.::|.:||.|:.|.|:........|
  Rat    89 GGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIGLWSLVVLAIERYVVVCKPMSNFRFGENHA 153

  Fly   164 VLRLMVVWTICGAWALMPLFGWN----------RYVPEGNMTACGTDYFA-KDWWNRSYIIVYSL 217
            ::.:...|.:..|.|..||.||:          ||:|||...:||.||:. |...|....::|..
  Rat   154 IMGVAFTWVMALACAAPPLVGWSSVFSPCFITLRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMF 218

  Fly   218 WVYLT-PLLTIIFSYWHIMKAVAAHEKAMREQAKKMNVASLRNSEADKSKAIEIKLAKVALTTIS 281
            .|:.| |::.|.|.|..::..|  .|.|.::|            |:..::..|.::.::.:..:.
  Rat   219 VVHFTIPMIVIFFCYGQLVFTV--KEAAAQQQ------------ESATTQKAEKEVTRMVIIMVI 269

  Fly   282 LWFFAWTPY-TIINYAGIFESMHLSPLSTICGSVFAKANAVCNPIVYGLSHPKYKQVLREKMPCL 345
            .:...|.|| ::..|....:..:..|:.....:.|||..::.|||:|.:.:.:::..:   :..|
  Rat   270 FFLICWLPYASVAMYIFTHQGSNFGPIFMTLPAFFAKTASIYNPIIYIMMNKQFRNCM---LTTL 331

  Fly   346 ACGKDDLTSDSRTQATAEISES 367
            .|||:.| .|....|||..:|:
  Rat   332 CCGKNPL-GDDEASATASKTET 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh6	NP_524368.5	7tmA_photoreceptors_insect	48..338	CDD:320207	78/302 (26%)
		TM helix 1	50..74	CDD:320207	4/23 (17%)
		TM helix 2	83..105	CDD:320207	8/21 (38%)
		TM helix 3	121..143	CDD:320207	7/21 (33%)
		TM helix 4	165..181	CDD:320207	3/15 (20%)
		TM helix 5	209..232	CDD:320207	6/23 (26%)
		TM helix 6	273..295	CDD:320207	3/22 (14%)
		TM helix 7	306..331	CDD:320207	8/24 (33%)
Rho	XP_038962987.1	Rhodopsin_N	3..37	CDD:313611	4/12 (33%)
		7tmA_MWS_opsin	38..327	CDD:381742	78/302 (26%)
		TM helix 1	40..64	CDD:381742	4/23 (17%)
		TM helix 2	73..95	CDD:381742	8/21 (38%)
		TM helix 3	111..133	CDD:381742	7/21 (33%)
		TM helix 4	155..171	CDD:381742	3/15 (20%)
		TM helix 5	211..234	CDD:381742	6/22 (27%)
		TM helix 6	261..283	CDD:381742	3/21 (14%)
		TM helix 7	295..320	CDD:381742	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910